SNAREs and cholesterol movement for steroidogenesis

Molecular and Cellular Endocrinology

Volumn 441, Issue , 2017, Pages 17-21

  Kraemer, Fredric B ^a,b   Shen, Wen Jun ^a,b   Azhar, Salman ^a,b  

^a STANFORD UNIVERSITY   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

Cholesterol; Lipid droplet; Mitochondria; SNARE; Steroidogenesis

Indexed keywords

CHOLESTEROL; FAT DROPLET; LIPOPROTEIN; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; SNARE PROTEIN; STEROID HORMONE; STEROID;

CELL ASSAY; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; CYTOPLASM; ENDOCRINE CELL; GENE SILENCING; GRANULOSA CELL; HUMAN; IN VITRO STUDY; INTRACELLULAR TRANSPORT; LIPID MEMBRANE; LIPID STORAGE; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; REVIEW; STEROIDOGENESIS; ANIMAL; BIOSYNTHESIS; METABOLISM; MITOCHONDRION; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CHOLESTEROL; HUMANS; LIPID DROPLETS; MITOCHONDRIA; SNARE PROTEINS; STEROIDS;

EID: 84997605055     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2016.07.034     Document Type: Review

References (34)

1. Andersen, J.M., Dietschy, J.M., Regulation of sterol synthesis in 16 tissues of the rat. J. Biol. Chem. 252 (1977), 3646–3651.
2. Andersen, J.M., Dietschy, J.M., Relative importance of high and low density lipoproteins in the regulation of cholesterol synthesis in the adrenal gland, ovary, and testis of the rat. J. Biol. Chem. 253 (1978), 9024–9032.
3. Azhar, S., Reaven, E., Scavenger receptor class BI and selective cholesteryl ester uptake: partners in the regulation of steroidogenesis. Mol. Cell Endocrinol. 195 (2002), 1–26.
4. Connelly, M.A., Kellner-Weibel, G., Rothblat, G.H., Williams, D.L., SR-BI-directed HDL-cholesteryl ester hydrolysis. J. Lipid Res. 44 (2003), 331–341.
5. Crivello, J.F., Jefcoate, C.R., Intracellular movement of cholesterol in rat adrenal cells. Kinetics and effects of inhibitors. J. Biol. Chem. 255 (1980), 8144–8151.
6. Enrich, C., Rentero, C., Hierro, A., Grewal, T., Role of cholesterol in SNARE-mediated trafficking on intracellular membranes. J. Cell Sci. 128 (2015), 1071–1081.
7. Freeman, D.A., Regulation of the cholesterol ester cycle of cultured Leydig tumor cells. Eur. J. Biochem. 164 (1987), 351–356.
8. Greenberg, A.S., Coleman, R.A., Kraemer, F.B., McManaman, J.L., Obin, M.S., Puri, V., Yan, Q.W., Miyoshi, H., Mashek, D.G., The role of lipid droplets in metabolic disease in rodents and humans. J. Clin. Invest. 121 (2011), 2102–2110.
9. Gwynne, J.T., Strauss, J.F. III, The role of lipoproteins in steroidogenesis and cholesterol metabolism in steroidogenic glands. Endocr. Rev. 3 (1982), 299–329.
10. Hulce, J.J., Cognetta, A.B., Niphakis, M.J., Tully, S.E., Cravatt, B.F., Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells. Nat. Methods 10 (2013), 259–264.
11. Ikonen, E., Cellular cholesterol trafficking and compartmentalization. Nat. Rev. Mol. Cell Biol. 9 (2008), 125–138.
12. Jägerström, S., Polesie, S., Wickström, Y., Johansson, B.R., Schröder, H.D., Højlund, K., Boström, P., Lipid droplets interact with mitochondria using SNAP23. Cell Biol. Int. 33 (2009), 934–940.
13. Khor, V.K., Ahrends, R., Lin, Y., Shen, W.J., Adams, C.M., Roseman, A.N., Cortez, Y., Teruel, M.N., Azhar, S., Kraemer, F.B., The proteome of cholesteryl-ester-enriched versus triacylglycerol-enriched lipid droplets. Plos One, 9, 2014, e105047.
14. Kovanen, P.T., Faust, J.R., Brown, M.S., Goldstein, J.L., Low density lipoprotein receptors in bovine adrenal cortex. I. receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured adrenocortical cells. Endocrinology 104 (1979), 599–609.
15. Kraemer, F.B., Adrenal cholesterol utilization. Mol. Cell Endocrinol. 265–266 (2007), 42–45.
16. Kraemer, F.B., Shen, W.J., Natu, V., Patel, S., Osuga, J., Ishibashi, S., Azhar, S., Adrenal neutral cholesteryl ester hydrolase: identification, subcellular distribution, and sex differences. Endocrinology 143 (2002), 801–806.
17. Kraemer, F.B., Shen, W.J., Harada, K., Patel, S., Osuga, J., Ishibashi, S., Azhar, S., Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis. Mol. Endocrinol. 18 (2004), 549–557.
18. Lin, Y., Hou, X., Shen, W.J., Hanssen, R., Khor, V.K., Cortez, Y., Roseman, A.N., Azhar, S., Kraemer, F.B., SNARE-mediated cholesterol movement to mitochondria supports steroidogenesis in rodent cells. Mol. Endocrinol. 30 (2016), 234–247.
19. Merry, B.J., Mitochondrial structure in the rat adrenal cortex. J. Anat. 119 (1975), 611–618.
20. Miller, W.L., StAR search–what we know about how the steroidogenic acute regulatory protein mediates mitochondrial cholesterol import. Mol. Endocrinol. 21 (2007), 589–601.
21. Miller, W.L., Steroidogenic enzymes. Endocr. Dev. 13 (2008), 1–18.
22. Miller, W.L., A brief history of adrenal research: Steroidogenesis–The soul of the adrenal. Mol. Cell. Endocrinol. 371 (2013), 5–14.
23. Miller, W.L., Bose, H.S., Early steps in steroidogenesis: intracellular cholesterol trafficking. J. Lipid Res. 52 (2011), 2111–2135.
24. Murphy, S., Martin, S., Parton, R.G., Lipid droplet-organelle interactions; sharing the fats. Biochim. Biophys. Acta 1791 (2009), 441–447.
25. Shen, W.J., Hu, J., Hu, Z., Kraemer, F.B., Azhar, S., Scavenger receptor class B type I (SR-BI): a versatile receptor with multiple functions and actions. Metabolism 63 (2014), 875–886.
26. Shen, W.-J., Azhar, S., Kraemer, F.B., Lipid droplets and steroidogenic cells. Exp. Cell Res. 340 (2016), 209–214.
27. Soccio, R.E., Breslow, J.L., Intracellular cholesterol transport. Arterioscler. Thromb. Vasc. Biol. 24 (2004), 1150–1160.
28. Stocco, D.M., StAR protein and the regulation of steroid hormone biosynthesis. Annu. Rev. Physiol. 63 (2001), 193–213.
29. Südhof, T.C., Rothman, J.E., Membrane fusion: grappling with SNARE and SM proteins. Science 323 (2009), 474–477.
30. Toaff, M.E., Strauss, J.F. 3rd, Flickinger, G.L., Shattil, S.J., Relationship of cholesterol supply to luteal mitochondrial steroid synthesis. J. Biol. Chem. 254 (1979), 3977–3982.
31. Wang, W., Wei, S., Li, L., Su, X., Du, C., Li, F., Geng, B., Liu, P., Xu, G., Proteomic analysis of murine testes lipid droplets. Sci. Rep., 5, 2015, 12070.
32. Yamaguchi, T., Fujikawa, N., Nimura, S., Tokuoka, Y., Tsuda, S., Aiuchi, T., Kato, R., Obama, T., Itabe, H., Characterization of lipid droplets in steroidogenic MLTC-1 Leydig cells: Protein profiles and the morphological change induced by hormone stimulation. Biochim. Biophys. Acta 1851 (2015), 1285–1295.
33. Yang, L., Ding, Y., Chen, Y., Zhang, S., Huo, C., Wang, Y., Yu, J., Zhang, P., Na, H., Zhang, H., Ma, Y., Liu, P., The proteomics of lipid droplets: structure, dynamics, and functions of the organelle conserved from bacteria to humans. J. Lipid Res. 53 (2012), 1245–1253.
34. Yang, S.T., Kreutzberger, A.J., Lee, J., Kiessling, V., Tamm, L.K., The role of cholesterol in membrane fusion. Chem. Phys. Lipids, 2016, 10.1016/j.chemphyslip.2016.05.003 pii: S0009-3084(16)30055-X. [Epub ahead of print].