Lithocholic acid induces endoplasmic reticulum stress, autophagy and mitochondrial dysfunction in human prostate cancer cells

PeerJ

Volumn 2016, Issue 11, 2016, Pages

  Gafar, Ahmed A ^a,b   Draz, Hossam M ^a,c   Goldberg, Alexander A ^a,d   Bashandy, Mohamed A ^b   Bakry, Sayed ^b   Khalifa, Mahmoud A ^b   AbuShair, Walid ^b   Titorenko, Vladimir I ^e   Sanderson, J Thomas ^a  

^a INRS INSTITUT ARMAND FRAPPIER   (Canada)

^b Assiut Branch   (Egypt)

^c NATIONAL RESEARCH CENTRE   (Egypt)

^d MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^e Gina Cody School of Engineering and Computer Science   (Canada)

Author keywords

Autophagy; Cell death; Du 145; Endoplasmic reticulum stress; Lithocholic acid; Pc 3; Prostate cancer cells; Reactive oxygen species; RWPE 1; Tocotrienol

Indexed keywords

ALPHA TOCOTRIENOL; BAFILOMYCIN A1; CCAAT ENHANCER BINDING PROTEIN; INITIATION FACTOR 2; LITHOCHOLIC ACID; SALUBRINAL; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL LINE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DU 145 CELL LINE; ENDOPLASMIC RETICULUM STRESS; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NECROSIS; PC3 CELL LINE; PHOSPHORYLATION; PROSTATE CANCER CELL LINE;

EID: 84995877318     PISSN: None     EISSN: 21678359     Source Type: Journal    
DOI: 10.7717/peerj.2445     Document Type: Article

References (40)

1. Adachi T, Kaminaga T, Yasuda H, Kamiya T, Hara H. 2014. The involvement of endoplasmic reticulum stress in bile acid-induced hepatocellular injury. Journal of Clinical Biochemistry and Nutrition 54:129-135 DOI 10.3164/jcbn.13-46
2. American Cancer Society. 2015. What are the key statistics about prostate cancer? Available at http://www.cancer.org/cancer/prostatecancer/detailedguide/prostate-cancer-key-statistics
3. Canadian Cancer Society's Advisory Committee on Cancer Statistics. 2016. Canadian cancer statistics 2016. Toronto: Canadian Cancer Society. Available at http://www.cancer.ca/en/cancer-information/cancer-type/prostate/statistics/?region=sk#ixzz4P4xXLTh4
4. Codogno P, Meijer AJ. 2005. Autophagy and signaling: their role in cell survival and cell death. Cell Death and Differentiation 12(Suppl 2):1509-1518 DOI 10.1038/sj.cdd.4401751
5. Conde FA, Aronson WJ. 2003. Risk factors for male osteoporosis. Urologic Oncology 21:380-383 DOI 10.1016/S1078-1439(03)00109-1
6. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. 2015. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer 136:E359-E386 DOI 10.1002/ijc.29210
7. Fimognari C, Lenzi M, Cantelli-Forti G, Hrelia P. 2009. Apoptosis and modulation of cell cycle control by bile acids in human leukemia T cells. Annals of the New York Academy of Sciences 1171:264-269 DOI 10.1111/j.1749-6632.2009.04710.x
8. Fiorucci S, Distrutti E. 2015. Bile acid-activated receptors, intestinal microbiota, and the treatment of metabolic disorders. Trends in Molecular Medicine 21:702-714 DOI 10.1016/j.molmed.2015.09.001
9. Gankhuyag N, Singh B, Maharjan S, Choi Y-J, Cho C-S, Cho M-H. 2015. Galactosylated poly(ethyleneglycol)-lithocholic acid selectively kills hepatoma cells, while sparing normal liver cells. Macromolecular Bioscience 15:777-787 DOI 10.1002/mabi.201400475
10. Gao L, Lv G, Guo X, Jing Y, Han Z, Zhang S, Sun K, Li R, Yang Y, Wei L. 2014. Activation of autophagy protects against cholestasis-induced hepatic injury. Cell & Bioscience 4:47 DOI 10.1186/2045-3701-4-47
11. Giordano C, Catalano S, Panza S, Vizza D, Barone I, Bonofiglio D, Gelsomino L, Rizza P, Fuqua SA, Ando S. 2011. Farnesoid X receptor inhibits tamoxifen-resistant MCF-7 breast cancer cell growth through downregulation of HER2 expression. Oncogene 30:4129-4140 DOI 10.1038/onc.2011.124
12. Goldberg AA, Beach A, Davies GF, Harkness TA, Leblanc A, Titorenko VI. 2011. Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget 2:761-782 DOI 10.18632/oncotarget.338
13. Goldberg AA, Draz H, Montes-Grajales D, Olivero-Verbel J, Safe SH, Sanderson JT. 2015. 3,3'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgendependent and-independent prostate cancer cells. Genes Cancer 6:265-280
14. Goldberg AA, Titorenko VI, Beach A, Sanderson JT. 2013. Bile acids induce apoptosis selectively in androgen-dependent and-independent prostate cancer cells. PeerJ 1:e122 DOI 10.7717/peerj.122
15. Hadji A, Clybouw C, Auffredou MT, Alexia C, Poalas K, Burlion A, Feraud O, Leca G, Vazquez A. 2010. Caspase-3 triggers a TPCK-sensitive protease pathway leading to degradation of the BH3-only protein puma. Apoptosis 15:1529-1539 DOI 10.1007/s10495-010-0528-2
16. Iizaka T, Tsuji M, Oyamada H, Morio Y, Oguchi K. 2007. Interaction between caspase-8 activation and endoplasmic reticulum stress in glycochenodeoxycholic acid-induced apoptotic HepG2 cells. Toxicology 241:146-156 DOI 10.1016/j.tox.2007.08.095
17. Katona BW, Anant S, Covey DF, Stenson WF. 2009. Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines. Journal of Biological Chemistry 284:3354-3364 DOI 10.1074/jbc. M805804200
18. Levine B, Yuan J. 2005. Autophagy in cell death: an innocent convict? The Journal of Clinical Investigation 115:2679-2688 DOI 10.1172/JCI26390
19. Li T, Chiang JY. 2015. Bile acids as metabolic regulators. Current Opinion in Gastroen-terology 31:159-165 DOI 10.1097/MOG.0000000000000156
20. Malvezzi M, Bertuccio P, Rosso T, Rota M, Levi F, La Vecchia C, Negri E. 2015. European cancer mortality predictions for the year 2015: does lung cancer have the highest death rate in EU women? Annals of Oncology 26:779-786 DOI 10.1093/annonc/mdv001
21. Marciniak SJ, Yun CY, Oyadomari S, Novoa I, Zhang Y, Jungreis R, Nagata K, Harding HP, Ron D. 2004. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes & Development 18:3066-3077 DOI 10.1101/gad.1250704
22. Martin NE, D'Amico AV. 2014. Progress and controversies: radiation therapy for prostate cancer. CA: A Cancer Journal for Clinicians 64:389-407 DOI 10.3322/caac.21250
23. Matsumoto H, Miyazaki S, Matsuyama S, Takeda M, Kawano M, Nakagawa H, Nishimura K, Matsuo S. 2013. Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression. Biology Open 2:1084-1090 DOI 10.1242/bio.20135033
24. Mizushima N, Noda T, Yoshimori T, Tanaka Y, Ishii T, George MD, Klionsky DJ, Ohsumi M, Ohsumi Y. 1998a. A protein conjugation system essential for autophagy. Nature 395:395-398 DOI 10.1038/26506
25. Mizushima N, Sugita H, Yoshimori T, Ohsumi Y. 1998b. A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. Journal of Biological Chemistry 273:33889-33892 DOI 10.1074/jbc.273.51.33889
26. Mizushima N, Yamamoto A, Hatano M, Kobayashi Y, Kabeya Y, Suzuki K, Tokuhisa T, Ohsumi Y, Yoshimori T. 2001. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. Journal of Cell Biology 152(4):657-668 DOI 10.1083/jcb.152.4.657
27. Nguyen PL, Alibhai SM, Basaria S, D'amico AV, KantoffPW, Keating NL, Penson DF, Rosario DJ, Tombal B, Smith MR. 2015. Adverse effects of androgen deprivation therapy and strategies to mitigate them. European Urology 67:825-836 DOI 10.1016/j.eururo.2014.07.010
28. Nie YF, Hu J, Yan XH. 2015. Cross-talk between bile acids and intestinal microbiota in host metabolism and health. Journal of Zhejiang University Science B 16:436-446 DOI 10.1631/jzus. B1400327
29. Perez MJ, Briz O. 2009. Bile-acid-induced cell injury and protection. World Journal of Gastroenterology 15:1677-1689
30. Perino A, Schoonjans K. 2015. TGR5 and immunometabolism: insights from physiology and pharmacology. Trends in Pharmacological Sciences 36:847-857 DOI 10.1016/j.tips.2015.08.002
31. Reggiori F, Klionsky DJ. 2002. Autophagy in the eukaryotic cell. Eukaryotic Cell 1:11-21 DOI 10.1128/EC.01.1.11-21.2002
32. Rubin SJ, Hallahan DE, Ashman CR, Brachman DG, Beckett MA, Virudachalam S, Yandell DW, Weichselbaum RR. 1991. Two prostate carcinoma cell lines demonstrate abnormalities in tumor suppressor genes. Journal of Surgical Oncology 46:31-36 DOI 10.1002/jso.2930460108
33. Sanda MG, Dunn RL, Michalski J, Sandler HM, Northouse L, HembroffL, Lin X, Greenfield TK, Litwin MS, Saigal CS, Mahadevan A, Klein E, Kibel A, Pisters LL, Kuban D, Kaplan I, Wood D, Ciezki J, Shah N, Wei JT. 2008. Quality of life and satisfaction with outcome among prostate-cancer survivors. The New England Journal of Medicine 358:1250-1261 DOI 10.1056/NEJMoa074311
34. Shimodaira Y, Takahashi S, Kinouchi Y, Endo K, Shiga H, Kakuta Y, Kuroha M, Shimosegawa T. 2014. Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol-requiring enzyme 1alpha (IRE1alpha) in human colon cancer cells. Biochemical and Biophysical Research Communications 445:524-533 DOI 10.1016/j.bbrc.2014.02.054
35. Stepanov V, Stankov K, Mikov M. 2013. The bile acid membrane receptor TGR5: a novel pharmacological target in metabolic, inflammatory and neoplastic disorders. Journal of Receptor and Signal Transduction Research 33:213-223 DOI 10.3109/10799893.2013.802805
36. Tanida I, Ueno T, Kominami E. 2004. LC3 conjugation system in mammalian autophagy. The International Journal of Biochemistry & Cell Biology 36(12):2503-2518 DOI 10.1016/j.biocel.2004.05.009
37. Tiwari A, Maiti P. 2009. TGR5: an emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders. Drug Discovery Today 14:523-530 DOI 10.1016/j.drudis.2009.02.005
38. Tsuchiya S, Tsuji M, Morio Y, Oguchi K. 2006. Involvement of endoplasmic reticulum in glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes. Toxicology Letters 166:140-149 DOI 10.1016/j.toxlet.2006.06.006
39. Wakeyama H, Akiyama T, Takahashi K, Amano H, Kadono Y, Nakamura M, Oshima Y, Itabe H, Nakayama KI, Nakayama K, Nakamura K, Tanaka S. 2007. Negative feedback loop in the Bim-caspase-3 axis regulating apoptosis and activity of osteoclasts. Journal of Bone and Mineral Research 22:1631-1639 DOI 10.1359/jbmr.070619
40. Webster CR, Usechak P, Anwer MS. 2002. cAMP inhibits bile acid-induced apoptosis by blocking caspase activation and cytochrome c release. American Journal of Physiology. Gastrointestinal and Liver Physiology 283:G727-G738 DOI 10.1152/ajpgi.00410.2001