Immunomodulatory effect of characterized extract of Zataria multiflora on Th1, Th2 and Th17 in normal and Th2 polarization state

Food and Chemical Toxicology

Volumn 99, Issue , 2017, Pages 119-127

  Kianmehr, Majid ^a,b   Rezaei, Abdolrahim ^b   Hosseini, Mahmoud ^a   Khazdair, Mohammad Reza ^a   Rezaee, Ramin ^c   Askari, Vahid Reza ^a   Boskabady, Mohammad Hossein ^a,b  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cytokines; Gene expression; Immune system; Real time PCR; Splenocyte; Zataria multiflora

Indexed keywords

DEXAMETHASONE; GAMMA INTERFERON; IMMUNOMODULATING AGENT; INTERLEUKIN 17; INTERLEUKIN 4; PLANT EXTRACT; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ZATARIA MULTIFLORA EXTRACT; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; IFNG PROTEIN, MOUSE; IMMUNOLOGIC FACTOR; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG DETERMINATION; FOXP3 GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; IMMUNOMODULATION; INTERFERON GAMMA GENE; INTERLEUKIN 17 GENE; INTERLEUKIN 4 GENE; MALE; MOUSE; NONHUMAN; SPLEEN CELL; TH1 CELL; TH17 CELL; TH2 CELL; TRANSFORMING GROWTH FACTOR BETA GENE; UPREGULATION; ZATARIA MULTIFLORA; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DRUG EFFECTS; GENETICS; IMMUNOLOGY; LAMIACEAE; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY TRACT ALLERGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN;

ANIMALS; FORKHEAD TRANSCRIPTION FACTORS; IMMUNOLOGIC FACTORS; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-4; LAMIACEAE; MALE; MICE; MICE, INBRED BALB C; PLANT EXTRACTS; REAL-TIME POLYMERASE CHAIN REACTION; RESPIRATORY HYPERSENSITIVITY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPLEEN; TH1 CELLS; TH17 CELLS; TH2 CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84999700126     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2016.11.019     Document Type: Article

References (50)

1. A, M.G.N.H.M.M.G.G.V.H., Antispasmodic effect of zataria multiflora boiss. Leaf extract on the rat uterus. Iran. J. Pharm. Res. 5 (2006), 131–136.
2. Ali, M.S., Saleem, M., Ali, Z., Ahmad, V.U., Chemistry of Zataria multiflora (Lamiaceae). Phytochem 55 (2000), 933–936.
3. Annunziato, F., Cosmi, L., Liotta, F., Maggi, E., Romagnani, S., The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation. Int. Immunol. 20 (2008), 1361–1368.
4. Babayigit, A., Olmez, D., Karaman, O., Ozogul, C., Yilmaz, O., Kivcak, B., Erbil, G., Uzuner, N., Effects of Ginkgo biloba on airway histology in a mouse model of chronic asthma. Allergy. Asthma. Proc. 30 (2009), 186–191.
5. Bellinghausen, I., Klostermann, B., Knop, J., Saloga, J., Human CD4+CD25+ T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production. J. Allergy. Clin. Immunol. 111 (2003), 862–868.
6. Boskabady, M.H., Gholami Mahtaj, L., Lung inflammation changes and oxidative stress induced by cigarette smoke exposure in Guinea pigs affected by Zataria multiflora and its constituent, carvacrol. BMC. Complement. Altern. Med., 15, 2015, 39.
7. Boskabady, M.H., Gholami Mhtaj, L., Effect of the Zataria multiflora on systemic inflammation of experimental animals model of COPD. Biomed. Res. Int., 2014, 2014, 802189.
8. Boskabady, M.H., Tabanfar, H., Effect of Zataria multiflora Bois L. on histamine (H1) receptor of Guinea pig tracheal chains. India J. Exp. Biol. 49 (2011), 679–683.
9. Boskabady, M.H., Aslani, M.,R., Kiani, S., Relaxant effect of Thymus vulgaris on Guinea-pig tracheal chains and its possible mechanism(s). Phytother. Res. 20 (2006), 28–33.
10. Boskabady, M.H., Jafari, Z., Pouraboli, I., The effect of carvacrol on muscarinic receptors of Guinea-pig tracheal chains. Phytother. Res. 25 (2011), 530–535.
11. Boskabady, M.H., Kaveh, M., Eftekhar, N., Nemati, A., Zataria multiflora boiss and carvacrol affect beta(2)-adrenoceptors of Guinea pig trachea. Evid. Based. Complement. Altern. Med., 2011, 2011, 857124.
12. Boskabady, M.H., Jafari, Z., Pouraboli, I., Babazade, B., Rahbardar, M.G., Anti-cholinergic effect of Zataria multiflora Boiss on Guinea pig tracheal chains. Nat. Prod. Res. 26 (2012), 1523–1528.
13. Boskabady, M.H., Mehrjardi, S.S., Rezaee, A., Rafatpanah, H., Jalali, S., The impact of Zataria multiflora Boiss extract on in vitro and in vivo Th1/Th2 cytokine (IFN-gamma/IL4) ba.lance. J. Ethnopharmacol. 150 (2013), 1024–1031.
14. Boskabady, M.H., Jalali, S., Farkhondeh, T., Byrami, G., The extract of Zataria multiflora affect tracheal responsiveness, serum levels of NO, nitrite, PLA2, TP and histamine in sensitized Guinea pigs. J. Ethnopharmacol. 156 (2014), 301–308.
15. Boskabady, M.H., Tabatabaee, A., Jalali, S., Potential effect of the extract of Zataria multiflora and its constituent, carvacrol, on lung pathology,total and differential WBC, IgE and eosinophil peroxidase levels in sensitized Guinea pigs. J. Func. Foods 11 (2014), 49–61.
16. Chatila, T.A., Role of regulatory T cells in human diseases. J. Allergy Clin. Immunol. 116 (2005), 949–959 quiz 960.
17. Duvernelle C, F.V., Frossard, N., Transforming growth factor-b and its role in asthma. Pulm. Pharmacol. Ther. 16 (2003), 181–196.
18. Duvernelle C, K.O., De Blay, F., Krieger, P., Spirlet, F., Pauli, G., Frossard, N., Transforming growth factor-b1 (TGF-b1) expression after inhalations of low subclinical doses of cat allergen in asthmatic patients. Am. J. Respir. Crit. Care. Med., 157, 1998 Abstract.
19. Fontenot, J.D., Gavin, M.,A., Rudensky, A.Y., Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4 (2003), 330–336.
20. Ghannadi, A., Sajjadi, S.-E., Abedi, D., Yousefi, J., Daraei-Ardekani, R., The in vitro activity of seven Iranian plants of the Lamiaceae family against Helicobacter pylori. Nig. J. Nat. Prod. Med. 8 (2004), 40–42.
21. Gharib Naseri, M., Mazlomi, H., Goshaiesh, M., Vakilzadeh, G., Heidari, A., Antispasmodic effect of Zataria multiflora Boiss. Leaf extract on the rat uterus. Iran. J. Pharmac. Res. 5 (2010), 131–136.
22. Gholami Mahtaj, L., Boskabady, M.H., Mohamadian Roshan, N., The effect of Zataria multiflora and its constituent, carvacrol, on tracheal responsiveness and lung pathology in Guinea pig model of COPD. Phytother. Res. 29 (2015), 730–736.
23. Hocaoglu, A.B., Karaman, O., Erge, D.O., Erbil, G., Yilmaz, O., Kivcak, B., Bagriyanik, H.A., Uzuner, N., Effect of Hedera helix on lung histopathology in chronic asthma. Iran J. Allergy Asthma Immunol. 11 (2012), 316–323.
24. Hori, S., Nomura, T., Sakaguchi, S., Control of regulatory T cell development by the transcription factor Foxp3. Science 299 (2003), 1057–1061.
25. Hosseinzadeh, H., Ramezani, M., Salmani, G., Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss extracts in mice and rats. J. Ethnopharmacol. 73 (2000), 379–385.
26. Ivanova, E.A., Orekhov, A.N., T helper lymphocyte subsets and plasticity in autoimmunity and Cancer: an overview. BioMed. Res. Int., 2015, 2015 327470.
27. Jafari, Z., Boskabady, M.H., Pouraboli, I., Babazade, B., Zataria multiflora Boiss. inhibited muscarinic receptors of incubated tracheal smooth muscle with propranolol. Avicenna J. Phytomed 1 (2011), 7–13.
28. Jalali, S., Boskabady, M.H., Haeri Rohani, A., Eidi, A., The effect of carvacrol on serum cytokines and endothelin levels of ovalbumin sensitized Guinea-pigs. Iran. J. Basic Med. Sci. 16 (2013), 615–619.
29. Kavoosia, G., Teixeira Da Silva, J.A., Inhibitory effects of Zataria multiflora essential oil and its main components on nitric oxide and hydrogen peroxide production in glucose-stimulated human monocyte. Food Chem. Tox 50 (2012), 3079–3085.
30. Khattri, R., Cox, T., Yasayko, S.A., Ramsdell, F., An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4 (2003), 337–342.
31. Kianmehr, M., Rezaei, A., Boskabady, M.H., Effect of carvacrol on various cytokines genes expression in splenocytes of asthmatic mice. Iran. J. Basic Med. Sci. 19 (2016), 402–410.
32. Magnan, A., Mege, J.L., Escallier, J.C., Brisse, J., Capo, C., Reynaud, M., Thomas, P., Meric, B., Garbe, L., Badier, M., Viard, L., Bongrand, P., Giudicelli, R., Metras, D., Fuentes, P., Vervloet, D., Noirclerc, M., Balance between alveolar macrophage IL-6 and TGF-beta in lung-transplant recipients. Marseille and montreal lung transplantation group. Am. J. Respir. Crit. Care. Med. 153 (1996), 1431–1436.
33. Meister, A., Bernhardt, G., Christoffel, V., Buschauer, A., Antispasmodic activity of Thymus vulgaris extract on the isolated Guinea-pig trachea: discrimination between drug and ethanol effects. Planta Med. 65 (1999), 512–516.
34. Molet, S., Hamid, Q., Davoine, F., Nutku, E., Taha, R., Page, N., Olivenstein, R., Elias, J., Chakir, J., IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J. Allergy. Clin. Immunol. 108 (2001), 430–438.
35. Nakae, S., Komiyama, Y., Nambu, A., Sudo, K., Iwase, M., Homma, I., Sekikawa, K., Asano, M., Iwakura, Y., Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17 (2002), 375–387.
36. Nakhai, L.A., Mohammadirad, A., Yasa, N., Minaie, B., Nikfar, S., Ghazanfari, G., Zamani, M.J., Dehghan, G., Jamshidi, H., Boushehri, V.S., Khorasani, R., Abdollahi, M., Benefits of Zataria multiflora boiss in experimental model of mouse inflammatory bowel disease. Evid. Based Complement. Altern. Med. 4 (2007), 43–50.
37. Provoost, S., Maes, T., Van Durme, Y.M., Gevaert, P., Bachert, C., Schmidt-Weber, C.B., Brusselle, G.G., Joos, G.F., Tournoy, K.G., Decreased FOXP3 protein expression in patients with asthma. Allergy 64 (2009), 1539–1546.
38. Randolph, D.A., Stephens, R., Carruthers, C.J., Chaplin, D.D., Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation. J. Clin. Invest 104 (1999), 1021–1029.
39. Ray, A., Cohn, L., Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation. J. Clin. Invest 104 (1999), 985–993.
40. Reiter, M., Brandt, W., Relaxant effects on tracheal and ileal smooth muscles of the Guinea pig. Arzneimittelforschung 35 (1985), 408–414.
41. Robinson, D.S., Hamid, Q., Ying, S., Tsicopoulos, A., Barkans, J., Bentley, A.M., Corrigan, C., Durham, S.R., Kay, A.B., Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326 (1992), 298–304.
42. Scop, Thymi herba, Monographs on the Medicinal Uses of Plant Drugs, European Scientific Cooperative on Phytotherapy. Exeter, UK, 1997.
43. Sharaf-Kandi, E.B.A.R., The Canon of Medicine. Avicenna, Book 2. 1st ed, 1985, Soroush Press, Tehran, Iran.
44. Shokri, H., Asadi, F., Bahonar, A.R., Khosravi, A.R., The role of zataria multiflora essence (Iranian herb) on innate immunity of animal model. Iran. J. Immunol. 3 (2006), 164–168.
45. Temelkovski, J., Hogan, S.P., Shepherd, D.P., Foster, P.S., Kumar, R.K., An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen. Thorax 53 (1998), 849–856.
46. Walker, C., Bode, E., Boer, L., Hansel, T.T., Blaser, K., Virchow, J.C. Jr., Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am. Rev. Respir. Dis. 146 (1992), 109–115.
47. Wang, Y.H., Voo, K.S., Liu, B., Chen, C.Y., Uygungil, B., Spoede, W., Bernstein, J.A., Huston, D.P., Liu, Y.J., A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma. J. Exp. Med. 207 (2010), 2479–2491.
48. Wang, Y.H., Wills-Karp, M., The potential role of interleukin-17 in severe asthma. Curr. Allergy Asthma Rep. 11 (2011), 388–394.
49. Wong, C.K., Ho, C.Y., Ko, F.W., Chan, C.H., Ho, A.S., Hui, D.S., Lam, C.W., Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin. Exp. Immunol. 125 (2001), 177–183.
50. Ye, P., Rodriguez, F.H., Kanaly, S., Stocking, K.L., Schurr, J., Schwarzenberger, P., Oliver, P., Huang, W., Zhang, P., Zhang, J., Shellito, J.E., Bagby, G.J., Nelson, S., Charrier, K., Peschon, J.J., Kolls, J.K., Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J. Exp. Med. 194 (2001), 519–527.