Uptake of inorganic mercury by human locus ceruleus and corticomotor neurons: Implications for amyotrophic lateral sclerosis

Acta Neuropathologica Communications

Volumn 2, Issue 1, 2014, Pages

  Pamphlett, Roger ^a   Kum Jew, Stephen ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Amyotrophic lateral sclerosis; Corticomotor neuron; Exercise; Locus ceruleus; Mercury; Motor neuron disease; Neurotoxin; Stress

Indexed keywords

EID: 85005900971     PISSN: None     EISSN: 20515960     Source Type: Journal    
DOI: 10.1186/2051-5960-1-13     Document Type: Article

References (71)

1. Kiernan MC, Vucic S, Cheah BC, Turner MR, Eisen A, Hardiman O, Burrell JR, Zoing MC: Amyotrophic lateral sclerosis. Lancet 2011, 377: 942-955. 10.1016/S0140-6736(10)61156-7
2. Chio A, Calvo A, Mazzini L, Cantello R, Mora G, Moglia C, Corrado L, D'Alfonso S, Majounie E, Renton A, Pisano F, Ossola I, Brunetti M, Traynor BJ, Restagno G: Extensive genetics of ALS: a population-based study in italy. Neurology 2012, 79: 1983-1989. 10.1212/WNL.0b013e3182735d36
3. Belzil VV, Rouleau GA: Familial ALS: less common than we think? J Neurol Neurosurg Psychiatry 2012, 83: 1133-1133. 10.1136/jnnp-2012-303127
4. Conte A, Lattante S, Luigetti M, Del Grande A, Romano A, Marcaccio A, Marangi G, Rossini PM, Neri G, Zollino M, Sabatelli M: Classification of familial amyotrophic lateral sclerosis by family history: effects on frequency of genes mutation. J Neurol Neurosurg Psychiatry 2012, 83: 1201-1203. 10.1136/jnnp-2012-302897
5. Shaw CA, Hoglinger GU: Neurodegenerative diseases: neurotoxins as sufficient etiologic agents? Neuromolecular Med 2008, 10: 1-9. 10.1007/s12017-007-8016-8
6. Callaghan B, Feldman D, Gruis K, Feldman E: The association of exposure to lead, mercury, and selenium and the development of amyotrophic lateral sclerosis and the epigenetic implications. Neurodegener Dis 2011, 8: 1-8.
7. Moller-Madsen B: Localization of mercury in CNS of the rat. An autometallographic study. Pharmacol Toxicol 1994,75(Suppl 1):1-41.
8. Sutedja NA, Fischer K, Veldink JH, van der Heijden GJ, Kromhout H, Heederik D, Huisman MH, Wokke JJ, van den Berg LH: What we truly know about occupation as a risk factor for ALS: a critical and systematic review. Amyotroph Lateral Scler 2009, 10: 295-301. 10.3109/17482960802430799
9. Morahan JM, Yu B, Trent RJ, Pamphlett R: A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis. Neurotoxicology 2007, 28: 532-540. 10.1016/j.neuro.2006.11.007
10. Mandybur TL, Cooper GP: Increased lead uptake by spinal cord during experimental allergic encephalomyelitis in rats. Toxicol Appl Pharmacol 1979, 50: 163-165. 10.1016/0041-008X(79)90504-0
11. Autometallography DG: A new technique for light and electron microscopic visualization of metals in biological tissues (gold, silver, metal sulphides and metal selenides). Histochemistry 1984, 81: 331-335. 10.1007/BF00514327
12. Hargreaves RJ, Evans JG, Janota I, Magos L, Cavanagh JB: Persistent mercury in nerve cells 16 years after metallic mercury poisoning. Neuropathol Appl Neurobiol 1988, 14: 443-452. 10.1111/j.1365-2990.1988.tb01336.x
13. Opitz H, Schweinsberg F, Grossmann T, Wendt-Gallitelli MF, Meyermann R: Demonstration of mercury in the human brain and other organs 17 years after metallic mercury exposure. Clin Neuropathol 1996, 15: 139-144.
14. Pamphlett R, Waley P: Uptake of inorganic mercury by the human brain. Acta Neuropathol 1996, 92: 525-527. 10.1007/s004010050556
15. Danscher G, Moller-Madsen B: Silver amplification of mercury sulfide and selenide: a histochemical method for light and electron microscopic localization of mercury in tissue. J Histochem Cytochem 1985, 33: 219-228. 10.1177/33.3.2579122
16. Lasiene J, Yamanaka K: Glial cells in amyotrophic lateral sclerosis. Neurol Res Int 2011, 2011: 718987.
17. Tiffany-Castiglioni E, Qian Y: Astroglia as metal depots: molecular mechanisms for metal accumulation, storage and release. Neurotoxicology 2001, 22: 577-592. 10.1016/S0161-813X(01)00050-X
18. Moller-Madsen B: Localization of mercury in CNS of the rat. II. Intraperitoneal injection of methylmercuric chloride (CH3HgCl) and mercuric chloride (HgCl2). Toxicol Appl Pharmacol 1990, 103: 303-323. 10.1016/0041-008X(90)90232-J
19. Moller-Madsen B: Localization of mercury in CNS of the rat. V. Inhalation exposure to metallic mercury. Arch Toxicol 1992, 66: 79-89. 10.1007/BF02342499
20. Pamphlett R, Waley P: Motor neuron uptake of low dose inorganic mercury. J Neurol Sci 1996, 135: 63-67. 10.1016/0022-510X(95)00258-4
21. Levinthal DJ, Strick PL: The motor cortex communicates with the kidney. J Neurosci 2012, 32: 6726-6731. 10.1523/JNEUROSCI.0406-12.2012
22. Pamphlett R, Kril J, Hng TM: Motor neuron disease: a primary disorder of corticomotoneurons? Muscle Nerve 1995, 18: 314-318. 10.1002/mus.880180308
23. Ross JF, Switzer RC, Poston MR, Lawhorn GT: Distribution of bismuth in the brain after intraperitoneal dosing of bismuth subnitrate in mice: implications for routes of entry of xenobiotic metals into the brain. Brain Res 1996, 725: 137-154.
24. Moller-Madsen B, Danscher G: Localization of mercury in CNS of the rat. I. Mercuric chloride (HgCl2) per os. Environ Res 1986, 41: 29-43. 10.1016/S0013-9351(86)80165-7
25. Warfvinge K: Mercury distribution in the mouse brain after mercury vapour exposure. Int J Exp Pathol 1995, 76: 29-35.
26. Warfvinge K, Hua J, Logdberg B: Mercury distribution in cortical areas and fiber systems of the neonatal and maternal adult cerebrum after exposure of pregnant squirrel monkeys to mercury vapor. Environ Res 1994, 67: 196-208. 10.1006/enrs.1994.1074
27. Porter R: The corticomotoneuronal component of the pyramidal tract: corticomotoneuronal connections and functions in primates. Brain Res 1985, 357: 1-26.
28. Gordon PH, Meininger V: How can we improve clinical trials in amyotrophic lateral sclerosis? Nat Rev Neurol 2011, 7: 650-654. 10.1038/nrneurol.2011.147
29. Warfvinge K, Hua J, Berlin M: Mercury distribution in the rat brain after mercury vapor exposure. Toxicol Appl Pharmacol 1992, 117: 46-52. 10.1016/0041-008X(92)90215-E
30. Danscher G, Horsted-Bindslev P, Rungby J: Traces of mercury in organs from primates with amalgam fillings. Exp Mol Pathol 1990, 52: 291-299. 10.1016/0014-4800(90)90070-T
31. Sofroniew MV, Vinters HV: Astrocytes: biology and pathology. Acta Neuropathol 2010, 119: 7-35. 10.1007/s00401-009-0619-8
32. Killinger S, Li Y, Balcar VJ: Sensitivity of the binding sites on glutamate transporters to neurotoxic agents. Neuroreport 1995, 6: 1290-1292. 10.1097/00001756-199506090-00015
33. Allen JW, Mutkus LA, Aschner M: Mercuric chloride, but not methylmercury, inhibits glutamine synthetase activity in primary cultures of cortical astrocytes. Brain Res 2001, 891: 148-157. 10.1016/S0006-8993(00)03185-1
34. Aschner M, Syversen T, Souza DO, Rocha JB, Farina M: Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity. Braz J Med Biol Res 2007, 40: 285-291. 10.1590/S0100-879X2007000300001
35. Philips T, Robberecht W: Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease. Lancet Neurol 2011, 10: 253-263. 10.1016/S1474-4422(11)70015-1
36. Pamphlett R, Png FY: Shrinkage of motor axons following systemic exposure to inorganic mercury. J Neuropathol Exp Neurol 1998, 57: 360-366.
37. Kvetnansky R, Sabban EL, Palkovits M: Catecholaminergic systems in stress: structural and molecular genetic approaches. Physiol Rev 2009, 89: 535-606. 10.1152/physrev.00042.2006
38. Clarkson TW, Magos L: The toxicology of mercury and its chemical compounds. Crit Rev Toxicol 2006, 36: 609-662. 10.1080/10408440600845619
39. Bridges CC, Zalups RK: Molecular and ionic mimicry and the transport of toxic metals. Toxicol Appl Pharmacol 2005, 204: 274-308. 10.1016/j.taap.2004.09.007
40. Cohen Z, Molinatti G, Hamel E: Astroglial and vascular interactions of noradrenaline terminals in the rat cerebral cortex. J Cereb Blood Flow Metab 1997, 17: 894-904.
41. Arvidson B: A review of axonal transport of metals. Toxicology 1994, 88: 1-14. 10.1016/0300-483X(94)90107-4
42. Benarroch EE: The locus ceruleus norepinephrine system: functional organization and potential clinical significance. Neurology 2009, 73: 1699-1704. 10.1212/WNL.0b013e3181c2937c
43. Torres GE, Gainetdinov RR, Caron MG: Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci 2003, 4: 13-25.
44. Aoyama K, Watabe M, Nakaki T: Regulation of neuronal glutathione synthesis. J Pharmacol Sci 2008, 108: 227-238. 10.1254/jphs.08R01CR
45. Sabban EL, Kvetnansky R: Stress-triggered activation of gene expression in catecholaminergic systems: dynamics of transcriptional events. Trends Neurosci 2001, 24: 91-98. 10.1016/S0166-2236(00)01687-8
46. Arango V, Underwood MD, Mann JJ: Fewer pigmented locus coeruleus neurons in suicide victims: preliminary results. Biol Psychiatry 1996, 39: 112-120. 10.1016/0006-3223(95)00107-7
47. Haley RW: Excess incidence of ALS in young Gulf War veterans. Neurology 2003, 61: 750-756. 10.1212/WNL.61.6.750
48. Horner RD, Kamins KG, Feussner JR, Grambow SC, Hoff-Lindquist J, Harati Y, Mitsumoto H, Pascuzzi R, Spencer PS, Tim R, Howard D, Smith TC, Ryan MA, Coffman CJ, Kasarskis EJ: Occurrence of amyotrophic lateral sclerosis among Gulf War veterans. Neurology 2003, 61: 742-749. 10.1212/01.WNL.0000069922.32557.CA
49. Weisskopf MG, O'Reilly EJ, McCullough ML, Calle EE, Thun MJ, Cudkowicz M, Ascherio A: Prospective study of military service and mortality from ALS. Neurology 2005, 64: 32-37. 10.1212/01.WNL.0000148649.17706.D9
50. Beghi E, Morrison KE: ALS and military service. Neurology 2005, 64: 6-7. 10.1212/01.WNL.0000150535.90358.2D
51. Bracha HS, Garcia-Rill E, Mrak RE, Skinner R: Postmortem locus coeruleus neuron count in three American veterans with probable or possible war-related PTSD. J Neuropsychiatry Clin Neurosci 2005, 17: 503-509. 10.1176/appi.neuropsych.17.4.503
52. Kurtzke JF, Beebe GW: Epidemiology of amyotrophic lateral sclerosis: 1. A case-control comparison based on ALS deaths. Neurology 1980, 30: 453-462. 10.1212/WNL.30.5.453
53. Ulhoa MA, Marqueze EC, Kantermann T, Skene D, Moreno C: When Does Stress End? Evidence of a Prolonged Stress Reaction in Shiftworking Truck Drivers. Chronobiol Int 2011, 28: 810-818. 10.3109/07420528.2011.613136
54. Nicholas JS, Butler GC, Lackland DT, Tessier GS, Mohr LC, Hoel DG: Health among commercial airline pilots. Aviat Space and Env Med 2001, 72: 821-826.
55. Chio A, Benzi G, Dossena M, Mutani R, Mora G: Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players. Brain 2005, 128: 472-476. 10.1093/brain/awh373
56. Okamoto K, Kihira T, Kondo T, Kobashi G, Washio M, Sasaki S, Yokoyama T, Miyake Y, Sakamoto N, Inaba Y, Nagai M: Lifestyle factors and risk of amyotrophic lateral sclerosis: a case-control study in Japan. Ann Epidemiol 2009, 19: 359-364. 10.1016/j.annepidem.2009.01.015
57. Fang F, Ye W, Fall K, Lekander M, Wigzell H, Sparen P, Adami HO, Valdimarsdottir U: Loss of a child and the risk of amyotrophic lateral sclerosis. Am J Epidemiol 2008, 167: 203-210.
58. Schwab ME, Thoenen H: Electron microscopic evidence for a transsynaptic migration of tetanus toxin in spinal cord motoneurons: an autoradiographic and morphometric study. Brain Res 1976, 105: 213-227. 10.1016/0006-8993(76)90422-4
59. Pamphlett R, Bayliss A: The effect of nerve crush and botulinum toxin on lead uptake in motor axons. Acta Neuropathol 1992, 84: 89-93. 10.1007/BF00427220
60. Kristensson K: Retrograde axonal transport of horseradish peroxidase. Uptake at mouse neuromuscular junctions following systemic injection. Acta Neuropathol 1977, 38: 143-147. 10.1007/BF00688561
61. Deschenes MR, Maresh CM, Crivello JF, Armstrong LE, Kraemer WJ, Covault J: The effects of exercise training of different intensities on neuromuscular junction morphology. J Neurocytol 1993, 22: 603-615. 10.1007/BF01181487
62. Desaulniers P, Lavoie PA, Gardiner PF: Habitual exercise enhances neuromuscular transmission efficacy of rat soleus muscle in situ. J Appl Physiol 2001, 90: 1041-1048.
63. Scarmeas N, Shih T, Stern Y, Ottman R, Rowland LP: Premorbid weight, body mass, and varsity athletics in ALS. Neurology 2002, 59: 773-775. 10.1212/WNL.59.5.773
64. Harwood CA, McDermott CJ, Shaw PJ: Physical activity as an exogenous risk factor in motor neuron disease (MND): a review of the evidence. Amyotroph Lateral Scler 2009, 10: 191-204.
65. Beghi E, Logroscino G, Chio A, Hardiman O, Millul A, Mitchell D, Swingler R, Traynor BJ: Amyotrophic lateral sclerosis, physical exercise, trauma and sports: results of a population-based pilot case-control study. Amyotroph Lateral Scler 2010, 11: 289-292. 10.3109/17482960903384283
66. Mattsson P, Lonnstedt I, Nygren I, Askmark H: Physical fitness, but not muscle strength, is a risk factor for death in amyotrophic lateral sclerosis at an early age. J Neurol Neurosurg Psychiatry 2012, 83: 390-394. 10.1136/jnnp.2010.218982
67. Wiley RG, Blessing WW, Reis DJ: Suicide transport: destruction of neurons by retrograde transport of ricin, abrin, and modeccin. Science 1982, 216: 889-890. 10.1126/science.6177039
68. Eisen A, Weber M: The motor cortex and amyotrophic lateral sclerosis. Muscle Nerve 2001, 24: 564-573. 10.1002/mus.1042
69. Vucic S, Nicholson GA, Kiernan MC: Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis. Brain 2008, 131: 1540-1550. 10.1093/brain/awn071
70. Gutierrez F, Leon L: Images in clinical medicine. Elemental mercury embolism to the lung. N Engl J Med 2000, 342: 1791. 10.1056/NEJM200006153422405
71. Pamphlett R, Coote P: Entry of low doses of mercury vapor into the nervous system. Neurotoxicology 1998, 19: 39-47.