-
1
-
-
84855474159
-
Endothelin antagonists in clinical trials: Lessons learned
-
Barton M and Kohan DE (2011) Endothelin antagonists in clinical trials: lessons learned. Contrib Nephrol 172:255-260.
-
(2011)
Contrib Nephrol
, vol.172
, pp. 255-260
-
-
Barton, M.1
Kohan, D.E.2
-
2
-
-
48849094089
-
Endothelin: 20 years from discovery to therapy
-
Barton M and Yanagisawa M (2008) Endothelin: 20 years from discovery to therapy. Can J Physiol Pharmacol 86:485-498.
-
(2008)
Can J Physiol Pharmacol
, vol.86
, pp. 485-498
-
-
Barton, M.1
Yanagisawa, M.2
-
3
-
-
33744922911
-
Profile of past and current clinical trials involving endothelin receptor antagonists: The novel "-sentan" class of drug
-
Battistini B, Berthiaume N, Kelland NF, Webb DJ, and Kohan DE (2006) Profile of past and current clinical trials involving endothelin receptor antagonists: the novel "-sentan" class of drug. Exp Biol Med (Maywood) 231:653-695.
-
(2006)
Exp Biol Med (Maywood)
, vol.231
, pp. 653-695
-
-
Battistini, B.1
Berthiaume, N.2
Kelland, N.F.3
Webb, D.J.4
Kohan, D.E.5
-
4
-
-
78649972833
-
Cooperative role of ETA and ETB receptors in mediating the diuretic response to intramedullary hyperosmotic NaCl infusion
-
Boesen EI and Pollock DM (2010) Cooperative role of ETA and ETB receptors in mediating the diuretic response to intramedullary hyperosmotic NaCl infusion. Am J Physiol Renal Physiol 299:F1424-F1432.
-
(2010)
Am J Physiol Renal Physiol
, vol.299
-
-
Boesen, E.I.1
Pollock, D.M.2
-
7
-
-
48849094291
-
Sustained Ca21 signaling and delayed internalization associated with endothelin receptor heterodimers linked through a PDZ finger
-
Evans NJ and Walker JW (2008) Sustained Ca21 signaling and delayed internalization associated with endothelin receptor heterodimers linked through a PDZ finger. Can J Physiol Pharmacol 86:526-535.
-
(2008)
Can J Physiol Pharmacol
, vol.86
, pp. 526-535
-
-
Evans, N.J.1
Walker, J.W.2
-
8
-
-
33845423984
-
Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention
-
Ge Y, Bagnall A, Stricklett PK, Strait K, Webb DJ, Kotelevtsev Y, and Kohan DE (2006) Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention. Am J Physiol Renal Physiol 291:F1274-F1280.
-
(2006)
Am J Physiol Renal Physiol
, vol.291
-
-
Ge, Y.1
Bagnall, A.2
Stricklett, P.K.3
Strait, K.4
Webb, D.J.5
Kotelevtsev, Y.6
Kohan, D.E.7
-
9
-
-
57349141943
-
Combined knockout of collecting duct endothelin A and B receptors causes hypertension and sodium retention
-
Ge Y, Bagnall A, Stricklett PK, Webb D, Kotelevtsev Y, and Kohan DE (2008) Combined knockout of collecting duct endothelin A and B receptors causes hypertension and sodium retention. Am J Physiol Renal Physiol 295:F1635-F1640.
-
(2008)
Am J Physiol Renal Physiol
, vol.295
-
-
Ge, Y.1
Bagnall, A.2
Stricklett, P.K.3
Webb, D.4
Kotelevtsev, Y.5
Kohan, D.E.6
-
10
-
-
24944554452
-
Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure
-
Ge Y, Stricklett PK, Hughes AK, Yanagisawa M, and Kohan DE (2005) Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure. Am J Physiol Renal Physiol 289:F692-F698.
-
(2005)
Am J Physiol Renal Physiol
, vol.289
-
-
Ge, Y.1
Stricklett, P.K.2
Hughes, A.K.3
Yanagisawa, M.4
Kohan, D.E.5
-
11
-
-
62649134676
-
Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: A double-blind, placebocontrolled, randomised, phase 2 trial
-
James ND, Caty A, Borre M, Zonnenberg BA, Beuzeboc P, Morris T, Phung D, and Dawson NA (2009) Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: a double-blind, placebocontrolled, randomised, phase 2 trial. Eur Urol 55:1112-1123.
-
(2009)
Eur Urol
, vol.55
, pp. 1112-1123
-
-
James, N.D.1
Caty, A.2
Borre, M.3
Zonnenberg, B.A.4
Beuzeboc, P.5
Morris, T.6
Phung, D.7
Dawson, N.A.8
-
12
-
-
0242664032
-
Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol
-
Kedzierski RM, Grayburn PA, Kisanuki YY, Williams CS, Hammer RE, Richardson JA, Schneider MD, and Yanagisawa M (2003) Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol. Mol Cell Biol 23:8226-8232.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8226-8232
-
-
Kedzierski, R.M.1
Grayburn, P.A.2
Kisanuki, Y.Y.3
Williams, C.S.4
Hammer, R.E.5
Richardson, J.A.6
Schneider, M.D.7
Yanagisawa, M.8
-
13
-
-
84867578602
-
Clinical trials with endothelin receptor antagonists: What went wrong and where can we improve?
-
Kohan DE, Cleland JG, Rubin LJ, Theodorescu D, and Barton M(2012) Clinical trials with endothelin receptor antagonists: what went wrong and where can we improve? Life Sci 91:528-539.
-
(2012)
Life Sci
, vol.91
, pp. 528-539
-
-
Kohan, D.E.1
Cleland, J.G.2
Rubin, L.J.3
Theodorescu, D.4
Barton, M.5
-
14
-
-
79953295959
-
Addition of atrasentan to renin-angiotensin system blockade reduces albuminuria in diabetic nephropathy
-
Kohan DE, Pritchett Y, Molitch M, Wen S, Garimella T, Audhya P, and Andress DL (2011a) Addition of atrasentan to renin-angiotensin system blockade reduces albuminuria in diabetic nephropathy. J Am Soc Nephrol 22:763-772.
-
(2011)
J Am Soc Nephrol
, vol.22
, pp. 763-772
-
-
Kohan, D.E.1
Pritchett, Y.2
Molitch, M.3
Wen, S.4
Garimella, T.5
Audhya, P.6
Andress, D.L.7
-
16
-
-
84880409755
-
Endothelin-1 inhibits sodium reabsorption by ETA and ETB receptors in the mouse cortical collecting duct
-
DOI: 10.1152/ajprenal.00613.2012
-
Lynch IJ, Welch AK, Kohan DE, Cain BD, and Wingo CS (2013) Endothelin-1 inhibits sodium reabsorption by ETA and ETB receptors in the mouse cortical collecting duct. Am J Physiol Renal Physiol DOI: 10.1152/ajprenal.00613.2012.
-
(2013)
Am J Physiol Renal Physiol
-
-
Lynch, I.J.1
Welch, A.K.2
Kohan, D.E.3
Cain, B.D.4
Wingo, C.S.5
-
17
-
-
77949877308
-
Avosentan for overt diabetic nephropathy
-
Mann JF, Green D, Jamerson K, Ruilope LM, Kuranoff SJ, Littke T, Viberti G, and ASCEND Study Group (2010) Avosentan for overt diabetic nephropathy. J Am Soc Nephrol 21:527-535.
-
(2010)
J Am Soc Nephrol
, vol.21
, pp. 527-535
-
-
Mann, J.F.1
Green, D.2
Jamerson, K.3
Ruilope, L.M.4
Kuranoff, S.J.5
Littke, T.6
Viberti, G.7
Study Group, A.8
-
18
-
-
59849119855
-
Contribution of endothelin A receptors in endothelin 1-dependent natriuresis in female rats
-
Nakano D and Pollock DM (2009) Contribution of endothelin A receptors in endothelin 1-dependent natriuresis in female rats. Hypertension 53:324-330.
-
(2009)
Hypertension
, vol.53
, pp. 324-330
-
-
Nakano, D.1
Pollock, D.M.2
-
19
-
-
1242341961
-
Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy
-
Shohet RV, Kisanuki YY, Zhao XS, Siddiquee Z, Franco F, and Yanagisawa M (2004) Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy. Proc Natl Acad Sci USA 101:2088-2093.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 2088-2093
-
-
Shohet, R.V.1
Kisanuki, Y.Y.2
Zhao, X.S.3
Siddiquee, Z.4
Franco, F.5
Yanagisawa, M.6
-
20
-
-
84870329393
-
Disruption of the endothelin A receptor in the nephron causes mild fluid volume expansion
-
Stuart D, Rees S, Woodward SK, Koesters R, Strait KA, and Kohan DE (2012) Disruption of the endothelin A receptor in the nephron causes mild fluid volume expansion. BMC Nephrol 13:166.
-
(2012)
BMC Nephrol
, vol.13
, pp. 166
-
-
Stuart, D.1
Rees, S.2
Woodward, S.K.3
Koesters, R.4
Strait, K.A.5
Kohan, D.E.6
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