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Volumn 106, Issue , 2016, Pages 402-409

The immune system of the gut and potential adverse effects of oral nanocarriers on its function

Author keywords

Gut microbiome; Intestinal permeation enhancers; Oral nanotechnology; Oral peptides; Peptide clinical trials; Therapeutic peptides

Indexed keywords

DRUG PRODUCTS; PEPTIDES; TISSUE; TOXICITY; VACCINES; VIRUSES;

EID: 84996528914     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2016.09.009     Document Type: Review
Times cited : (29)

References (81)
  • 1
    • 0017198772 scopus 로고
    • Morphological methods in the study of the gut immune system in man
    • [1] Skinner, J.M., Whitehead, R., Morphological methods in the study of the gut immune system in man. J. Clin. Pathol. 29 (1976), 564–567.
    • (1976) J. Clin. Pathol. , vol.29 , pp. 564-567
    • Skinner, J.M.1    Whitehead, R.2
  • 2
    • 0019765403 scopus 로고
    • Ontogeny of the gut-associated immune system
    • [2] Husband, A.J., Ontogeny of the gut-associated immune system. Adv. Exp. Med. Biol. 137 (1981), 633–647.
    • (1981) Adv. Exp. Med. Biol. , vol.137 , pp. 633-647
    • Husband, A.J.1
  • 3
    • 0020359471 scopus 로고
    • Immunoregulation by the gut-associated immune system
    • [3] Schmiegel, W.H., Thiele, H.G., Immunoregulation by the gut-associated immune system. Immun. Infekt. 10 (1982), 169–174.
    • (1982) Immun. Infekt. , vol.10 , pp. 169-174
    • Schmiegel, W.H.1    Thiele, H.G.2
  • 4
    • 0020650509 scopus 로고
    • The immunology and molecular biology of the gut-associated immune system
    • [4] Woloschak, G.E., Tomasi, T.B., The immunology and molecular biology of the gut-associated immune system. Crit. Rev. Immunol. 4 (1983), 1–18.
    • (1983) Crit. Rev. Immunol. , vol.4 , pp. 1-18
    • Woloschak, G.E.1    Tomasi, T.B.2
  • 5
    • 0021235623 scopus 로고
    • The gastrointestinal tract as an immunologic organ: the gut-associated immune system
    • [5] Borsch, G., The gastrointestinal tract as an immunologic organ: the gut-associated immune system. Klin. Wochenschr. 62 (1984), 699–709.
    • (1984) Klin. Wochenschr. , vol.62 , pp. 699-709
    • Borsch, G.1
  • 6
    • 0023712778 scopus 로고
    • Immunological functions of the gut—role of the mucosal immune system
    • [6] Nagura, H., Sumi, Y., Immunological functions of the gut—role of the mucosal immune system. Toxicol. Pathol. 16 (1988), 154–164.
    • (1988) Toxicol. Pathol. , vol.16 , pp. 154-164
    • Nagura, H.1    Sumi, Y.2
  • 7
    • 0027363853 scopus 로고
    • Immunophysiology of the gut: a research frontier for integrative studies of the common mucosal immune system
    • [7] Castro, G.A., Arntzen, C.J., Immunophysiology of the gut: a research frontier for integrative studies of the common mucosal immune system. Am. J. Phys. 265 (1993), G599–G610.
    • (1993) Am. J. Phys. , vol.265 , pp. G599-G610
    • Castro, G.A.1    Arntzen, C.J.2
  • 8
    • 0031926105 scopus 로고    scopus 로고
    • Gut epithelium: food processor for the mucosal immune system?
    • [8] Bland, P.W., Gut epithelium: food processor for the mucosal immune system?. Gut 42 (1998), 455–456.
    • (1998) Gut , vol.42 , pp. 455-456
    • Bland, P.W.1
  • 9
    • 0031868262 scopus 로고    scopus 로고
    • Nutrition and the immune system of the gut
    • [9] Cunningham-Rundles, S., Lin, D.H., Nutrition and the immune system of the gut. Nutrition 14 (1998), 573–579.
    • (1998) Nutrition , vol.14 , pp. 573-579
    • Cunningham-Rundles, S.1    Lin, D.H.2
  • 10
    • 58449109276 scopus 로고    scopus 로고
    • Structure and function of the gut mucosal immune system
    • [10] Pabst, R., Rothkotter, H.J., Structure and function of the gut mucosal immune system. Adv. Exp. Med. Biol. 579 (2006), 1–14.
    • (2006) Adv. Exp. Med. Biol. , vol.579 , pp. 1-14
    • Pabst, R.1    Rothkotter, H.J.2
  • 11
    • 84880946214 scopus 로고    scopus 로고
    • The gut mucosal immune system in the neonatal period
    • [11] Battersby, A.J., Gibbons, D.L., The gut mucosal immune system in the neonatal period. Pediatr. Allergy Immunol. 24 (2013), 414–421.
    • (2013) Pediatr. Allergy Immunol. , vol.24 , pp. 414-421
    • Battersby, A.J.1    Gibbons, D.L.2
  • 12
    • 84873800448 scopus 로고    scopus 로고
    • Gut immune system and oral tolerance
    • [12] Castro-Sanchez, P., Martin-Villa, J.M., Gut immune system and oral tolerance. Br. J. Nutr. 109:Suppl. 2 (2013), S3–S11.
    • (2013) Br. J. Nutr. , vol.109 , pp. S3-S11
    • Castro-Sanchez, P.1    Martin-Villa, J.M.2
  • 13
    • 84880976146 scopus 로고    scopus 로고
    • The interaction between gut microbiota and age-related changes in immune function and inflammation
    • [13] Magrone, T., Jirillo, E., The interaction between gut microbiota and age-related changes in immune function and inflammation. Immun. Ageing, 10, 2013, 31.
    • (2013) Immun. Ageing , vol.10 , pp. 31
    • Magrone, T.1    Jirillo, E.2
  • 14
    • 84876708979 scopus 로고    scopus 로고
    • The interplay between the gut immune system and microbiota in health and disease: nutraceutical intervention for restoring intestinal homeostasis
    • [14] Magrone, T., Jirillo, E., The interplay between the gut immune system and microbiota in health and disease: nutraceutical intervention for restoring intestinal homeostasis. Curr. Pharm. Des. 19 (2013), 1329–1342.
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 1329-1342
    • Magrone, T.1    Jirillo, E.2
  • 15
    • 0028099487 scopus 로고
    • Phenotypic and functional assessment of intraepithelial lymphocytes bearing a ‘forbidden’ alpha beta TCR
    • [15] Croitoru, K., Bienenstock, J., Ernst, P.B., Phenotypic and functional assessment of intraepithelial lymphocytes bearing a ‘forbidden’ alpha beta TCR. Int. Immunol. 6 (1994), 1467–1473.
    • (1994) Int. Immunol. , vol.6 , pp. 1467-1473
    • Croitoru, K.1    Bienenstock, J.2    Ernst, P.B.3
  • 16
    • 0031656176 scopus 로고    scopus 로고
    • Nasal immune system: distinctive Th0 and Th1/Th2 type environments in murine nasal-associated lymphoid tissues and nasal passage, respectively
    • [16] Hiroi, T., Iwatani, K., Iijima, H., Kodama, S., Yanagita, M., Kiyono, H., Nasal immune system: distinctive Th0 and Th1/Th2 type environments in murine nasal-associated lymphoid tissues and nasal passage, respectively. Eur. J. Immunol. 28 (1998), 3346–3353.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 3346-3353
    • Hiroi, T.1    Iwatani, K.2    Iijima, H.3    Kodama, S.4    Yanagita, M.5    Kiyono, H.6
  • 17
    • 4544258068 scopus 로고    scopus 로고
    • NALT- versus Peyer's-patch-mediated mucosal immunity
    • [17] Kiyono, H., Fukuyama, S., NALT- versus Peyer's-patch-mediated mucosal immunity. Nat. Rev. Immunol. 4 (2004), 699–710.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 699-710
    • Kiyono, H.1    Fukuyama, S.2
  • 18
    • 3142740243 scopus 로고    scopus 로고
    • Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunity
    • [18] Yamamoto, M., Kweon, M.N., Rennert, P.D., Hiroi, T., Fujihashi, K., McGhee, J.R., Kiyono, H., Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunity. J. Immunol. 173 (2004), 762–769.
    • (2004) J. Immunol. , vol.173 , pp. 762-769
    • Yamamoto, M.1    Kweon, M.N.2    Rennert, P.D.3    Hiroi, T.4    Fujihashi, K.5    McGhee, J.R.6    Kiyono, H.7
  • 19
    • 2442479518 scopus 로고    scopus 로고
    • IgA class switch occurs in the organized nasopharynx- and gut-associated lymphoid tissue, but not in the diffuse lamina propria of airways and gut
    • [19] Shikina, T., Hiroi, T., Iwatani, K., Jang, M.H., Fukuyama, S., Tamura, M., Kubo, T., Ishikawa, H., Kiyono, H., IgA class switch occurs in the organized nasopharynx- and gut-associated lymphoid tissue, but not in the diffuse lamina propria of airways and gut. J. Immunol. 172 (2004), 6259–6264.
    • (2004) J. Immunol. , vol.172 , pp. 6259-6264
    • Shikina, T.1    Hiroi, T.2    Iwatani, K.3    Jang, M.H.4    Fukuyama, S.5    Tamura, M.6    Kubo, T.7    Ishikawa, H.8    Kiyono, H.9
  • 21
    • 0038329305 scopus 로고    scopus 로고
    • Structural and cellular architecture of conjunctival lymphoid follicles in the baboon (Papio anubis)
    • [21] Astley, R.A., Kennedy, R.C., Chodosh, J., Structural and cellular architecture of conjunctival lymphoid follicles in the baboon (Papio anubis). Exp. Eye Res. 76 (2003), 685–694.
    • (2003) Exp. Eye Res. , vol.76 , pp. 685-694
    • Astley, R.A.1    Kennedy, R.C.2    Chodosh, J.3
  • 22
    • 0023190922 scopus 로고
    • Intravascular and mucosal immunoglobulin A: two separate but related systems of immune defense?
    • [22] Conley, M.E., Delacroix, D.L., Intravascular and mucosal immunoglobulin A: two separate but related systems of immune defense?. Ann. Intern. Med. 106 (1987), 892–899.
    • (1987) Ann. Intern. Med. , vol.106 , pp. 892-899
    • Conley, M.E.1    Delacroix, D.L.2
  • 23
    • 0035074535 scopus 로고    scopus 로고
    • Vaccination strategies for mucosal immune responses
    • [23] Ogra, P.L., Faden, H., Welliver, R.C., Vaccination strategies for mucosal immune responses. Clin. Microbiol. Rev. 14 (2001), 430–445.
    • (2001) Clin. Microbiol. Rev. , vol.14 , pp. 430-445
    • Ogra, P.L.1    Faden, H.2    Welliver, R.C.3
  • 24
    • 15544382565 scopus 로고    scopus 로고
    • Immunity, inflammation, and allergy in the gut
    • [24] Macdonald, T.T., Monteleone, G., Immunity, inflammation, and allergy in the gut. Science 307 (2005), 1920–1925.
    • (2005) Science , vol.307 , pp. 1920-1925
    • Macdonald, T.T.1    Monteleone, G.2
  • 25
    • 84879336857 scopus 로고    scopus 로고
    • Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium
    • [25] Mabbott, N.A., Donaldson, D.S., Ohno, H., Williams, I.R., Mahajan, A., Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium. Mucosal Immunol. 6 (2013), 666–677.
    • (2013) Mucosal Immunol. , vol.6 , pp. 666-677
    • Mabbott, N.A.1    Donaldson, D.S.2    Ohno, H.3    Williams, I.R.4    Mahajan, A.5
  • 26
    • 0031254999 scopus 로고    scopus 로고
    • Peyer's patch dendritic cells and the induction of mucosal immune responses
    • [26] Kelsall, B.L., Strober, W., Peyer's patch dendritic cells and the induction of mucosal immune responses. Res. Immunol. 148 (1997), 490–498.
    • (1997) Res. Immunol. , vol.148 , pp. 490-498
    • Kelsall, B.L.1    Strober, W.2
  • 27
    • 80054919389 scopus 로고    scopus 로고
    • Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut
    • [27] Mantis, N.J., Rol, N., Corthesy, B., Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunol. 4 (2011), 603–611.
    • (2011) Mucosal Immunol. , vol.4 , pp. 603-611
    • Mantis, N.J.1    Rol, N.2    Corthesy, B.3
  • 28
    • 0037299933 scopus 로고    scopus 로고
    • Long-term follow up of gastric low-grade mucosa-associated lymphoid tissue lymphoma by endosonography emphasizing the application of a miniature ultrasound probe
    • [28] Yeh, H.Z., Chen, G.H., Chang, W.D., Poon, S.K., Yang, S.S., Lien, H.C., Chang, C.S., Chou, G., Long-term follow up of gastric low-grade mucosa-associated lymphoid tissue lymphoma by endosonography emphasizing the application of a miniature ultrasound probe. J. Gastroenterol. Hepatol. 18 (2003), 162–167.
    • (2003) J. Gastroenterol. Hepatol. , vol.18 , pp. 162-167
    • Yeh, H.Z.1    Chen, G.H.2    Chang, W.D.3    Poon, S.K.4    Yang, S.S.5    Lien, H.C.6    Chang, C.S.7    Chou, G.8
  • 29
    • 80054946067 scopus 로고    scopus 로고
    • Rediscovering IgA
    • [29] Mantis, N.J., Rediscovering IgA. Mucosal Immunol. 4 (2011), 588–589.
    • (2011) Mucosal Immunol. , vol.4 , pp. 588-589
    • Mantis, N.J.1
  • 30
    • 0023212298 scopus 로고
    • The anatomical basis for the immune function of the gut
    • [30] Pabst, R., The anatomical basis for the immune function of the gut. Anat. Embryol. 176 (1987), 135–144.
    • (1987) Anat. Embryol. , vol.176 , pp. 135-144
    • Pabst, R.1
  • 31
    • 1342300522 scopus 로고    scopus 로고
    • Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine
    • [31] Pabst, O., Ohl, L., Wendland, M., Wurbel, M.A., Kremmer, E., Malissen, B., Forster, R., Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine. J. Exp. Med. 199 (2004), 411–416.
    • (2004) J. Exp. Med. , vol.199 , pp. 411-416
    • Pabst, O.1    Ohl, L.2    Wendland, M.3    Wurbel, M.A.4    Kremmer, E.5    Malissen, B.6    Forster, R.7
  • 32
    • 3042720708 scopus 로고    scopus 로고
    • Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat + cells
    • [32] Eberl, G., Littman, D.R., Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat + cells. Science 305 (2004), 248–251.
    • (2004) Science , vol.305 , pp. 248-251
    • Eberl, G.1    Littman, D.R.2
  • 33
    • 0030067796 scopus 로고    scopus 로고
    • Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch
    • [33] Kelsall, B.L., Strober, W., Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch. J. Exp. Med. 183 (1996), 237–247.
    • (1996) J. Exp. Med. , vol.183 , pp. 237-247
    • Kelsall, B.L.1    Strober, W.2
  • 35
    • 84959109645 scopus 로고    scopus 로고
    • Gut microbiota regulates key modulators of social behavior
    • [35] Parashar, A., Udayabanu, M., Gut microbiota regulates key modulators of social behavior. Eur. Neuropsychopharmacol. 26 (2016), 78–91.
    • (2016) Eur. Neuropsychopharmacol. , vol.26 , pp. 78-91
    • Parashar, A.1    Udayabanu, M.2
  • 36
    • 84887851957 scopus 로고    scopus 로고
    • Gut bacteria in health and disease
    • [36] Quigley, E.M., Gut bacteria in health and disease. Gastroenterol. Hepatol. 9 (2013), 560–569.
    • (2013) Gastroenterol. Hepatol. , vol.9 , pp. 560-569
    • Quigley, E.M.1
  • 37
    • 84909581895 scopus 로고    scopus 로고
    • The future of probiotics for disorders of the brain-gut axis
    • [37] Quigley, E.M., Shanahan, F., The future of probiotics for disorders of the brain-gut axis. Adv. Exp. Med. Biol. 817 (2014), 417–432.
    • (2014) Adv. Exp. Med. Biol. , vol.817 , pp. 417-432
    • Quigley, E.M.1    Shanahan, F.2
  • 38
    • 84996533502 scopus 로고    scopus 로고
    • Prokaryotes Versus Eukaryotes: Who is Hosting Whom?
    • [38] Tellez, G., Prokaryotes Versus Eukaryotes: Who is Hosting Whom?. Front. Vet. Sci., 1, 2014, 3.
    • (2014) Front. Vet. Sci. , vol.1 , pp. 3
    • Tellez, G.1
  • 40
    • 0036960764 scopus 로고    scopus 로고
    • Gut flora in gastrointestinal disease
    • [40] Shanahan, F., Gut flora in gastrointestinal disease. Eur. J. Surg. Suppl., 2002, 47–52.
    • (2002) Eur. J. Surg. Suppl. , pp. 47-52
    • Shanahan, F.1
  • 41
    • 0026569336 scopus 로고
    • The neglected organ: bacterial flora has a crucial immunostimulatory role
    • [41] Bocci, V., The neglected organ: bacterial flora has a crucial immunostimulatory role. Perspect. Biol. Med. 35 (1992), 251–260.
    • (1992) Perspect. Biol. Med. , vol.35 , pp. 251-260
    • Bocci, V.1
  • 42
    • 0038440515 scopus 로고    scopus 로고
    • Gut flora in health and disease
    • [42] Knight, D.J., Girling, K.J., Gut flora in health and disease. Lancet, 361, 2003, 1831.
    • (2003) Lancet , vol.361 , pp. 1831
    • Knight, D.J.1    Girling, K.J.2
  • 43
    • 0037425743 scopus 로고    scopus 로고
    • Gut flora in health and disease
    • [43] Guarner, F., Malagelada, J.R., Gut flora in health and disease. Lancet 361 (2003), 512–519.
    • (2003) Lancet , vol.361 , pp. 512-519
    • Guarner, F.1    Malagelada, J.R.2
  • 44
    • 84962177621 scopus 로고    scopus 로고
    • Mood by microbe: towards clinical translation
    • [44] Dinan, T.G., Cryan, J.F., Mood by microbe: towards clinical translation. Genome Med., 8, 2016, 36.
    • (2016) Genome Med. , vol.8 , pp. 36
    • Dinan, T.G.1    Cryan, J.F.2
  • 45
    • 0345303939 scopus 로고    scopus 로고
    • Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing
    • [45] Girardin, S.E., Hugot, J.P., Sansonetti, P.J., Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing. Trends Immunol. 24 (2003), 652–658.
    • (2003) Trends Immunol. , vol.24 , pp. 652-658
    • Girardin, S.E.1    Hugot, J.P.2    Sansonetti, P.J.3
  • 46
    • 79551699386 scopus 로고    scopus 로고
    • Viral nanoparticles and virus-like particles: platforms for contemporary vaccine design
    • [46] Plummer, E.M., Manchester, M., Viral nanoparticles and virus-like particles: platforms for contemporary vaccine design. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 3 (2011), 174–196.
    • (2011) Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. , vol.3 , pp. 174-196
    • Plummer, E.M.1    Manchester, M.2
  • 47
    • 84881799557 scopus 로고    scopus 로고
    • Complement activation, immunogenicity, and immune suppression as potential side effects of liposomes
    • D. Peer Pan Standford Publishing Pte. Ltd. Singapure
    • [47] Szebeni, J., Barenholz, Y., Complement activation, immunogenicity, and immune suppression as potential side effects of liposomes. Peer, D., (eds.) Handbook of Harnessing Biomaterials in Nanomedicine: Prepara!on,Toxicity, and Applications, 2012, Pan Standford Publishing Pte. Ltd., Singapure, 309–334.
    • (2012) Handbook of Harnessing Biomaterials in Nanomedicine: Prepara!on,Toxicity, and Applications , pp. 309-334
    • Szebeni, J.1    Barenholz, Y.2
  • 48
    • 84860463126 scopus 로고    scopus 로고
    • Development and characterization of solid lipid nanoparticles for enhancement of oral bioavailability of Raloxifene
    • [48] Patel, B.D., Modi, R.V., Thakkar, N.A., Patel, A.A., Thakkar, P.H., Development and characterization of solid lipid nanoparticles for enhancement of oral bioavailability of Raloxifene. J. Pharm. Bioallied Sci. 4 (2012), S14–S16.
    • (2012) J. Pharm. Bioallied Sci. , vol.4 , pp. S14-S16
    • Patel, B.D.1    Modi, R.V.2    Thakkar, N.A.3    Patel, A.A.4    Thakkar, P.H.5
  • 49
    • 84897948292 scopus 로고    scopus 로고
    • Polio vaccines: WHO position paper
    • [49] WHO, Polio vaccines: WHO position paper. Wkly Epidemiol. Rec. 89 (2014), 73–92.
    • (2014) Wkly Epidemiol. Rec. , vol.89 , pp. 73-92
  • 51
    • 84878417756 scopus 로고    scopus 로고
    • Liposomes containing monophosphoryl lipid A: a potent adjuvant system for inducing antibodies to heroin hapten analogs
    • [51] Matyas, G.R., Mayorov, A.V., Rice, K.C., Jacobson, A.E., Cheng, K., Iyer, M.R., Li, F., Beck, Z., Janda, K.D., Alving, C.R., Liposomes containing monophosphoryl lipid A: a potent adjuvant system for inducing antibodies to heroin hapten analogs. Vaccine 31 (2013), 2804–2810.
    • (2013) Vaccine , vol.31 , pp. 2804-2810
    • Matyas, G.R.1    Mayorov, A.V.2    Rice, K.C.3    Jacobson, A.E.4    Cheng, K.5    Iyer, M.R.6    Li, F.7    Beck, Z.8    Janda, K.D.9    Alving, C.R.10
  • 52
    • 84855354748 scopus 로고    scopus 로고
    • Phase I study of a Neisseria meningitidis liposomal vaccine containing purified outer membrane proteins and detoxified lipooligosaccharide
    • [52] Zollinger, W.D., Babcock, J.G., Moran, E.E., Brandt, B.L., Matyas, G.R., Wassef, N.M., Alving, C.R., Phase I study of a Neisseria meningitidis liposomal vaccine containing purified outer membrane proteins and detoxified lipooligosaccharide. Vaccine 30 (2012), 712–721.
    • (2012) Vaccine , vol.30 , pp. 712-721
    • Zollinger, W.D.1    Babcock, J.G.2    Moran, E.E.3    Brandt, B.L.4    Matyas, G.R.5    Wassef, N.M.6    Alving, C.R.7
  • 53
    • 84864924172 scopus 로고    scopus 로고
    • Liposomes containing lipid A: an effective, safe, generic adjuvant system for synthetic vaccines
    • [53] Alving, C.R., Rao, M., Steers, N.J., Matyas, G.R., Mayorov, A.V., Liposomes containing lipid A: an effective, safe, generic adjuvant system for synthetic vaccines. Expert Rev. Vaccines 11 (2012), 733–744.
    • (2012) Expert Rev. Vaccines , vol.11 , pp. 733-744
    • Alving, C.R.1    Rao, M.2    Steers, N.J.3    Matyas, G.R.4    Mayorov, A.V.5
  • 54
    • 0030444302 scopus 로고    scopus 로고
    • Liposomal subunit vaccines: effects of lipid A and aluminum hydroxide on immunogenicity
    • [54] Richards, R.L., Alving, C.R., Wassef, N.M., Liposomal subunit vaccines: effects of lipid A and aluminum hydroxide on immunogenicity. J. Pharm. Sci. 85 (1996), 1286–1289.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 1286-1289
    • Richards, R.L.1    Alving, C.R.2    Wassef, N.M.3
  • 55
    • 0029023980 scopus 로고
    • Liposomal vaccines: clinical status and immunological presentation for humoral and cellular immunity
    • [55] Alving, C.R., Liposomal vaccines: clinical status and immunological presentation for humoral and cellular immunity. Ann. N. Y. Acad. Sci. 754 (1995), 143–152.
    • (1995) Ann. N. Y. Acad. Sci. , vol.754 , pp. 143-152
    • Alving, C.R.1
  • 57
    • 79957861493 scopus 로고    scopus 로고
    • Nanosizing for oral and parenteral drug delivery: a perspective on formulating poorly-water soluble compounds using wet media milling technology
    • [57] Merisko-Liversidge, E., Liversidge, G.G., Nanosizing for oral and parenteral drug delivery: a perspective on formulating poorly-water soluble compounds using wet media milling technology. Adv. Drug Deliv. Rev. 63 (2011), 427–440.
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , pp. 427-440
    • Merisko-Liversidge, E.1    Liversidge, G.G.2
  • 58
    • 0017346930 scopus 로고
    • Histamine release in dogs by Cremophor EL and its derivatives: oxyethylated oleic acid is the most effective constituent
    • [58] Lorenz, W., Riemann, H.J., Schmal, A., Histamine release in dogs by Cremophor EL and its derivatives: oxyethylated oleic acid is the most effective constituent. Agents Actions 7 (1977), 63–67.
    • (1977) Agents Actions , vol.7 , pp. 63-67
    • Lorenz, W.1    Riemann, H.J.2    Schmal, A.3
  • 59
    • 0032542499 scopus 로고    scopus 로고
    • Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: an in vitro study
    • [59] Szebeni, J., Muggia, F.M., Alving, C.R., Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: an in vitro study. J. Natl. Cancer Inst. 90 (1998), 300–306.
    • (1998) J. Natl. Cancer Inst. , vol.90 , pp. 300-306
    • Szebeni, J.1    Muggia, F.M.2    Alving, C.R.3
  • 60
    • 0021964058 scopus 로고
    • Modulation of histamine release by fatty acids. A new in vitro model investigating adverse drug reactions in various species
    • [60] Ennis, M., Lorenz, W., Modulation of histamine release by fatty acids. A new in vitro model investigating adverse drug reactions in various species. Ann. Fr. Anesth. Reanim. 4 (1985), 124–128.
    • (1985) Ann. Fr. Anesth. Reanim. , vol.4 , pp. 124-128
    • Ennis, M.1    Lorenz, W.2
  • 61
  • 62
    • 34347378637 scopus 로고    scopus 로고
    • Animal models of complement-mediated hypersensitivity reactions to liposomes and other lipid-based nanoparticles
    • [62] Szebeni, J., Alving, C.R., Rosivall, L., Bünger, R., Baranyi, L., Bedöcs, P., Tóth, M., Barenholz, Y., Animal models of complement-mediated hypersensitivity reactions to liposomes and other lipid-based nanoparticles. J. Liposome Res. 17 (2007), 107–117.
    • (2007) J. Liposome Res. , vol.17 , pp. 107-117
    • Szebeni, J.1    Alving, C.R.2    Rosivall, L.3    Bünger, R.4    Baranyi, L.5    Bedöcs, P.6    Tóth, M.7    Barenholz, Y.8
  • 63
    • 84961276010 scopus 로고    scopus 로고
    • Comparison of complement activation-related pseudoallergy in miniature and domestic pigs: foundation of a validatable immune toxicity model
    • [63] Jackman, J.A., Meszaros, T., Fulop, T., Urbanics, R., Szebeni, J., Cho, N.J., Comparison of complement activation-related pseudoallergy in miniature and domestic pigs: foundation of a validatable immune toxicity model. Nanomedicine 12 (2016), 933–943.
    • (2016) Nanomedicine , vol.12 , pp. 933-943
    • Jackman, J.A.1    Meszaros, T.2    Fulop, T.3    Urbanics, R.4    Szebeni, J.5    Cho, N.J.6
  • 66
    • 0021955562 scopus 로고
    • Comparison of the histamine-releasing activity of cremophor E1 and some of its derivatives in two experimental models: the in vivo anaesthetized dog and in vitro rat peritoneal mast cells
    • [66] Ennis, M., Lorenz, W., Kapp, B., Luben, L., Schmal, A., Comparison of the histamine-releasing activity of cremophor E1 and some of its derivatives in two experimental models: the in vivo anaesthetized dog and in vitro rat peritoneal mast cells. Agents Actions 16 (1985), 265–268.
    • (1985) Agents Actions , vol.16 , pp. 265-268
    • Ennis, M.1    Lorenz, W.2    Kapp, B.3    Luben, L.4    Schmal, A.5
  • 67
    • 84996488200 scopus 로고    scopus 로고
    • What Is Colace (Docusate Sodium)?
    • [67] Colace, What Is Colace (Docusate Sodium)?. http://www.everydayhealth.com/drugs/colace, 2016.
    • (2016)
    • Colace1
  • 68
    • 80052174164 scopus 로고    scopus 로고
    • Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: prediction and prevention
    • [68] Szebeni, J., Muggia, F., Gabizon, A., Barenholz, Y., Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: prediction and prevention. Adv. Drug Deliv. Rev. 63 (2011), 1020–1030.
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , pp. 1020-1030
    • Szebeni, J.1    Muggia, F.2    Gabizon, A.3    Barenholz, Y.4
  • 69
    • 85019952245 scopus 로고    scopus 로고
    • Case study: Complement activation related hypersensitivity reactions to PEGylated liposomal doxorubicin: Experimental and clinical evidence, mechanisms and approaches to Inhibition
    • M.A. Dobrovolskaia S.E. McNeil 2nd edition World Scientific Publishing Company
    • [69] Szebeni, J., Muggia, F., Barenholz, Y., Case study: Complement activation related hypersensitivity reactions to PEGylated liposomal doxorubicin: Experimental and clinical evidence, mechanisms and approaches to Inhibition. Dobrovolskaia, M.A., McNeil, S.E., (eds.) Handbook of Immunological Properties of Engineered Nanomaterials, 2nd edition, 2015, World Scientific Publishing Company, 331–361.
    • (2015) Handbook of Immunological Properties of Engineered Nanomaterials , pp. 331-361
    • Szebeni, J.1    Muggia, F.2    Barenholz, Y.3
  • 70
    • 0032817055 scopus 로고    scopus 로고
    • Complement component C3 production in IL-1beta-stimulated human intestinal epithelial cells is blocked by NF-kappaB inhibitors and by transfection with ser 32/36 mutant IkappaBalpha
    • [70] Moon, M.R., Parikh, A.A., Pritts, T.A., Fischer, J.E., Cottongim, S., Szabo, C., Salzman, A.L., Hasselgren, P.O., Complement component C3 production in IL-1beta-stimulated human intestinal epithelial cells is blocked by NF-kappaB inhibitors and by transfection with ser 32/36 mutant IkappaBalpha. J. Surg. Res. 82 (1999), 48–55.
    • (1999) J. Surg. Res. , vol.82 , pp. 48-55
    • Moon, M.R.1    Parikh, A.A.2    Pritts, T.A.3    Fischer, J.E.4    Cottongim, S.5    Szabo, C.6    Salzman, A.L.7    Hasselgren, P.O.8
  • 71
    • 0027526976 scopus 로고
    • Differential cytokine regulation of complement C3, C4, and factor B synthesis in human intestinal epithelial cell line, Caco-2
    • [71] Andoh, A., Fujiyama, Y., Bamba, T., Hosoda, S., Differential cytokine regulation of complement C3, C4, and factor B synthesis in human intestinal epithelial cell line, Caco-2. J. Immunol. 151 (1993), 4239–4247.
    • (1993) J. Immunol. , vol.151 , pp. 4239-4247
    • Andoh, A.1    Fujiyama, Y.2    Bamba, T.3    Hosoda, S.4
  • 72
    • 84996550942 scopus 로고    scopus 로고
    • Nanoparticle toxicity by the gastrointestinal route: evidence and knowledge gaps, International journal of biomedical nanoscience and nanotechnology, 3
    • [72] Bergin, I.L., Witzmann, F.A., Nanoparticle toxicity by the gastrointestinal route: evidence and knowledge gaps, International journal of biomedical nanoscience and nanotechnology, 3. 2013.
    • (2013)
    • Bergin, I.L.1    Witzmann, F.A.2
  • 74
    • 84952896924 scopus 로고    scopus 로고
    • Insights into the protective role of solid lipid nanoparticles on rosmarinic acid bioactivity during exposure to simulated gastrointestinal conditions
    • [74] Madureira, A.R., Campos, D.A., Oliveira, A., Sarmento, B., Pintado, M.M., Gomes, A.M., Insights into the protective role of solid lipid nanoparticles on rosmarinic acid bioactivity during exposure to simulated gastrointestinal conditions. Colloids Surf. B Biointerfaces 139 (2016), 277–284.
    • (2016) Colloids Surf. B Biointerfaces , vol.139 , pp. 277-284
    • Madureira, A.R.1    Campos, D.A.2    Oliveira, A.3    Sarmento, B.4    Pintado, M.M.5    Gomes, A.M.6
  • 75
    • 84952002660 scopus 로고    scopus 로고
    • New frontiers in nanotoxicology: Gut microbiota/microbiome-mediated effects of engineered nanomaterials
    • [75] Pietroiusti, A., Magrini, A., Campagnolo, L., New frontiers in nanotoxicology: Gut microbiota/microbiome-mediated effects of engineered nanomaterials. Toxicol. Appl. Pharmacol. 299 (2016), 90–95.
    • (2016) Toxicol. Appl. Pharmacol. , vol.299 , pp. 90-95
    • Pietroiusti, A.1    Magrini, A.2    Campagnolo, L.3
  • 76
    • 84963857369 scopus 로고    scopus 로고
    • Amorphous nanosilica particles block induction of oral tolerance in mice
    • [76] Toda, T., Yoshino, S., Amorphous nanosilica particles block induction of oral tolerance in mice. J. Immunotoxicol. 13 (2016), 723–728.
    • (2016) J. Immunotoxicol. , vol.13 , pp. 723-728
    • Toda, T.1    Yoshino, S.2
  • 77
    • 84962878719 scopus 로고    scopus 로고
    • Cytotoxicity of Nanoparticles Contained in Food on Intestinal Cells and the Gut Microbiota
    • [77] Frohlich, E.E., Frohlich, E., Cytotoxicity of Nanoparticles Contained in Food on Intestinal Cells and the Gut Microbiota. Int. J. Mol. Sci., 17, 2016, 509.
    • (2016) Int. J. Mol. Sci. , vol.17 , pp. 509
    • Frohlich, E.E.1    Frohlich, E.2
  • 79
    • 84929675174 scopus 로고    scopus 로고
    • Effects of subchronic exposure of silver nanoparticles on intestinal microbiota and gut-associated immune responses in the ileum of Sprague-Dawley rats
    • [79] Williams, K., Milner, J., Boudreau, M.D., Gokulan, K., Cerniglia, C.E., Khare, S., Effects of subchronic exposure of silver nanoparticles on intestinal microbiota and gut-associated immune responses in the ileum of Sprague-Dawley rats. Nanotoxicology 9 (2015), 279–289.
    • (2015) Nanotoxicology , vol.9 , pp. 279-289
    • Williams, K.1    Milner, J.2    Boudreau, M.D.3    Gokulan, K.4    Cerniglia, C.E.5    Khare, S.6
  • 80
    • 84871818445 scopus 로고    scopus 로고
    • Ingestion of metal-nanoparticle contaminated food disrupts endogenous microbiota in zebrafish (Danio rerio)
    • [80] Merrifield, D.L., Shaw, B.J., Harper, G.M., Saoud, I.P., Davies, S.J., Handy, R.D., Henry, T.B., Ingestion of metal-nanoparticle contaminated food disrupts endogenous microbiota in zebrafish (Danio rerio). Environ. Pollut. 174 (2013), 157–163.
    • (2013) Environ. Pollut. , vol.174 , pp. 157-163
    • Merrifield, D.L.1    Shaw, B.J.2    Harper, G.M.3    Saoud, I.P.4    Davies, S.J.5    Handy, R.D.6    Henry, T.B.7


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