메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

FOXA1, GATA3 and PPARIγ Cooperate to drive luminal subtype in bladder cancer: A molecular analysis of established human cell lines

Author keywords

[No Author keywords available]

Indexed keywords

FOXA1 PROTEIN, HUMAN; GATA3 PROTEIN, HUMAN; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR GATA 3; TUMOR MARKER;

EID: 85002807915     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep38531     Document Type: Article
Times cited : (101)

References (55)
  • 2
    • 84893520397 scopus 로고    scopus 로고
    • Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy
    • doi: 10.1016/j.ccr.2014.01.009
    • Choi, W. et al. Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy. Cancer cell 25, 152-165, doi: 10.1016/j.ccr.2014.01.009 (2014).
    • (2014) Cancer Cell , vol.25 , pp. 152-165
    • Choi, W.1
  • 4
    • 84897022815 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of urothelial bladder carcinoma
    • Cancer Genome Atlas Research, N doi: 10.1038/nature12965
    • Cancer Genome Atlas Research, N. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 507, 315-322, doi: 10.1038/nature12965 (2014).
    • (2014) Nature , vol.507 , pp. 315-322
  • 5
    • 84896844735 scopus 로고    scopus 로고
    • Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology
    • doi: 10.1073/pnas.1318376111
    • Damrauer, J. S. et al. Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology. Proceedings of the National Academy of Sciences of the United States of America 111, 3110-3115, doi: 10.1073/pnas.1318376111 (2014).
    • (2014) Proceedings of the National Academy of Sciences of the United States of America , vol.111 , pp. 3110-3115
    • Damrauer, J.S.1
  • 6
    • 84990825826 scopus 로고    scopus 로고
    • Bladder cancer molecular taxonomy: Summary from a consensus meeting
    • doi: 10.3233/BLC-150037
    • Lerner, S. P. et al. Bladder Cancer Molecular Taxonomy: Summary from a Consensus Meeting. Bladder Cancer 2, 37-47, doi: 10.3233/BLC-150037 (2016).
    • (2016) Bladder Cancer , vol.2 , pp. 37-47
    • Lerner, S.P.1
  • 7
    • 84979732333 scopus 로고    scopus 로고
    • Comprehensive transcriptional analysis of early-stage urothelial carcinoma
    • doi: 10.1016/j.ccell.2016.05.004
    • Hedegaard, J. et al. Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma. Cancer cell 30, 27-42, doi: 10.1016/j.ccell.2016.05.004 (2016).
    • (2016) Cancer Cell , vol.30 , pp. 27-42
    • Hedegaard, J.1
  • 8
    • 84940703220 scopus 로고    scopus 로고
    • A prognostic gene expression signature in the molecular classification of chemotherapy-naive urothelial cancer is predictive of clinical outcomes from neoadjuvant chemotherapy: A phase 2 trial of dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin with bevacizumab in urothelial cancer
    • doi: 10.1016/jeururo.2015.08.034
    • McConkey, D. J. et al. A Prognostic Gene Expression Signature in the Molecular Classification of Chemotherapy-naive Urothelial Cancer is Predictive of Clinical Outcomes from Neoadjuvant Chemotherapy: A Phase 2 Trial of Dose-dense Methotrexate, Vinblastine, Doxorubicin, and Cisplatin with Bevacizumab in Urothelial Cancer. European urology, doi: 10.1016/j. eururo.2015.08.034 (2015).
    • (2015) European Urology
    • McConkey, D.J.1
  • 9
    • 84928041218 scopus 로고    scopus 로고
    • Loss of FOXA1 drives sexually dimorphic changes in urothelial differentiation and is an independent predictor of poor prognosis in bladder cancer
    • doi: 10.1016/j.ajpath.2015.01.014
    • Reddy, O. L. et al. Loss of FOXA1 Drives Sexually Dimorphic Changes in Urothelial Differentiation and Is an Independent Predictor of Poor Prognosis in Bladder Cancer. The American journal of pathology 185, 1385-1395, doi: 10.1016/j.ajpath.2015.01.014 (2015).
    • (2015) The American Journal of Pathology , vol.185 , pp. 1385-1395
    • Reddy, O.L.1
  • 10
    • 84872703824 scopus 로고    scopus 로고
    • Deficiency in metabolic regulators PPARgamma and PTEN cooperates to drive keratinizing squamous metaplasia in novel models of human tissue regeneration
    • doi: 10.1016/j.ajpath.2012.10.007
    • Strand, D. W. et al. Deficiency in metabolic regulators PPARgamma and PTEN cooperates to drive keratinizing squamous metaplasia in novel models of human tissue regeneration. The American journal of pathology 182, 449-459, doi: 10.1016/j. ajpath.2012.10.007 (2013).
    • (2013) The American Journal of Pathology , vol.182 , pp. 449-459
    • Strand, D.W.1
  • 11
    • 1942437006 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells
    • Varley, C. L., Stahlschmidt, J., Smith, B., Stower, M. and Southgate, J. Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells. The American journal of pathology 164, 1789-1798 (2004).
    • (2004) The American Journal of Pathology , vol.164 , pp. 1789-1798
    • Varley, C.L.1    Stahlschmidt, J.2    Smith, B.3    Stower, M.4    Southgate, J.5
  • 12
    • 84930208685 scopus 로고    scopus 로고
    • Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems
    • doi: 10.1186/s12920-015-0101-5
    • Eriksson, P. et al. Molecular subtypes of urothelial carcinoma are defined by specific gene regulatory systems. BMC medical genomics 8, 25, doi: 10.1186/s12920-015-0101-5 (2015).
    • (2015) BMC Medical Genomics , vol.8 , pp. 25
    • Eriksson, P.1
  • 13
    • 80052619766 scopus 로고    scopus 로고
    • Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium
    • doi: 10.1016/j.ydbio.2011.07.020
    • Bell, S. M. et al. Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium. Developmental biology 358, 79-90, doi: 10.1016/j.ydbio.2011.07.020 (2011).
    • (2011) Developmental Biology , vol.358 , pp. 79-90
    • Bell, S.M.1
  • 14
    • 84892878110 scopus 로고    scopus 로고
    • Identification of ELF3 as an early transcriptional regulator of human urothelium
    • doi: 10.1016/j.ydbio.2013.12.028
    • Bock, M. et al. Identification of ELF3 as an early transcriptional regulator of human urothelium. Developmental biology 386, 321-330, doi: 10.1016/j.ydbio.2013.12.028 (2014).
    • (2014) Developmental Biology , vol.386 , pp. 321-330
    • Bock, M.1
  • 15
    • 67650427106 scopus 로고    scopus 로고
    • The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation
    • doi: 10.1038/emboj.2009.142
    • Yu, Z., Mannik, J., Soto, A., Lin, K. K. and Andersen, B. The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation. The EMBO journal 28, 1890-1903, doi: 10.1038/emboj.2009.142 (2009).
    • (2009) The EMBO Journal , vol.28 , pp. 1890-1903
    • Yu, Z.1    Mannik, J.2    Soto, A.3    Lin, K.K.4    Andersen, B.5
  • 16
    • 49949091267 scopus 로고    scopus 로고
    • Effects of PPAR agonists on proliferation and differentiation in human urothelium
    • doi: 10.1016/j.etp.2008.04.009
    • Varley, C. L. and Southgate, J. Effects of PPAR agonists on proliferation and differentiation in human urothelium. Exp Toxicol Pathol 60, 435-441, doi: 10.1016/j.etp.2008.04.009 (2008).
    • (2008) Exp Toxicol Pathol , vol.60 , pp. 435-441
    • Varley, C.L.1    Southgate, J.2
  • 17
    • 84904036353 scopus 로고    scopus 로고
    • Intrinsic basal and luminal subtypes of muscle-invasive bladder cancer
    • doi: 10.1038/nrurol.2014.129
    • Choi, W. et al. Intrinsic basal and luminal subtypes of muscle-invasive bladder cancer. Nature reviews. Urology 11, 400-410, doi: 10.1038/nrurol.2014.129 (2014).
    • (2014) Nature Reviews. Urology , vol.11 , pp. 400-410
    • Choi, W.1
  • 18
    • 84860999189 scopus 로고    scopus 로고
    • Loss of the urothelial differentiation marker FOXA1 is associated with high grade, late stage bladder cancer and increased tumor proliferation
    • doi: 10.1371/journal.pone.0036669
    • DeGraff, D. J. et al. Loss of the urothelial differentiation marker FOXA1 is associated with high grade, late stage bladder cancer and increased tumor proliferation. PloS one 7, e36669, doi: 10.1371/journal.pone.0036669 (2012).
    • (2012) PloS One , vol.7 , pp. e36669
    • DeGraff, D.J.1
  • 19
    • 79952747169 scopus 로고    scopus 로고
    • Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression
    • doi: 10.1016/j.ajpath.2010.11.061
    • Karni-Schmidt, O. et al. Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression. The American journal of pathology 178, 1350-1360, doi: 10.1016/j.ajpath.2010.11.061 (2011).
    • (2011) The American Journal of Pathology , vol.178 , pp. 1350-1360
    • Karni-Schmidt, O.1
  • 20
    • 0036510402 scopus 로고    scopus 로고
    • Molecular regulation of urothelial renewal and host defenses during infection with uropathogenic Escherichia coli
    • doi: 10.1074/jbc.M110560200
    • Mysorekar, I. U., Mulvey, M. A., Hultgren, S. J. and Gordon, J. I. Molecular regulation of urothelial renewal and host defenses during infection with uropathogenic Escherichia coli. The Journal of biological chemistry 277, 7412-7419, doi: 10.1074/jbc.M110560200 (2002).
    • (2002) The Journal of Biological Chemistry , vol.277 , pp. 7412-7419
    • Mysorekar, I.U.1    Mulvey, M.A.2    Hultgren, S.J.3    Gordon, J.I.4
  • 21
    • 84912071423 scopus 로고    scopus 로고
    • Independent component analysis uncovers the landscape of the bladder tumor transcriptome and reveals insights into luminal and basal subtypes
    • doi: 10.1016/j.celrep.2014.10.035
    • Biton, A. et al. Independent component analysis uncovers the landscape of the bladder tumor transcriptome and reveals insights into luminal and basal subtypes. Cell Rep 9, 1235-1245, doi: 10.1016/j.celrep.2014.10.035 (2014).
    • (2014) Cell Rep , vol.9 , pp. 1235-1245
    • Biton, A.1
  • 22
    • 84859169877 scopus 로고    scopus 로고
    • The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
    • doi: 10.1038/nature11003
    • Barretina, J. et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483, 603-607, doi: 10.1038/nature11003 (2012).
    • (2012) Nature , vol.483 , pp. 603-607
    • Barretina, J.1
  • 23
    • 84935895322 scopus 로고    scopus 로고
    • The UBC-40 Urothelial Bladder Cancer cell line index: A genomic resource for functional studies
    • doi: 10.1186/s12864-015-1450-3
    • Earl, J. et al. The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies. BMC genomics 16, 403, doi: 10.1186/s12864-015-1450-3 (2015).
    • (2015) BMC Genomics , vol.16 , pp. 403
    • Earl, J.1
  • 24
    • 0023070014 scopus 로고
    • Mesenchymal-epithelial interactions: Technical considerations
    • Cunha, G. R. and Donjacour, A. Mesenchymal-epithelial interactions: technical considerations. Prog Clin Biol Res 239, 273-282 (1987).
    • (1987) Prog Clin Biol Res , vol.239 , pp. 273-282
    • Cunha, G.R.1    Donjacour, A.2
  • 25
    • 0014913045 scopus 로고
    • M. A human tissue culture cell line from a transitional cell tumour of the urinary bladder: Growth, chromosone pattern and ultrastructure
    • Rigby, C. C. and Franks, L. M. A human tissue culture cell line from a transitional cell tumour of the urinary bladder: growth, chromosone pattern and ultrastructure. British journal of cancer 24, 746-754 (1970).
    • (1970) British Journal of Cancer , vol.24 , pp. 746-754
    • Rigby, C.C.1    Franks, L.2
  • 26
    • 0015782448 scopus 로고
    • Established cell line of urinary bladder carcinoma (T24) containing tumour-specific antigen
    • Bubenik, J. et al. Established cell line of urinary bladder carcinoma (T24) containing tumour-specific antigen. International journal of cancer. Journal international du cancer 11, 765-773 (1973).
    • (1973) International Journal of Cancer. Journal International du Cancer , vol.11 , pp. 765-773
    • Bubenik, J.1
  • 27
    • 0021140515 scopus 로고
    • UM-UC-1 and UM-UC-2: Characterization of two new human transitional cell carcinoma lines
    • Grossman, H. B., Wedemeyer, G. and Ren, L. UM-UC-1 and UM-UC-2: characterization of two new human transitional cell carcinoma lines. The Journal of urology 132, 834-837 (1984).
    • (1984) The Journal of Urology , vol.132 , pp. 834-837
    • Grossman, H.B.1    Wedemeyer, G.2    Ren, L.3
  • 31
    • 0017334184 scopus 로고
    • H. A cell line from an anaplastic transitional cell carcinoma of human urinary bladder
    • Nayak, S. K., OToole, C. and Price, Z. H. A cell line from an anaplastic transitional cell carcinoma of human urinary bladder. British journal of cancer 35, 142-151 (1977).
    • (1977) British Journal of Cancer , vol.35 , pp. 142-151
    • Nayak, S.K.1    O'Toole, C.2    Price, Z.3
  • 32
    • 0017412603 scopus 로고
    • One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice
    • Fogh, J., Fogh, J. M. and Orfeo, T. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. Journal of the National Cancer Institute 59, 221-226 (1977).
    • (1977) Journal of the National Cancer Institute , vol.59 , pp. 221-226
    • Fogh, J.1    Fogh, J.M.2    Orfeo, T.3
  • 33
    • 0018218840 scopus 로고
    • Cultivation characterization, and identification of human tumor cells with emphasis on kidney, testis, and bladder tumors
    • Fogh, J. Cultivation, characterization, and identification of human tumor cells with emphasis on kidney, testis, and bladder tumors. National Cancer Institute monograph, 5-9 (1978).
    • (1978) National Cancer Institute Monograph , pp. 5-9
    • Fogh, J.1
  • 34
    • 65449136284 scopus 로고    scopus 로고
    • TopHat: Discovering splice junctions with RNA-Seq
    • doi: 10.1093/bioinformatics/btp120
    • Trapnell, C., Pachter, L. and Salzberg, S. L. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25, 1105-1111, doi: 10.1093/bioinformatics/btp120 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 1105-1111
    • Trapnell, C.1    Pachter, L.2    Salzberg, S.L.3
  • 35
    • 84859885816 scopus 로고    scopus 로고
    • Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
    • doi: 10.1038/nprot.2012.016
    • Trapnell, C. et al. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc 7, 562-578, doi: 10.1038/nprot.2012.016 (2012).
    • (2012) Nat Protoc , vol.7 , pp. 562-578
    • Trapnell, C.1
  • 36
    • 77958471357 scopus 로고    scopus 로고
    • Differential expression analysis for sequence count data
    • doi: 10.1186/gb-2010-11- 10-r106
    • Anders, S. and Huber, W. Differential expression analysis for sequence count data. Genome biology 11, R106, doi: 10.1186/gb-2010-11- 10-r106 (2010).
    • (2010) Genome Biology , vol.11 , pp. R106
    • Anders, S.1    Huber, W.2
  • 38
    • 84926507971 scopus 로고    scopus 로고
    • Limma powers differential expression analyses for RNA-sequencing and microarray studies
    • doi: 10.1093/nar/gkv007
    • Ritchie, M. E. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic acids research 43, e47, doi: 10.1093/nar/gkv007 (2015).
    • (2015) Nucleic Acids Research , vol.43 , pp. e47
    • Ritchie, M.E.1
  • 39
    • 84859210032 scopus 로고    scopus 로고
    • Fast gapped-read alignment with Bowtie 2
    • doi: 10.1038/nmeth.1923
    • Langmead, B. and Salzberg, S. L. Fast gapped-read alignment with Bowtie 2. Nat Methods 9, 357-359, doi: 10.1038/nmeth.1923 (2012).
    • (2012) Nat Methods , vol.9 , pp. 357-359
    • Langmead, B.1    Salzberg, S.L.2
  • 40
    • 68549104404 scopus 로고    scopus 로고
    • The Sequence Alignment/Map format and SAMtools
    • doi: 10.1093/bioinformatics/btp352
    • Li, H. et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078-2079, doi: 10.1093/bioinformatics/btp352 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 2078-2079
    • Li, H.1
  • 41
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    • doi: 10.1016/j.molcel.2010.05.004
    • Heinz, S. et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Molecular cell 38, 576-589, doi: 10.1016/j.molcel.2010.05.004 (2010).
    • (2010) Molecular Cell , vol.38 , pp. 576-589
    • Heinz, S.1
  • 43
    • 84904479838 scopus 로고    scopus 로고
    • EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a basal-like phenotype
    • doi: 10.1126/scitranslmed.3008970
    • Rebouissou, S. et al. EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a basal-like phenotype. Science translational medicine 6, 244-291, doi: 10.1126/scitranslmed.3008970 (2014).
    • (2014) Science Translational Medicine , vol.6 , pp. 244-291
    • Rebouissou, S.1
  • 44
    • 27944493276 scopus 로고    scopus 로고
    • Classification of microarrays to nearest centroids
    • doi: 10.1093/bioinformatics/bti681
    • Dabney, A. R. Classification of microarrays to nearest centroids. Bioinformatics 21, 4148-4154, doi: 10.1093/bioinformatics/bti681 (2005).
    • (2005) Bioinformatics , vol.21 , pp. 4148-4154
    • Dabney, A.R.1
  • 45
    • 84942191632 scopus 로고    scopus 로고
    • Urothelial carcinoma with squamous differentiation: Response to chemotherapy and radiation
    • doi: 10.1016/j.urolonc.2015.06.019
    • Clark, P. E. Urothelial carcinoma with squamous differentiation: response to chemotherapy and radiation. Urologic oncology 33, 434-436, doi: 10.1016/j.urolonc.2015.06.019 (2015).
    • (2015) Urologic Oncology , vol.33 , pp. 434-436
    • Clark, P.E.1
  • 46
    • 84942195011 scopus 로고    scopus 로고
    • Surgical management of bladder urothelial carcinoma with squamous differentiation
    • doi: 10.1016/j.urolonc.2015.06.010
    • Raman, J. D. and Jafri, S. M. Surgical management of bladder urothelial carcinoma with squamous differentiation. Urologic oncology 33, 429-433, doi: 10.1016/j.urolonc.2015.06.010 (2015).
    • (2015) Urologic Oncology , vol.33 , pp. 429-433
    • Raman, J.D.1    Jafri, S.M.2
  • 47
    • 84862198697 scopus 로고    scopus 로고
    • AnimalTFDB: A comprehensive animal transcription factor database
    • doi: 10.1093/nar/gkr965
    • Zhang, H. M. et al. AnimalTFDB: a comprehensive animal transcription factor database. Nucleic acids research 40, D144-149, doi: 10.1093/nar/gkr965 (2012).
    • (2012) Nucleic Acids Research , vol.40 , pp. D144-D149
    • Zhang, H.M.1
  • 48
    • 57649215886 scopus 로고    scopus 로고
    • FOXA1 and IRF-1 intermediary transcriptional regulators of PPARgammainduced urothelial cytodifferentiation
    • doi: 10.1038/cdd.2008.116
    • Varley, C. L., Bacon, E. J., Holder, J. C. and Southgate, J. FOXA1 and IRF-1 intermediary transcriptional regulators of PPARgammainduced urothelial cytodifferentiation. Cell Death Differ 16, 103-114, doi: 10.1038/cdd.2008.116 (2009).
    • (2009) Cell Death Differ , vol.16 , pp. 103-114
    • Varley, C.L.1    Bacon, E.J.2    Holder, J.C.3    Southgate, J.4
  • 49
    • 84903184142 scopus 로고    scopus 로고
    • Differential expression of GATA-3 in urothelial carcinoma variants
    • doi: 10.1016/j. humpath.2014.02.023
    • Liang, Y. et al. Differential expression of GATA-3 in urothelial carcinoma variants. Human pathology 45, 1466-1472, doi: 10.1016/j. humpath.2014.02.023 (2014).
    • (2014) Human Pathology , vol.45 , pp. 1466-1472
    • Liang, Y.1
  • 50
    • 84960402719 scopus 로고    scopus 로고
    • The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice
    • doi: 10.1136/gutjnl-2014-308042
    • Martinelli, P. et al. The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice. Gut 65, 476-486, doi: 10.1136/gutjnl-2014-308042 (2016).
    • (2016) Gut , vol.65 , pp. 476-486
    • Martinelli, P.1
  • 51
    • 84942934311 scopus 로고    scopus 로고
    • Oncogenic HRAS activates epithelial-to-mesenchymal transition and confers stemness to p53-deficient urothelial cells to drive muscle invasion of basal subtype carcinomas
    • doi: 10.1158/0008-5472.CAN-14-3067
    • He, F., Melamed, J., Tang, M. S., Huang, C. and Wu, X. R. Oncogenic HRAS Activates Epithelial-to-Mesenchymal Transition and Confers Stemness to p53-Deficient Urothelial Cells to Drive Muscle Invasion of Basal Subtype Carcinomas. Cancer research 75, 2017-2028, doi: 10.1158/0008-5472.CAN-14-3067 (2015).
    • (2015) Cancer Research , vol.75 , pp. 2017-2028
    • He, F.1    Melamed, J.2    Tang, M.S.3    Huang, C.4    Wu, X.R.5
  • 52
    • 79953897139 scopus 로고    scopus 로고
    • Increased expression of transcription factor TFAP2alpha correlates with chemosensitivity in advanced bladder cancer
    • doi: 10.1186/1471-2407-11-135
    • Nordentoft, I. et al. Increased expression of transcription factor TFAP2alpha correlates with chemosensitivity in advanced bladder cancer. BMC cancer 11, 135, doi: 10.1186/1471-2407-11-135 (2011).
    • (2011) BMC Cancer , vol.11 , pp. 135
    • Nordentoft, I.1
  • 54
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • doi: 10.1038/nature13904
    • Powles, T. et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 515, 558-562, doi: 10.1038/nature13904 (2014).
    • (2014) Nature , vol.515 , pp. 558-562
    • Powles, T.1
  • 55
    • 84906276694 scopus 로고    scopus 로고
    • MicroRNA-99a and 100 mediated upregulation of FOXA1 in bladder cancer
    • doi: 10.18632/oncotarget.2221
    • Drayton, R. M. et al. MicroRNA-99a and 100 mediated upregulation of FOXA1 in bladder cancer. Oncotarget 5, 6375-6386, doi: 10.18632/oncotarget.2221 (2014).
    • (2014) Oncotarget , vol.5 , pp. 6375-6386
    • Drayton, R.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.