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Volumn 6, Issue 10, 2016, Pages 2289-2298

Inhibition of mTORC1 signaling sensitizes hepatocellular carcinoma cells to glycolytic stress

Author keywords

Glycolysis; Hepatocellular carcinoma; Lactate dehydrogenase a; MTOR signaling

Indexed keywords

DEOXYGLUCOSE; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE A; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MYC PROTEIN; RAPAMYCIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG;

EID: 84995549384     PISSN: None     EISSN: 21566976     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (15)

References (26)
  • 3
    • 84922459814 scopus 로고    scopus 로고
    • Liver resection for patients with hepatocellular carcinoma and macrovascular invasion, multiple tumours, or portal hypertension
    • Zhong JH, Ke Y, Wang YY and Li LQ. Liver resection for patients with hepatocellular carcinoma and macrovascular invasion, multiple tumours, or portal hypertension. Gut 2015; 64: 520-521
    • (2015) Gut , vol.64 , pp. 520-521
    • Zhong, J.H.1    Ke, Y.2    Wang, Y.Y.3    Li, L.Q.4
  • 5
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D and Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 84959451365 scopus 로고    scopus 로고
    • The Warburg Effect: How Does it Benefit Cancer Cells?
    • Liberti MV and Locasale JW. The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci 2016; 41: 211-218
    • (2016) Trends Biochem Sci , vol.41 , pp. 211-218
    • Liberti, M.V.1    Locasale, J.W.2
  • 7
    • 84908220531 scopus 로고    scopus 로고
    • 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy
    • Zhang D, Li J, Wang F, Hu J, Wang S and Sun Y. 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy. Cancer Lett 2014; 355: 176-183
    • (2014) Cancer Lett , vol.355 , pp. 176-183
    • Zhang, D.1    Li, J.2    Wang, F.3    Hu, J.4    Wang, S.5    Sun, Y.6
  • 8
    • 69849087571 scopus 로고    scopus 로고
    • Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy
    • Dwarakanath B and Jain V. Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy. Future Oncol 2009; 5: 581-585
    • (2009) Future Oncol , vol.5 , pp. 581-585
    • Dwarakanath, B.1    Jain, V.2
  • 9
    • 84903954969 scopus 로고    scopus 로고
    • Tumor aerobic glycolysis: new insights into therapeutic strategies with targeted delivery
    • Talekar M, Boreddy SR, Singh A and Amiji M. Tumor aerobic glycolysis: new insights into therapeutic strategies with targeted delivery. Expert Opin Biol Ther 2014; 14: 1145-1159
    • (2014) Expert Opin Biol Ther , vol.14 , pp. 1145-1159
    • Talekar, M.1    Boreddy, S.R.2    Singh, A.3    Amiji, M.4
  • 10
    • 34547902505 scopus 로고    scopus 로고
    • Differential toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells
    • Kurtoglu M, Maher JC and Lampidis TJ. Differential toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells. Antioxid Redox Signal 2007; 9: 1383-1390
    • (2007) Antioxid Redox Signal , vol.9 , pp. 1383-1390
    • Kurtoglu, M.1    Maher, J.C.2    Lampidis, T.J.3
  • 11
    • 36749078674 scopus 로고    scopus 로고
    • Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation
    • Kurtoglu M, Gao N, Shang J, Maher JC, Lehrman MA, Wangpaichitr M, Savaraj N, Lane AN and Lampidis TJ. Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation. Mol Cancer Ther 2007; 6: 3049-3058
    • (2007) Mol Cancer Ther , vol.6 , pp. 3049-3058
    • Kurtoglu, M.1    Gao, N.2    Shang, J.3    Maher, J.C.4    Lehrman, M.A.5    Wangpaichitr, M.6    Savaraj, N.7    Lane, A.N.8    Lampidis, T.J.9
  • 12
    • 84939881422 scopus 로고    scopus 로고
    • Impact of MYC in regulation of tumor cell metabolism
    • Wahlstrom T and Henriksson MA. Impact of MYC in regulation of tumor cell metabolism. Biochim Biophys Acta 2015; 1849: 563-569
    • (2015) Biochim Biophys Acta , vol.1849 , pp. 563-569
    • Wahlstrom, T.1    Henriksson, M.A.2
  • 13
    • 65949122722 scopus 로고    scopus 로고
    • Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway
    • Schmidt EV, Ravitz MJ, Chen L and Lynch M. Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway. Cell Cycle 2009; 8: 1344-1351
    • (2009) Cell Cycle , vol.8 , pp. 1344-1351
    • Schmidt, E.V.1    Ravitz, M.J.2    Chen, L.3    Lynch, M.4
  • 14
    • 77951234870 scopus 로고    scopus 로고
    • Differential responses of tumors and normal brain to the combined treatment of 2-DG and radiation in glioablastoma
    • Prasanna VK, Venkataramana NK, Dwara-Kanath BS and Santhosh V. Differential responses of tumors and normal brain to the combined treatment of 2-DG and radiation in glioablastoma. J Cancer Res Ther 2009; 5 Suppl 1: S44-47
    • (2009) J Cancer Res Ther , vol.5 , pp. S44-47
    • Prasanna, V.K.1    Venkataramana, N.K.2    Dwara-Kanath, B.S.3    Santhosh, V.4
  • 15
    • 84867097473 scopus 로고    scopus 로고
    • Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma
    • Sheng SL, Liu JJ, Dai YH, Sun XG, Xiong XP and Huang G. Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma. FEBS J 2012; 279: 3898-3910
    • (2012) FEBS J , vol.279 , pp. 3898-3910
    • Sheng, S.L.1    Liu, J.J.2    Dai, Y.H.3    Sun, X.G.4    Xiong, X.P.5    Huang, G.6
  • 19
    • 77952562382 scopus 로고    scopus 로고
    • Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply
    • Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC and Blenis J. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol Cell 2010; 38: 487-499
    • (2010) Mol Cell , vol.38 , pp. 487-499
    • Choo, A.Y.1    Kim, S.G.2    Vander Heiden, M.G.3    Mahoney, S.J.4    Vu, H.5    Yoon, S.O.6    Cantley, L.C.7    Blenis, J.8
  • 22
    • 0037192868 scopus 로고    scopus 로고
    • The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites
    • Herbert TP, Tee AR and Proud CG. The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites. J Biol Chem 2002; 277: 11591-11596
    • (2002) J Biol Chem , vol.277 , pp. 11591-11596
    • Herbert, T.P.1    Tee, A.R.2    Proud, C.G.3
  • 23
    • 70350728803 scopus 로고    scopus 로고
    • MYC-induced cancer cell energy metabolism and therapeutic opportunities
    • Dang CV, Le A and Gao P. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res 2009; 15: 6479-6483
    • (2009) Clin Cancer Res , vol.15 , pp. 6479-6483
    • Dang, C.V.1    Le, A.2    Gao, P.3
  • 24
    • 84968928065 scopus 로고    scopus 로고
    • Icariside II, a natural mTOR inhibitor, disrupts aberrant energy homeostasis via suppressing mTORC1-4E-BP1 axis in sarcoma cells
    • Zhang C, Yang L, Geng YD, An FL, Xia YZ, Guo C, Luo JG, Zhang LY, Guo QL and Kong LY. Icariside II, a natural mTOR inhibitor, disrupts aberrant energy homeostasis via suppressing mTORC1-4E-BP1 axis in sarcoma cells. Oncotarget 2016; 7: 27819-37
    • (2016) Oncotarget , vol.7 , pp. 27819-27837
    • Zhang, C.1    Yang, L.2    Geng, Y.D.3    An, F.L.4    Xia, Y.Z.5    Guo, C.6    Luo, J.G.7    Zhang, L.Y.8    Guo, Q.L.9    Kong, L.Y.10
  • 25
    • 52149083002 scopus 로고    scopus 로고
    • Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival
    • Barnhart BC, Lam JC, Young RM, Houghton PJ, Keith B and Simon MC. Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival. Cancer Biol Ther 2008; 7: 1441-1449
    • (2008) Cancer Biol Ther , vol.7 , pp. 1441-1449
    • Barnhart, B.C.1    Lam, J.C.2    Young, R.M.3    Houghton, P.J.4    Keith, B.5    Simon, M.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.