-
2
-
-
84920740857
-
Molecu-larly targeted therapies in non-small-cell lung cancer annual update 2014
-
Morgensztern D, Campo MJ, Dahlberg SE, et al. Molecu-larly targeted therapies in non-small-cell lung cancer annual update 2014. J Thorac Oncol. 2015;10:S1-S63.
-
(2015)
J Thorac Oncol.
, vol.10
, pp. S1-S63
-
-
Morgensztern, D.1
Campo, M.J.2
Dahlberg, S.E.3
-
3
-
-
84875947292
-
New targetable onco-genes in non-small-cell lung cancer
-
Oxnard GR, Binder A, Janne PA. New targetable onco-genes in non-small-cell lung cancer. J Clin Oncol. 2013;31:1097-1104.
-
(2013)
J Clin Oncol.
, vol.31
, pp. 1097-1104
-
-
Oxnard, G.R.1
Binder, A.2
Janne, P.A.3
-
4
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012;12:252-264.
-
(2012)
Nat Rev Cancer.
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
5
-
-
84927150740
-
Immune checkpoint blockade in cancer therapy
-
Postow MA, Callahan MK, Wolchok JD. Immune checkpoint blockade in cancer therapy. J Clin Oncol. 2015;33:1974-1982.
-
(2015)
J Clin Oncol.
, vol.33
, pp. 1974-1982
-
-
Ma, P.1
Callahan, M.K.2
Wolchok, J.D.3
-
6
-
-
84919385463
-
Programmed cell death 1 (PD-1) and its ligand (PD-L1) in common cancers and their correlation with molecular cancer type
-
Gatalica Z, Snyder C, Maney T, et al. Programmed cell death 1 (PD-1) and its ligand (PD-L1) in common cancers and their correlation with molecular cancer type. Cancer Epidemiol Biomarkers Prev. 2014;23:2965-2970.
-
(2014)
Cancer Epidemiol Biomarkers Prev.
, vol.23
, pp. 2965-2970
-
-
Gatalica, Z.1
Snyder, C.2
Maney, T.3
-
7
-
-
84935474357
-
PD-L1 Expression as a predictive biomarker in cancer immunotherapy
-
Patel SP, Kurzrock R. PD-L1 Expression as a predictive biomarker in cancer immunotherapy. Mol Cancer Ther. 2015;14:847-856.
-
(2015)
Mol Cancer Ther.
, vol.14
, pp. 847-856
-
-
Patel, S.P.1
Kurzrock, R.2
-
8
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443-2454.
-
(2012)
N Engl J Med.
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
9
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366:2455-2465.
-
(2012)
N Engl J Med.
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
-
10
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
-
Brahmer J, Reckamp KL, Baas P, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med. 2015;373:123-135.
-
(2015)
N Engl J Med.
, vol.373
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
-
11
-
-
84929481480
-
Pembrolizumab for the treatment of non-small-cell lung cancer
-
Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med. 2015;372:2018-2028.
-
(2015)
N Engl J Med.
, vol.372
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
-
12
-
-
84920956735
-
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
-
Herbst RS, Soria JC, Kowanetz M, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 2014;515:563-567.
-
(2014)
Nature.
, vol.515
, pp. 563-567
-
-
Herbst, R.S.1
Soria, J.C.2
Kowanetz, M.3
-
13
-
-
84890020587
-
Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors
-
Akbay EA, Koyama S, Carretero J, et al. Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov. 2013;3:1355-1363.
-
(2013)
Cancer Discov.
, vol.3
, pp. 1355-1363
-
-
Akbay, E.A.1
Koyama, S.2
Carretero, J.3
-
14
-
-
84938289871
-
Upregulation of PD-L1 by EGFR activation mediates the immune escape in EGFR-driven NSCLC: Implication for optional immune targeted therapy for NSCLC patients with EGFR mutation
-
Chen N, Fang W, Zhan J, et al. Upregulation of PD-L1 by EGFR activation mediates the immune escape in EGFR-driven NSCLC: implication for optional immune targeted therapy for NSCLC patients with EGFR mutation. J Thorac Oncol. 2015;10:910-923.
-
(2015)
J Thorac Oncol.
, vol.10
, pp. 910-923
-
-
Chen, N.1
Fang, W.2
Zhan, J.3
-
15
-
-
84923072443
-
Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer
-
Azuma K, Ota K, Kawahara A, et al. Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer. Ann Oncol. 2014;25:1935-1940.
-
(2014)
Ann Oncol.
, vol.25
, pp. 1935-1940
-
-
Azuma, K.1
Ota, K.2
Kawahara, A.3
-
16
-
-
84937629074
-
PD-L1 expression is a favorable prognostic factor in early stage non-small cell carcinoma
-
Cooper WA, Tran T, Vilain RE, et al. PD-L1 expression is a favorable prognostic factor in early stage non-small cell carcinoma. Lung Cancer. 2015;89:181-188.
-
(2015)
Lung Cancer.
, vol.89
, pp. 181-188
-
-
Cooper, W.A.1
Tran, T.2
Vilain, R.E.3
-
17
-
-
84897404380
-
Programmed cell death-ligand 1 expression in surgically resected stage i pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes
-
Yang CY, Lin MW, Chang YL, et al. Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes. Eur J Cancer. 2014;50:1361-1369.
-
(2014)
Eur J Cancer.
, vol.50
, pp. 1361-1369
-
-
Yang, C.Y.1
Lin, M.W.2
Chang, Y.L.3
-
18
-
-
84898843963
-
Protein expression of programmed death 1 ligand 1 and ligand 2 independently predict poor prognosis in surgically resected lung adenocarcinoma
-
Zhang Y, Wang L, Li Y, et al. Protein expression of programmed death 1 ligand 1 and ligand 2 independently predict poor prognosis in surgically resected lung adenocarcinoma. Onco Targets Ther. 2014;7: 567-573.
-
(2014)
Onco Targets Ther.
, vol.7
, pp. 567-573
-
-
Zhang, Y.1
Wang, L.2
Li, Y.3
-
19
-
-
84956607290
-
Expression of programmed death ligand-1 on tumor cells varies pre and post chemotherapy in non-small cell lung cancer
-
Sheng J, Fang W, Yu J, et al. Expression of programmed death ligand-1 on tumor cells varies pre and post chemotherapy in non-small cell lung cancer. Sci Rep. 2016;6:20090.
-
(2016)
Sci Rep.
, vol.6
, pp. 20090
-
-
Sheng, J.1
Fang, W.2
Yu, J.3
-
20
-
-
84903841837
-
Prognostic and therapeutic implications of aromatase expression in lung adenocarcinomas with EGFR mutations
-
Kohno M, Okamoto T, Suda K, et al. Prognostic and therapeutic implications of aromatase expression in lung adenocarcinomas with EGFR mutations. Clin Cancer Res. 2014;20:3613-3622.
-
(2014)
Clin Cancer Res.
, vol.20
, pp. 3613-3622
-
-
Kohno, M.1
Okamoto, T.2
Suda, K.3
-
21
-
-
80052476869
-
High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation
-
Mu CY, Huang JA, Chen Y, et al. High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation. Med Oncol. 2011;28:682-688.
-
(2011)
Med Oncol.
, vol.28
, pp. 682-688
-
-
Mu, C.Y.1
Huang, J.A.2
Chen, Y.3
-
22
-
-
84873666114
-
Clinical significance of programmed death-1 ligand-1 expression in patients with non-small cell lung cancer: A 5-year-follow-up study
-
Chen YB, Mu CY, Huang JA. Clinical significance of programmed death-1 ligand-1 expression in patients with non-small cell lung cancer: a 5-year-follow-up study. Tumori. 2012;98:751-755.
-
(2012)
Tumori.
, vol.98
, pp. 751-755
-
-
Chen, Y.B.1
Mu, C.Y.2
Huang, J.A.3
-
23
-
-
84891534246
-
Programmed death ligand-1 expression in non-small cell lung cancer
-
Velcheti V, Schalper KA, Carvajal DE, et al. Programmed death ligand-1 expression in non-small cell lung cancer. Lab Invest. 2014;94:107-116.
-
(2014)
Lab Invest.
, vol.94
, pp. 107-116
-
-
Velcheti, V.1
Schalper, K.A.2
De, C.3
-
24
-
-
84943340055
-
PD-1 and PD-L1 Expression in NSCLC indicate a favorable prognosis in defined subgroups
-
Schmidt LH, Kummel A, Gorlich D, et al. PD-1 and PD-L1 Expression in NSCLC indicate a favorable prognosis in defined subgroups. PloS One. 2015;10:e0136023.
-
(2015)
PloS One.
, vol.10
, pp. e0136023
-
-
Schmidt, L.H.1
Kummel, A.2
Gorlich, D.3
-
25
-
-
84924577386
-
Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic drivers
-
Kim MY, Koh J, Kim S, et al. Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: comparison with tumor-infiltrating T cells and the status of oncogenic drivers. Lung Cancer. 2015;88:24-33.
-
(2015)
Lung Cancer.
, vol.88
, pp. 24-33
-
-
Kim, M.Y.1
Koh, J.2
Kim, S.3
-
26
-
-
84920655625
-
PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients
-
D'Incecco A, Andreozzi M, Ludovini V, et al. PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients. Br J Cancer. 2015;112:95-102.
-
(2015)
Br J Cancer.
, vol.112
, pp. 95-102
-
-
D'Incecco, A.1
Andreozzi, M.2
Ludovini, V.3
-
27
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
-
Borghaei H, Paz-Ares L, Horn L, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med. 2015;373:1627-1639.
-
(2015)
N Engl J Med.
, vol.373
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
-
28
-
-
84939227614
-
Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): Sensitivity analysis of trials in melanoma, lung and genitourinary cancers
-
Carbognin L, Pilotto S, Milella M, et al. Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): sensitivity analysis of trials in melanoma, lung and genitourinary cancers. PloS One. 2015;10:e0130142.
-
(2015)
PloS One.
, vol.10
, pp. e0130142
-
-
Carbognin, L.1
Pilotto, S.2
Milella, M.3
-
29
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi NA, Hellmann MD, Snyder A, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015;348:124-128.
-
(2015)
Science.
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
-
30
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov LB, Nik-Zainal S, Wedge DC, et al. Signatures of mutational processes in human cancer. Nature. 2013;500:415-421.
-
(2013)
Nature.
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
Nik-Zainal, S.2
Wedge, D.C.3
-
31
-
-
84899061145
-
Exomics and immunogenics: Bridging mutational load and immune checkpoints efficacy
-
Champiat S, Ferte C, Lebel-Binay S, et al. Exomics and immunogenics: bridging mutational load and immune checkpoints efficacy. Oncoimmunology. 2014;3:e27817.
-
(2014)
Oncoimmunology.
, vol.3
, pp. e27817
-
-
Champiat, S.1
Ferte, C.2
Lebel-Binay, S.3
-
33
-
-
79955571953
-
Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: Prognostic subgroups and implications for further revision of staging based on analysis of 514 stage i cases
-
Yoshizawa A, Motoi N, Riely GJ, et al. Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases. Mod Pathol. 2011;24:653-664.
-
(2011)
Mod Pathol.
, vol.24
, pp. 653-664
-
-
Yoshizawa, A.1
Motoi, N.2
Riely, G.J.3
-
34
-
-
0037214215
-
Early-stage lung adenocarcinomas with a micropapillary pattern, a distinct pathologic marker for a significantly poor prognosis
-
Miyoshi T, Satoh Y, Okumura S, et al. Early-stage lung adenocarcinomas with a micropapillary pattern, a distinct pathologic marker for a significantly poor prognosis. Am J Surg Pathol. 2003;27:101-109.
-
(2003)
Am J Surg Pathol.
, vol.27
, pp. 101-109
-
-
Miyoshi, T.1
Satoh, Y.2
Okumura, S.3
-
35
-
-
0036187436
-
Micropapillary component in lung adenocarcinoma: A distinctive histo-logic feature with possible prognostic significance
-
Amin MB, Tamboli P, Merchant SH, et al. Micropapillary component in lung adenocarcinoma: a distinctive histo-logic feature with possible prognostic significance. Am J Surg Pathol. 2002;26:358-364.
-
(2002)
Am J Surg Pathol.
, vol.26
, pp. 358-364
-
-
Amin, M.B.1
Tamboli, P.2
Merchant, S.H.3
-
36
-
-
84875238628
-
Tumor B7-H1 and B7-H3 expression in squamous cell carcinoma of the lung
-
Boland JM, Kwon ED, Harrington SM, et al. Tumor B7-H1 and B7-H3 expression in squamous cell carcinoma of the lung. Clin Lung Cancer. 2013;14:157-163.
-
(2013)
Clin Lung Cancer.
, vol.14
, pp. 157-163
-
-
Boland, J.M.1
Kwon, E.D.2
Harrington, S.M.3
-
37
-
-
84883249629
-
The impact of EGFR mutation status on outcomes in patients with resected stage i non-small cell lung cancers
-
Izar B, Sequist L, Lee M, et al. The impact of EGFR mutation status on outcomes in patients with resected stage I non-small cell lung cancers. Ann Thorac Surg. 2013;96:962-968.
-
(2013)
Ann Thorac Surg.
, vol.96
, pp. 962-968
-
-
Izar, B.1
Sequist, L.2
Lee, M.3
-
38
-
-
70349758654
-
Activating mutations within the EGFR kinase domain: Amolecular predictorofdisease-free survival in resected pulmonary adenocarcinoma
-
Lee YJ, Park IK, Park MS, et al. Activating mutations within the EGFR kinase domain: amolecular predictorofdisease-free survival in resected pulmonary adenocarcinoma. J Cancer Res Clin Oncol. 2009;135:1647-1654.
-
(2009)
J Cancer Res Clin Oncol.
, vol.135
, pp. 1647-1654
-
-
Lee, Y.J.1
Park, I.K.2
Park, M.S.3
|