Activation of PI3Kγ/Akt pathway increases cardiomyocyte HMGB1 expression in diabetic environment

Oncotarget

Volumn 7, Issue 49, 2016, Pages 80803-80810

  Song, Jia ^a   Liu, Qian ^a   Tang, Han ^a   Tao, Aibin ^a,b   Wang, Hao ^a   Kao, Raymond ^b   Rui, Tao ^a,b,c  

^a AFFILIATED PEOPLE S HOSPITAL OF JIANGSU UNIVERSITY   (China)

^b LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^c WESTERN UNIVERSITY   (Canada)

Author keywords

Akt; Cardiomyocyte; Diabetes mellitus; HMGB1; PI3KK

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; AKT1 PROTEIN, RAT; AKT2 PROTEIN, RAT; AKT3 PROTEIN, RAT; GLUCOSE; HBP1 PROTEIN, RAT; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PIK3CG PROTEIN, RAT;

ANIMAL CELL; ARTICLE; CARDIAC MUSCLE CELL; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; INTRACELLULAR SIGNALING; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CRISPR CAS SYSTEM; DIABETIC CARDIOMYOPATHY; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTOR; TUMOR MICROENVIRONMENT; UPREGULATION;

ANIMALS; CELLS, CULTURED; CELLULAR MICROENVIRONMENT; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; CRISPR-CAS SYSTEMS; DIABETIC CARDIOMYOPATHIES; GLUCOSE; HMGB1 PROTEIN; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; UP-REGULATION;

EID: 85001052484     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.13096     Document Type: Article

References (24)

1. Pergialiotis V, Prodromidou A, Frountzas M, Korou LM, Vlachos GD, Perrea D. Diabetes mellitus and functional sperm characteristics: A meta-analysis of observational studies. J Diabetes Complications. 2016; 30:1167-76.
2. Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives. Nat Rev Endocrinol. 2011; 8:228-36.
3. Cai L, Kang YJ. Oxidative stress and diabetic cardiomyopathy: a brief review. Cardiovasc Toxicol. 2001; 1:181-93.
4. Battiprolu PK, Lopez-Crisosto C, Wang ZV, Nemchenko A, Lavandero S, Hill JA. Diabetic cardiomyopathy and metabolic remodeling of the heart. Life Sci. 2013; 92:609-15.
5. Pappachan JM, Varughese GI, Sriraman R, Arunagirinathan G. Diabetic cardiomyopathy: Pathophysiology, diagnostic evaluation and management. World J Diabetes 2013; 4: 177-89.
6. Banerjee I, Fuseler JW, Price RL, Borg TK, Baudino TA. Determination of cell types and numbers during cardiac development in the neonatal and adult rat and mouse. Am J Physiol Heart Circ Physiol. 2007; 293:H1883-H1891.
7. Zhang P, Su J, Mende U. Cross talk between cardiac myocytes and fibroblasts: from multiscale investigative approaches to mechanisms and functional consequences. Am J Physiol Heart Circ Physiol. 2012; 303:H1385-H1396.
8. Camelliti P, Borg TK, Kohl P. Structural and functional characterisation of cardiac fibroblasts. Cardiovasc Res. 2005; 65:40-51.
9. Bang C, Antoniades C, Antonopoulos AS, Eriksson U, Franssen C, Hamdani N, Lehmann L, Mongillo M, Muhl L, Speer T, Thum T. Intercellular communication lessons in heart failure. Eur J Heart Fail. 2015; 17:1091-103.
10. Tao A, Song J, Lan T, Xu X, Kvietys P, Kao R, Martin C, Rui T. Cardiomyocyte-fibroblast interaction contributes to diabetic cardiomyopathy in mice: Role of HMGB1/TLR4/IL-33 axis. Biochim Biophys Acta. 2015; 1852:2075-85.
11. Ban K, Cooper AJ, Samuel S, Bhatti A, Patel M, Izumo S, Penninger JM, Backx PH, Oudit GY, Tsushima RG. Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning. Circ Res. 2008; 103:643-53.
12. O'Neill BT, Abel ED. Akt1 in the cardiovascular system: friend or foe? J Clin Invest. 2005; 115:2059-64.
13. Xu H, Su Z, Wu J, Yang M, Penninger JM, Martin CM, Kvietys PR, Rui T. The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway. J Immunol. 2010; 184:1492-8.
14. Andrassy M, Volz HC, Igwe JC, Funke B, Eichberger SN, Kaya Z, Buss S, Autschbach F, Pleger ST, Lukic IK, Bea F, Hardt SE, Humpert PM, et al. High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation 2008; 117:3216-26.
15. Harris HE, Andersson U, Pisetsky DS. HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease. Nat Rev Rheumatol. 2012; 8: 195-202.
16. Bertheloot D, Latz E. HMGB1, IL-1alpha, IL-33 and S100 proteins: dual-function alarmins. Cell Mol Immunol. 2016.
17. Im KI, Kim N, Lim JY, Nam YS, Lee ES, Kim EJ, Kim HJ, Kim SH, Cho SG. The Free Radical Scavenger NecroX-7 Attenuates Acute Graft-versus-Host Disease via Reciprocal Regulation of Th1/Regulatory T Cells and Inhibition of HMGB1 Release. J Immunol. 2015; 194:5223-32.
18. Hwaiz R, Hasan Z, Rahman M, Zhang S, Palani K, Syk I, Jeppsson B, Thorlacius H. Rac1 signaling regulates sepsisinduced pathologic inflammation in the lung via attenuation of Mac-1 expression and CXC chemokine formation. J Surg Res. 2013; 183:798-807.
19. Davalos AR, Kawahara M, Malhotra GK, Schaum N, Huang J, Ved U, Beausejour CM, Coppe JP, Rodier F, Campisi J. p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol 2013; 201:613-29.
20. Li X, Hu X, Wang J, Xu W, Yi C, Ma R, Jiang H. Short-Term Hesperidin Pretreatment Attenuates Rat Myocardial Ischemia/Reperfusion Injury by Inhibiting High Mobility Group Box 1 Protein Expression via the PI3K/Akt Pathway. Cell Physiol Biochem. 2016; 39:1850-62.
21. Yao Y, Xu X, Zhang G, Zhang Y, Qian W, Rui T. Role of HMGB1 in doxorubicin-induced myocardial apoptosis and its regulation pathway. Basic Res Cardiol. 2012; 107:267.
22. Rui T, Zhang J, Xu X, Yao Y, Kao R, Martin CM. Reduction in IL-33 expression exaggerates ischaemia/reperfusioninduced myocardial injury in mice with diabetes mellitus. Cardiovasc Res. 2012; 94:370-8.
23. Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F. Genome engineering using the CRISPR-Cas9 system. Nat Protoc. 2013; 8:2281-308.
24. Yang M, Wu J, Martin CM, Kvietys PR, Rui T. Important role of p38 MAP kinase/NF-kappaB signaling pathway in the sepsis-induced conversion of cardiac myocytes to a proinflammatory phenotype. Am J Physiol Heart Circ Physiol. 2008; 294:H994-1001.