Design, Optimization, and Evaluation of a Novel Metronidazole-Loaded Gastro-Retentive pH-Sensitive Hydrogel

AAPS PharmSciTech

Volumn 17, Issue 6, 2016, Pages 1285-1297

  El Mahrouk, Galal M ^a   Aboul Einien, Mona H ^a   Makhlouf, Amal I ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

chitosan; floating drug delivery system; gastric retention; metronidazole; pH sensitive swelling

Indexed keywords

CHITOSAN; CITRIC ACID; METRONIDAZOLE; TRIPOLYPHOSPHATE; DRUG CARRIER; HYDROGEL; POLYPHOSPHATE; TRIPHOSPHORIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS LINKING; DOG; DRUG RELEASE; FACTORIAL DESIGN; FREEZE DRYING; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; HUMIDITY; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; MOISTURE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RADIOGRAPHY; STOMACH BIOPSY; STOMACH PH; ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; HELICOBACTER INFECTIONS; MEDICINAL CHEMISTRY; METABOLISM; MICROBIOLOGY; PH; PROCEDURES; STOMACH;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DOGS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HYDROGEL; HYDROGEN-ION CONCENTRATION; METRONIDAZOLE; POLYPHOSPHATES; STOMACH;

EID: 84995777941     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-015-0467-x     Document Type: Article

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