Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps

Annals of the New York Academy of Sciences

Volumn 1137, Issue , 2008, Pages 197-206

  Su, Ying Hsiu ^a   Wang, Mengjun ^a   Brenner, Dean E ^b   Norton, Pamela A ^a   Block, Timothy M ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Cancer biomarkers; Cancer detection; Circulating DNA; K ras mutations; Urine DNA

Indexed keywords

ADENOMATOUS POLYP; ADULT; AGED; BLOOD LEVEL; BODY FLUID; CANCER PATIENT; CLINICAL ARTICLE; COLORECTAL CARCINOMA; CONFERENCE PAPER; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; DIAGNOSTIC VALUE; DNA DETERMINATION; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; INCIDENCE; MALE; ONCOGENE K RAS; URINE LEVEL;

EID: 52249107130     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1448.027     Document Type: Conference Paper

References (43)

1. Utting, M. et al. 2002. Microsatellite analysis of free tumor DNA in urine, serum, and plasma of patients: a minimally invasive method for the detection of bladder cancer. Clin. Cancer Res. 8 : 35 40.
2. Hoque, M.O. et al. 2003. High-throughput molecular analysis of urine sediment for the detection of bladder cancer by high-density single-nucleotide polymorphism array. Cancer Res. 63 : 5723 5726.
3. Cairns, P. 2004. Detection of promoter hypermethylation of tumor suppressor genes in urine from kidney cancer patients. Ann. N.Y. Acad. Sci. 1022 : 40 43.
4. Dulaimi, E. et al. 2004. Promoter hypermethylation profile of kidney cancer. Clin. Cancer Res. 10 : 3972 3979.
5. Dulaimi, E. et al. 2004. Detection of bladder cancer in urine by a tumor suppressor gene hypermethylation panel. Clin. Cancer Res. 10 : 1887 1893.
6. Cairns, P. et al. 2001. Molecular detection of prostate cancer in urine by GSTP1 hypermethylation. Clin. Cancer Res. 7 : 2727 2730.
7. Papadopoulou, E. et al. 2004. Cell-free DNA and RNA in plasma as a new molecular marker for prostate cancer. Oncol. Res. 14 : 439 445.
8. Su, Y.H. et al. 2004. Human urine contains small, 150 to 250 nucleotide-sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer. J. Mol. Diagn. 6 : 101 107.
9. Botezatu, I. et al. 2000. Genetic analysis of DNA excreted in urine: a new approach for detecting specific genomic DNA sequences from cells dying in an organism. Clin. Chem. 46 : 1078 1084.
10. Serdyuk, O.I. et al. 2001. Detection of mutant k-ras sequences in the urine of cancer patients. Bull. Exp. Biol. Med. 131 : 283 284.
11. Taback, B. & Hoon, D.S.B. 2004. Circulating nucleic acids and proteomics of plasma/serum: clinical utility. Ann. N.Y. Acad. Sci. 1022 : 1 8.
12. Chan, A.K.C. et al. 2003. Cell-free nucleic acids in plasma, serum and urine: a new tool in molecular diagnosis. Ann. Clin. Biochem. 40 : 122 130.
13. Lo, Y.M. et al. 1997. Presence of fetal DNA in maternal plasma and serum. Lancet 350 : 485 487.
14. Nawroz, H. et al. 1996. Microsatellite alterations in serum DNA of head and neck cancer patients. Nat. Med. 2 : 1035 1037.
15. Chen, X.Q. et al. 1996. Microsatellite alterations in plasma DNA of small cell lung cancer patients. Nat. Med. 2 : 1033 1035.
16. Goessl, C. et al. 1998. Microsatellite analysis of plasma DNA from patients with clear renal carcinoma. Cancer Res. 58 : 4728 4732.
17. Wong, I.H.N. et al. 1999. Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients. Cancer Res. 59 : 71 73.
18. Esteller, M. et al. 1999. Detection of abbertant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res. 59 : 67 70.
19. Pathak, A.K. et al. 2006. Circulating cell-free DNA in plasma/serum of lung cancer patients as a potential screening and prognostic tool. Clin. Chem. 52 : 1833 1842.
20. Shapiro, B. et al. 1983. Determination of circulating DNA Levels in patients with benign of malignant gastrointestinal disease. Cancer 51 : 2116 2120.
21. Maltzman, T. et al. 2001. Ki-ras proto-oncogene mutations in sporadic colorectal adenomas: relationship to histologic and clinical characteristics. Gastroenterology 121 : 302 309.
22. Ahlquist D.A. et al. 2000. Colorectal cancer screening by detection of altered human DNA in stool: feasibility of a multitarget assay panel. Gastroenterology 119 : 1219 1227.
23. Rashid, A. et al. 2002. K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China. Clin. Cancer Res. 8 : 3156 3163.
24. Vogelstein, B. et al. 1998. Genetic alterations during colorectal-tumor development. New Engl. J. Med. 319 : 525 532.
25. Andersen, S. et al. 1999. Villous, hypermucinous mucosa in long standing ulcerative colitis shows high frequency of K-ras mutations. Gut 45 : 686 692.
26. Otori, K. et al. 1997. High frequency of K-ras mutations in human colorectal hyperplastic polyps. Gut 40 : 660 663.
27. Takayama, T. et al. 2001. Analysis of K-ras, APC, and B-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis. Gastroenterology 121 : 599 611.
28. Przybojewska, B. et al. 2000. H-RAS, K-RAS, and N-RAS gene activation in human bladder cancers. Cancer Genet. Cytogenet. 121 : 73 77.
29. Su, Y.H. et al. 2004. Transrenal DNA as a diagnostic tool: important technical notes. Ann. N.Y. Acad. Sci. 1022 : 81 89.
30. Wang, M. et al. 2004. Preferential isolation of fragmented DNA enhances the detection of circulating mutated k-ras DNA. Clin. Chem. 50 : 211 213.
31. Chan, K.C.A. et al. 2003. Molecular characterization of circulating EBV DNA in the plasma of nasopharyngeal carcinoma and lymphoma patients. Cancer Res. 63 : 2028 2032.
32. Taback, B. et al. 2004. Quantification of circulating DNA in the plasma and serum of cancer patients. Ann. N.Y. Acad. Sci. 1022 : 17 24.
33. Jorg, H.H. et al. 2004. Patterns of circulating hepatitis B virus serum nucleic acids during lamivudine therapy. Ann. N.Y. Acad. Sci. 1022 : 271 281.
34. Koffler, D. et al. 2006. The occurrence of single-stranded DNA in the serum of patients with systemic lupus erythematosus and other diseases. J. Clin. Invest. 52 : 198 204.
35. Leon, S.A. et al. 1997. Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res. 37 : 646 650.
36. Steinman, C.R. 1982. Circulating DNA in polyarteritis nodosa and related syndromes. Arthritis Rheum. 25 : 1425 1430.
37. Steinman, C.R. 1984. Circulating DNA in systemic lupus erthematosus. J. Clin. Invest. 73 : 832 841.
38. Neurath, A.R. et al. 1994. Strategies for detection of transfusion-transmitted viruses eluding identification by conventional serologic tests II. Detection of host DNA in human plasmas with elevated alanine aminotransferase. J. Virol. Methods 8 : 73 86.
39. Jahr, S. et al. 2001. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res. 61 : 1659 1665.
40. Anker, P. et al. 1999. Detection of circulating tumor DNA in the blood (plasma/serum) of cancer patients. Cancer Metast. Rev. 18 : 65 73.
41. Arai, N. et al. 1999. Enhanced epithelial cell turnover associated with p53 accumulation and high p21WAF1/CIP1 expression in ulcerative colitis. Modern Pathol. 12 : 604 611.
42. Nakamura, T. et al. 1995. Cell death in colorectal polyps as evaluated by in situ 3′-tailinig reaction and its relationship to BCL-2 expression. Pathol. Int. 45 : 721 728.
43. Schulte-Hermann, R. et al. 1995. Role of active cell death (apoptosis) in multi-stage carcinogenesis. Toxicol. Lett. 82/83 : 143 148.