SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors

Oncotarget

Volumn 7, Issue 50, 2016, Pages 83088-83100

  Xue, Wei ^a   Brentville, Victoria A ^a   Symonds, Peter ^a   Cook, Katherine W ^a   Yagita, Hideo ^b   Metheringham, Rachael L ^a   Durrant, Lindy G ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

DNA vaccine; Fc targeting; Melanoma; PD 1 blockade; Tumor rejection

Indexed keywords

DNA VACCINE; FINGOLIMOD; GAMMA INTERFERON; HLA DR4 ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY PD 1; PROGRAMMED DEATH 1 RECEPTOR; SCIB 1; UNCLASSIFIED DRUG; CANCER VACCINE; IMMUNOLOGICAL ANTINEOPLASTIC AGENT; PDCD1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER IMMUNIZATION; CANCER SURVIVAL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CUTANEOUS MELANOMA; DNA IMMUNIZATION; DRUG EFFECT; DRUG POTENCY; DRUG RESPONSE; IMMUNOGENICITY; LEUKOCYTE COUNT; LONG TERM SURVIVAL; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; T LYMPHOCYTE; TRANSGENIC MOUSE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CYTOTOXICITY; DRUG EFFECTS; EXPERIMENTAL MELANOMA; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PATHOLOGY; SKIN TUMOR; TIME FACTOR;

ANIMALS; ANTINEOPLASTIC AGENTS, IMMUNOLOGICAL; CANCER VACCINES; CELL PROLIFERATION; CYTOTOXICITY, IMMUNOLOGIC; HLA-DR4 ANTIGEN; LYMPHOCYTE ACTIVATION; LYMPHOCYTES, TUMOR-INFILTRATING; MELANOMA, EXPERIMENTAL; MICE, TRANSGENIC; PROGRAMMED CELL DEATH 1 RECEPTOR; SKIN NEOPLASMS; T-LYMPHOCYTES; TIME FACTORS; TUMOR MICROENVIRONMENT; VACCINES, DNA;

EID: 85004098379     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.13070     Document Type: Article

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