Increased liver stiffness denotes hepatic dysfunction and mortality risk in critically ill noncirrhotic patients at a medical ICU

Critical Care

Volumn 15, Issue 6, 2011, Pages

  Koch, Alexander ^a   Horn, Andreas ^a   Dückers, Hanna ^a   Yagmur, Eray ^b   Sanson, Edouard ^a   Bruensing, Jan ^a   Buendgens, Lukas ^a   Voigt, Sebastian ^a   Trautwein, Christian ^a   Tacke, Frank ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b Medical Centre Stein and Partner   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; AGED; ARTICLE; ARTIFICIAL VENTILATION; CENTRAL VENOUS PRESSURE; CHOLESTASIS; CLINICAL OBSERVATION; COMORBIDITY; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE MARKER; EARLY DIAGNOSIS; FEMALE; GENDER; HEART FAILURE; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; HYPERVOLEMIA; INTENSIVE CARE UNIT; KIDNEY FAILURE; LIVER CIRRHOSIS; LIVER DYSFUNCTION; LIVER FIBROSIS; LIVER STIFFNESS; MAJOR CLINICAL STUDY; MALE; MORTALITY; OBESITY; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; RELIABILITY; RISK ASSESSMENT; SEPSIS;

EID: 84999944428     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc10543     Document Type: Article

References (37)

1. Castera L, Forns X, Alberti A: Non-invasive evaluation of liver fibrosis using transient elastography. J Hepatol 2008, 48:835-847.
2. Martinez SM, Crespo G, Navasa M, Forns X: Noninvasive assessment of liver fibrosis. Hepatology 2011, 53:325-335.
3. Wong VW, Vergniol J, Wong GL, Foucher J, Chan HL, Le Bail B, Choi PC, Kowo M, Chan AW, Merrouche W, Sung JJ, de Lédinghen V: Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology 2010, 51:454-462.
4. Castera L, Vergniol J, Foucher J, Le Bail B, Chanteloup E, Haaser M, Darriet M, Couzigou P, de Ledinghen V: Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology 2005, 128:343-350.
5. Tsochatzis EA, Gurusamy KS, Ntaoula S, Cholongitas E, Davidson BR, Burroughs AK: Elastography for the diagnosis of severity of fibrosis in chronic liver disease: A meta-analysis of diagnostic accuracy. J Hepatol 2011, 54:650-659.
6. Castera L, Foucher J, Bernard PH, Carvalho F, Allaix D, Merrouche W, Couzigou P, de Ledinghen V: Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations. Hepatology 2010, 51:828-835.
7. Baranova A, Lal P, Birerdinc A, Younossi ZM: Non-Invasive markers for hepatic fibrosis. BMC Gastroenterol 2011, 11:91.
8. Motosugi U, Ichikawa T, Amemiya F, Sou H, Sano K, Muhi A, Enomoto N, Araki T: Cross-validation of MR elastography and ultrasound transient elastography in liver stiffness measurement: discrepancy in the results of cirrhotic liver. J Magn Reson Imaging 2011.
9. Rizzo L, Calvaruso V, Cacopardo B, Alessi N, Attanasio M, Petta S, Fatuzzo F, Montineri A, Mazzola A, L'abbate L, Nunnari G, Bronte F, Di Marco V, Craxì A, Cammà C: Comparison of transient elastography and acoustic radiation force impulse for non-invasive staging of liver fibrosis in patients with chronic hepatitis C. Am J Gastroenterol 2011.
10. Chen S, Urban MW, Pislaru C, Kinnick R, Greenleaf JF: Liver elasticity and viscosity quantification using shearwave dispersion ultrasound vibrometry (SDUV). Conf Proc IEEE Eng Med Biol Soc 2009, 2009:2252-2255.
11. Bavu E, Gennisson JL, Couade M, Bercoff J, Mallet V, Fink M, Badel A, Vallet-Pichard A, Nalpas B, Tanter M, Pol S: Noninvasive in vivo liver fibrosis evaluation using supersonic shear imaging: a clinical study on 113 hepatitis C virus patients. Ultrasound Med Biol 2011, 37:1361-1373.
12. Dechene A, Sowa JP, Gieseler RK, Jochum C, Bechmann LP, El Fouly A, Schlattjan M, Saner F, Baba HA, Paul A, Dries V, Odenthal M, Gerken G, Friedman SL, Canbay A: Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation. Hepatology 2010, 52:1008-1016.
13. Sagir A, Erhardt A, Schmitt M, Haussinger D: Transient elastography is unreliable for detection of cirrhosis in patients with acute liver damage. Hepatology 2008, 47:592-595.
14. Bansal V, Schuchert VD: Jaundice in the intensive care unit. Surg Clin North Am 2006, 86:1495-1502.
15. Brienza N, Dalfino L, Cinnella G, Diele C, Bruno F, Fiore T: Jaundice in critical illness: promoting factors of a concealed reality. Intensive Care Med 2006, 32:267-274.
16. Kramer L, Jordan B, Druml W, Bauer P, Metnitz PG: Incidence and prognosis of early hepatic dysfunction in critically ill patients-a prospective multicenter study. Crit Care Med 2007, 35:1099-1104.
17. Vincent JL, Moreno R: Clinical review: scoring systems in the critically ill. Crit Care 2010, 14:207.
18. Sakka SG, Reinhart K, Meier-Hellmann A: Prognostic value of the indocyanine green plasma disappearance rate in critically ill patients. Chest 2002, 122:1715-1720.
19. Koch A, Gressner OA, Sanson E, Tacke F, Trautwein C: Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients. Crit Care 2009, 13:R95.
20. Zimmermann HW, Seidler S, Nattermann J, Gassler N, Hellerbrand C, Zernecke A, Tischendorf JJ, Luedde T, Weiskirchen R, Trautwein C, Tacke F: Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosis. PLoS One 2010, 5:e11049.
21. Koch A, Voigt S, Sanson E, Duckers H, Horn A, Zimmermann HW, Trautwein C, Tacke F: Prognostic value of circulating amino-terminal pro-C-type natriuretic peptide in critically ill patients. Crit Care 2011, 15:R45.
22. Yagmur E, Tacke F, Weiss C, Lahme B, Manns MP, Kiefer P, Trautwein C, Gressner AM: Elevation of Nepsilon-(carboxymethyl)lysine-modified advanced glycation end products in chronic liver disease is an indicator of liver cirrhosis. Clin Biochem 2006, 39:39-45.
23. Koch A, Sanson E, Helm A, Voigt S, Trautwein C, Tacke F: Regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis. Crit Care 2010, 14:R94.
24. Koch A, Weiskirchen R, Sanson E, Zimmermann HW, Voigt S, Duckers H, Trautwein C, Tacke F: Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation. Crit Care 2010, 14: R179.
25. Tacke F, Fiedler K, Trautwein C: A simple clinical score predicts high risk for upper gastrointestinal hemorrhages from varices in patients with chronic liver disease. Scand J Gastroenterol 2007, 42:374-382.
26. Koch A, Voigt S, Kruschinski C, Sanson E, Duckers H, Horn A, Yagmur E, Zimmermann H, Trautwein C, Tacke F: Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients. Crit Care 2011, 15:R63.
27. Kim BK, Kim do Y, Han KH, Park JY, Kim JK, Paik YH, Lee KS, Chon CY, Ahn SH: Risk assessment of esophageal variceal bleeding in B-viral liver cirrhosis by a liver stiffness measurement-based model. Am J Gastroenterol 2011, 106:1654-1662, 1730. Erratum in: Am J Gastroenterol. 2011 Sep;106(9):1730.
28. Vincent JL, Gustot T: Sepsis and cirrhosis: many similarities. Acta Gastroenterol Belg 2010, 73:472-478.
29. Robic MA, Procopet B, Metivier S, Peron JM, Selves J, Vinel JP, Bureau C: Liver stiffness accurately predicts portal hypertension related complications in patients with chronic liver disease: a prospective study. J Hepatol 2011, 55:1017-1024.
30. Arena U, Vizzutti F, Corti G, Ambu S, Stasi C, Bresci S, Moscarella S, Boddi V, Petrarca A, Laffi G, Marra F, Pinzani M: Acute viral hepatitis increases liver stiffness values measured by transient elastography. Hepatology 2008, 47:380-384.
31. Millonig G, Reimann FM, Friedrich S, Fonouni H, Mehrabi A, Buchler MW, Seitz HK, Mueller S: Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis. Hepatology 2008, 48:1718-1723.
32. Millonig G, Friedrich S, Adolf S, Fonouni H, Golriz M, Mehrabi A, Stiefel P, Pöschl G, Büchler MW, Seitz HK, Mueller S: Liver stiffness is directly influenced by central venous pressure. J Hepatol 2010, 52:206-210.
33. Colli A, Pozzoni P, Berzuini A, Gerosa A, Canovi C, Molteni EE, Barbarini M, Bonino F, Prati D: Decompensated chronic heart failure: increased liver stiffness measured by means of transient elastography. Radiology 2010, 257:872-878.
34. Olsen AL, Bloomer SA, Chan EP, Gaca MD, Georges PC, Sackey B, Uemura M, Janmey PA, Wells RG: Hepatic stellate cells require a stiff environment for myofibroblastic differentiation. Am J Physiol Gastrointest Liver Physiol 2011, 301:G110-118.
35. Vergniol J, Foucher J, Terrebonne E, Bernard PH, Le Bail B, Merrouche W, Couzigou P, de Ledinghen V: Non-Invasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C. Gastroenterology 2011, 140:1970-1979.
36. Fung J, Lai CL, Seto WK, Wong DK, Yuen MF: Prognostic significance of liver stiffness for hepatocellular carcinoma and mortality in HBeAgnegative chronic hepatitis B. J Viral Hepat 2011, 18:738-744.
37. Hirooka M, Koizumi Y, Hiasa Y, Abe M, Ikeda Y, Matsuura B, Onji M: Hepatic elasticity in patients with ascites: evaluation with real-time tissue elastography. AJR Am J Roentgenol 2011, 196:W766-771.