Therapeutic targeting of the G-CSF receptor reduces neutrophil trafficking and joint inflammation in antibody-mediated inflammatory arthritis

Journal of Immunology

Volumn 197, Issue 11, 2016, Pages 4392-4402

  Campbell, Ian K ^a   Leong, David ^a   Edwards, Kirsten M ^a   Rayzman, Veronika ^a   Ng, Milica ^a   Goldberg, Gabrielle L ^b   Wilson, Nicholas J ^a   Scalzo Inguanti, Karen ^a   MacKenzie Kludas, Charley ^c   Lawlor, Kate E ^b   Wicks, Ian P ^b   Brown, Lorena E ^c   Morelli, Adriana Baz ^a   Panousis, Con ^a   Wilson, Michael J ^a   Nash, Andrew D ^a   McKenzie, Brent S ^a,d   Andrews, Arna E ^a  

^a CSL LIMITED   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; L SELECTIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 5E2; MONOCYTE CHEMOTACTIC PROTEIN 1; STAT3 PROTEIN; UNCLASSIFIED DRUG; CYTOKINE; NEUTRALIZING ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL HOMING; COLLAGEN ANTIBODY-INDUCED ARTHRITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; GENE EXPRESSION; INFLUENZA; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RHEUMATOID ARTHRITIS; VIRAL CLEARANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTHRITIS, EXPERIMENTAL; CHEMICALLY INDUCED; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; INFLAMMATION; JOINT; KNOCKOUT MOUSE; NEUTROPHIL; PATHOLOGY;

ANIMALS; ANTIBODIES, NEUTRALIZING; ARTHRITIS, EXPERIMENTAL; CYTOKINES; GENE EXPRESSION REGULATION; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; INFLAMMATION; JOINTS; MALE; MICE; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; NEUTROPHILS; RECEPTORS, GRANULOCYTE COLONY-STIMULATING FACTOR;

EID: 84996598266     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1600121     Document Type: Article

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