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Volumn 7, Issue 7, 2016, Pages

Tweak favors phosphate-induced calcification of vascular smooth muscle cells through canonical and non-canonical activation of NFκB

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR; ACTA2 PROTEIN, HUMAN; ACTIN; ALPL PROTEIN, HUMAN; BMP2 PROTEIN, HUMAN; MAPK1 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN; MYH11 PROTEIN, HUMAN; MYOSIN HEAVY CHAIN; PHOSPHATE; PROTEIN BINDING; RELB PROTEIN, HUMAN; TNFSF12 PROTEIN, HUMAN; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR RECEPTOR; TWEAK RECEPTOR;

EID: 85000874000     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2016.220     Document Type: Article
Times cited : (40)

References (60)
  • 3
    • 80052561697 scopus 로고    scopus 로고
    • Arterial calcification in chronic kidney disease: Key roles for calcium and phosphate
    • Shanahan CM, Crouthamel MH, Kapustin A, Giachelli CM. Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Circ Res 2011; 109: 697–711.
    • (2011) Circ Res , vol.109 , pp. 697-711
    • Shanahan, C.M.1    Crouthamel, M.H.2    Kapustin, A.3    Giachelli, C.M.4
  • 5
    • 0034918979 scopus 로고    scopus 로고
    • The microinflammatory state in uremia: Causes and potential consequences
    • Kaysen GA. The microinflammatory state in uremia: causes and potential consequences. J Am Soc Nephrol 2001; 12: 1549–1557.
    • (2001) J am Soc Nephrol , vol.12 , pp. 1549-1557
    • Kaysen, G.A.1
  • 6
    • 84930542744 scopus 로고    scopus 로고
    • Inflammation: A culprit for vascular calcification in atherosclerosis and diabetes
    • Bessueille L, Magne D. Inflammation: a culprit for vascular calcification in atherosclerosis and diabetes. Cell Mol Life Sci 2015; 72: 2475–2489.
    • (2015) Cell Mol Life Sci , vol.72 , pp. 2475-2489
    • Bessueille, L.1    Magne, D.2
  • 8
    • 84895558806 scopus 로고    scopus 로고
    • TWEAK/Fn14 axis: A promising target for the treatment of cardiovascular diseases
    • Blanco-Colio LM. TWEAK/Fn14 axis: a promising target for the treatment of cardiovascular diseases. Front Immunol 2014; 5: 3.
    • (2014) Front Immunol , vol.5 , pp. 3
    • Blanco-Colio, L.M.1
  • 9
    • 0031465594 scopus 로고    scopus 로고
    • TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis
    • Chicheportiche Y, Bourdon PR, Xu H, Hsu YM, Scott H, Hession C et al. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J Biol Chem 1997; 272: 32401–32410.
    • (1997) J Biol Chem , vol.272 , pp. 32401-32410
    • Chicheportiche, Y.1    Bourdon, P.R.2    Xu, H.3    Hsu, Y.M.4    Scott, H.5    Hession, C.6
  • 11
    • 78751635006 scopus 로고    scopus 로고
    • Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer
    • Yoriki R, Akashi S, Sho M, Nomi T, Yamato I, Hotta K et al. Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer. Exp Ther Med 2011; 2: 103–108.
    • (2011) Exp Ther Med , vol.2 , pp. 103-108
    • Yoriki, R.1    Akashi, S.2    Sho, M.3    Nomi, T.4    Yamato, I.5    Hotta, K.6
  • 13
    • 84879595462 scopus 로고    scopus 로고
    • TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast
    • Ucero AC, Benito-Martin A, Fuentes-Calvo I, Santamaria B, Blanco J, Lopez-Novoa JM et al. TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast. Biochim Biophys Acta 2013; 1832: 1744–1755.
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 1744-1755
    • Ucero, A.C.1    Benito-Martin, A.2    Fuentes-Calvo, I.3    Santamaria, B.4    Blanco, J.5    Lopez-Novoa, J.M.6
  • 14
    • 33747173077 scopus 로고    scopus 로고
    • Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: Modulation by atorvastatin
    • Muñoz-García B, Martín-Ventura JL, Martínez E, Sánchez S, Hernández G, Ortega L et al. Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin. Stroke 2006; 37: 2044–2053.
    • (2006) Stroke , vol.37 , pp. 2044-2053
    • Muñoz-García, B.1    Martín-Ventura, J.L.2    Martínez, E.3    Sánchez, S.4    Hernández, G.5    Ortega, L.6
  • 15
    • 36049022442 scopus 로고    scopus 로고
    • TWEAKing tissue remodeling by a multifunctional cytokine: Role of TWEAK/Fn14 pathway in health and disease
    • Burkly LC, Michaelson JS, Hahm K, Jakubowski A, Zheng TS. TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease. Cytokine 2007; 40: 1–16.
    • (2007) Cytokine , vol.40 , pp. 1-16
    • Burkly, L.C.1    Michaelson, J.S.2    Hahm, K.3    Jakubowski, A.4    Zheng, T.S.5
  • 17
    • 84922679209 scopus 로고    scopus 로고
    • Tumor necrosis factor-like weak inducer of apoptosis or Fn14 deficiency reduce elastase perfusion-induced aortic abdominal aneurysm in mice
    • Tarín C, Fernández-Laso V, Sastre C, Madrigal-Matute J, Gómez M, Zaragoza C et al. Tumor necrosis factor-like weak inducer of apoptosis or Fn14 deficiency reduce elastase perfusion-induced aortic abdominal aneurysm in mice. J Am Heart Assoc 2014; 3: e000723.
    • (2014) J am Heart Assoc , vol.3
    • Tarín, C.1    Fernández-Laso, V.2    Sastre, C.3    Madrigal-Matute, J.4    Gómez, M.5    Zaragoza, C.6
  • 19
    • 84881087204 scopus 로고    scopus 로고
    • Multisystemic functions of alkaline phosphatases
    • Buchet R, Millán JL, Magne D. Multisystemic functions of alkaline phosphatases. Methods Mol Biol 2013; 1053: 27–51.
    • (2013) Methods Mol Biol , vol.1053 , pp. 27-51
    • Buchet, R.1    Millán, J.L.2    Magne, D.3
  • 22
    • 10644222796 scopus 로고    scopus 로고
    • New aspects in the pathogenesis of diabetic atherothrombosis
    • Moreno PR, Fuster V. New aspects in the pathogenesis of diabetic atherothrombosis. J Am Coll Cardiol 2004; 44: 2293–2300.
    • (2004) J am Coll Cardiol , vol.44 , pp. 2293-2300
    • Moreno, P.R.1    Fuster, V.2
  • 24
    • 60749133542 scopus 로고    scopus 로고
    • Peripheral vascular calcification in long-haemodialysis patients: Associated factors and survival consequences
    • Jean G, Bresson E, Terrat JC, Vanel T, Hurot JM, Lorriaux C et al. Peripheral vascular calcification in long-haemodialysis patients: associated factors and survival consequences. Nephrol Dial Transplant 2009; 24: 948–955.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 948-955
    • Jean, G.1    Bresson, E.2    Terrat, J.C.3    Vanel, T.4    Hurot, J.M.5    Lorriaux, C.6
  • 27
    • 84890483229 scopus 로고    scopus 로고
    • Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and kidney disease
    • Ruiz-Ortega M, Ortiz A, Ramos AM. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and kidney disease. Curr Opin Nephrol Hypertens 2014; 23: 93–100.
    • (2014) Curr Opin Nephrol Hypertens , vol.23 , pp. 93-100
    • Ruiz-Ortega, M.1    Ortiz, A.2    Ramos, A.M.3
  • 29
    • 70350673929 scopus 로고    scopus 로고
    • Decreased soluble TWEAK levels predict an adverse prognosis in patients with chronic stable heart failure
    • Chorianopoulos E, Rosenberg M, Zugck C, Wolf J, Katus HA, Frey N. Decreased soluble TWEAK levels predict an adverse prognosis in patients with chronic stable heart failure. Eur J Heart Fail 2009; 11: 1050–1056.
    • (2009) Eur J Heart Fail , vol.11 , pp. 1050-1056
    • Chorianopoulos, E.1    Rosenberg, M.2    Zugck, C.3    Wolf, J.4    Katus, H.A.5    Frey, N.6
  • 31
  • 32
    • 47649121369 scopus 로고    scopus 로고
    • Serum levels of the atherosclerosis biomarker sTWEAK are decreased in type 2 diabetes and end-stage renal disease
    • Kralisch S, Ziegelmeier M, Bachmann A, Seeger J, Lössner U, Blüher M et al. Serum levels of the atherosclerosis biomarker sTWEAK are decreased in type 2 diabetes and end-stage renal disease. Atherosclerosis 2008; 199: 440–444.
    • (2008) Atherosclerosis , vol.199 , pp. 440-444
    • Kralisch, S.1    Ziegelmeier, M.2    Bachmann, A.3    Seeger, J.4    Lössner, U.5    Blüher, M.6
  • 33
    • 84872450180 scopus 로고    scopus 로고
    • Soluble TWEAK level: Is it a marker for cardiovascular disease in long-term hemodialysis patients?
    • Gungor O, Kircelli F, Asci G, Carrero JJ, Tatar E, Demirci MS et al. Soluble TWEAK level: is it a marker for cardiovascular disease in long-term hemodialysis patients? J Nephrol 2013; 26: 136–143.
    • (2013) J Nephrol , vol.26 , pp. 136-143
    • Gungor, O.1    Kircelli, F.2    Asci, G.3    Carrero, J.J.4    Tatar, E.5    Demirci, M.S.6
  • 35
    • 84911462482 scopus 로고    scopus 로고
    • Role of bone-type tissue-nonspecific alkaline phosphatase and PHOSPO1 in vascular calcification
    • Bobryshev YV, Orekhov AN, Sobenin I, Chistiakov DA. Role of bone-type tissue-nonspecific alkaline phosphatase and PHOSPO1 in vascular calcification. Curr Pharm Des 2014; 20: 5821–5828.
    • (2014) Curr Pharm Des , vol.20 , pp. 5821-5828
    • Bobryshev, Y.V.1    Orekhov, A.N.2    Sobenin, I.3    Chistiakov, D.A.4
  • 36
    • 70349576584 scopus 로고    scopus 로고
    • Vascular smooth muscle cell calcification and SLC20 inorganic phosphate transporters: Effects of PDGF, TNF-alpha, and Pi
    • Villa-Bellosta R, Levi M, Sorribas V. Vascular smooth muscle cell calcification and SLC20 inorganic phosphate transporters: effects of PDGF, TNF-alpha, and Pi. Pflugers Arch 2009; 458: 1151–1161.
    • (2009) Pflugers Arch , vol.458 , pp. 1151-1161
    • Villa-Bellosta, R.1    Levi, M.2    Sorribas, V.3
  • 38
    • 0038708366 scopus 로고    scopus 로고
    • The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation
    • Brown SA, Richards CM, Hanscom HN, Feng SL, Winkles JA. The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation. Biochem J 2003; 371: 395–403.
    • (2003) Biochem J , vol.371 , pp. 395-403
    • Brown, S.A.1    Richards, C.M.2    Hanscom, H.N.3    Feng, S.L.4    Winkles, J.A.5
  • 39
    • 0141815764 scopus 로고    scopus 로고
    • TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation
    • Saitoh T, Nakayama M, Nakano H, Yagita H, Yamamoto N, Yamaoka S. TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation. J Biol Chem 2003; 278: 36005–36012.
    • (2003) J Biol Chem , vol.278 , pp. 36005-36012
    • Saitoh, T.1    Nakayama, M.2    Nakano, H.3    Yagita, H.4    Yamamoto, N.5    Yamaoka, S.6
  • 41
    • 84862793637 scopus 로고    scopus 로고
    • Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression
    • Zhao G, Xu MJ, Zhao MM, Dai XY, Kong W, Wilson GM et al. Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression. Kidney Int 2012; 82: 34–44.
    • (2012) Kidney Int , vol.82 , pp. 34-44
    • Zhao, G.1    Xu, M.J.2    Zhao, M.M.3    Dai, X.Y.4    Kong, W.5    Wilson, G.M.6
  • 43
    • 36348963624 scopus 로고    scopus 로고
    • Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr-/-mice
    • Al-Aly Z, Shao JS, Lai CF, Huang E, Cai J, Behrmann A et al. Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr-/-mice. Arterioscler Thromb Vasc Biol 2007; 27: 2589–2596.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2589-2596
    • Al-Aly, Z.1    Shao, J.S.2    Lai, C.F.3    Huang, E.4    Cai, J.5    Behrmann, A.6
  • 44
    • 0034700234 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway
    • Tintut Y, Patel J, Parhami F, Demer LL. Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway. Circulation 2000; 102: 2636–2642.
    • (2000) Circulation , vol.102 , pp. 2636-2642
    • Tintut, Y.1    Patel, J.2    Parhami, F.3    Demer, L.L.4
  • 45
    • 72949101767 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha increases alkaline phosphatase expression in vascular smooth muscle cells via MSX2 induction
    • Lee HL, Woo KM, Ryoo HM, Baek JH. Tumor necrosis factor-alpha increases alkaline phosphatase expression in vascular smooth muscle cells via MSX2 induction. Biochem Biophys Res Commun 2010; 391: 1087–1092.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 1087-1092
    • Lee, H.L.1    Woo, K.M.2    Ryoo, H.M.3    Baek, J.H.4
  • 46
    • 80053342747 scopus 로고    scopus 로고
    • Cell-specific effects of TNF-α and IL-1β on alkaline phosphatase: Implication for syndesmophyte formation and vascular calcification
    • Lencel P, Delplace S, Pilet P, Leterme D, Miellot F, Sourice S et al. Cell-specific effects of TNF-α and IL-1β on alkaline phosphatase: implication for syndesmophyte formation and vascular calcification. Lab Invest 2011; 91: 1434–1442.
    • (2011) Lab Invest , vol.91 , pp. 1434-1442
    • Lencel, P.1    Delplace, S.2    Pilet, P.3    Leterme, D.4    Miellot, F.5    Sourice, S.6
  • 47
    • 41549125017 scopus 로고    scopus 로고
    • Adiponectin antagonizes stimulatory effect of tumor necrosis factor-alpha on vascular smooth muscle cell calcification: Regulation of growth arrest-specific gene 6-mediated survival pathway by adenosine 5'-monophosphate-activated protein kinase
    • Son BK, Akishita M, Iijima K, Kozaki K, Maemura K, Eto M et al. Adiponectin antagonizes stimulatory effect of tumor necrosis factor-alpha on vascular smooth muscle cell calcification: regulation of growth arrest-specific gene 6-mediated survival pathway by adenosine 5'-monophosphate-activated protein kinase. Endocrinology 2008; 149: 1646–1653.
    • (2008) Endocrinology , vol.149 , pp. 1646-1653
    • Son, B.K.1    Akishita, M.2    Iijima, K.3    Kozaki, K.4    Maemura, K.5    Eto, M.6
  • 48
    • 0016363786 scopus 로고
    • Calcium binding to elastin
    • Rucker RB. Calcium binding to elastin. Adv Exp Med Biol 1974; 48: 185–209.
    • (1974) Adv Exp Med Biol , vol.48 , pp. 185-209
    • Rucker, R.B.1
  • 49
    • 10044280353 scopus 로고    scopus 로고
    • Elastin degradation and calcification in an abdominal aorta injury model: Role of matrix metalloproteinases
    • Basalyga DM, Simionescu DT, Xiong W, Baxter BT, Starcher BC, Vyavahare NR. Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinases. Circulation 2004; 110: 3480–3487.
    • (2004) Circulation , vol.110 , pp. 3480-3487
    • Basalyga, D.M.1    Simionescu, D.T.2    Xiong, W.3    Baxter, B.T.4    Starcher, B.C.5    Vyavahare, N.R.6
  • 50
    • 84924918627 scopus 로고    scopus 로고
    • Artemisinin inhibits the proliferation, migration, and inflammatory reaction induced by tumor necrosis factor-α in vascular smooth muscle cells through nuclear factor kappa B pathway
    • Cao Q, Jiang Y, Shi J, Xu C, Liu X, Yang T et al. Artemisinin inhibits the proliferation, migration, and inflammatory reaction induced by tumor necrosis factor-α in vascular smooth muscle cells through nuclear factor kappa B pathway. J Surg Res 2015; 194: 667–678.
    • (2015) J Surg Res , vol.194 , pp. 667-678
    • Cao, Q.1    Jiang, Y.2    Shi, J.3    Xu, C.4    Liu, X.5    Yang, T.6
  • 51
    • 10744223993 scopus 로고    scopus 로고
    • Interleukin-1 beta promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosis
    • Kaden JJ, Dempfle CE, Grobholz R, Tran HT, Kiliç R, Sarikoç A et al. Interleukin-1 beta promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosis. Atherosclerosis 2003; 170: 205–211.
    • (2003) Atherosclerosis , vol.170 , pp. 205-211
    • Kaden, J.J.1    Dempfle, C.E.2    Grobholz, R.3    Tran, H.T.4    Kiliç, R.5    Sarikoç, A.6
  • 52
    • 77950839484 scopus 로고    scopus 로고
    • Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 during cardiac remodelling in rats
    • Mustonen E, Säkkinen H, Tokola H, Isopoussu E, Aro J, Leskinen H et al. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 during cardiac remodelling in rats. Acta Physiol (Oxf) 2010; 199: 11–22.
    • (2010) Acta Physiol (Oxf) , vol.199 , pp. 11-22
    • Mustonen, E.1    Säkkinen, H.2    Tokola, H.3    Isopoussu, E.4    Aro, J.5    Leskinen, H.6
  • 54
    • 0037390762 scopus 로고    scopus 로고
    • And Winkles JA. TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity
    • Donohue PJ, Richards CM, Brown SA, Hanscom HN, Buschman J, Thangada S et al. and Winkles JA. TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity. Arterioscler Thromb Vasc Biol 2003; 23: 594–600.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 594-600
    • Donohue, P.J.1    Richards, C.M.2    Brown, S.A.3    Hanscom, H.N.4    Buschman, J.5    Thangada, S.6
  • 55
    • 77950364992 scopus 로고    scopus 로고
    • FGF-inducible 14-kDa protein (Fn14) is regulated via the RhoA/ROCK kinase pathway in cardiomyocytes and mediates nuclear factor-kappaB activation by TWEAK
    • Chorianopoulos E, Heger T, Lutz M, Frank D, Bea F, Katus HA et al. FGF-inducible 14-kDa protein (Fn14) is regulated via the RhoA/ROCK kinase pathway in cardiomyocytes and mediates nuclear factor-kappaB activation by TWEAK. Basic Res Cardiol 2010; 105: 301–313.
    • (2010) Basic Res Cardiol , vol.105 , pp. 301-313
    • Chorianopoulos, E.1    Heger, T.2    Lutz, M.3    Frank, D.4    Bea, F.5    Katus, H.A.6
  • 56
    • 73849087983 scopus 로고    scopus 로고
    • Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) enhances vascular and renal damage induced by hyperlipidemic diet in ApoE-knockout mice
    • Muñoz-García B, Moreno JA, López-Franco O, Sanz AB, Martín-Ventura JL, Blanco J et al. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) enhances vascular and renal damage induced by hyperlipidemic diet in ApoE-knockout mice. Arterioscler Thromb Vasc Biol 2009; 29: 2061–2068.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 2061-2068
    • Muñoz-García, B.1    Moreno, J.A.2    López-Franco, O.3    Sanz, A.B.4    Martín-Ventura, J.L.5    Blanco, J.6
  • 57
    • 84888206020 scopus 로고    scopus 로고
    • High mobility group box 1 (HMGB1) mediates high-glucose-induced calcification in vascular smooth muscle cells of saphenous veins
    • Wang Y, Shan J, Yang W, Zheng H, Xue S. High mobility group box 1 (HMGB1) mediates high-glucose-induced calcification in vascular smooth muscle cells of saphenous veins. Inflammation 2013; 36: 1592–1604.
    • (2013) Inflammation , vol.36 , pp. 1592-1604
    • Wang, Y.1    Shan, J.2    Yang, W.3    Zheng, H.4    Xue, S.5
  • 59
    • 84893032723 scopus 로고    scopus 로고
    • Calcimimetics increase CaSR expression and reduce mineralization in vascular smooth muscle cells: Mechanisms of action
    • Hénaut L, Boudot C, Massy ZA, Lopez-Fernandez I, Dupont S, Mary A et al. Calcimimetics increase CaSR expression and reduce mineralization in vascular smooth muscle cells: mechanisms of action. Cardiovasc Res 2014; 101: 256–265.
    • (2014) Cardiovasc Res , vol.101 , pp. 256-265
    • Hénaut, L.1    Boudot, C.2    Massy, Z.A.3    Lopez-Fernandez, I.4    Dupont, S.5    Mary, A.6
  • 60
    • 84879297808 scopus 로고    scopus 로고
    • Defective extracellular pyrophosphate metabolism promotes vascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is ameliorated on pyrophosphate treatment
    • Villa-Bellosta R, Rivera-Torres J, Osorio FG, Acín-Pérez R, Enriquez JA, López-Otín C et al. Defective extracellular pyrophosphate metabolism promotes vascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is ameliorated on pyrophosphate treatment. Circulation 2013; 127: 2442–2451.
    • (2013) Circulation , vol.127 , pp. 2442-2451
    • Villa-Bellosta, R.1    Rivera-Torres, J.2    Osorio, F.G.3    Acín-Pérez, R.4    Enriquez, J.A.5    López-Otín, C.6


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