An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease

Journal of Medicinal Chemistry

Volumn 59, Issue 22, 2016, Pages 10113-10126

  Carbo, Adria ^a   Gandour, Richard D ^a   Hontecillas, Raquel ^a   Philipson, Noah ^a   Uren, Aykut ^b   Bassaganya Riera, Josep ^a  

^a BIOTHERAPEUTICS INC   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 (1 HYDROXY 4 OXOCYCLOHEXYL)VINYL]BENZOIC ACID; 3 [2 (8 HYDROXY 1,4 DIOXASPIRO[4.5]DECAN 8 YL]VINYL]BENZOIC ACID; 4 [6 (1H BENZO[D]IMIDAZOL 2 YL)PICOLINOYL]PIPERAZIN 1 IUM CHLORIDE; 4 [6 (BENZO[D]OXAZOL 2 YL)PICOLINOYL]PIPERAZIN 1 IUM CHLORIDE; 5 [2 (1 HYDROXY 4 OXOCYCLOHEXYL)VINYL]FURAN 2 CARBOXYLIC ACID; 5 [2 (8 HYDROXY 1,4 DIOXASPIRO[4.5]DECAN 8 YL)VINYL]FURAN 2 CARBOXYLIC ACID; ANTIINFLAMMATORY AGENT; ETHYL 3 [2 (8 HYDROXY 1,4 DIOXASPIRO[4.5]DECAN 8 YL]VINYL]BENZOATE; GASTROINTESTINAL AGENT; LANTHIONINE; METHYL 5 [2 (1 HYDROXY 4 OXOCYCLOHEXYL)VINYL]FURAN 2 CARBOXYLATE; METHYL 5 [2 (8 HYDROXY 1,4 DIOXASPIRO[4.5]DECAN 8 YL)VINYL]FURAN 2 CARBOXYLATE; N,N' (1,4 PHENYLENE)BIS[3 (1H BENZO[D]IMIDAZOL 2 YL)BENZAMIDE]; N,N' (1,4 PHENYLENE)BIS[3 (1H BENZO[D]OXAZOL 2 YL)BENZAMIDE]; N,N' (1,4 PHENYLENE)BIS[6 (1H BENZO[D]IMIDAZOL 2 YL)PICOLINAMIDE]; N,N' (1,4 PHENYLENE)BIS[6 (1H BENZO[D]OXAZOL 2 YL)PICOLINAMIDE]; PIPERAZINE 1,4 DIYLBIS(6 BENZO[D]IMIDAZOLE 2 YL)PYRIDINE 2 YL)METHANONE; PIPERAZINE 1,4 DIYLBIS[[3 (1H BENZO[D]IMIDAZOL 2 YL)PHENYL]METHANONE]; PIPERAZINE 1,4 DIYLBIS[[3 (BENZO[D]IMIDAZOL 2 YL)PHENYL]METHANONE]; PIPERAZINE 1,4 DIYLBIS[[6 (1H BENZO[D]IMIDAZOL 2 YL)PHENYL]METHANONE]; PIPERAZINE 1,4 DIYLBIS[[6 (1H BENZO[D]IMIDAZOL 2 YL)PYRIDIN 2 YL]METHANONE]; PIPERAZINE 1,4 DIYLBIS[[6 (1H BENZO[D]OXAZOL 2 YL)PYRIDIN 2 YL]METHANONE]; PIPERAZINE DERIVATIVE; SYNTHETASE; TERT BUTYL 4 [6 (1H BENZO[D]IMIDAZOL 2 YL)PICOLINOYL]PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 [6 (BENZO[D]OXAZOL 2 YL)PICOLINOYL]PIPERAZINE 1 CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; [4 [6 (1H BENZO[D]IMIDAZOL 2 YL)PICOLINOYL]PIPERAZIN 1 YL)[6 (BENZO[D]OXAZOL 2 YL)PYRIDIN 2 YL]METHANONE; [6 (1H BENZO[D]IMIDAZOL 2 YL)PYRIDIN 2 YL](PIPERAZIN 1 YL) METHANONE; [6 (BENZO[D]OXAZOL 2 YL)PYRIDIN 2 YL](PIPERAZIN 1 YL)METHANONE; BENZIMIDAZOLE DERIVATIVE; CELL SURFACE RECEPTOR; ENZYME INHIBITOR; LANCL2 PROTEIN, MOUSE; N,N-BIS(BENZIMIDAZOLYLPICOLINOYL)PIPERAZINE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; COLITIS; CONTROLLED STUDY; DISEASE ACTIVITY; DRUG DESIGN; DRUG EFFICACY; DRUG SAFETY; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DOCKING; MOUSE; NONHUMAN; PHARMACOPHORE; PHYSICAL CHEMISTRY; SPLEEN CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; DEFICIENCY; DOSE RESPONSE; INFLAMMATORY BOWEL DISEASES; KNOCKOUT MOUSE; METABOLISM; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; SYNTHESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZIMIDAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; INFLAMMATORY BOWEL DISEASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERAZINES; RECEPTORS, CELL SURFACE; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

EID: 84999115116     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b00412     Document Type: Article

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