Nobiletin attenuates lipopolysaccharide/D-galactosamine-induced liver injury in mice by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated cytokine production

Molecular Medicine Reports

Volumn 14, Issue 6, 2016, Pages 5595-5600

  He, Zhenxing ^a,b   Li, Xuanfei ^a   Chen, Hao ^a   He, Kun ^a   Liu, Yiming ^a   Gong, Junhua ^a   Gong, Jianping ^a  

^a THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b Pre Clinical College   (China)

Author keywords

D galactosamine; Lipopolysaccharide; NF B; Nobiletin; Nrf2

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYCLOOXYGENASE 2; GALACTOSAMINE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LIVER ENZYME; NOBILETIN; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR; ANTIOXIDANT; CYTOKINE; FLAVONE DERIVATIVE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; HISTOPATHOLOGY; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TREATMENT OUTCOME; UPREGULATION; WESTERN BLOTTING; ANIMAL; CHEMICAL AND DRUG INDUCED LIVER INJURY; DRUG EFFECTS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; LIVER FUNCTION TEST; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; CHEMICAL AND DRUG INDUCED LIVER INJURY; CYCLOOXYGENASE 2; CYTOKINES; FLAVONES; GALACTOSAMINE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; LIPOPOLYSACCHARIDES; LIVER FUNCTION TESTS; MALE; MICE; NF-E2-RELATED FACTOR 2; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; SIGNAL TRANSDUCTION;

EID: 84999266713     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2016.5943     Document Type: Article

References (37)

1. Pierre PG, Solbreux P and Vaerman JP: Cholera toxin-induced fluid secretion in rat gut ligated loops: Influence of bile from normal or cholera toxin-immunized rats. Immunology 68: 319-324, 1989.
2. Forbes SJ, Gupta S and Dhawan A: Cell therapy for liver disease: From liver transplantation to cell factory. J Hepatol 62 (Suppl 1): S157-S169, 2015.
3. Bernal W, Lee WM, Wendon J, Larsen FS and Williams R: Acute liver failure: A curable disease by 2024? J Hepatol 62 (Suppl 1): S112-S120, 2015.
4. Kuroda N, Inoue K, Ikeda T, Hara Y, Wake K and Sato T: Apoptotic response through a high mobility box 1 protein-dependent mechanism in LPS/GalN-induced mouse liver failure and glycyrrhizin-mediated inhibition. PLoS One 9: e92884, 2014.
5. Shukla P, Rao GM, Pandey G, Sharma S, Mittapelly N, Shegokar R and Mishra PR: Therapeutic interventions in sepsis: Current and anticipated pharmacological agents. Br J Pharmacol 171: 5011-5031, 2014.
6. Tsutsui H and Nishiguchi S: Importance of Kupffer cells in the development of acute liver injuries in mice. Int J Mol Sci 15: 7711-7730, 2014.
7. Moratalla A, Caparrós E, Juanola O, Portune K, Puig-Kröger A, Estrada-Capetillo L, Bellot P, Gómez-Hurtado I, Piñero P, Zapater P, et al: Bifidobacterium pseudocatenulatum CECT7765 induces an M2 anti-inflammatory transition in macrophages from patients with cirrhosis. J Hepatol 64: 135-145, 2015.
8. Nakajima A, Ohizumi Y and Yamada K: Anti-dementia activity of nobiletin, a citrus flavonoid: A review of animal studies. Clin Psychopharmacol Neurosci 12: 75-82, 2014.
9. Xiu LJ, Sun DZ, Jiao JP, Yan B, Qin ZF, Liu X, Wei PK and Yue XQ: Anticancer effects of traditional Chinese herbs with phlegm-eliminating properties-An overview. J Ethnopharmacol 172: 155-161, 2015.
10. Horigome S, Yoshida I, Tsuda A, Harada T, Yamaguchi A, Yamazaki K, Inohana S, Isagawa S, Kibune N, Satoyama T, et al: Identification and evaluation of anti-inflammatory compounds from Kaempferia parviflora. Biosci Biotechnol Biochem 78: 851-860, 2014.
11. Malik S, Bhatia J, Suchal K, Gamad N, Dinda AK, Gupta YK and Arya DS: Nobiletin ameliorates cisplatin-induced acute kidney injury due to its anti-oxidant, anti-inflammatory and anti-apoptotic effects. Exp Toxicol Pathol 67: 427-433, 2015.
12. Choi BK, Kim TW, Lee DR, Jung WH, Lim JH, Jung JY, Yang SH and Suh JW: A polymethoxy flavonoids-rich Citrus aurantium extract ameliorates ethanol-induced liver injury through modulation of AMPK and Nrf2-related signals in a binge drinking mouse model. Phytother Res 29: 1577-1584, 2015.
13. Tominari T, Hirata M, Matsumoto C, Inada M and Miyaura C: Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis. J Pharmacol Sci 119: 390-394, 2012.
14. Mair F, Joller S, Hoeppli R, Onder L, Hahn M, Ludewig B, Waisman A and Becher B: The NF kappa B-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing gamma delta T cells. eLife 4: e10087, 2015.
15. Lu MC, Ji JA, Jiang ZY and You QD: The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update. Med Res Rev 36: 924-963, 2016.
16. van Beek JH, de Moor MH, de Geus EJ, Lubke GH, Vink JM, Willemsen G and Boomsma Di: The genetic architecture of liver enzyme levels: GGT, ALT and AST. Behav Genet 43: 329-339, 2013.
17. Liang DY, Liu LM, Ye CG, Zhao L, Yu FP, Gao DY, Wang YY, Yang ZW and Wang YY: Inhibition of UII/UTR system relieves acute inflammation of liver through preventing activation of NF-kappaB pathway in ALF mice. PLoS One 8: e64895, 2014.
18. Liu LM, Liang DY, Ye CG, Tu WJ and Zhu T: The UII/UT system mediates upregulation of proinflammatory cytokines through p38 MAPK and NF-κB pathways in LPS-stimulated Kupffer cells. PLoS One 10: e0121383, 2015.
19. Yang P, Zhou W, Li C, Zhang M, Jiang Y, Jiang R, Ba H, Li C, Wang J, Yin B, et al: Kupffer-cell-expressed transmembrane TNF-α is a major contributor to lipopolysaccharide and D-galactosamine-induced liver injury. Cell Tissue Res 363: 371-383, 2016.
20. Ahmad A, Raish M, Ganaie MA, Ahmad SR, Mohsin K, Al-Jenoobi FI, Al-Mohizea AM and Alkharfy KM: Hepatoprotective effect of Commiphora myrrha against d-GalN/LPS-induced hepatic injury in a rat model through attenuation of pro inflammatory cytokines and related genes. Pharm Biol 53: 1759-1767, 2015.
21. Ma L, Gong X, Kuang G, Jiang R, Chen R and Wan J: Sesamin ameliorates lipopolysaccharide/d-galactosamine-induced fulminant hepatic failure by suppression of Toll-like receptor 4 signaling in mice. Biochem Biophys Res Commun 461: 230-236, 2015.
22. Yamada Y, Ishizaki M, Kido T, Honda R, Tsuritani I, Nogawa K and Yamaya H: Relationship between serum gamma-glutamyl transpeptidase activity, blood pressure and alcohol consumption. J Hum Hypertens 3: 409-417, 1989.
23. Cordero-Coma M and Sobrin L: Anti-tumor necrosis factor-alpha therapy in uveitis. Surv Ophthalmol 60: 575-589, 2015.
24. Ma Z, Hou T, Shi W, Liu W and He H: Inhibition of hepatocyte apoptosis: An important mechanism of corn peptides attenuating liver injury induced by ethanol. Int J Mol Sci 16: 22062-22080, 2015.
25. Peixoto CA and Gomes FO: The role of phosphodiesterase-5 inhibitors in prostatic inflammation: A review. J Inflamm (Lond) 12: 54, 2015.
26. Sun J, Zhang S, Zhang X, Zhang X, Dong H and Qian Y: IL-17A is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation. J Neuroinflammation 12: 165, 2015.
27. Li J, Zhang X and Huang H: Protective effect of linalool against lipopolysaccharide/D-galactosamine-induced liver injury in mice. Int Immunopharmacol 23: 523-529, 2014.
28. Senegas A, Gautheron J, Maurin AG and Courtois G: IKK-related genetic diseases: Probing NF-κB functions in humans and other matters. Cell Mol Life Sci 72: 1275-1287, 2015.
29. Verstrepen L and Beyaert R: Receptor proximal kinases in NF-κB signaling as potential therapeutic targets in cancer and inflammation. Biochem Pharmacol 92: 519-529, 2014.
30. Muriach M, Flores-Bellver M, Romero FJ and Barcia JM: Diabetes and the brain: Oxidative stress, inflammation, and autophagy. Oxid Med Cell Longev 2014: 102158, 2014.
31. Dodson M, Redmann M, Rajasekaran NS, Darley-Usmar V and Zhang J: KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity. Biochem J 469: 347-355, 2015.
32. Jiménez-Osorio AS, González-Reyes S and Pedraza-Chaverri J: Natural Nrf2 activators in diabetes. Clin Chim Acta 448: 182-192, 2015.
33. Hahn ME, Timme-Laragy AR, Karchner SI and Stegeman JJ: Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio). Free Radic Biol Med 88: 275-289, 2015.
34. Kanninen KM, Pomeshchik Y, Leinonen H, Malm T, Koistinaho J and Levonen AL: Applications of the Keap1-Nrf2 system for gene and cell therapy. Free Radic Biol Med 88: 350-361, 2015.
35. Buelna-Chontal M and Zazueta C: Redox activation of Nrf2 & NF-κB: A double end sword? Cell Signal 25: 2548-2557, 2013.
36. Agca CA, Tuzcu M, Hayirli A and Sahin K: Taurine ameliorates neuropathy via regulating NF-κB and Nrf2/HO-1 signaling cascades in diabetic rats. Food Chem Toxicol 71: 116-121, 2014.
37. Jiang T, Tian F, Zheng H, Whitman SA, Lin Y, Zhang Z, Zhang N and Zhang DD: Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response. Kidney Int 85: 333-343, 2014.