Transdermal delivery of estradiol-loaded PLGA nanoparticles using iontophoresis for treatment of osteoporosis

Bio-Medical Materials and Engineering

Volumn 27, Issue 5, 2016, Pages 475-483

  Takeuchi, Issei ^a   Fukuda, Kohta ^a   Kobayashi, Shiori ^a   Makino, Kimiko ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Estradiol; iontophoresis; nanoparticle; osteoporosis; therapeutic efficacy; transdermal administration

Indexed keywords

COMPUTERIZED TOMOGRAPHY; DISEASES; ELECTROPHORESIS; ELECTROTHERAPEUTICS; NANOPARTICLES; POLYELECTROLYTES;

ESTRADIOL; IONTOPHORESIS; OSTEOPOROSIS; THERAPEUTIC EFFICACY; TRANSDERMAL ADMINISTRATION;

BONE;

ESTRADIOL; NANOPARTICLE; POLYELECTROLYTE; POLYGLACTIN; ESTROGEN; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; CAPILLARY; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; DENSITY; DIFFUSION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG PENETRATION; ELECTROPHORETIC MOBILITY; FEMALE; IN VIVO STUDY; IONTOPHORESIS; NONHUMAN; OVARIECTOMY-INDUCED OSTEOPOROSIS; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SPINE; SPRAGUE DAWLEY RAT; STRATUM CORNEUM; SURFACE CHARGE; SURFACE PROPERTY; TRABECULAR BONE; TRANSDERMAL DRUG DELIVERY SYSTEM; ANIMAL; CHEMISTRY; CUTANEOUS DRUG ADMINISTRATION; DRUG DELIVERY SYSTEM; DRUG EFFECTS; OSTEOPOROSIS; PATHOPHYSIOLOGY; PROCEDURES;

ADMINISTRATION, CUTANEOUS; ANIMALS; BONE DENSITY; DRUG DELIVERY SYSTEMS; ESTRADIOL; ESTROGENS; FEMALE; IONTOPHORESIS; LACTIC ACID; NANOPARTICLES; OSTEOPOROSIS; POLYGLYCOLIC ACID; RATS, SPRAGUE-DAWLEY; SPINE;

EID: 84999009632     PISSN: 09592989     EISSN: 18783619     Source Type: Journal    
DOI: 10.3233/BME-161601     Document Type: Article

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