-
1
-
-
78751672175
-
Regulation of blood pressure and salt homeostasis by endothelin
-
COI: 1:CAS:528:DC%2BC3MXisVChtrY%3D, PID: 21248162
-
Kohan DE, Rossi NF, Inscho EW, Pollock DM (2011) Regulation of blood pressure and salt homeostasis by endothelin. Physiol Rev 91(1):1–77
-
(2011)
Physiol Rev
, vol.91
, Issue.1
, pp. 1-77
-
-
Kohan, D.E.1
Rossi, N.F.2
Inscho, E.W.3
Pollock, D.M.4
-
2
-
-
33847031260
-
Contrasting actions of endothelin ET(A) and ET(B) receptors in cardiovascular disease
-
COI: 1:CAS:528:DC%2BD2sXit1alurc%3D, PID: 17002597
-
Schneider MP, Boesen EI, Pollock DM (2007) Contrasting actions of endothelin ET(A) and ET(B) receptors in cardiovascular disease. Annu Rev Pharmacol Toxicol 47:731–759
-
(2007)
Annu Rev Pharmacol Toxicol
, vol.47
, pp. 731-759
-
-
Schneider, M.P.1
Boesen, E.I.2
Pollock, D.M.3
-
3
-
-
48849094089
-
Endothelin: 20 years from discovery to therapy
-
COI: 1:CAS:528:DC%2BD1cXhtVGnurfM, PID: 18758495
-
Barton M, Yanagisawa M (2008) Endothelin: 20 years from discovery to therapy. Can J Physiol Pharmacol 86(8):485–498
-
(2008)
Can J Physiol Pharmacol
, vol.86
, Issue.8
, pp. 485-498
-
-
Barton, M.1
Yanagisawa, M.2
-
4
-
-
84881152296
-
Endothelin antagonists for diabetic and non-diabetic chronic kidney disease
-
COI: 1:CAS:528:DC%2BC3sXhsFGgurrO, PID: 23228194
-
Kohan DE, Pollock DM (2013) Endothelin antagonists for diabetic and non-diabetic chronic kidney disease. Br J Clin Pharmacol 76(4):573–579
-
(2013)
Br J Clin Pharmacol
, vol.76
, Issue.4
, pp. 573-579
-
-
Kohan, D.E.1
Pollock, D.M.2
-
5
-
-
35648968713
-
A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer
-
COI: 1:CAS:528:DC%2BD2sXhtlertbrP, PID: 17886253
-
Carducci MA, Saad F, Abrahamsson PA et al (2007) A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer. Cancer 110(9):1959–1966
-
(2007)
Cancer
, vol.110
, Issue.9
, pp. 1959-1966
-
-
Carducci, M.A.1
Saad, F.2
Abrahamsson, P.A.3
-
6
-
-
77949877308
-
Avosentan for overt diabetic nephropathy
-
COI: 1:CAS:528:DC%2BC3cXjvFClu7k%3D, PID: 20167702
-
Mann JF, Green D, Jamerson K et al (2010) Avosentan for overt diabetic nephropathy. J Am Soc Nephrol 21(3):527–535
-
(2010)
J Am Soc Nephrol
, vol.21
, Issue.3
, pp. 527-535
-
-
Mann, J.F.1
Green, D.2
Jamerson, K.3
-
7
-
-
70350133404
-
A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trial
-
COI: 1:CAS:528:DC%2BD1MXhtlSru7jK, PID: 19748665
-
Weber MA, Black H, Bakris G et al (2009) A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trial. Lancet 374(9699):1423–1431
-
(2009)
Lancet
, vol.374
, Issue.9699
, pp. 1423-1431
-
-
Weber, M.A.1
Black, H.2
Bakris, G.3
-
8
-
-
52049097771
-
Efficacy and safety of atrasentan in patients with cardiovascular risk and early atherosclerosis
-
COI: 1:CAS:528:DC%2BD1cXpvFKgs7w%3D, PID: 18695150
-
Raichlin E, Prasad A, Mathew V et al (2008) Efficacy and safety of atrasentan in patients with cardiovascular risk and early atherosclerosis. Hypertension 52(3):522–528
-
(2008)
Hypertension
, vol.52
, Issue.3
, pp. 522-528
-
-
Raichlin, E.1
Prasad, A.2
Mathew, V.3
-
9
-
-
33746206340
-
Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study
-
PID: 16801459
-
Galiè N, Beghetti M, Gatzoulis MA et al (2006) Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study. Circulation 114(1):48–54
-
(2006)
Circulation
, vol.114
, Issue.1
, pp. 48-54
-
-
Galiè, N.1
Beghetti, M.2
Gatzoulis, M.A.3
-
10
-
-
3242810591
-
Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial
-
COI: 1:CAS:528:DC%2BD2cXmtVSktbg%3D, PID: 15276394
-
Anand I, McMurray J, Cohn JN et al (2004) Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial. Lancet 364(9431):347–354
-
(2004)
Lancet
, vol.364
, Issue.9431
, pp. 347-354
-
-
Anand, I.1
McMurray, J.2
Cohn, J.N.3
-
11
-
-
0037137297
-
Hemodynamic and neurohumoral effects of selective endothelin A (ET(A)) receptor blockade in chronic heart failure: the Heart Failure ET(A) Receptor Blockade Trial (HEAT)
-
PID: 12438291
-
Lüscher TF, Enseleit F, Pacher R et al (2002) Hemodynamic and neurohumoral effects of selective endothelin A (ET(A)) receptor blockade in chronic heart failure: the Heart Failure ET(A) Receptor Blockade Trial (HEAT). Circulation 106(21):2666–2672
-
(2002)
Circulation
, vol.106
, Issue.21
, pp. 2666-2672
-
-
Lüscher, T.F.1
Enseleit, F.2
Pacher, R.3
-
12
-
-
20844459311
-
Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study
-
COI: 1:CAS:528:DC%2BD2MXhtVOmsr8%3D, PID: 15704058
-
Packer M, McMurray J, Massie BM et al (2005) Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study. J Card Fail 11(1):12–20
-
(2005)
J Card Fail
, vol.11
, Issue.1
, pp. 12-20
-
-
Packer, M.1
McMurray, J.2
Massie, B.M.3
-
13
-
-
80051566676
-
BUILD-3: a randomized, controlled trial of bosentan in idiopathic pulmonary fibrosis
-
PID: 21474646
-
King TE Jr, Brown KK, Raghu G et al (2011) BUILD-3: a randomized, controlled trial of bosentan in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 184(1):92–99
-
(2011)
Am J Respir Crit Care Med
, vol.184
, Issue.1
, pp. 92-99
-
-
King, T.E.1
Brown, K.K.2
Raghu, G.3
-
14
-
-
84877297353
-
Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial
-
PID: 23648946
-
Raghu G, Behr J, Brown KK et al (2013) Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial. Ann Intern Med 158(9):641–649
-
(2013)
Ann Intern Med
, vol.158
, Issue.9
, pp. 641-649
-
-
Raghu, G.1
Behr, J.2
Brown, K.K.3
-
15
-
-
84888166435
-
Macitentan for the treatment of idiopathic pulmonary fibrosis: the randomised controlled MUSIC trial
-
COI: 1:CAS:528:DC%2BC2cXktlagtQ%3D%3D, PID: 23682110
-
Raghu G, Million-Rousseau R, Morganti A, Perchenet L, Behr J; MUSIC Study Group (2013) Macitentan for the treatment of idiopathic pulmonary fibrosis: the randomised controlled MUSIC trial. Eur Respir J 42(6):1622–1632
-
(2013)
Eur Respir J
, vol.42
, Issue.6
, pp. 1622-1632
-
-
Raghu, G.1
Million-Rousseau, R.2
Morganti, A.3
Perchenet, L.4
Behr, J.5
-
16
-
-
77950414996
-
A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy
-
PID: 20350333
-
Kefford RF, Clingan PR, Brady B, Ballmer A, Morganti A, Hersey P (2010) A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy. Mol Cancer 9:69
-
(2010)
Mol Cancer
, vol.9
, pp. 69
-
-
Kefford, R.F.1
Clingan, P.R.2
Brady, B.3
Ballmer, A.4
Morganti, A.5
Hersey, P.6
-
17
-
-
33646255654
-
Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan
-
COI: 1:CAS:528:DC%2BD28XksFalsbs%3D, PID: 16697324
-
Barst RJ, Langleben D, Badesch D et al (2006) Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan. J Am Coll Cardiol 47(10):2049–2056
-
(2006)
J Am Coll Cardiol
, vol.47
, Issue.10
, pp. 2049-2056
-
-
Barst, R.J.1
Langleben, D.2
Badesch, D.3
-
18
-
-
84906922433
-
Bosentan in pulmonary hypertension associated with fibrotic idiopathic interstitial pneumonia
-
COI: 1:CAS:528:DC%2BC2cXhsFert73N, PID: 24937643
-
Corte TJ, Keir GJ, Dimopoulos K et al (2014) Bosentan in pulmonary hypertension associated with fibrotic idiopathic interstitial pneumonia. Am J Respir Crit Care Med 190(2):208–217
-
(2014)
Am J Respir Crit Care Med
, vol.190
, Issue.2
, pp. 208-217
-
-
Corte, T.J.1
Keir, G.J.2
Dimopoulos, K.3
-
19
-
-
46449124591
-
Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2
-
PID: 18506008
-
Galiè N, Olschewski H, Oudiz RJ et al (2008) Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2. Circulation 117(23):3010–3019
-
(2008)
Circulation
, vol.117
, Issue.23
, pp. 3010-3019
-
-
Galiè, N.1
Olschewski, H.2
Oudiz, R.J.3
-
20
-
-
45249119855
-
Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial
-
PID: 18572079
-
Galiè N, Rubin LJ, Hoeper M et al (2008) Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial. Lancet 371(9630):2093–2100
-
(2008)
Lancet
, vol.371
, Issue.9630
, pp. 2093-2100
-
-
Galiè, N.1
Rubin, L.J.2
Hoeper, M.3
-
21
-
-
4544383466
-
Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2
-
COI: 1:CAS:528:DC%2BD2cXotlyrtL4%3D, PID: 15358690
-
Humbert M, Barst RJ, Robbins IM et al (2004) Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2. Eur Respir J 24(3):353–359
-
(2004)
Eur Respir J
, vol.24
, Issue.3
, pp. 353-359
-
-
Humbert, M.1
Barst, R.J.2
Robbins, I.M.3
-
22
-
-
57449103127
-
Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial
-
PID: 19095129
-
Jaïs X, D’Armini AM, Jansa P et al (2008) Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial. J Am Coll Cardiol 52(25):2127–2134
-
(2008)
J Am Coll Cardiol
, vol.52
, Issue.25
, pp. 2127-2134
-
-
Jaïs, X.1
D’Armini, A.M.2
Jansa, P.3
-
23
-
-
84883108940
-
Macitentan and morbidity and mortality in pulmonary arterial hypertension
-
COI: 1:CAS:528:DC%2BC3sXhtlyis7fP, PID: 23984728
-
Pulido T, Adzerikho I, Channick RN et al (2013) Macitentan and morbidity and mortality in pulmonary arterial hypertension. N Engl J Med 369(9):809–818
-
(2013)
N Engl J Med
, vol.369
, Issue.9
, pp. 809-818
-
-
Pulido, T.1
Adzerikho, I.2
Channick, R.N.3
-
24
-
-
0037149718
-
Bosentan therapy for pulmonary arterial hypertension
-
COI: 1:CAS:528:DC%2BD38Xit1ekur0%3D, PID: 11907289
-
Rubin LJ, Badesch DB, Barst RJ et al (2002) Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 346(12):896–903
-
(2002)
N Engl J Med
, vol.346
, Issue.12
, pp. 896-903
-
-
Rubin, L.J.1
Badesch, D.B.2
Barst, R.J.3
-
25
-
-
84856779653
-
Safety and efficacy of sitaxsentan 50 and 100 mg in patients with pulmonary arterial hypertension
-
COI: 1:CAS:528:DC%2BC38XitFOktLg%3D, PID: 22079088
-
Sandoval J, Torbicki A, Souza R et al (2012) Safety and efficacy of sitaxsentan 50 and 100 mg in patients with pulmonary arterial hypertension. Pulm Pharmacol Ther 25(1):33–39
-
(2012)
Pulm Pharmacol Ther
, vol.25
, Issue.1
, pp. 33-39
-
-
Sandoval, J.1
Torbicki, A.2
Souza, R.3
-
26
-
-
84879466638
-
Phase III, randomized, placebo-controlled study of docetaxel in combination with zibotentan in patients with metastatic castration-resistant prostate cancer
-
COI: 1:CAS:528:DC%2BC3sXptVOrt7o%3D, PID: 23569308
-
Fizazi K, Higano CS, Nelson JB et al (2013) Phase III, randomized, placebo-controlled study of docetaxel in combination with zibotentan in patients with metastatic castration-resistant prostate cancer. J Clin Oncol 31(14):1740–1747
-
(2013)
J Clin Oncol
, vol.31
, Issue.14
, pp. 1740-1747
-
-
Fizazi, K.1
Higano, C.S.2
Nelson, J.B.3
-
27
-
-
62649134676
-
Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: a double-blind, placebo-controlled, randomised, phase 2 trial
-
COI: 1:CAS:528:DC%2BD1MXnvF2qtrk%3D, PID: 19042080
-
James ND, Caty A, Borre M et al (2009) Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: a double-blind, placebo-controlled, randomised, phase 2 trial. Eur Urol 55(5):1112–1123
-
(2009)
Eur Urol
, vol.55
, Issue.5
, pp. 1112-1123
-
-
James, N.D.1
Caty, A.2
Borre, M.3
-
28
-
-
77956634017
-
Final safety and efficacy analysis of the specific endothelin A receptor antagonist zibotentan (ZD4054) in patients with metastatic castration-resistant prostate cancer and bone metastases who were pain-free or mildly symptomatic for pain: a double-blind, placebo-controlled, randomized Phase II trial
-
COI: 1:CAS:528:DC%2BC3cXhsVSksrfL, PID: 20840318
-
James ND, Caty A, Payne H et al (2010) Final safety and efficacy analysis of the specific endothelin A receptor antagonist zibotentan (ZD4054) in patients with metastatic castration-resistant prostate cancer and bone metastases who were pain-free or mildly symptomatic for pain: a double-blind, placebo-controlled, randomized Phase II trial. BJU Int 106(7):966–973
-
(2010)
BJU Int
, vol.106
, Issue.7
, pp. 966-973
-
-
James, N.D.1
Caty, A.2
Payne, H.3
-
29
-
-
84882450996
-
Phase III, randomized, placebo-controlled study of once-daily oral zibotentan (ZD4054) in patients with non-metastatic castration-resistant prostate cancer
-
COI: 1:CAS:528:DC%2BC3sXnvFyht7w%3D, PID: 23381694
-
Miller K, Moul JW, Gleave M et al (2013) Phase III, randomized, placebo-controlled study of once-daily oral zibotentan (ZD4054) in patients with non-metastatic castration-resistant prostate cancer. Prostate Cancer Prostatic Dis 16(2):187–192
-
(2013)
Prostate Cancer Prostatic Dis
, vol.16
, Issue.2
, pp. 187-192
-
-
Miller, K.1
Moul, J.W.2
Gleave, M.3
-
30
-
-
84868200731
-
Phase 3, randomized, placebo-controlled study of zibotentan (ZD4054) in patients with castration-resistant prostate cancer metastatic to bone
-
COI: 1:CAS:528:DC%2BC38Xhs1ShsbvM, PID: 22786751
-
Nelson JB, Fizazi K, Miller K et al (2012) Phase 3, randomized, placebo-controlled study of zibotentan (ZD4054) in patients with castration-resistant prostate cancer metastatic to bone. Cancer 118(22):5709–5718
-
(2012)
Cancer
, vol.118
, Issue.22
, pp. 5709-5718
-
-
Nelson, J.B.1
Fizazi, K.2
Miller, K.3
-
31
-
-
84880772151
-
Docetaxel and atrasentan versus docetaxel and placebo for men with advanced castration-resistant prostate cancer (SWOG S0421): a randomised phase 3 trial
-
COI: 1:CAS:528:DC%2BC3sXhtFCitr7J, PID: 23871417
-
Quinn DI, Tangen CM, Hussain M et al (2013) Docetaxel and atrasentan versus docetaxel and placebo for men with advanced castration-resistant prostate cancer (SWOG S0421): a randomised phase 3 trial. Lancet Oncol 14(9):893–900
-
(2013)
Lancet Oncol
, vol.14
, Issue.9
, pp. 893-900
-
-
Quinn, D.I.1
Tangen, C.M.2
Hussain, M.3
-
32
-
-
78149244260
-
Divergent results using clinic and ambulatory blood pressures: report of a darusentan-resistant hypertension trial
-
COI: 1:CAS:528:DC%2BC3cXhtlSqurfJ, PID: 20921430
-
Bakris GL, Lindholm LH, Black HR et al (2010) Divergent results using clinic and ambulatory blood pressures: report of a darusentan-resistant hypertension trial. Hypertension 56(5):824–830
-
(2010)
Hypertension
, vol.56
, Issue.5
, pp. 824-830
-
-
Bakris, G.L.1
Lindholm, L.H.2
Black, H.R.3
-
33
-
-
43049099531
-
Efficacy and safety of darusentan in patients with resistant hypertension: results from a randomized, double-blind, placebo-controlled dose-ranging study
-
COI: 1:CAS:528:DC%2BD2sXht12rt7%2FE
-
Black HR, Bakris GL, Weber MA et al (2007) Efficacy and safety of darusentan in patients with resistant hypertension: results from a randomized, double-blind, placebo-controlled dose-ranging study. J Clin Hypertens (Greenwich) 9(10):760–769
-
(2007)
J Clin Hypertens (Greenwich)
, vol.9
, Issue.10
, pp. 760-769
-
-
Black, H.R.1
Bakris, G.L.2
Weber, M.A.3
-
34
-
-
78650678451
-
Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial
-
COI: 1:CAS:528:DC%2BC3MXhtleitrg%3D, PID: 20805294
-
Matucci-Cerinic M, Denton CP, Furst DE et al (2011) Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial. Ann Rheum Dis 70(1):32–38
-
(2011)
Ann Rheum Dis
, vol.70
, Issue.1
, pp. 32-38
-
-
Matucci-Cerinic, M.1
Denton, C.P.2
Furst, D.E.3
-
35
-
-
84867418316
-
Clinical efficacy of the selective endothelin A receptor antagonist, atrasentan, in patients with diabetes and chronic kidney disease (CKD)
-
COI: 1:CAS:528:DC%2BC38XisFyis7s%3D, PID: 22326504
-
Andress DL, Coll B, Pritchett Y, Brennan J, Molitch M, Kohan DE (2012) Clinical efficacy of the selective endothelin A receptor antagonist, atrasentan, in patients with diabetes and chronic kidney disease (CKD). Life Sci 91(13–14):739–742
-
(2012)
Life Sci
, vol.91
, Issue.13-14
, pp. 739-742
-
-
Andress, D.L.1
Coll, B.2
Pritchett, Y.3
Brennan, J.4
Molitch, M.5
Kohan, D.E.6
-
36
-
-
84906540059
-
The endothelin antagonist atrasentan lowers residual albuminuria in patients with type 2 diabetic nephropathy
-
PID: 24722445
-
de Zeeuw D, Coll B, Andress D et al (2014) The endothelin antagonist atrasentan lowers residual albuminuria in patients with type 2 diabetic nephropathy. J Am Soc Nephrol 25(5):1083–1093
-
(2014)
J Am Soc Nephrol
, vol.25
, Issue.5
, pp. 1083-1093
-
-
de Zeeuw, D.1
Coll, B.2
Andress, D.3
-
37
-
-
79953295959
-
Addition of atrasentan to renin-angiotensin system blockade reduces albuminuria in diabetic nephropathy
-
COI: 1:CAS:528:DC%2BC3MXlslOjs7s%3D, PID: 21372210
-
Kohan DE, Pritchett Y, Molitch M et al (2011) Addition of atrasentan to renin-angiotensin system blockade reduces albuminuria in diabetic nephropathy. J Am Soc Nephrol 22(4):763–772
-
(2011)
J Am Soc Nephrol
, vol.22
, Issue.4
, pp. 763-772
-
-
Kohan, D.E.1
Pritchett, Y.2
Molitch, M.3
-
38
-
-
62149126622
-
Avosentan reduces albumin excretion in diabetics with macroalbuminuria
-
PID: 19144760
-
Wenzel RR, Littke T, Kuranoff S et al (2009) Avosentan reduces albumin excretion in diabetics with macroalbuminuria. J Am Soc Nephrol 20(3):655–664
-
(2009)
J Am Soc Nephrol
, vol.20
, Issue.3
, pp. 655-664
-
-
Wenzel, R.R.1
Littke, T.2
Kuranoff, S.3
-
39
-
-
84911459288
-
Current state of endothelin receptor antagonism in hypertension and pulmonary hypertension
-
COI: 1:CAS:528:DC%2BC2MXisFWisbo%3D, PID: 24990369
-
Miyagawa K, Emoto N (2014) Current state of endothelin receptor antagonism in hypertension and pulmonary hypertension. Ther Adv Cardiovasc Dis 8(5):202–216
-
(2014)
Ther Adv Cardiovasc Dis
, vol.8
, Issue.5
, pp. 202-216
-
-
Miyagawa, K.1
Emoto, N.2
-
40
-
-
0036774973
-
Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure?
-
PID: 12208583
-
Kalra PR, Moon JC, Coats AJ (2002) Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure? Int J Cardiol 85(2–3):195–197
-
(2002)
Int J Cardiol
, vol.85
, Issue.2-3
, pp. 195-197
-
-
Kalra, P.R.1
Moon, J.C.2
Coats, A.J.3
-
41
-
-
0034816975
-
Endothelin antagonists for chronic heart failure: do they have a role?
-
COI: 1:CAS:528:DC%2BD3MXnslKhu7k%3D, PID: 11549299
-
Cowburn PJ, Cleland JG (2001) Endothelin antagonists for chronic heart failure: do they have a role? Eur Heart J 22(19):1772–1784
-
(2001)
Eur Heart J
, vol.22
, Issue.19
, pp. 1772-1784
-
-
Cowburn, P.J.1
Cleland, J.G.2
-
42
-
-
0034869408
-
The underreporting of results and possible mechanisms of ‘negative’ drug trials in patients with chronic heart failure
-
PID: 11532543
-
van Veldhuisen DJ, Poole-Wilson PA (2001) The underreporting of results and possible mechanisms of ‘negative’ drug trials in patients with chronic heart failure. Int J Cardiol 80(1):19–27
-
(2001)
Int J Cardiol
, vol.80
, Issue.1
, pp. 19-27
-
-
van Veldhuisen, D.J.1
Poole-Wilson, P.A.2
-
43
-
-
84855474159
-
Endothelin antagonists in clinical trials: lessons learned
-
COI: 1:CAS:528:DC%2BC3MXhsFWjsrvM, PID: 21894005
-
Barton M, Kohan DE (2011) Endothelin antagonists in clinical trials: lessons learned. Contrib Nephrol 172:255–260
-
(2011)
Contrib Nephrol
, vol.172
, pp. 255-260
-
-
Barton, M.1
Kohan, D.E.2
-
44
-
-
84880402164
-
Myocardial, smooth muscle, nephron, and collecting duct gene targeting reveals the organ sites of endothelin A receptor antagonist fluid retention
-
COI: 1:CAS:528:DC%2BC3sXhtFOjsbnO, PID: 23709116
-
Stuart D, Chapman M, Rees S, Woodward S, Kohan DE (2013) Myocardial, smooth muscle, nephron, and collecting duct gene targeting reveals the organ sites of endothelin A receptor antagonist fluid retention. J Pharmacol Exp Ther 346(2):182–189
-
(2013)
J Pharmacol Exp Ther
, vol.346
, Issue.2
, pp. 182-189
-
-
Stuart, D.1
Chapman, M.2
Rees, S.3
Woodward, S.4
Kohan, D.E.5
-
45
-
-
33845423984
-
Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention
-
COI: 1:CAS:528:DC%2BD2sXktV2j, PID: 16868309
-
Ge Y, Bagnall A, Stricklett PK et al (2006) Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention. Am J Physiol Renal Physiol 291(6):F1274–F1280
-
(2006)
Am J Physiol Renal Physiol
, vol.291
, Issue.6
, pp. F1274-F1280
-
-
Ge, Y.1
Bagnall, A.2
Stricklett, P.K.3
-
46
-
-
33744944028
-
Endothelin B receptor antagonism in the rat renal medulla reduces urine flow rate and sodium excretion
-
COI: 1:CAS:528:DC%2BD28Xlt1ert74%3D
-
Guo X, Yang T (2006) Endothelin B receptor antagonism in the rat renal medulla reduces urine flow rate and sodium excretion. Exp Biol Med (Maywood) 231(6):1001–1005
-
(2006)
Exp Biol Med (Maywood)
, vol.231
, Issue.6
, pp. 1001-1005
-
-
Guo, X.1
Yang, T.2
-
47
-
-
20944450264
-
Extrarenal ETB plays a significant role in controlling cardiovascular responses to high dietary sodium in rats
-
COI: 1:CAS:528:DC%2BD2MXjtlymu70%3D, PID: 15809364
-
Ohkita M, Wang Y, Nguyen ND et al (2005) Extrarenal ETB plays a significant role in controlling cardiovascular responses to high dietary sodium in rats. Hypertension 45(5):940–946
-
(2005)
Hypertension
, vol.45
, Issue.5
, pp. 940-946
-
-
Ohkita, M.1
Wang, Y.2
Nguyen, N.D.3
-
48
-
-
84866270574
-
Antidiuretic effects of the endothelin receptor antagonist avosentan
-
PID: 22529820
-
Baltatu OC, Iliescu R, Zaugg CE et al (2012) Antidiuretic effects of the endothelin receptor antagonist avosentan. Front Physiol 3:103
-
(2012)
Front Physiol
, vol.3
, pp. 103
-
-
Baltatu, O.C.1
Iliescu, R.2
Zaugg, C.E.3
-
49
-
-
79953213661
-
Selective endothelin-A receptor antagonism reduces proteinuria, blood pressure, and arterial stiffness in chronic proteinuric kidney disease
-
COI: 1:CAS:528:DC%2BC3MXjt1Gns7c%3D, PID: 21357275
-
Dhaun N, MacIntyre IM, Kerr D et al (2011) Selective endothelin-A receptor antagonism reduces proteinuria, blood pressure, and arterial stiffness in chronic proteinuric kidney disease. Hypertension 57(4):772–779
-
(2011)
Hypertension
, vol.57
, Issue.4
, pp. 772-779
-
-
Dhaun, N.1
MacIntyre, I.M.2
Kerr, D.3
-
50
-
-
84867578602
-
Clinical trials with endothelin receptor antagonists: what went wrong and where can we improve?
-
COI: 1:CAS:528:DC%2BC38Xht1CgtL3N, PID: 22967485
-
Kohan DE, Cleland JG, Rubin LJ, Theodorescu D, Barton M (2012) Clinical trials with endothelin receptor antagonists: what went wrong and where can we improve? Life Sci 91(13–14):528–539
-
(2012)
Life Sci
, vol.91
, Issue.13-14
, pp. 528-539
-
-
Kohan, D.E.1
Cleland, J.G.2
Rubin, L.J.3
Theodorescu, D.4
Barton, M.5
-
51
-
-
34547558919
-
Results of European post-marketing surveillance of bosentan in pulmonary hypertension
-
COI: 1:CAS:528:DC%2BD2sXpvFCgs7k%3D, PID: 17504794
-
Humbert M, Segal ES, Kiely DG, Carlsen J, Schwierin B, Hoeper MM (2007) Results of European post-marketing surveillance of bosentan in pulmonary hypertension. Eur Respir J 30(2):338–344
-
(2007)
Eur Respir J
, vol.30
, Issue.2
, pp. 338-344
-
-
Humbert, M.1
Segal, E.S.2
Kiely, D.G.3
Carlsen, J.4
Schwierin, B.5
Hoeper, M.M.6
-
52
-
-
0036283401
-
Clinical efficacy of sitaxsentan, an endothelin-A receptor antagonist, in patients with pulmonary arterial hypertension: open-label pilot study
-
COI: 1:CAS:528:DC%2BD38XlsVejurw%3D, PID: 12065350
-
Barst RJ, Rich S, Widlitz A, Horn EM, McLaughlin V, McFarlin J (2002) Clinical efficacy of sitaxsentan, an endothelin-A receptor antagonist, in patients with pulmonary arterial hypertension: open-label pilot study. Chest 121(6):1860–1868
-
(2002)
Chest
, vol.121
, Issue.6
, pp. 1860-1868
-
-
Barst, R.J.1
Rich, S.2
Widlitz, A.3
Horn, E.M.4
McLaughlin, V.5
McFarlin, J.6
-
53
-
-
33846247928
-
Sitaxsentan treatment for patients with pulmonary arterial hypertension discontinuing bosentan
-
PID: 17234519
-
Benza RL, Mehta S, Keogh A, Lawrence EC, Oudiz RJ, Barst RJ (2007) Sitaxsentan treatment for patients with pulmonary arterial hypertension discontinuing bosentan. J Heart Lung Transplant 26(1):63–69
-
(2007)
J Heart Lung Transplant
, vol.26
, Issue.1
, pp. 63-69
-
-
Benza, R.L.1
Mehta, S.2
Keogh, A.3
Lawrence, E.C.4
Oudiz, R.J.5
Barst, R.J.6
-
54
-
-
0035036050
-
The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions
-
COI: 1:CAS:528:DC%2BD3MXjvVelsbo%3D, PID: 11309550
-
Fattinger K, Funk C, Pantze M et al (2001) The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions. Clin Pharmacol Ther 69(4):223–231
-
(2001)
Clin Pharmacol Ther
, vol.69
, Issue.4
, pp. 223-231
-
-
Fattinger, K.1
Funk, C.2
Pantze, M.3
-
55
-
-
79953654350
-
Hepatotoxicity by bosentan in a patient with portopulmonary hypertension: a case-report and review of the literature
-
PID: 21451802
-
Eriksson C, Gustavsson A, Kronvall T, Tysk C (2011) Hepatotoxicity by bosentan in a patient with portopulmonary hypertension: a case-report and review of the literature. J Gastrointestin Liver Dis 20(1):77–80
-
(2011)
J Gastrointestin Liver Dis
, vol.20
, Issue.1
, pp. 77-80
-
-
Eriksson, C.1
Gustavsson, A.2
Kronvall, T.3
Tysk, C.4
|