메뉴 건너뛰기




Volumn 1851, Issue 10, 2015, Pages 1285-1295

Characterization of lipid droplets in steroidogenic MLTC-1 Leydig cells: Protein profiles and the morphological change induced by hormone stimulation

Author keywords

17beta HSD11; 3beta HSD1; Lipid droplets; Lydig cells; MLTC 1; Steroidogenesis

Indexed keywords

17 BETA HYDROXYSTEROID DEHYDROGENASE TYPE 11; 3 BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1; ALPHA ENOLASE; CHOLESTEROL ESTER; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME P450 17; ELONGATION FACTOR 1ALPHA; FAT DROPLET; GLUCOSE REGULATED PROTEIN 94; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HORMONE SENSITIVE LIPASE; HYDROXYSTEROID DEHYDROGENASE; LUTEINIZING HORMONE; PERILIPIN; PERILIPIN 1; PERILIPIN 2; PERILIPIN 3; PEROXIREDOXIN 4; PROHIBITIN; RAB PROTEIN; RAS RELATED PROTEIN RAB 1A; RAS RELATED PROTEIN RAB 1B; RAS RELATED PROTEIN RAB 3A; RAS RELATED PROTEIN RAB 5A; RAS RELATED PROTEIN RAB 5B; RAS RELATED PROTEIN RAB 5C; STEROID HORMONE; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; TESTOSTERONE;

EID: 84937792736     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2015.06.007     Document Type: Article
Times cited : (35)

References (36)
  • 1
    • 70449769682 scopus 로고    scopus 로고
    • Lipid droplets finally get a little R-E-S-P-E-C-T
    • R.V. Farese Jr., and T.C. Walther Lipid droplets finally get a little R-E-S-P-E-C-T Cell 139 2009 855 860 10.1016/j.cell.2009.11.005
    • (2009) Cell , vol.139 , pp. 855-860
    • Farese, R.V.1    Walther, T.C.2
  • 2
    • 77950607704 scopus 로고    scopus 로고
    • Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins
    • A.R. Kimmel, D.L. Brasaemle, M. McAndrews-Hill, C. Sztalryd, and C. Londos Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins J. Lipid Res. 51 2010 468 471 10.1194/jlr.R000034
    • (2010) J. Lipid Res. , vol.51 , pp. 468-471
    • Kimmel, A.R.1    Brasaemle, D.L.2    McAndrews-Hill, M.3    Sztalryd, C.4    Londos, C.5
  • 3
    • 0034903123 scopus 로고    scopus 로고
    • The biogenesis and functions of lipid bodies in animals, plants and microorganisms
    • D.J. Murphy The biogenesis and functions of lipid bodies in animals, plants and microorganisms Prog. Lipid Res. 40 2001 325 438 10.1016/S0163-7827(01)00013-3
    • (2001) Prog. Lipid Res. , vol.40 , pp. 325-438
    • Murphy, D.J.1
  • 4
    • 84862313783 scopus 로고    scopus 로고
    • The proteomics of lipid droplets: structure, dynamics, and functions of the organelle conserved from bacteria to humans
    • L. Yang, Y. Ding, Y. Chen, S. Zhang, C. Huo, Y. Wang, J. Yu, P. Zhang, H. Na, H. Zhang, Y. Ma, and P. Liu The proteomics of lipid droplets: structure, dynamics, and functions of the organelle conserved from bacteria to humans J. Lipid Res. 53 2012 1245 1253 10.1194/jlr.R024117
    • (2012) J. Lipid Res. , vol.53 , pp. 1245-1253
    • Yang, L.1    Ding, Y.2    Chen, Y.3    Zhang, S.4    Huo, C.5    Wang, Y.6    Yu, J.7    Zhang, P.8    Na, H.9    Zhang, H.10    Ma, Y.11    Liu, P.12
  • 5
    • 77949524635 scopus 로고    scopus 로고
    • Proteomic insights into an expanded cellular role for cytoplasmic lipid droplets
    • B.D. Hodges, and C.C. Wu Proteomic insights into an expanded cellular role for cytoplasmic lipid droplets J. Lipid Res. 51 2010 262 273 10.1194/jlr.R003582
    • (2010) J. Lipid Res. , vol.51 , pp. 262-273
    • Hodges, B.D.1    Wu, C.C.2
  • 6
    • 8744267532 scopus 로고    scopus 로고
    • Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3 T3-L1 adipocytes
    • D.L. Brasaemle, G. Dolios, L. Shapiro, and R. Wang Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3 T3-L1 adipocytes J. Biol. Chem. 279 2004 46835 46842 10.1074/jbc.M409340200
    • (2004) J. Biol. Chem. , vol.279 , pp. 46835-46842
    • Brasaemle, D.L.1    Dolios, G.2    Shapiro, L.3    Wang, R.4
  • 7
    • 1642565185 scopus 로고    scopus 로고
    • Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7
    • Y. Fujimoto, H. Itabe, J. Sakai, M. Makita, J. Noda, M. Mori, Y. Higashi, S. Kojima, and T. Takanko Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7 Biochim. Biophys. Acta 1644 2004 47 59 10.1016/j.bbamcr.2003.10.018
    • (2004) Biochim. Biophys. Acta , vol.1644 , pp. 47-59
    • Fujimoto, Y.1    Itabe, H.2    Sakai, J.3    Makita, M.4    Noda, J.5    Mori, M.6    Higashi, Y.7    Kojima, S.8    Takanko, T.9
  • 8
    • 33745756902 scopus 로고    scopus 로고
    • Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein
    • S. Sato, M. Fukasawa, Y. Yamakawa, T. Natsume, T. Suzuki, I. Shoji, H. Aizaki, T. Miyamura, and M. Nishijima Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein J. Biochem. 139 2006 921 930 10.1093/jb/mvj104
    • (2006) J. Biochem. , vol.139 , pp. 921-930
    • Sato, S.1    Fukasawa, M.2    Yamakawa, Y.3    Natsume, T.4    Suzuki, T.5    Shoji, I.6    Aizaki, H.7    Miyamura, T.8    Nishijima, M.9
  • 9
    • 0942287191 scopus 로고    scopus 로고
    • Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic
    • P. Liu, Y. Ying, Y. Zhao, D.I. Mundy, M. Zhu, and R.G.W. Anderson Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic J. Biol. Chem. 279 2004 3787 3792 10.1074/jbc.M311945200
    • (2004) J. Biol. Chem. , vol.279 , pp. 3787-3792
    • Liu, P.1    Ying, Y.2    Zhao, Y.3    Mundy, D.I.4    Zhu, M.5    Anderson, R.G.W.6
  • 10
    • 0030724392 scopus 로고    scopus 로고
    • Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein
    • D.L. Brasaemle, T. Barber, N.E. Wolins, G. Serrero, E.J. Blanchette-Mackie, and C. Londos Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein J. Lipid Res. 38 1997 2249 2263
    • (1997) J. Lipid Res. , vol.38 , pp. 2249-2263
    • Brasaemle, D.L.1    Barber, T.2    Wolins, N.E.3    Serrero, G.4    Blanchette-Mackie, E.J.5    Londos, C.6
  • 11
    • 84881007851 scopus 로고    scopus 로고
    • Crucial role of perilipin-3 (TIP47) in formation of lipid droplets and PGE2 production in HL-60-derived neutrophils
    • F. Nose, T. Yamaguchi, R. Kato, T. Aiuchi, T. Obama, S. Hara, M. Yamamoto, and H. Itabe Crucial role of perilipin-3 (TIP47) in formation of lipid droplets and PGE2 production in HL-60-derived neutrophils PLoS One 8 2013 e71542 10.1371/journal.pone.0071542
    • (2013) PLoS One , vol.8
    • Nose, F.1    Yamaguchi, T.2    Kato, R.3    Aiuchi, T.4    Obama, T.5    Hara, S.6    Yamamoto, M.7    Itabe, H.8
  • 12
    • 84862668222 scopus 로고    scopus 로고
    • The dynamic roles of intracellular lipid droplets: from archaea to mammals
    • D.J. Murphy The dynamic roles of intracellular lipid droplets: from archaea to mammals Protoplasma 249 2012 541 585 10.1007/s00709-011-0329-7
    • (2012) Protoplasma , vol.249 , pp. 541-585
    • Murphy, D.J.1
  • 13
    • 33744913055 scopus 로고    scopus 로고
    • MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha
    • T. Yamaguchi, S. Matsushita, K. Motojima, F. Hirose, and T. Osumi MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha J. Biol. Chem. 281 2006 14232 14240 10.1074/jbc.M601682200
    • (2006) J. Biol. Chem. , vol.281 , pp. 14232-14240
    • Yamaguchi, T.1    Matsushita, S.2    Motojima, K.3    Hirose, F.4    Osumi, T.5
  • 15
    • 34248189053 scopus 로고    scopus 로고
    • CGI-58 facilitates lipolysis on lipid droplets but is not involved in the vesiculation of lipid droplets caused by hormonal stimulation
    • T. Yamaguchi, N. Omatsu, E. Morimoto, H. Nakashima, K. Ueno, T. Tanaka, K. Satouchi, F. Hirose, and T. Osumi CGI-58 facilitates lipolysis on lipid droplets but is not involved in the vesiculation of lipid droplets caused by hormonal stimulation J. Lipid Res. 48 2007 1078 1089 10.1194/jlr.M600493-JLR200
    • (2007) J. Lipid Res. , vol.48 , pp. 1078-1089
    • Yamaguchi, T.1    Omatsu, N.2    Morimoto, E.3    Nakashima, H.4    Ueno, K.5    Tanaka, T.6    Satouchi, K.7    Hirose, F.8    Osumi, T.9
  • 19
    • 0028998905 scopus 로고
    • Perilipins are associated with cholesteryl ester droplets in steroidogenic adrenal cortical and Leydig cells
    • D.A. Servetnick, D.L. Brasaemle, J. Gruia-Gray, A.R. Kimmel, J. Wolff, and C. Londos Perilipins are associated with cholesteryl ester droplets in steroidogenic adrenal cortical and Leydig cells J. Biol. Chem. 270 1995 16970 16973 10.1074/jbc.270.28.16970
    • (1995) J. Biol. Chem. , vol.270 , pp. 16970-16973
    • Servetnick, D.A.1    Brasaemle, D.L.2    Gruia-Gray, J.3    Kimmel, A.R.4    Wolff, J.5    Londos, C.6
  • 20
    • 36649015243 scopus 로고    scopus 로고
    • Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis
    • D.L. Brasaemle Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis J. Lipid Res. 48 2007 2547 2559 10.1194/jlr.R700014-JLR200
    • (2007) J. Lipid Res. , vol.48 , pp. 2547-2559
    • Brasaemle, D.L.1
  • 21
    • 84866143955 scopus 로고    scopus 로고
    • Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets
    • K. Hsieh, Y.K. Lee, C. Londos, B.M. Raaka, K.T. Dalen, and A.R. Kimmel Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets J. Cell Sci. 125 2012 4067 4076 10.1242/jcs.104943
    • (2012) J. Cell Sci. , vol.125 , pp. 4067-4076
    • Hsieh, K.1    Lee, Y.K.2    Londos, C.3    Raaka, B.M.4    Dalen, K.T.5    Kimmel, A.R.6
  • 22
    • 39749145871 scopus 로고    scopus 로고
    • Isolation of lipid droplets from cells by density gradient centrifugation
    • Chapter 3: Unit 3.15
    • D.L. Brasaemle, and N.E. Wolins Isolation of lipid droplets from cells by density gradient centrifugation Curr. Protoc. Cell Biol. 2006 10.1002/0471143030.cb0315s29 (Chapter 3: Unit 3.15)
    • (2006) Curr. Protoc. Cell Biol.
    • Brasaemle, D.L.1    Wolins, N.E.2
  • 23
    • 33745122924 scopus 로고    scopus 로고
    • A novel 21-kDa cytochrome c-releasing factor is generated upon treatment of human leukemia U937 cells with geranylgeraniol
    • Y. Masuda, S. Maeda, A. Watanabe, Y. Sano, T. Aiuchi, S. Nakajo, H. Itabe, and K. Nakaya A novel 21-kDa cytochrome c-releasing factor is generated upon treatment of human leukemia U937 cells with geranylgeraniol Biochem. Biophys. Res. Commun. 346 2006 454 460 10.1016/j.bbrc.2006.05.161
    • (2006) Biochem. Biophys. Res. Commun. , vol.346 , pp. 454-460
    • Masuda, Y.1    Maeda, S.2    Watanabe, A.3    Sano, Y.4    Aiuchi, T.5    Nakajo, S.6    Itabe, H.7    Nakaya, K.8
  • 24
    • 79958712557 scopus 로고    scopus 로고
    • Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine
    • C. Moessinger, L. Kuerschner, J. Spandl, A. Shevchenko, and C. Thiele Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine J. Biol. Chem. 286 2011 21330 21339 10.1074/jbc.M110.202424
    • (2011) J. Biol. Chem. , vol.286 , pp. 21330-21339
    • Moessinger, C.1    Kuerschner, L.2    Spandl, J.3    Shevchenko, A.4    Thiele, C.5
  • 26
    • 0033544923 scopus 로고    scopus 로고
    • Formation of peroxisomes from peroxisomal ghosts in a peroxisome-deficient mammalian cell mutant upon complementation by protein microinjection
    • M. Yamasaki, N. Hashiguchi, C. Fujiwara, T. Imanaka, T. Tsukamoto, and T. Osumi Formation of peroxisomes from peroxisomal ghosts in a peroxisome-deficient mammalian cell mutant upon complementation by protein microinjection J. Biol. Chem. 274 1999 35293 35296 10.1074/jbc.274.50.35293
    • (1999) J. Biol. Chem. , vol.274 , pp. 35293-35296
    • Yamasaki, M.1    Hashiguchi, N.2    Fujiwara, C.3    Imanaka, T.4    Tsukamoto, T.5    Osumi, T.6
  • 27
    • 0037333285 scopus 로고    scopus 로고
    • Mouse Leydig tumor cells produce C-19 steroids, including testosterone
    • N.S. Panesar, K.W. Chan, and C.S. Ho Mouse Leydig tumor cells produce C-19 steroids, including testosterone Steroids 68 2003 245 251 10.1016/S0039-128X(02)00183-6
    • (2003) Steroids , vol.68 , pp. 245-251
    • Panesar, N.S.1    Chan, K.W.2    Ho, C.S.3
  • 28
    • 0029805305 scopus 로고    scopus 로고
    • Immunocytochemical demonstration of a lipid droplet-specific capsule in cultured Leydig cells of the golden hamsters
    • T.H. Fong, S.M. Wang, and H.S. Lin Immunocytochemical demonstration of a lipid droplet-specific capsule in cultured Leydig cells of the golden hamsters J. Cell. Biochem. 63 1996 366 373
    • (1996) J. Cell. Biochem. , vol.63 , pp. 366-373
    • Fong, T.H.1    Wang, S.M.2    Lin, H.S.3
  • 29
    • 54249166513 scopus 로고    scopus 로고
    • Identification and characterization of the ER/lipid droplet-targeting sequence in 17beta-hydroxysteroid dehydrogenase type 11
    • Y. Horiguchi, M. Araki, and K. Motojima Identification and characterization of the ER/lipid droplet-targeting sequence in 17beta-hydroxysteroid dehydrogenase type 11 Arch. Biochem. Biophys. 479 2008 121 130
    • (2008) Arch. Biochem. Biophys. , vol.479 , pp. 121-130
    • Horiguchi, Y.1    Araki, M.2    Motojima, K.3
  • 31
    • 0035895982 scopus 로고    scopus 로고
    • TIP47 associates with lipid droplets
    • N.E. Wolins, B. Rubins, and D.L. Brasaemle TIP47 associates with lipid droplets J. Biol. Chem. 279 2001 5101 5108 10.1074/jbc.M006775200
    • (2001) J. Biol. Chem. , vol.279 , pp. 5101-5108
    • Wolins, N.E.1    Rubins, B.2    Brasaemle, D.L.3
  • 32
    • 27244437730 scopus 로고    scopus 로고
    • Continuous monitoring of cholesterol oleate hydrolysis by hormone-sensitive lipase and other cholesterol esterases
    • Y.B. Ali, F. Carriere, R. Verger, S. Petry, G. Muller, and A. Abousalham Continuous monitoring of cholesterol oleate hydrolysis by hormone-sensitive lipase and other cholesterol esterases J. Lipid Res. 46 2005 994 1000 10.1194/jlr.M400509-JLR200
    • (2005) J. Lipid Res. , vol.46 , pp. 994-1000
    • Ali, Y.B.1    Carriere, F.2    Verger, R.3    Petry, S.4    Muller, G.5    Abousalham, A.6
  • 33
    • 77952800717 scopus 로고    scopus 로고
    • Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones
    • J. Hu, Z. Zhang, W.J. Shen, and S. Azhar Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones Nutr. Metab. (Lond.) 7 2010 47 10.1186/1743-7075-7-47
    • (2010) Nutr. Metab. (Lond.) , vol.7 , pp. 47
    • Hu, J.1    Zhang, Z.2    Shen, W.J.3    Azhar, S.4
  • 34
    • 0028104418 scopus 로고
    • The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR)
    • B.J. Clark, J. Wells, S.R. King, and D.M. Stocco The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR) J. Biol. Chem. 269 1994 28314 28322
    • (1994) J. Biol. Chem. , vol.269 , pp. 28314-28322
    • Clark, B.J.1    Wells, J.2    King, S.R.3    Stocco, D.M.4
  • 35
    • 84921929741 scopus 로고    scopus 로고
    • Mitochondria associated ER-Membrane (MAM) regulates steroidogenic activity via StAR-VDAC2 interaction
    • M. Prasad, J. Kaur, K.J. Pawlak, M. Bose, R.M. Whittal, and H.S. Bose Mitochondria associated ER-Membrane (MAM) regulates steroidogenic activity via StAR-VDAC2 interaction J. Biol. Chem. 290 2014 2604 2616 10.1074/jbc.M114.605808
    • (2014) J. Biol. Chem. , vol.290 , pp. 2604-2616
    • Prasad, M.1    Kaur, J.2    Pawlak, K.J.3    Bose, M.4    Whittal, R.M.5    Bose, H.S.6
  • 36
    • 67349280293 scopus 로고    scopus 로고
    • Lipid droplet-organelle interactions; sharing the fats
    • S. Murphy, S. Martin, and R.G. Parton Lipid droplet-organelle interactions; sharing the fats Biochim. Biophys. Acta 1791 2009 441 447 10.1016/j.bbalip.2008.07.004
    • (2009) Biochim. Biophys. Acta , vol.1791 , pp. 441-447
    • Murphy, S.1    Martin, S.2    Parton, R.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.