ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice

Nature Genetics

Volumn 49, Issue 2, 2017, Pages 296-302

  Mathur, Radhika ^a,b   Alver, Burak H ^a   San Roman, Adrianna K ^a,b   Wilson, Boris G ^b   Wang, Xiaofeng ^b   Agoston, Agoston T ^c   Park, Peter J ^a,c   Shivdasani, Ramesh A ^b,c   Roberts, Charles W M ^b,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; ARID1A PROTEIN; BETA CATENIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; ARID1A PROTEIN, HUMAN; DNA BINDING PROTEIN; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON ADENOCARCINOMA; CONTROLLED STUDY; DEREGULATION; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; ANIMAL; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; COLON TUMOR; ENHANCER REGION; GENETICS; HCT 116 CELL LINE; MUTATION; TUMOR CELL LINE;

ANIMALS; BETA CATENIN; CELL LINE, TUMOR; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION REGULATION; HCT116 CELLS; HUMANS; MICE; MUTATION; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS;

EID: 85003952292     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3744     Document Type: Article

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