Antisense locked nucleic acids targeting agrA inhibit quorum sensing and pathogenesis of community-associated methicillin-resistant Staphylococcus aureus

Journal of Applied Microbiology

Volumn 122, Issue 1, 2017, Pages 257-267

  Da, F ^a   Yao, L ^a   Su, Z ^a   Hou, Z ^a   Li, Z ^a   Xue, X ^a   Meng, J ^a   Luo, X ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

agr; antisense; locked nucleic acid; methicillin resistant Staphylococcus aureus; skin infection; virulence

Indexed keywords

BACTERIA; BIOCHEMISTRY; GENE EXPRESSION; LOCKS (FASTENERS); OLIGONUCLEOTIDES; POLYMERASE CHAIN REACTION;

ACCESSORY GENE REGULATOR; ANTISENSE; GENE REGULATORS; INFECTION MODELS; LOCKED NUCLEIC ACID; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MOUSE SKIN; QUORUM-SENSING; SKIN INFECTION; VIRULENCE;

MAMMALS;

AGRA PROTEIN; ANTISENSE OLIGONUCLEOTIDE; BACTERIAL PROTEIN; LACTATE DEHYDROGENASE; LOCKED NUCLEIC ACID; MESSENGER RNA; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; OLIGONUCLEOTIDE;

BACTERIUM; CHEMOTAXIS; GENETIC ENGINEERING; INFECTIVITY; INHIBITION; MOLECULAR ANALYSIS; PATHOGENICITY; SENSORY SYSTEM; SKIN DISORDER; VIRULENCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTISENSE THERAPY; ARTICLE; BACTERIAL GROWTH; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; BACTERIOSTASIS; CHEMOTAXIS ASSAY; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; GENE EXPRESSION REGULATION; GROWTH CURVE; HEMOLYSIS; HEMOLYSIS ASSAY; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MOUSE; NONHUMAN; PROTEIN SECONDARY STRUCTURE; QUORUM SENSING; RELEASE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN INFECTION; ANIMAL; COMMUNITY-ACQUIRED INFECTIONS; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PHYSIOLOGY; STAPHYLOCOCCAL INFECTIONS; VIRULENCE;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

ANIMALS; BACTERIAL PROTEINS; COMMUNITY-ACQUIRED INFECTIONS; DNA, ANTISENSE; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; OLIGONUCLEOTIDES; QUORUM SENSING; STAPHYLOCOCCAL INFECTIONS; VIRULENCE;

EID: 85006026383     PISSN: 13645072     EISSN: 13652672     Source Type: Journal    
DOI: 10.1111/jam.13321     Document Type: Article

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