Kynurenic acid and alcohol and cocaine dependence: novel effects and multiple mechanisms?

Psychopharmacology

Volumn 234, Issue 1, 2017, Pages 169-171

  Badawy, Abdulla A B ^a  

^a CARDIFF METROPOLITAN UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYKYNURENINE; 3,4 DIMETHOXY N [4 (3 NITROPHENYL) THIAZOL 2 YL] BENZENE SULPHONAMIDE; ALDEHYDE DEHYDROGENASE; BUNGAROTOXIN RECEPTOR; DISULFIRAM; DOPAMINE BETA MONOOXYGENASE; DRUGS USED IN THE TREATMENT OF ADDICTION; GLUTAMIC ACID; KYNURENIC ACID; KYNURENINE 3 MONOOXYGENASE; KYNURENINE AMINOTRANSFERASE; N METHYL DEXTRO ASPARTIC ACID; QUINOLINIC ACID; UNCLASSIFIED DRUG; ALCOHOL; COCAINE;

ALCOHOLISM; AMINO ACID METABOLISM; BRAIN LEVEL; BRAIN REGION; COCAINE DEPENDENCE; CONCENTRATION RESPONSE; DRUG SEEKING BEHAVIOR; ENZYME METABOLISM; LETTER; LIVER HOMOGENATE; NONHUMAN; PRIORITY JOURNAL; RECURRENCE RISK; REWARD; HUMAN;

ALCOHOLISM; COCAINE; COCAINE-RELATED DISORDERS; ETHANOL; HUMANS; KYNURENIC ACID;

EID: 84996931649     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-016-4486-4     Document Type: Letter

References (19)

1. Badawy AA-B, Bano S (2016) Elevation of kynurenine metabolites in rat liver and serum: a potential additional mechanism of the alcohol aversive and anti-cancer effects of disulfiram? Alcohol Alcohol 51:20–26
2. m aldehyde dehydrogenase activity, elevate blood acetaldehyde concentration and induce aversion to alcohol. Alcohol Alcohol 46:651–660
3. Badawy AA-B, Dougherty DM (2016) Assessment of the human kynurenine pathway: comparisons and clinical implications of ethnic and gender differences in plasma tryptophan, kynurenine metabolites and enzyme expressions at baseline and after acute tryptophan loading and depletion. Int J Tryptophan Res 9:31–49
4. Badawy AA-B, Morgan CJ (2007) Tryptophan metabolites as potent inhibitors of aldehyde dehydrogenase activity and potential alcoholism-aversion therapeutic agents. Int Cong Series 1304:344–351
5. Carpenedo R, Chiarugi A, Russi P, Lombardi G, Carla V, Pellicciari R, Mattoli L, Moroni F (1994) Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities. Neuroscience 61:237–244
6. Chiarugi A, Carpenedo R, Molina MT, Mattoli L, Pellicciari R, Moroni F (1995) Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and kynureninase. J Neurochem 65:1176–1183
7. Clark CJ, Mackay GM, Smythe GA, Bustamante S, Stone TW, Phillips RS (2005) Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition. Infect Immunity 73:5249–5251
8. Garver E, Ross AD, Tu G-C, Cao QN, Zhou F, Israel Y (2000) Paradigm to test drug-induced aversion to ethanol. Alcohol Alcohol 35:435–438
9. Justinova Z, Mascia P, Wu H-Q, Secci ME, Redhi GH, Panlilio LV, Scherma M, Barnes C, Parashos A, Zara T, Fratta W, Solinas M, Pistis M, Bergman J, Kangas BD, Ferré S, Tanda G, Schwarcz R, Goldberg SR (2013) Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid. Nature Neurosci 16:1652–1661
10. Kita T, Morrison PF, Heyes MP, Markey SP (2002) Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain. J Neurochem 82:258–268
11. Murakami Y, Saito K (2013) Species and cell types difference in tryptophan metabolism. Int J Tryptophan Res 6(Suppl 1):47–54
12. Okuno A, Fukuwatari T, Shibata K (2011) High tryptophan diet reduced extracellular dopamine release via kynurenic acid production in rat striatum. J Neurochem 118:796–805
13. Pawlak D, Tankiewicz A, Matys T, Buczko W (2003) Peripheral distribution of kynurenine metabolites and activity of kynurenine pathway enzymes in renal failure. J Physiol Pharmacol (Krakow) 54:175–189
14. Röver S, Cesura A, Huguenin P, Ketter R, Szente A (1997) Synthesis and biochemical evaluation of N-(4phenylthiazol-2-yl) benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem 40:4378–4385
15. Saito K, Fujigaki S, Heyes MP, Shibata K, Takemura M, Fujii H, Wada H, Noma A, Seishima M (2000) Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency. Am J Physiol Renal Physiol 279:F565–F572
16. Schroeder JP, Cooper DA, Schank JR, Lyle MA, Gaval-Cruz M, Ogbonmwan YE, Pozdeyev N, Freeman IPM, Edwards GL, Holmes PV, Weinshenker D (2010) Disulfiram attenuates drug-primed reinstatement of cocaine seeking via inhibition of dopamine b-hydroxylase. Neuropsychopharmacol 35:2440–2449
17. Stone W (1993) The neuropharmacology of quinolinic and kynurenic acids. Pharmacol Rev 45:309–385
18. Vengeliene V, Cannella N, Takahashi T, Spanagel R (2016) Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse. Psychopharmacol 233:3449–3459
19. Zwilling D, Huang S-Y, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu H-Q, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, Giorgini F, Moussaoui S, Laue G, Rassoulpour A, Flik G, Huang Y, Muchowski JM, Masliah E, Schwarcz R, Muchowski PJ (2011) Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Cell 145:863–874