Fused bicyclic pyrrolizinones as new scaffolds for human NK1 antagonists

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 5, 2008, Pages 2156-2170

  Morriello, Gregori J ^a   DeVita, Robert J ^a   Mills, Sander G ^a   Young, Jonathan R ^a   Lin, Peter ^a   Doss, George ^a   Chicchi, Gary G ^a   DeMartino, Julie ^a   Kurtz, Marc M ^a   Tsao, Kwei Lan C ^a   Carlson, Emma ^a   Townson, Karen ^a   Wheeldon, Alan ^a   Boyce, Susan ^a   Collinson, Neil ^a   Rupniak, Nadia ^a   Moore, Stephen ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMIC ACID DERIVATIVE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; PYRROLIDINE DERIVATIVE; PYRROLIZINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BRAIN; CONTROLLED STUDY; DRUG ACTIVITY; DRUG PENETRATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; EXPERIMENTAL TEST; GERBIL; HUMAN; IN VIVO STUDY; NONHUMAN; STEREOCHEMISTRY;

AMIDES; BICYCLO COMPOUNDS, HETEROCYCLIC; EPOXY COMPOUNDS; HUMANS; HYDROXYLATION; METHYLATION; MOLECULAR STRUCTURE; PYRROLES; RECEPTORS, NEUROKININ-1; STEREOISOMERISM; UREA;

GERBILLINAE;

EID: 40749106942     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.081     Document Type: Article

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