A multi-endpoint matched molecular pair (MMP) analysis of 6-membered heterocycles

Bioorganic and Medicinal Chemistry

Volumn 25, Issue 1, 2017, Pages 381-388

  Chang, George ^a   Huard, Kim ^a   Kauffman, Gregory W ^a   Stepan, Antonia F ^a   Keefer, Christopher E ^a  

^a PFIZER INC   (United States)

Author keywords

Human liver microsomal metabolism; Log D lipophilicity; Matched molecular pair; Multiparameter optimization; P gp efflux; Passive membrane permeability

Indexed keywords

ANALYTIC METHOD; ARTICLE; CELL METABOLISM; DATA PROCESSING; DRUG DEVELOPMENT; EFFUSION; HEAT; LIPOPHILICITY; LIVER MICROSOME; MATCHED MOLECULAR PAIR ANALYSIS; MICROSOMAL METABOLISM; MOLECULAR BIOLOGY; PERMEABILITY; PROCESS OPTIMIZATION; STATISTICAL ANALYSIS; ANIMAL; CELL MEMBRANE PERMEABILITY; CHEMISTRY; DOG; HUMAN; MDCK CELL LINE; METABOLISM; PROCEDURES;

MULTIDRUG RESISTANCE PROTEIN 1; SINGLE HETEROCYCLIC RINGS;

ANIMALS; ATP-BINDING CASSETTE, SUB-FAMILY B, MEMBER 1; CELL MEMBRANE PERMEABILITY; DOGS; DRUG DISCOVERY; HETEROCYCLIC COMPOUNDS, 1-RING; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; MICROSOMES, LIVER;

EID: 85003844975     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.11.004     Document Type: Article

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