West nile virus population structure, injury, and interferon-stimulated gene expression in the brain from a fatal case of encephalitis

Open Forum Infectious Diseases

Volumn 3, Issue 1, 2016, Pages

  Grubaugh, Nathan D ^a   Massey, Aaron ^b   Shives, Katherine D ^c   Stenglein, Mark D ^a   Ebel, Gregory D ^a   Beckham, J David ^b,c  

^a Veterinary Dentistry and Oral Surgery   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Apoptosis; Encephalitis; Interferon stimulated genes; Next generation sequencing; west Nile virus

Indexed keywords

CASPASE 3; IMMUNOGLOBULIN M ANTIBODY; INTERFERON;

ADULT; APOPTOSIS; ARTICLE; AUTOPSY; BASAL GANGLION; CASE REPORT; CULEX; ELECTROENCEPHALOGRAPHY; ENCEPHALITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENETIC VARIABILITY; GRAY MATTER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; MIDDLE AGED; NERVE INJURY; NEXT GENERATION SEQUENCING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; POPULATION STRUCTURE; PRIORITY JOURNAL; TEMPORAL LOBE; THALAMUS; VIRUS CELL INTERACTION; VIRUS ENVELOPE; VIRUS LOAD; VIRUS REPLICATION; WEST NILE VIRUS;

EID: 85000733428     PISSN: None     EISSN: 23288957     Source Type: Journal    
DOI: 10.1093/ofid/ofv182     Document Type: Article

References (16)

1. Armah HB, Wang G, Omalu BI, et al. Systemic distribution of West Nile virus infection: postmortem immunohistochemical study of six cases. Brain Pathol 2007; 17:354-62.
2. Samuel MA, Diamond MS. Alpha/beta interferon protects against lethalWest Nile virus infection by restricting cellular tropism and enhancing neuronal survival. J Virol 2005; 79:13350-61.
3. Lazear HM, Pinto AK, Vogt MR, et al. Beta interferon controls West Nile virus infection and pathogenesis in mice. J Virol 2011; 85:7186-94.
4. Lanciotti RS, Kerst AJ, Nasci RS, et al. Rapid detection of West Nile virus from human clinical specimens, field-collected mosquitoes, and avian samples by a TaqMan reverse transcriptase-PCR assay. J Clin Microbiol 2000; 38:4066-71.
5. Grubaugh ND, Smith DR, Brackney DE, et al. Experimental evolution of an RNA virus in wild birds: evidence for host-dependent impacts on population structure and competitive fitness. PLoS Pathog 2015; 11:e1004874.
6. Lee WP, Stromberg MP, Ward A, et al. MOSAIK: a hash-based algorithm for accurate next-generation sequencing short-read mapping. PLoS One 2014; 9: e90581.
7. Grabherr MG, Haas BJ, Yassour M, et al. Full-length transcriptome assembly from RNA-Seq data without a reference genome. Nat Biotechnol 2011; 29:644-52.
8. Yang X, Charlebois P, Macalalad A, et al. V-Phaser 2: variant inference for viral populations. BMC Genomics 2013; 14:674.
9. Jerzak G, Bernard KA, Kramer LD, Ebel GD. Genetic variation in West Nile virus from naturally infected mosquitoes and birds suggests quasispecies structure and strong purifying selection. J Gen Virol 2005; 86:2175-83.
10. Romano CM, Lauck M, Salvador FS, et al. Inter- and intra-host viral diversity in a large seasonal DENV2 outbreak. PLoS One 2013; 8:e70318.
11. Beckham JD, Tyler KL. Neuro-intensive care of patients with acute CNS infections. Neurotherapeutics 2012; 9:124-38.
12. Ali M, Safriel Y, Sohi J, et al. West Nile virus infection: MR imaging findings in the nervous system. AJNR Am J Neuroradiol 2005; 26:289-97.
13. Petropoulou KA, Gordon SM, Prayson RA, Ruggierri PM. West Nile virus meningoencephalitis: MR imaging findings. AJNR Am J Neuroradiol 2005; 26:1986-95.
14. Cho H, Proll SC, Szretter KJ, et al. Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positivestranded RNA viruses. Nat Med 2013; 19:458-64.
15. Ciota AT, Ngo KA, Lovelace AO, et al. Role of the mutant spectrum in adaptation and replication of West Nile virus. J Gen Virol 2007; 88:865-74.
16. Jerzak GV, Bernard K, Kramer LD, et al. The West Nile virus mutant spectrum is host-dependant and a determinant of mortality in mice. Virology 2007; 360: 469-76.