Bifidobacterium pseudocatenulatum CECT7765 induces an M2 anti-inflammatory transition in macrophages from patients with cirrhosis

Journal of Hepatology

Volumn 64, Issue 1, 2016, Pages 135-145

  Moratalla, Alba ^a   Caparrós, Esther ^a,b   Juanola, Oriol ^a   Portune, Kevin ^c   Puig Kröger, Amaya ^d   Estrada Capetillo, Lizbeth ^d   Bellot, Pablo ^a,e   Gómez Hurtado, Isabel ^a   Piñero, Paula ^b   Zapater, Pedro ^a,e   González Navajas, José M ^a   Such, José ^a,f   Sanz, Yolanda ^c   Francés, Rubén ^a,b  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^c INSTITUTO DE AGROQUÍMICA Y TECNOLOGÍA DE ALIMENTOS CSIC   (Spain)

^d HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^e HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

^f HEART AND VASCULAR INSTITUTE   (United Arab Emirates)

Author keywords

Bifidobacterium pseudocatenulatum CECT7765; Cirrhosis; Cytokines; Macrophages

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; ANTIINFLAMMATORY AGENT; CYTOKINE; LIPOPOLYSACCHARIDE;

ADULT; ARTICLE; ASCITES; BACTERICIDAL ACTIVITY; BIFIDOBACTERIUM; BIFIDOBACTERIUM PSEUDOCATENULATUM; BILE DUCT; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; KUPFFER CELL; LIVER CIRRHOSIS; MACROPHAGE; MACROPHAGE FUNCTION; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; AGED; BIOSYNTHESIS; CELL POLARITY; IMMUNOLOGY; MIDDLE AGED; PROSPECTIVE STUDY;

AGED; ANTI-INFLAMMATORY AGENTS; BIFIDOBACTERIUM; CELL POLARITY; CYTOKINES; FEMALE; HUMANS; KUPFFER CELLS; LIPOPOLYSACCHARIDES; LIVER CIRRHOSIS; MACROPHAGES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 84949267361     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.08.020     Document Type: Article

References (39)

1. A. Albillos, A.L. Hera Ad, E. Reyes, J. Monserrat, L. Munoz, M. Nieto, and et al. Tumour necrosis factor-alpha expression by activated monocytes and altered T-cell homeostasis in ascitic alcoholic cirrhosis: amelioration with norfloxacin J Hepatol 40 2004 624 631
2. L. Munoz, A. Albillos, M. Nieto, E. Reyes, L. Lledo, J. Monserrat, and et al. Mesenteric Th1 polarization and monocyte TNF-alpha production: first steps to systemic inflammation in rats with cirrhosis Hepatology 42 2005 411 419
3. M. Perez-Paramo, J. Munoz, A. Albillos, I. Freile, F. Portero, M. Santos, and et al. Effect of propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascites Hepatology 31 2000 43 48
4. R. Wiest, M. Lawson, and M. Geuking Pathological bacterial translocation in liver cirrhosis J Hepatol 60 2014 197 209
5. A. Rimola, R. Soto, F. Bory, V. Arroyo, C. Piera, and J. Rodes Reticuloendothelial system phagocytic activity in cirrhosis and its relation to bacterial infections and prognosis Hepatology 4 1984 53 58
6. A. Sica, and A. Mantovani Macrophage plasticity and polarization: in vivo veritas J Clin Invest 122 2012 787 795
7. F.A. Verreck, T. de Boer, D.M. Langenberg, M.A. Hoeve, M. Kramer, E. Vaisberg, and et al. Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria Proc Natl Acad Sci USA 101 2004 4560 4565
8. A.J. Fleetwood, T. Lawrence, J.A. Hamilton, and A.D. Cook Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation J Immunol 178 2007 5245 5252
9. E. Sierra-Filardi, A. Puig-Kroger, F.J. Blanco, C. Nieto, R. Bragado, M.I. Palomero, and et al. Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers Blood 117 2011 5092 5101
10. A. Sica, P. Invernizzi, and A. Mantovani Macrophage plasticity and polarization in liver homeostasis and pathology Hepatology 59 2014 2034 2042
11. A. Moratalla, I. Gómez-Hurtado, A. Santacruz, Á. Moya, G. Peiró, P. Zapater, and et al. Protective effect of Bifidobacterium pseudocatenulatum CECT7765 against induced bacterial antigen translocation in experimental cirrhosis Liver Int 34 2014 850 858
12. P.G. Cano, A. Santacruz, F.M. Trejo, and Y. Sanz Bifidobacterium CECT 7765 improves metabolic and immunological alterations associated with obesity in high-fat diet fed mice Obesity (Silver Spring) 21 2013 2310 2321
13. M.S. Rangel-Frausto, D. Pittet, M. Costigan, T. Hwang, C.S. Davis, and R.P. Wenzel The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study JAMA 273 1995 117 123
14. P. Zapater, R. Cano, L. Llanos, A.J. Ruiz-Alcaraz, S. Pascual, C. Barquero, and et al. Norfloxacin modulates the inflammatory response and directly affects neutrophils in patients with decompensated cirrhosis Gastroenterology 137 2009 1669 1679
15. B.A. Runyon Paracentesis of ascitic fluid: a safe procedure Arch Intern Med 146 1986 2259 2261
16. B.A. Runyon, H.N. Canawati, and E.A. Akriviadis Optimization of ascitic fluid culture technique Gastroenterology 95 1988 1351 1355
17. A. Moratalla, I. Gómez-Hurtado, A. Moya-Pérez, P. Zapater, G. Peiró, J.M. González-Navajas, and et al. Bifidobacterium pseudocatenulatum CECT7765 promotes a TLR2-dependent anti-inflammatory response in intestinal lymphocytes from mice with cirrhosis Eur J Nutr 2015 [Epub ahead of print]
18. W. Xu, X. Zhao, M.R. Daha, and C. van Kooten Reversible differentiation of pro- and anti-inflammatory macrophages Mol Immunol 53 2013 179 186
19. A.J. O'Brien, J.N. Fullerton, K.A. Massey, G. Auld, G. Sewell, S. James, and et al. Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2 Nat Med 20 2014 518 523
20. A.C. Labonte, A.C. Tosello-Trampont, and Y.S. Hahn The role of macrophage polarization in infectious and inflammatory diseases Mol Cells 37 2014 275 285
21. E. Liaskou, H.W. Zimmermann, K.K. Li, Y.H. Oo, S. Suresh, Z. Stamataki, and et al. Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics Hepatology 57 2013 385 398
22. B.A. Runyon, S. Sugano, G. Kanel, and M.A. Mellencamp A rodent model of cirrhosis, ascites, and bacterial peritonitis Gastroenterology 100 1991 489 493
23. R. Wiest, and G. Garcia-Tsao Bacterial translocation (BT) in cirrhosis Hepatology 41 2005 422 433
24. A. Aderem, and R.J. Ulevitch Toll-like receptors in the induction of the innate immune response Nature 406 2000 782 787
25. A. Albillos, M. Lario, and M. Alvarez-Mon Cirrhosis-associated immune dysfunction: distinctive features and clinical relevance J Hepatol 61 2014 1385 1396
26. J. Du Plessis, H. Vanheel, C.E. Janssen, L. Roos, T. Slavik, P.I. Stivaktas, and et al. Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function J Hepatol 58 2013 1125 1132
27. R. Frances, M. Chiva, E. Sanchez, J.M. Gonzalez-Navajas, T. Llovet, P. Zapater, and et al. Bacterial translocation is downregulated by anti-TNF-alpha monoclonal antibody administration in rats with cirrhosis and ascites J Hepatol 46 2007 797 803
28. H. Doi, T.K. Iyer, E. Carpenter, H. Li, K.M. Chang, R.H. Vonderheide, and et al. Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-positive B-cell population Hepatology 55 2012 709 719
29. A. Albillos, H.A. de La, M. Gonzalez, J.L. Moya, J.L. Calleja, J. Monserrat, and et al. Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement Hepatology 37 2003 208 217
30. R. Frances, J.M. Gonzalez-Navajas, P. Zapater, C. Munoz, R. Cano, S. Pascual, and et al. Bacterial DNA induces the complement system activation in serum and ascitic fluid from patients with advanced cirrhosis J Clin Immunol 27 2007 438 444
31. R. Frances, P. Zapater, J.M. Gonzalez-Navajas, C. Munoz, R. Cano, R. Moreu, and et al. Bacterial DNA in patients with cirrhosis and noninfected ascites mimics the soluble immune response established in patients with spontaneous bacterial peritonitis Hepatology 47 2008 978 985
32. F. Rey-Giraud, M. Hafner, and C.H. Ries In vitro generation of monocyte-derived macrophages under serum-free conditions improves their tumor promoting functions PLoS One 7 2012 e42656
33. S. Edin, M.L. Wikberg, J. Rutegard, P.A. Oldenborg, and R. Palmqvist Phenotypic skewing of macrophages in vitro by secreted factors from colorectal cancer cells PLoS One 8 2013 e74982
34. F.Y. McWhorter, T. Wang, P. Nguyen, T. Chung, and W.F. Liu Modulation of macrophage phenotype by cell shape Proc Natl Acad Sci USA 110 2013 17253 17258
35. R.A. Isidro, F.J. Bonilla, H. Pagan, M.L. Cruz, P. Lopez, L. Godoy, and et al. The probiotic mixture VSL#3 alters the morphology and secretion profile of both polarized and unpolarized human macrophages in a polarization-dependent manner J Clin Cell Immunol 5 2014 1000227
36. H. Van Gorp, P.L. Delputte, and H.J. Nauwynck Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy Mol Immunol 47 2010 1650 1660
37. 4-induced fibrosis PLoS One 6 2011 e23037
38. R. Frances, C. Munoz, P. Zapater, F. Uceda, I. Gascon, S. Pascual, and et al. Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites Gut 53 2004 860 864
39. D. Gosselin, V.M. Link, C.E. Romanoski, G.J. Fonseca, D.Z. Eichenfield, N.J. Spann, and et al. Environment drives selection and function of enhancers controlling tissue-specific macrophage identities Cell 159 2014 1327 1340