Diazoxide in children with obesity after hypothalamic-pituitary lesions: A randomized, placebo-controlled trial

Journal of Clinical Endocrinology and Metabolism

Volumn 101, Issue 12, 2016, Pages 4825-4833

  Brauner, Raja ^a   Serreau, Raphaël ^a   Souberbielle, Jean Claude ^b   Pouillot, Monique ^a   Grouazel, Sophie ^a   Recasens, Christophe ^c   Zerah, Michel ^a   Sainte Rose, Christian ^a   Treluyer, Jean Marc ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c Institut Médico Educatif Armonia   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; DESMOPRESSIN; DIAZOXIDE; ESTRADIOL; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HYDROCORTISONE; INSULIN; PLACEBO; RECOMBINANT GROWTH HORMONE; TESTOSTERONE; ANTIDIABETIC AGENT;

ADOLESCENT; ARTICLE; ASTHENIA; CHILD; CHILDHOOD OBESITY; CLINICAL ARTICLE; CONTROLLED STUDY; CRANIOPHARYNGIOMA; DIABETES MELLITUS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; ENDOCRINE DISEASE; EVENING DOSAGE; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSURIA; HEMOGLOBIN BLOOD LEVEL; HIRSUTISM; HUMAN; HYPERINSULINEMIA; HYPOPHYSIS DISEASE; HYPOPITUITARISM; HYPOTHALAMUS HYPOPHYSIS LESION; INSULIN BLOOD LEVEL; KETONURIA; LUNG INFECTION; MALE; MORNING DOSAGE; NONFUNCTIONING PITUITARY ADENOMA; OPTIC NERVE GLIOMA; ORAL GLUCOSE TOLERANCE TEST; OUTCOME ASSESSMENT; PARALLEL DESIGN; PILOCYTIC ASTROCYTOMA; PITUITARY NECROSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; WEIGHT CHANGE; BLOOD; CHEMICALLY INDUCED; COMPLICATION; HYPERINSULINISM; HYPOTHALAMUS DISEASE; PEDIATRIC OBESITY;

ADOLESCENT; CHILD; DIABETES MELLITUS; DIAZOXIDE; DOUBLE-BLIND METHOD; HUMANS; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; HYPOTHALAMIC DISEASES; OUTCOME ASSESSMENT (HEALTH CARE); PEDIATRIC OBESITY; PITUITARY DISEASES;

EID: 85003666504     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2016-2126     Document Type: Article

References (35)

1. Jeanrenaud B. Hyperinsulinemia in obesity syndromes: Its metabolic consequences and possible etiology. Metabolism. 1978;27(12 suppl 2):1881-1892
2. Inoue S, Bray G. The effects of subdiaphragmatic vagotomy in rats with ventromedial hypothalamic obesity. Endocrinology. 1977; 100:108-114
3. Pinto, G, Bussières L, Recasens C, Souberbielle JC, Zerah M, Brauner R. Hormonal factors influencing weight and growth pattern in craniopharyngioma. Horm Res 2000;53:163-169
4. Lustig RH, Post SR, Srivannaboon K, et al. Risk factors for the development of obesity in children surviving brain tumors. J Clin Endocrinol Metab. 2003;88:611-616
5. Gautier A, Godbout A, Grosheny C, et al. Markers of recurrence and long-term morbidity in craniopharyngioma: A systematic analysis of 171 patients. J Clin Endocrinol Metab. 2012;97:1258-1267
6. de Vile CJ, Grant DB, Hayward RD, Kendall BE, Neville BG, Stanhope R. Obesity in childhood craniopharyngioma: Relation to postoperative hypothalamic damage shown by magnetic resonance imaging. J Clin Endocrinol Metab. 1996;81:2734-2737
7. Müller HL, Bueb K, Bartels U, et al. Obesity after childhood craniopharyngioma-German multicenter study on pre-operative risk factors and quality of life. Klin Pädiatr. 2001;213:244-249
8. Meuric S, Brauner R, Trivin C, Souberbielle JC, Zerah M, Sainte-Rose C. Influence of tumor location on the presentation and evolution of craniopharyngiomas. J Neurosurg. 2005;103:421-426
9. Talvensaari KK, Lanning M, Tapanainen P, Knip M. Long-term survivors of childhood cancer have an increased risk of manifesting the metabolic syndrome. J Clin Endocrinol Metab. 1996;81:3051-3055
10. Adams LA, Feldstein A, Lindor KD, Angulo P. Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction. Hepatology. 2004;39:909-914
11. Hoffmann A, Bootsveld K, Gebhardt U, Daubenbüchel AM, Sterkenburg AS, Müller HL. Nonalcoholic fatty liver disease and fatigue in long-term survivors of childhood-onset craniopharyngioma. Eur J Endocrinol. 2015;173:389-397
12. Lustig RH, Rose SR, Burghen GA, et al. Hypothalamic obesity caused by cranial insult in children: Altered glucose and insulin dynamics and reversal by a somatostatin agonist. J Pediatr. 1999;135: 162-168
13. Lustig RH, Hinds PS, Ringwald-Smith K, et al. Octreotide therapy of pediatric hypothalamic obesity: A double-blind, placebo-controlled trial. J Clin Endocrinol Metab. 2003;88:2586-2592
14. Srinivasan S, Ogle GD, Garnett SP, Briody JN, Lee JW, Cowell CT. Features of the metabolic syndrome after childhood craniopharyngioma. J Clin Endocrinol Metab. 2004;89:81-86
15. Geffner M, Lundberg M, Koltowska-Häggström M, et al. Changes in height, weight, and body mass index in children with craniopharyngioma after three years of growth hormone therapy: Analysis of KIGS (Pfizer international growth database). J Clin Endocrinol Metab. 2004;89:5435-5440
16. Mason PW, Krawiecki N, Meacham LR. The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma. Arch Pediatr Adolesc Med. 2002;156:887-892
17. Touati, G, Poggi-Travert F, Ogier de Baulny H, et al. Long-term treatment of persistent hyperinsulinaemic hypoglycaemia of infancy with diazoxide: A retrospective review of 77 cases and analysis of efficacy-predicting criteria. Eur J Pediatr. 1998;157(8):628-633
18. Alemzadeh R, Jacobs W, Pitukcheewanont P. Antiobesity effect of diazoxide in obese Zucker rats. Metabolism. 1996;45(3):334-341
19. Alemzadeh R, Langley G, Upchurch L, Smith P, Slonim AE. Beneficial effect of diazoxide in obese hyperinsulinemic adults. J Clin Endocrinol Metab. 1998;83:1911-1915
20. Schreuder T, Karreman M, Rennings A, Ruinemans-Koerts J, Jansen M, de Boer H. Diazoxide-mediated insulin suppression in obese men: A dose-response study. Diabetes Obes Metab. 2005;7(3):239-245
21. Hamilton JK, Conwell LS, Syme C, Ahmet A, Jeffery A, Daneman D. Hypothalamic obesity following craniopharyngioma surgery: Results of a pilot trial of combined diazoxide and metformin therapy. Int J Pediatr Endocrinol. 2011;2011:417949
22. Taylor M, Couto-Silva AC, Adan L, et al. Hypothalamic-pituitary lesions in pediatric patients: Endocrine symptoms often precede neuro-ophthalmic presenting symptoms. J Pediatr. 2012;161:855-863
23. Trivin C, Busiah K, Mahlaoui N, et al. Childhood craniopharyngioma: Greater hypothalamic involvement before surgery is associated with higher homeostasis model insulin resistance index. BMC Pediatr. 2009;9:24
24. Brauner R, Trivin C, Zerah M, et al. Diencephalic syndrome due to hypothalamic tumor: A model of the relationship between weight and puberty onset. J Clin Endocrinol Metab. 2006;91:2467-2473
25. Rolland-Cachera MF, Cole TJ, Sempé M, Tichet J, Rossignol C, Charraud A. Body mass index variations: Centiles from birth to 87 years. Eur J Clin Nutr. 1991;45:13-21
26. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419
27. Zoicas F, Droste M, Mayr B, Buchfelder M, Schöfl C. GLP-1 analogues as a new treatment option for hypothalamic obesity in adults: Report of nine cases. Eur J Endocrinol. 2013;168:699-706
28. Müller HL. Craniopharyngioma. Endocr Rev. 2014;35:513-543
29. Elowe-Gruau E, Beltrand J, Brauner R, et al. Childhood craniopharyngioma: Hypothalamus-sparing surgery decreases the risk of obesity. J Clin Endocrinol Metab. 2013;98:2376-2382
30. Bishop AJ, Greenfield B, Mahajan A, et al. Proton beam therapy versus conformal photon radiation therapy for childhood craniopharyngioma: Multi-institutional analysis of outcomes, cyst dynamics, and toxicity. Int J Radiat Oncol Biol Phys. 2014;90:354-561
31. Wynne K, Stanley S, McGowan B, Bloom S. Appetite control. J Endocrinol. 2005;184:291-318
32. Roemmler-Zehrer J, Geigenberger V, Störmann S, et al. Food intake regulating hormones in adult craniopharyngioma patients. Eur J Endocrinol. 2014;170:627-635
33. Kanumakala S, Greaves R, Pedreira CC, et al. Fasting ghrelin levels are not elevated in children with hypothalamic obesity. J Clin Endocrinol Metab. 2005;90:2691-2695
34. Brabant G, Horn R, Mayr B, von zur Mühlen A, Honegger J, Buchfelder M. Serum leptin levels following hypothalamic surgery. Horm Metab Res. 1996;28:728-731
35. Roth C, Wilken B, Hanefeld F, Schröter W, Leonhardt U. Hyperphagia in children with craniopharyngioma is associated with hyperleptinaemia and a failure in the downregulation of appetite. Eur J Endocrinol. 1998;138:89-91.