Synthesis and preliminary evaluation of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones as angiogenesis inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 7, 2016, Pages 1813-1816

  Kirk, Nicholas S ^a   Bezos, Anna ^b   Willis, Anthony C ^c   Sudta, Pichit ^d,e   Suksamrarn, Sunit ^e   Parish, Christopher R ^b   Ranson, Marie ^a   Kelso, Michael J ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b Biology and Environment   (Australia)

^c AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^d PHETCHABURI RAJABHAT UNIVERSITY   (Thailand)

^e SRINAKHARINWIROT UNIVERSITY   (Thailand)

Author keywords

3H Pyrrolizin 3 one; Angiogenesis inhibitor; Knoevenagel; Semaxanib; SU5416; Sunitinib

Indexed keywords

5,7 DIMETHYL 2 ARYL 3 H PYRROLIZIN 3 ONE; ACRYLIC ACID DERIVATIVE; ANGIOGENESIS INHIBITOR; ARYLACETIC ACID DERIVATIVE; PHENYLACETIC ACID; PHENYLACETIC ACID DERIVATIVE; POTASSIUM SALT; REAGENT; SEMAXANIB; SUNITINIB; UNCLASSIFIED DRUG; INDOLE DERIVATIVE; PYRROLE DERIVATIVE;

ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; AORTIC RING (SLICE); ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SYNTHESIS; EVALUATION STUDY; NONHUMAN; ONE POT SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY; ANGIOGENESIS; ANIMAL; AORTA; CHEMISTRY; DRUG EFFECTS; HUMAN; METHYLATION; MOLECULAR MODEL; PHYSIOLOGY; SYNTHESIS; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOGENESIS INHIBITORS; ANIMALS; AORTA; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INDOLES; METHYLATION; MODELS, MOLECULAR; NEOVASCULARIZATION, PHYSIOLOGIC; PYRROLES; RATS;

EID: 85006067081     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.02.033     Document Type: Article

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