Agmatine ameliorates high glucose-induced neuronal cell senescence by regulating the p21 and p53 signaling

Experimental Neurobiology

Volumn 25, Issue 1, 2016, Pages 24-32

  Song, Juhyun ^a   Lee, Byeori ^a   Kang, Somang ^a   Oh, Yumi ^a   Kim, Eosu ^a   Kim, Chul Hoon ^a   Song, Ho Taek ^a   Lee, Jong Eun ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Agmatine; Cell death; High glucose; Hyperglycemia; P21; P53; Pro inflammatory cytokines; Senescence

Indexed keywords

EID: 84995571187     PISSN: 12262560     EISSN: 20938144     Source Type: Journal    
DOI: 10.5607/en.2016.25.1.24     Document Type: Article

References (30)

1. Cowie CC, Rust KF, Ford ES, Eberhardt MS, Byrd-Holt DD, Li C, Williams DE, Gregg EW, Bainbridge KE, Saydah SH, Geiss LS (2009) Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006. Diabetes Care 32:287-294.
2. Senn JJ, Klover PJ, Nowak IA, Mooney RA (2002) Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 51:3391-3399.
3. Smith-West C, Garris DR (1983) Diabetes-associated hypothalamic neuronal depopulation in the aging Chinese hamster. Brain Res 285:385-389.
4. Campisi J (2005) Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120:513-522.
5. Licastro F, Pedrini S, Caputo L, Annoni G, Davis LJ, Ferri C, Casadei V, Grimaldi LM (2000) Increased plasma levels of interleukin-1, interleukin-6 and alpha-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain? J Neuroimmunol 103:97-102.
6. Noureddine H, Gary-Bobo G, Alifano M, Marcos E, Saker M, Vienney N, Amsellem V, Maitre B, Chaouat A, Chouaid C, Dubois-Rande JL, Damotte D, Adnot S (2011) Pulmonary artery smooth muscle cell senescence is a pathogenic mechanism for pulmonary hypertension in chronic lung disease. Circ Res 109:543-553.
7. Kruse JP, Gu W (2009) Modes of p53 regulation. Cell 137:609-622.
8. Sui X, Han W, Pan H (2015) p53-induced autophagy and senescence. Oncotarget 6:11723-11724.
9. Goldstein I, Yizhak K, Madar S, Goldfinger N, Ruppin E, Rotter V (2013) p53 promotes the expression of gluconeogenesisrelated genes and enhances hepatic glucose production. Cancer Metab 1:9.
10. Masgras I, Carrera S, de Verdier PJ, Brennan P, Majid A, Makhtar W, Tulchinsky E, Jones GD, Roninson IB, Macip S (2012) Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21. J Biol Chem 287:9845-9854.
11. Kitada K, Nakano D, Ohsaki H, Hitomi H, Minamino T, Yatabe J, Felder RA, Mori H, Masaki T, Kobori H, Nishiyama A (2014) Hyperglycemia causes cellular senescence via a SGLT2-and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy. J Diabetes Complications 28:604-611.
12. Mao D, Hinds PW (2010) p35 is required for CDK5 activation in cellular senescence. J Biol Chem 285:14671-14680.
13. Tabor CW, Tabor H (1984) Polyamines. Annu Rev Biochem 53:749-790.
14. Gilad GM, Salame K, Rabey JM, Gilad VH (1996) Agmatine treatment is neuroprotective in rodent brain injury models. Life Sci 58:PL 41-PL 46.
15. Song J, Hur BE, Bokara KK, Yang W, Cho HJ, Park KA, Lee WT, Lee KM, Lee JE (2014) Agmatine improves cognitive dysfunction and prevents cell death in a streptozotocininduced Alzheimer rat model. Yonsei Med J 55:689-699.
16. Gilad GM, Gilad VH, Finberg JP, Rabey JM (2005) Neurochemical evidence for agmatine modulation of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) neurotoxicity. Neurochem Res 30:713-719.
17. Cui H, Lee JH, Kim JY, Koo BN, Lee JE (2012) The neuroprotective effect of agmatine after focal cerebral ischemia in diabetic rats. J Neurosurg Anesthesiol 24:39-50.
18. Bokara KK, Kwon KH, Nho Y, Lee WT, Park KA, Lee JE (2011) Retroviral expression of arginine decarboxylase attenuates oxidative burden in mouse cortical neural stem cells. Stem Cells Dev 20:527-537.
19. Zhang J, Li B, Zheng Z, Kang T, Zeng M, Liu Y, Xia B (2015) Protective effects of Notch1 signaling activation against high glucose-induced myocardial cell injury: analysis of its mechanisms of action. Int J Mol Med 36:897-903.
20. Royall JA, Ischiropoulos H (1993) Evaluation of 2', 7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells. Arch Biochem Biophys 302:348-355.
21. Burn SF (2012) Detection of β-galactosidase activity: X-gal staining. Methods Mol Biol 886:241-250.
22. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88:593-602.
23. Waldman T, Kinzler KW, Vogelstein B (1995) p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res 55:5187-5190.
24. Chang BD, Watanabe K, Broude EV, Fang J, Poole JC, Kalinichenko TV, Roninson IB (2000) Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc Natl Acad Sci U S A 97:4291-4296.
25. Goretsky T, Dirisina R, Sinh P, Mittal N, Managlia E, Williams DB, Posca D, Ryu H, Katzman RB, Barrett TA (2012) p53 mediates TNF-induced epithelial cell apoptosis in IBD. Am J Pathol 181:1306-1315.
26. Volonte D, Zou H, Bartholomew JN, Liu Z, Morel PA, Galbiati F (2015) Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6). J Biol Chem 290:4202-4214.
27. Tang X, Asano M, O'Reilly A, Farquhar A, Yang Y, Amar S (2012) p53 is an important regulator of CCL2 gene expression. Curr Mol Med 12:929-943.
28. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW (1991) Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51:6304-6311.
29. Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B, Thompson CB (2007) Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 67:6745-6752.
30. Chae YB, Kim MM (2014) Activation of p53 by spermine mediates induction of autophagy in HT1080 cells. Int J Biol Macromol 63:56-63.