Identification of neutrophil exocytosis inhibitors (Nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: Druggability of the small GTPase Rab27a

Journal of Biological Chemistry

Volumn 291, Issue 50, 2016, Pages 25965-25982

  Johnson, Jennifer L ^a   Ramadass, Mahalakshmi ^a   He, Jing ^a   Brown, Steven J ^a   Zhang, Jinzhong ^a   Abgaryan, Lusine ^a   Biris, Nikolaos ^b   Gavathiotis, Evripidis ^b   Rosen, Hugh ^a   Catz, Sergio D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-ANTIBODY REACTIONS; ASSAYS; CELL MEMBRANES; GRANULATION; OXYGEN; PATHOLOGY; PROTEINS; TISSUE;

ADHESION MOLECULES; ANTI-INFLAMMATORY ACTIVITY; HIGH THROUGHPUT SCREENING; INNATE IMMUNE RESPONSE; SMALL MOLECULE INHIBITOR; SPECIFIC INHIBITORS; SUPEROXIDE ANIONS; SYSTEMIC INFLAMMATION;

MOLECULES;

ANTIGEN; CD11B ANTIGEN; CD66B ANTIGEN; RAB27A PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SECRETORY PROTEIN; SYNAPTOTAGMIN I; SYNAPTOTAGMIN LIKE PROTEIN 1; UNCLASSIFIED DRUG; CEACAM8 PROTEIN, HUMAN; CELL ADHESION MOLECULE; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; ITGAM PROTEIN, HUMAN; JFC1 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; RAB PROTEIN; RAB27A PROTEIN, HUMAN; RAB27A PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASSAY; CELL MEMBRANE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; EXOCYTOSIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; LIMIT OF QUANTITATION; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; FEMALE; MALE; METABOLISM;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD11B; CELL ADHESION MOLECULES; CELL MEMBRANE; EXOCYTOSIS; FEMALE; GPI-LINKED PROTEINS; HUMANS; MALE; MEMBRANE PROTEINS; MICE; NADPH OXIDASE; NEUTROPHILS; RAB GTP-BINDING PROTEINS;

EID: 85002575553     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.741884     Document Type: Article

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