메뉴 건너뛰기




Volumn 16, Issue 12, 2016, Pages 1283-1290

The potential use of urine cell free DNA as a marker for cancer

Author keywords

cancer; cell free DNA; liquid biopsy; markers; Urine

Indexed keywords

BIOPSY; CANCER DIAGNOSIS; CELL CULTURE MONITORING; GENETIC MARKER; HUMAN; HUMAN TISSUE; MEDLINE; PROGNOSIS; SYSTEMATIC REVIEW; URINE; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; GENETICS; HIGH THROUGHPUT SEQUENCING; MICROSATELLITE INSTABILITY; NEOPLASMS; UROLOGIC NEOPLASMS;

EID: 84996938017     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1080/14737159.2016.1254551     Document Type: Review
Times cited : (34)

References (50)
  • 1
    • 84896371874 scopus 로고    scopus 로고
    • Detection of circulating tumor DNA in early- and late-stage human malignancies
    • Bettegowda C, Sausen M, Leary RJ, et al. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med. 2014;6(224):224–24.
    • (2014) Sci Transl Med , vol.6 , Issue.224 , pp. 224
    • Bettegowda, C.1    Sausen, M.2    Leary, R.J.3
  • 2
    • 84862862840 scopus 로고    scopus 로고
    • Urinary biomarkers of non-muscle-invasive bladder cancer: current status and future potential
    • Calistri D, Casadio V, Bravaccini S, et al. Urinary biomarkers of non-muscle-invasive bladder cancer:current status and future potential. Expert Rev Anticancer Ther. 2012;12(6):743–752.
    • (2012) Expert Rev Anticancer Ther , vol.12 , Issue.6 , pp. 743-752
    • Calistri, D.1    Casadio, V.2    Bravaccini, S.3
  • 3
    • 0033870263 scopus 로고    scopus 로고
    • Genetic analysis of DNA excreted in urine: a new approach for detecting specific genomic DNA sequences from cells dying in an organism
    • Botezatu I, Serdyuk O, Potapova G, et al. Genetic analysis of DNA excreted in urine:a new approach for detecting specific genomic DNA sequences from cells dying in an organism. Clin Chem. 2000;46(8 Pt 1):1078–1084.• Pioneer study that deeply investigated the basis of PCR approaches for the study of transrenal DNA.
    • (2000) Clin Chem , vol.46 , Issue.8 , pp. 1078-1084
    • Botezatu, I.1    Serdyuk, O.2    Potapova, G.3
  • 4
    • 0031939927 scopus 로고    scopus 로고
    • Size-selectivity of the glomerular barrier to high molecular weight proteins: upper size limitations of shunt pathways
    • Tencer J, Frick I-M, Öquist BW, et al. Size-selectivity of the glomerular barrier to high molecular weight proteins:upper size limitations of shunt pathways. Kidney Int. 1998;53(3):709–715.
    • (1998) Kidney Int , vol.53 , Issue.3 , pp. 709-715
    • Tencer, J.1    Frick, I.-M.2    Öquist, B.W.3
  • 5
    • 2342642789 scopus 로고    scopus 로고
    • Human urine contains small, 150 to 250 nucleotide-sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer
    • Su Y-H, Wang M, Brenner DE, et al. Human urine contains small, 150 to 250 nucleotide-sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer. J Mol Diagn. 2004;6(2):101–107.• Interesting characterization of transrenal DNA fragmentation and its application for diagnosis of colorectal cancer.
    • (2004) J Mol Diagn , vol.6 , Issue.2 , pp. 101-107
    • Su, Y.-H.1    Wang, M.2    Brenner, D.E.3
  • 6
    • 84944572106 scopus 로고    scopus 로고
    • Extracellular nucleic acids in urine: sources, structure, diagnostic potential
    • Bryzgunova OE, Laktionov PP., Extracellular nucleic acids in urine:sources, structure, diagnostic potential. Acta Naturae. 2015;7(3):48–54.
    • (2015) Acta Naturae , vol.7 , Issue.3 , pp. 48-54
    • Bryzgunova, O.E.1    Laktionov, P.P.2
  • 7
    • 52249107130 scopus 로고    scopus 로고
    • Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps
    • Su Y-H, Wang M, Brenner DE, et al. Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps. Ann N Y Acad Sci. 2008;1137:197–206.
    • (2008) Ann N Y Acad Sci , vol.1137 , pp. 197-206
    • Su, Y.-H.1    Wang, M.2    Brenner, D.E.3
  • 8
    • 70449345868 scopus 로고    scopus 로고
    • Evaluation of cell-free DNA in urine as a marker for bladder cancer diagnosis
    • Zancan M, Galdi F, Di Tonno F, et al. Evaluation of cell-free DNA in urine as a marker for bladder cancer diagnosis. Int J Biol Markers. 2009;24(3):147–155.
    • (2009) Int J Biol Markers , vol.24 , Issue.3 , pp. 147-155
    • Zancan, M.1    Galdi, F.2    Di Tonno, F.3
  • 9
    • 39149118369 scopus 로고    scopus 로고
    • Urinary cell-free DNA as a potential tumor marker for bladder cancer
    • Chang HW, Tsui KH, Shen LC, et al. Urinary cell-free DNA as a potential tumor marker for bladder cancer. Int J Biol Markers. 2007;22(4):287–294.
    • (2007) Int J Biol Markers , vol.22 , Issue.4 , pp. 287-294
    • Chang, H.W.1    Tsui, K.H.2    Shen, L.C.3
  • 10
    • 84886249189 scopus 로고    scopus 로고
    • Urine cell-free DNA integrity as a marker for early prostate cancer diagnosis: A pilot study
    • Casadio V, Calistri D, Salvi S, et al. Urine cell-free DNA integrity as a marker for early prostate cancer diagnosis:A pilot study. Biomed Res Int. 2013;08:1744–1750.
    • (2013) Biomed Res Int , vol.8 , pp. 1744-1750
    • Casadio, V.1    Calistri, D.2    Salvi, S.3
  • 11
    • 84978062670 scopus 로고    scopus 로고
    • Copy number variations in urine cell free DNA as biomarkers in advanced prostate cancer
    • Xia Y, Huang -C-C, Dittmar R, et al. Copy number variations in urine cell free DNA as biomarkers in advanced prostate cancer. Oncotarget. 2016;7(24):35818–35831.•• First study that evaluated CNV in UcfDNA using NGS techniques.
    • (2016) Oncotarget , vol.7 , Issue.24 , pp. 35818-35831
    • Xia, Y.1    Huang, C.-C.2    Dittmar, R.3
  • 12
    • 84955259942 scopus 로고    scopus 로고
    • Genomic alterations in liquid biopsies from patients with bladder cancer
    • Birkenkamp-Demtröder K, Nordentoft I, Christensen E, et al. Genomic alterations in liquid biopsies from patients with bladder cancer. Eur Urol. 2016;70:75–82.•• Study showing the capacity of UcfDNA to anticipate the clinical evidence of disease progression.
    • (2016) Eur Urol , vol.70 , pp. 75-82
    • Birkenkamp-Demtröder, K.1    Nordentoft, I.2    Christensen, E.3
  • 13
    • 84996754769 scopus 로고    scopus 로고
    • Genomic complexity of urothelial bladder cancer revealed in urinary cfDNA
    • Togneri FS, Ward DG, Foster JM, et al. Genomic complexity of urothelial bladder cancer revealed in urinary cfDNA. Nat Publ Gr. 2016;1–8.•• Study showing that UcfDNA is more informative of bladder cancer mutation status than circulating cfDNA.
    • (2016) Nat Publ Gr , pp. 1-8
    • Togneri, F.S.1    Ward, D.G.2    Foster, J.M.3
  • 15
    • 34548535845 scopus 로고    scopus 로고
    • Deletion analysis of tumor and urinary DNA to detect bladder cancer: urine supernatant versus urine sediment
    • Szarvas T, Kovalszky I, Bedi K, et al. Deletion analysis of tumor and urinary DNA to detect bladder cancer:urine supernatant versus urine sediment. Oncol Rep. 2007;18(2):405–409.
    • (2007) Oncol Rep , vol.18 , Issue.2 , pp. 405-409
    • Szarvas, T.1    Kovalszky, I.2    Bedi, K.3
  • 16
    • 52249118141 scopus 로고    scopus 로고
    • Methylation-specific sequencing of GSTP1 gene promoter in circulating/extracellular DNA from blood and urine of healthy donors and prostate cancer patients
    • Bryzgunova OE, Morozkin ES, Yarmoschuk SV, et al. Methylation-specific sequencing of GSTP1 gene promoter in circulating/extracellular DNA from blood and urine of healthy donors and prostate cancer patients. Ann N Y Acad Sci. 2008;1137:222–225.• UcfDNA and plasma cfDNA for the study of GSTP1 promoter methylation in prostate cancer patients.
    • (2008) Ann N Y Acad Sci , vol.1137 , pp. 222-225
    • Bryzgunova, O.E.1    Morozkin, E.S.2    Yarmoschuk, S.V.3
  • 17
    • 84863115484 scopus 로고    scopus 로고
    • Detection of hypermethylated vimentin in urine of patients with colorectal cancer
    • Song BP, Jain S, Lin SY, et al. Detection of hypermethylated vimentin in urine of patients with colorectal cancer. J Mol Diagn. 2012;14(2):112–119.
    • (2012) J Mol Diagn , vol.14 , Issue.2 , pp. 112-119
    • Song, B.P.1    Jain, S.2    Lin, S.Y.3
  • 18
    • 82755191709 scopus 로고    scopus 로고
    • A locked nucleic acid clamp-mediated PCR assay for detection of a p53 codon 249 hotspot mutation in urine
    • Lin SY, Dhillon V, Jain S, et al. A locked nucleic acid clamp-mediated PCR assay for detection of a p53 codon 249 hotspot mutation in urine. J Mol Diagn. 2011;13(5):474–484.
    • (2011) J Mol Diagn , vol.13 , Issue.5 , pp. 474-484
    • Lin, S.Y.1    Dhillon, V.2    Jain, S.3
  • 19
    • 84991067919 scopus 로고    scopus 로고
    • A highly sensitive and quantitative test platform for detection of NSCLC EGFR mutations in urine and plasma
    • S1556-0864(16)30587-1
    • Reckamp KL, Melnikova VO, Karlovich C, et al. A highly sensitive and quantitative test platform for detection of NSCLC EGFR mutations in urine and plasma. J Thorac Oncol. 2016;11(10):S1556-0864(16)30587-1.•• Interesting comparison of UcfDNA and plasma cfDNA for the detection of EGFR mutation in NSCLC patients using NGS approach.
    • (2016) J Thorac Oncol
    • Reckamp, K.L.1    Melnikova, V.O.2    Karlovich, C.3
  • 20
    • 85012101195 scopus 로고    scopus 로고
    • Urinary circulating DNA detection for dynamic tracking of EGFR mutations for NSCLC patients treated with EGFR-TKIs
    • [Epub ahead of print]
    • Chen S, Zhao J, Cui L, et al. Urinary circulating DNA detection for dynamic tracking of EGFR mutations for NSCLC patients treated with EGFR-TKIs. Clin Transl Oncol. Forthcoming 2016. [Epub ahead of print].•• Comparison of UcfDNA and plasma cfDNA for the detection of EGFR mutation in NSCLC patients using droplet dPCR.
    • (2016) Clin Transl Oncol
    • Chen, S.1    Zhao, J.2    Cui, L.3
  • 21
    • 52249114928 scopus 로고    scopus 로고
    • Removal of high-molecular-weight DNA by carboxylated magnetic beads enhances the detection of mutated K-ras DNA in urine
    • Su Y-H, Song J, Wang Z, et al. Removal of high-molecular-weight DNA by carboxylated magnetic beads enhances the detection of mutated K-ras DNA in urine. Ann N Y Acad Sci. 2008;1137:82–91.
    • (2008) Ann N Y Acad Sci , vol.1137 , pp. 82-91
    • Su, Y.-H.1    Song, J.2    Wang, Z.3
  • 22
    • 84886249189 scopus 로고    scopus 로고
    • Urine cell-free DNA integrity as a marker for early bladder cancer diagnosis: preliminary data
    • Casadio V, Calistri D, Tebaldi M, et al. Urine cell-free DNA integrity as a marker for early bladder cancer diagnosis:preliminary data. Urol Oncol. 2013;31(8):1744–1750.• Innovative UcfDNA approach for the diagnosis of bladder cancer.
    • (2013) Urol Oncol , vol.31 , Issue.8 , pp. 1744-1750
    • Casadio, V.1    Calistri, D.2    Tebaldi, M.3
  • 23
    • 84941039754 scopus 로고    scopus 로고
    • Urine cell-free DNA integrity analysis for early detection of prostate cancer patients
    • Salvi S, Gurioli G, Martignano F, et al. Urine cell-free DNA integrity analysis for early detection of prostate cancer patients. Dis Markers. 2015;574120.• Innovative UcfDNA approach for the diagnosis of prostate cancer.
    • (2015) Dis Markers , pp. 574120
    • Salvi, S.1    Gurioli, G.2    Martignano, F.3
  • 24
    • 84868272966 scopus 로고    scopus 로고
    • High resolution size analysis of fetal DNA in the urine of pregnant women by paired-end massively parallel sequencing
    • Tsui NBY, Jiang P, Chow KCK, et al. High resolution size analysis of fetal DNA in the urine of pregnant women by paired-end massively parallel sequencing. PLoS One. 2012;7(10):e48319.
    • (2012) PLoS One , vol.7 , Issue.10 , pp. e48319
    • Tsui, N.B.Y.1    Jiang, P.2    Chow, K.C.K.3
  • 25
    • 52249088665 scopus 로고    scopus 로고
    • Transrenal nucleic acids: from proof of principle to clinical tests
    • Melkonyan HS, Feaver WJ, Meyer E, et al. Transrenal nucleic acids:from proof of principle to clinical tests. Ann N Y Acad Sci. 2008;1137:73–81.
    • (2008) Ann N Y Acad Sci , vol.1137 , pp. 73-81
    • Melkonyan, H.S.1    Feaver, W.J.2    Meyer, E.3
  • 26
    • 84938685598 scopus 로고    scopus 로고
    • Unreserved application of epigenetic methods to define differences of DNA methylation between urinary cellular and cell-free DNA
    • Ghanjati F, Beermann A, Hermanns T, et al. Unreserved application of epigenetic methods to define differences of DNA methylation between urinary cellular and cell-free DNA. Cancer Biomark. 2014;14(5):295–302.
    • (2014) Cancer Biomark , vol.14 , Issue.5 , pp. 295-302
    • Ghanjati, F.1    Beermann, A.2    Hermanns, T.3
  • 27
    • 63649129973 scopus 로고    scopus 로고
    • Elevated transrenal DNA (cell-free urine DNA) in patients with urinary tract infection compared to healthy controls
    • García Moreira V, Prieto García B, De La Cera Martínez T, et al. Elevated transrenal DNA (cell-free urine DNA) in patients with urinary tract infection compared to healthy controls. Clin Biochem. 2009;42(7–8):729–731.
    • (2009) Clin Biochem , vol.42 , Issue.7-8 , pp. 729-731
    • García Moreira, V.1    Prieto García, B.2    De La Cera Martínez, T.3
  • 28
    • 84989842529 scopus 로고    scopus 로고
    • Evaluation and comparison of in vitro degradation kinetics of DNA in serum, urine and saliva: a qualitative study
    • Yao W, Mei C, Nan X, et al. Evaluation and comparison of in vitro degradation kinetics of DNA in serum, urine and saliva:a qualitative study. Gene. 2016;590(1):142–148.
    • (2016) Gene , vol.590 , Issue.1 , pp. 142-148
    • Yao, W.1    Mei, C.2    Nan, X.3
  • 29
    • 84961262634 scopus 로고    scopus 로고
    • Urinary biomarkers indicative of apoptosis and acute kidney injury in the critically ill
    • Vaara ST, Lakkisto P, Immonen K, et al. Urinary biomarkers indicative of apoptosis and acute kidney injury in the critically ill. PLoS One. 2016;11(2):1–13.
    • (2016) PLoS One , vol.11 , Issue.2 , pp. 1-13
    • Vaara, S.T.1    Lakkisto, P.2    Immonen, K.3
  • 30
    • 22944444184 scopus 로고    scopus 로고
    • Free DNA in urine: a new marker for bladder cancer? Preliminary data
    • Zancan M, Franceschini R, Mimmo C, et al. Free DNA in urine:a new marker for bladder cancer? Preliminary data. Int J Biol Markers. 2005;20(2):134–136.
    • (2005) Int J Biol Markers , vol.20 , Issue.2 , pp. 134-136
    • Zancan, M.1    Franceschini, R.2    Mimmo, C.3
  • 31
    • 84922372527 scopus 로고    scopus 로고
    • Prospective blinded study of BRAFV600E mutation detection in cell-free DNA of patients with systemic histiocytic disorders
    • Hyman DM, Diamond EL, Vibat CRT, et al. Prospective blinded study of BRAFV600E mutation detection in cell-free DNA of patients with systemic histiocytic disorders. Cancer Discov. 2015;5(1):64–71.• Study that underlies the potential of UcfDNA for the detection of BRAFV600E mutation in nonurological diseases.
    • (2015) Cancer Discov , vol.5 , Issue.1 , pp. 64-71
    • Hyman, D.M.1    Diamond, E.L.2    Vibat, C.R.T.3
  • 32
    • 33646847495 scopus 로고    scopus 로고
    • Cell-free and cell-bound circulating DNA in breast tumours: DNA quantification and analysis of tumour-related gene methylation
    • Skvortsova TE, Rykova EY, Tamkovich SN, et al. Cell-free and cell-bound circulating DNA in breast tumours:DNA quantification and analysis of tumour-related gene methylation. Br J Cancer. 2006;94(10):1492–1495.
    • (2006) Br J Cancer , vol.94 , Issue.10 , pp. 1492-1495
    • Skvortsova, T.E.1    Rykova, E.Y.2    Tamkovich, S.N.3
  • 33
    • 84908672066 scopus 로고    scopus 로고
    • Circulating cell-free DNA in serum as a biomarker for diagnosis and prognostic prediction of colorectal cancer
    • Hao TB, Shi W, Shen XJ, et al. Circulating cell-free DNA in serum as a biomarker for diagnosis and prognostic prediction of colorectal cancer. Br J Cancer. 2014;111(8):1482–1489.
    • (2014) Br J Cancer , vol.111 , Issue.8 , pp. 1482-1489
    • Hao, T.B.1    Shi, W.2    Shen, X.J.3
  • 34
    • 84952719744 scopus 로고    scopus 로고
    • Assessment of DNA integrity, applications for cancer research
    • Zonta E, Nizard P, Taly V. Assessment of DNA integrity, applications for cancer research. Adv Clin Chem. 2015;70:197–246.
    • (2015) Adv Clin Chem , vol.70 , pp. 197-246
    • Zonta, E.1    Nizard, P.2    Taly, V.3
  • 35
    • 84940095522 scopus 로고    scopus 로고
    • Serial next-generation sequencing of circulating cell-free dna evaluating tumor clone response to molecularly targeted drug administration
    • Frenel JS, Carreira S, Goodall J, et al. Serial next-generation sequencing of circulating cell-free dna evaluating tumor clone response to molecularly targeted drug administration. Clin Cancer Res. 2015;21(20):4586–4596.
    • (2015) Clin Cancer Res , vol.21 , Issue.20 , pp. 4586-4596
    • Frenel, J.S.1    Carreira, S.2    Goodall, J.3
  • 36
    • 84978134356 scopus 로고    scopus 로고
    • Circulating AR copy number and outcome to enzalutamide in docetaxel-treated metastatic castration-resistant prostate cancer
    • 7(25):37839–37845
    • Salvi S, Casadio V, Conteduca V, et al. Circulating AR copy number and outcome to enzalutamide in docetaxel-treated metastatic castration-resistant prostate cancer. Oncotarget. 2016;7(25):37839–37845.
    • (2016) Oncotarget
    • Salvi, S.1    Casadio, V.2    Conteduca, V.3
  • 37
    • 84898542288 scopus 로고    scopus 로고
    • Liquid biopsies: genotyping circulating tumor DNA
    • Diaz LA, Bardelli A. Liquid biopsies:genotyping circulating tumor DNA. J Clin Oncol. 2014;32(6):579–586.
    • (2014) J Clin Oncol , vol.32 , Issue.6 , pp. 579-586
    • Diaz, L.A.1    Bardelli, A.2
  • 41
    • 84996724916 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) genotyping of matched urine, plasma and tumor tissue from non-small cell lung cancer (NSCLC) patients (pts) treated with rociletinib
    • Wakelee HA, Gadgeel SM, Wade Goldman J, et al. Epidermal growth factor receptor (EGFR) genotyping of matched urine, plasma and tumor tissue from non-small cell lung cancer (NSCLC) patients (pts) treated with rociletinib. J Clin Oncol. 2016;34:9001.•• Innovative characterization with NGS techniques of UcfDNA in NSCLC.
    • (2016) J Clin Oncol , vol.34 , pp. 9001
    • Wakelee, H.A.1    Gadgeel, S.M.2    Wade Goldman, J.3
  • 42
  • 43
    • 84886257639 scopus 로고    scopus 로고
    • Cancer development, progression, and therapy: an epigenetic overview
    • Sarkar S, Horn G, Moulton K, et al. Cancer development, progression, and therapy:an epigenetic overview. Int J Mol Sci. 2013;14(10):21087–21113.
    • (2013) Int J Mol Sci , vol.14 , Issue.10 , pp. 21087-21113
    • Sarkar, S.1    Horn, G.2    Moulton, K.3
  • 44
    • 84925680102 scopus 로고    scopus 로고
    • Epigenetic biomarkers in the blood of patients with urological malignancies
    • Ellinger J, Müller SC, Dietrich D. Epigenetic biomarkers in the blood of patients with urological malignancies. Expert Rev Mol Diagn. 2015;15(4):505–516.
    • (2015) Expert Rev Mol Diagn , vol.15 , Issue.4 , pp. 505-516
    • Ellinger, J.1    Müller, S.C.2    Dietrich, D.3
  • 45
    • 5144220196 scopus 로고    scopus 로고
    • Molecular detection of prostate cancer: a role for GSTP1 hypermethylation
    • Henrique R, Jerónimo C. Molecular detection of prostate cancer:a role for GSTP1 hypermethylation. Eur Urol. 2004;46(5):660–669.
    • (2004) Eur Urol , vol.46 , Issue.5 , pp. 660-669
    • Henrique, R.1    Jerónimo, C.2
  • 46
    • 84951000985 scopus 로고    scopus 로고
    • Cell-free Epstein–Barr virus-DNA in patients with nasopharyngeal carcinoma: plasma versus urine
    • Sengar M, Chorghe S, Jadhav K, et al. Cell-free Epstein–Barr virus-DNA in patients with nasopharyngeal carcinoma:plasma versus urine. Head Neck. 2016;38:E1666–E1673.
    • (2016) Head Neck , vol.38 , pp. E1666-E1673
    • Sengar, M.1    Chorghe, S.2    Jadhav, K.3
  • 47
    • 85008415004 scopus 로고    scopus 로고
    • Molecular triage of premalignant lesions in liquid-based cervical cytology and circulating cell free DNA from urine, using methylated viral and host genes
    • [Epub ahead of print]
    • Guerrero-Preston R, Valle BL, Jedlicka A, et al. Molecular triage of premalignant lesions in liquid-based cervical cytology and circulating cell free DNA from urine, using methylated viral and host genes. Cancer Prev Res. Forthcoming 2016. [Epub ahead of print].
    • (2016) Cancer Prev Res
    • Guerrero-Preston, R.1    Valle, B.L.2    Jedlicka, A.3
  • 48
    • 84920508228 scopus 로고    scopus 로고
    • Circulating tumor DNA as a liquid biopsy for cancer
    • Heitzer E, Ulz P, Geigl JB. Circulating tumor DNA as a liquid biopsy for cancer. Clin Chem. 2015;61(1):112–123.
    • (2015) Clin Chem , vol.61 , Issue.1 , pp. 112-123
    • Heitzer, E.1    Ulz, P.2    Geigl, J.B.3
  • 49
    • 84903512238 scopus 로고    scopus 로고
    • BRAF V600E mutations in urine and plasma cell-free DNA from patients with Erdheim-Chester disease
    • Janku F, Rose C, Vibat T, et al. BRAF V600E mutations in urine and plasma cell-free DNA from patients with Erdheim-Chester disease. Oncotarget. 2014;5(11):3607–3610.
    • (2014) Oncotarget , vol.5 , Issue.11 , pp. 3607-3610
    • Janku, F.1    Rose, C.2    Vibat, T.3
  • 50
    • 84929190486 scopus 로고    scopus 로고
    • Urine TMPRSS2: ERGPlus PCA3 for individualized prostate cancer risk assessment
    • Tomlins SA, Day JR, Lonigro RJ, et al. Urine TMPRSS2:ERGPlus PCA3 for individualized prostate cancer risk assessment. Eur Urol. 2016;70(1):45–53.
    • (2016) Eur Urol , vol.70 , Issue.1 , pp. 45-53
    • Tomlins, S.A.1    Day, J.R.2    Lonigro, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.