The N14 anti-afamin antibody Fab: A rare VL1 CDR glycosylation, crystallographic re-sequencing, molecular plasticity and conservative versus enthusiastic modelling

Acta Crystallographica Section D: Structural Biology

Volumn 72, Issue 12, 2016, Pages 1267-1280

  Naschberger, Andreas ^a   Fürnrohr, Barbara G ^a   Lenac Rovis, Tihana ^b   Malic, Suzana ^b   Scheffzek, Klaus ^a   Dieplinger, Hans ^a,c   Rupp, Bernhard ^a,d  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF RIJEKA   (Croatia)

^c Vitateq Biotechnology GmbH   (Austria)

^d K k Hofkristallamt   (United States)

Author keywords

accuracy; antibody fragment; elbow angle; flexibility; non apparent isomorphism; precision; solvent; solvent modelling; variable chain glycosylation

Indexed keywords

AFM PROTEIN, HUMAN; ANTIGEN ANTIBODY COMPLEX; CARRIER PROTEIN; COMPLEMENTARITY DETERMINING REGION; GLYCOPROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN VARIABLE REGION; MONOCLONAL ANTIBODY; SERUM ALBUMIN;

ANIMAL; ANTIGEN ANTIBODY COMPLEX; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; GLYCOSYLATION; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; MOLECULAR MODEL; MOUSE; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY COMPLEX; CARRIER PROTEINS; COMPLEMENTARITY DETERMINING REGIONS; CRYSTALLOGRAPHY, X-RAY; GLYCOPROTEINS; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MODELS, MOLECULAR; SERUM ALBUMIN;

EID: 85005980397     PISSN: None     EISSN: 20597983     Source Type: Journal    
DOI: 10.1107/S205979831601723X     Document Type: Article

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