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Volumn 3, Issue 3, 2012, Pages 243-250

Genetics and molecular pathology of gastric malignancy: Development of targeted therapies in the era of personalized medicine

Author keywords

Gastric malignancy; Genetics and molecular pathology; Targeted therapy

Indexed keywords

ANGIOGENESIS INHIBITOR; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; EVEROLIMUS; IMATINIB; IRINOTECAN; MATRIX METALLOPROTEINASE INHIBITOR; OCTREOTIDE; SOMATOSTATIN DERIVATIVE; TRASTUZUMAB;

EID: 84995740348     PISSN: 20786891     EISSN: 2219679X     Source Type: Journal    
DOI: 10.3978/j.issn.2078-6891.2012.017     Document Type: Review
Times cited : (10)

References (33)
  • 1
    • 84860487790 scopus 로고    scopus 로고
    • HER2 testing in gastric cancer: a practical approach
    • Rüschoff J, Hanna W, Bilous M, et al. HER2 testing in gastric cancer: a practical approach. Mod Pathol 2012;25:637-50.
    • (2012) Mod Pathol , vol.25 , pp. 637-650
    • Rüschoff, J.1    Hanna, W.2    Bilous, M.3
  • 2
    • 34249989159 scopus 로고    scopus 로고
    • Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer
    • Kaurah P, MacMillan A, Boyd N, et al. Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. JAMA 2007;297:2360-72.
    • (2007) JAMA , vol.297 , pp. 2360-2372
    • Kaurah, P.1    MacMillan, A.2    Boyd, N.3
  • 3
    • 33846599252 scopus 로고    scopus 로고
    • Pathogenesis and treatment of gastric carcinoma: " an up-date with brief review"
    • Khan FA, Shukla AN. Pathogenesis and treatment of gastric carcinoma: " an up-date with brief review" . J Cancer Res Ther 2006;2:196-9.
    • (2006) J Cancer Res Ther , vol.2 , pp. 196-199
    • Khan, F.A.1    Shukla, A.N.2
  • 4
    • 63849254269 scopus 로고    scopus 로고
    • Helicobacter Pylori associated global gastric cancer burden
    • Mbulaiteye SM, Hisada M, El-Omar EM. Helicobacter Pylori associated global gastric cancer burden. Front Biosci 2009;14:1490-504.
    • (2009) Front Biosci , vol.14 , pp. 1490-1504
    • Mbulaiteye, S.M.1    Hisada, M.2    El-Omar, E.M.3
  • 5
    • 0035661834 scopus 로고    scopus 로고
    • Helicobacter pylori infection and precancerous lesions of the stomach
    • Valle J, Gisbert JP. Helicobacter pylori infection and precancerous lesions of the stomach. Hepatogastroenterology 2001;48:1548-51.
    • (2001) Hepatogastroenterology , vol.48 , pp. 1548-1551
    • Valle, J.1    Gisbert, J.P.2
  • 6
    • 79955500519 scopus 로고    scopus 로고
    • Molecular classification of gastric cancer: a new paradigm
    • Shah MA, Khanin R, Tang L, et al. Molecular classification of gastric cancer: a new paradigm. Clin Cancer Res 2011;17:2693-701.
    • (2011) Clin Cancer Res , vol.17 , pp. 2693-2701
    • Shah, M.A.1    Khanin, R.2    Tang, L.3
  • 7
    • 68949088503 scopus 로고    scopus 로고
    • Expression and clinical significance of focal adhesion kinase in the two distinct histological types, intestinal and diffuse, of human gastric adenocarcinoma
    • Giaginis CT, Vgenopoulou S, Tsourouflis GS, et al. Expression and clinical significance of focal adhesion kinase in the two distinct histological types, intestinal and diffuse, of human gastric adenocarcinoma. Pathol Oncol Res 2009;15:173-81.
    • (2009) Pathol Oncol Res , vol.15 , pp. 173-181
    • Giaginis, C.T.1    Vgenopoulou, S.2    Tsourouflis, G.S.3
  • 8
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, openlabel, randomised controlled trial
    • Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, openlabel, randomised controlled trial. Lancet 2010;376:687-97.
    • (2010) Lancet , vol.376 , pp. 687-697
    • Bang, Y.J.1    Van Cutsem, E.2    Feyereislova, A.3
  • 9
    • 77956895978 scopus 로고    scopus 로고
    • HER2 diagnostics in gastric cancer-guideline validation and development of standardized immunohistochemical testing
    • Rüschoff J, Dietel M, Baretton G, et al. HER2 diagnostics in gastric cancer-guideline validation and development of standardized immunohistochemical testing. Virchows Arch 2010;457:299-307.
    • (2010) Virchows Arch , vol.457 , pp. 299-307
    • Rüschoff, J.1    Dietel, M.2    Baretton, G.3
  • 10
    • 79959313276 scopus 로고    scopus 로고
    • Changing pathology with changing drugs: tumors of the gastrointestinal tract
    • Cervera P, Fléjou JF. Changing pathology with changing drugs: tumors of the gastrointestinal tract. Pathobiology 2011;78:76-89.
    • (2011) Pathobiology , vol.78 , pp. 76-89
    • Cervera, P.1    Fléjou, J.F.2
  • 11
    • 75149163527 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: a review of the literature
    • Laurini JA, Carter JE. Gastrointestinal stromal tumors: a review of the literature. Arch Pathol Lab Med 2010;134:134-41.
    • (2010) Arch Pathol Lab Med , vol.134 , pp. 134-141
    • Laurini, J.A.1    Carter, J.E.2
  • 12
    • 15644363454 scopus 로고    scopus 로고
    • Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
    • Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998;279:577-80.
    • (1998) Science , vol.279 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3
  • 13
    • 70249090434 scopus 로고    scopus 로고
    • DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases
    • Miettinen M, Wang ZF, Lasota J. DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases. Am J Surg Pathol 2009;33:1401-8.
    • (2009) Am J Surg Pathol , vol.33 , pp. 1401-1408
    • Miettinen, M.1    Wang, Z.F.2    Lasota, J.3
  • 14
    • 33749459756 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis
    • Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med 2006;130:1466-78.
    • (2006) Arch Pathol Lab Med , vol.130 , pp. 1466-1478
    • Miettinen, M.1    Lasota, J.2
  • 15
    • 0033619142 scopus 로고    scopus 로고
    • Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction
    • Lennartsson J, Blume-Jensen P, Hermanson M, et al. Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction. Oncogene 1999;18:5546-53.
    • (1999) Oncogene , vol.18 , pp. 5546-5553
    • Lennartsson, J.1    Blume-Jensen, P.2    Hermanson, M.3
  • 16
    • 33644752349 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors in patients with neurofibromatosis 1 a clinicopathologic and molecular genetic study of 45 cases
    • Miettinen M, Fetsch JF, Sobin LH, et al. Gastrointestinal stromal tumors in patients with neurofibromatosis 1: a clinicopathologic and molecular genetic study of 45 cases.Am J Surg Pathol 2006;30:90-6.
    • (2006) Am J Surg Pathol , vol.30 , pp. 90-96
    • Miettinen, M.1    Fetsch, J.F.2    Sobin, L.H.3
  • 17
    • 0032953812 scopus 로고    scopus 로고
    • Mutations in exon 11 of c-kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas
    • Lasota J, Jasinski M, Sarlomo-Rikala M, et al. Mutations in exon 11 of c-kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas. Am J Pathol 1999;154:53-60.
    • (1999) Am J Pathol , vol.154 , pp. 53-60
    • Lasota, J.1    Jasinski, M.2    Sarlomo-Rikala, M.3
  • 18
    • 0036895022 scopus 로고    scopus 로고
    • Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours
    • Chen H, Hirota S, Isozaki K, et al. Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours. Gut 2002;51:793-6.
    • (2002) Gut , vol.51 , pp. 793-796
    • Chen, H.1    Hirota, S.2    Isozaki, K.3
  • 19
    • 77949535841 scopus 로고    scopus 로고
    • Pharmacological management of gastrointestinal stromal tumours: an update on the role of sunitinib
    • Blay JY. Pharmacological management of gastrointestinal stromal tumours: an update on the role of sunitinib. Ann Oncol 2010;21:208-15.
    • (2010) Ann Oncol , vol.21 , pp. 208-215
    • Blay, J.Y.1
  • 20
    • 64549106573 scopus 로고    scopus 로고
    • The syndrome of gastric carcinoid and hyperparathyroidism: a family study and literature review
    • Christopoulos C, Balatsos V, Rotas E, et al. The syndrome of gastric carcinoid and hyperparathyroidism: a family study and literature review. Eur J Endocrinol 2009;160:689-94.
    • (2009) Eur J Endocrinol , vol.160 , pp. 689-694
    • Christopoulos, C.1    Balatsos, V.2    Rotas, E.3
  • 21
    • 0142075701 scopus 로고    scopus 로고
    • Carcinoid tumors of the stomach
    • Modlin IM, Lye KD, Kidd M. Carcinoid tumors of the stomach. Surg Oncol 2003;12:153-72.
    • (2003) Surg Oncol , vol.12 , pp. 153-172
    • Modlin, I.M.1    Lye, K.D.2    Kidd, M.3
  • 22
    • 84857046133 scopus 로고    scopus 로고
    • Targeting the proteasome as a promising therapeutic strategy in thyroid cancer
    • Wunderlich A, Arndt T, Fischer M, et al. Targeting the proteasome as a promising therapeutic strategy in thyroid cancer. J Surg Oncol 2012;105:357-64.
    • (2012) J Surg Oncol , vol.105 , pp. 357-364
    • Wunderlich, A.1    Arndt, T.2    Fischer, M.3
  • 23
    • 79953306029 scopus 로고    scopus 로고
    • The origin of neuroendocrine tumors and the neural crest saga
    • Rosai J. The origin of neuroendocrine tumors and the neural crest saga. Mod Pathol 2011;24:S53-7.
    • (2011) Mod Pathol , vol.24
    • Rosai, J.1
  • 24
    • 0017625081 scopus 로고
    • Analysis of endoderm formation in the avian blastoderm by the use of quail-chick chimaeras The problem of the neurectodermal origin of the cells of the APUD series
    • Fontaine J, Le Douarin NM. Analysis of endoderm formation in the avian blastoderm by the use of quail-chick chimaeras. The problem of the neurectodermal origin of the cells of the APUD series. J Embryol Exp Morphol 1977;41:209-22.
    • (1977) J Embryol Exp Morphol , vol.41 , pp. 209-222
    • Fontaine, J.1    Le Douarin, N.M.2
  • 25
    • 0038632161 scopus 로고    scopus 로고
    • Biology and management of gastric carcinoid tumours: a review
    • Modlin IM, Kidd M, Lye KD. Biology and management of gastric carcinoid tumours: a review. Eur J Surg 2002;168:669-83.
    • (2002) Eur J Surg , vol.168 , pp. 669-683
    • Modlin, I.M.1    Kidd, M.2    Lye, K.D.3
  • 26
    • 58849090542 scopus 로고    scopus 로고
    • Genetics and molecular pathology of neuroendocrine gastrointestinal and pancreatic tumors (gastroenteropancreatic neuroendocrine tumors)
    • Oberg K. Genetics and molecular pathology of neuroendocrine gastrointestinal and pancreatic tumors (gastroenteropancreatic neuroendocrine tumors). Curr Opin Endocrinol Diabetes Obes 2009;16:72-8.
    • (2009) Curr Opin Endocrinol Diabetes Obes , vol.16 , pp. 72-78
    • Oberg, K.1
  • 28
    • 37449029464 scopus 로고    scopus 로고
    • Gastroenteropancreatic neuroendocrine tumours
    • Modlin IM, Oberg K, Chung DC, et al. Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol 2008;9:61-72.
    • (2008) Lancet Oncol , vol.9 , pp. 61-72
    • Modlin, I.M.1    Oberg, K.2    Chung, D.C.3
  • 29
    • 84873205909 scopus 로고    scopus 로고
    • World Health Organization International Agency for Research on Cancer
    • 4th ed. Lyon: International Agency for Research on Cancer
    • Bosman FT, World Health Organization. International Agency for Research on Cancer. WHO classification of tumours of the digestive system. 4th ed. Lyon: International Agency for Research on Cancer, 2010:417p.
    • (2010) WHO classification of tumours of the digestive system , pp. 417
    • Bosman, F.T.1
  • 30
    • 1042290315 scopus 로고    scopus 로고
    • Different molecular profiles characterize well-differentiated endocrine tumors and poorly differentiated endocrine carcinomas of the gastroenteropancreatic tract
    • Furlan D, Cerutti R, Uccella S, et al. Different molecular profiles characterize well-differentiated endocrine tumors and poorly differentiated endocrine carcinomas of the gastroenteropancreatic tract. Clin Cancer Res 2004;10:947-57.
    • (2004) Clin Cancer Res , vol.10 , pp. 947-957
    • Furlan, D.1    Cerutti, R.2    Uccella, S.3
  • 31
    • 33646688705 scopus 로고    scopus 로고
    • Signet ring cells in gastric carcinomas are derived from neuroendocrine cells
    • Bakkelund K, Fossmark R, Nordrum I, et al. Signet ring cells in gastric carcinomas are derived from neuroendocrine cells. J Histochem Cytochem 2006;54:615-21.
    • (2006) J Histochem Cytochem , vol.54 , pp. 615-621
    • Bakkelund, K.1    Fossmark, R.2    Nordrum, I.3
  • 32
    • 77950194045 scopus 로고    scopus 로고
    • Somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine tumours, current aspects and new perspectives
    • Appetecchia M, Baldelli R. Somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine tumours, current aspects and new perspectives. J Exp Clin Cancer Res 2010;29:19.
    • (2010) J Exp Clin Cancer Res , vol.29 , pp. 19
    • Appetecchia, M.1    Baldelli, R.2
  • 33
    • 79959375226 scopus 로고    scopus 로고
    • Neuroendocrine tumors of the stomach: chemotherapy with cisplatin plus irinotecan is effective for gastric poorly-differentiated neuroendocrine carcinoma
    • Okita NT, Kato K, Takahari D, et al. Neuroendocrine tumors of the stomach: chemotherapy with cisplatin plus irinotecan is effective for gastric poorly-differentiated neuroendocrine carcinoma. Gastric Cancer 2011;14:161-5.
    • (2011) Gastric Cancer , vol.14 , pp. 161-165
    • Okita, N.T.1    Kato, K.2    Takahari, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.