메뉴 건너뛰기




Volumn 41, Issue 9, 2016, Pages 539-545

Mirvetuximab soravtansine: FRα-targeting ADC Treatment of epithelial ovarian cancer

Author keywords

Antibody drug conjugate; Female reproductive system cancer therapy; Folate receptor alpha; IMGN 853; Mirvetuximab soravtansine; Oncolytic drugs; Ovarian cancer therapy

Indexed keywords

FOLATE RECEPTOR 1; MIRVETUXIMAB SORAVTANSINE; MONOCLONAL ANTIBODY;

EID: 84995543292     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2016.041.09.2544475     Document Type: Article
Times cited : (9)

References (34)
  • 1
    • 84961795345 scopus 로고    scopus 로고
    • American Cancer Society
    • American Cancer Society Cancer Facts & Figures. 2016.
    • (2016) Cancer Facts & Figures
  • 2
    • 84901674128 scopus 로고    scopus 로고
    • Platinum resistant ovarian cancer: What is it, who to treat and how to measure benefit?
    • Davis, A., Tinker, A.V., Friedlander, M. "Platinum resistant" ovarian cancer: what is it, who to treat and how to measure benefit? Gynecol Oncol 2014, 133(3): 624-31.
    • (2014) Gynecol Oncol , vol.133 , Issue.3 , pp. 624-631
    • Davis, A.1    Tinker, A.V.2    Friedlander, M.3
  • 3
    • 0032910470 scopus 로고    scopus 로고
    • Extending the platinum-free interval in recurrent ovarian cancer: The role of topotecan in second-line chemotherapy
    • Bookman, M.A. Extending the platinum-free interval in recurrent ovarian cancer: the role of topotecan in second-line chemotherapy. Oncologist 1999, 4(2): 87-94.
    • (1999) Oncologist , vol.4 , Issue.2 , pp. 87-94
    • Bookman, M.A.1
  • 4
    • 0026086870 scopus 로고
    • Second-line platinum therapy in patients with ovarian cancer previously treated with cisplatin
    • Markman, M., Rothman, R., Hakes, T. et al. Second-line platinum therapy in patients with ovarian cancer previously treated with cisplatin. J Clin Oncol 1991, 9(3): 389-93.
    • (1991) J Clin Oncol , vol.9 , Issue.3 , pp. 389-393
    • Markman, M.1    Rothman, R.2    Hakes, T.3
  • 5
    • 0025103224 scopus 로고
    • Treatment of relapsed carcinoma of the ovary with cisplatin or carboplatin following initial treatment with these compounds
    • Gore, M.E., Fryatt, I., Wiltshaw, E., Dawson, T. Treatment of relapsed carcinoma of the ovary with cisplatin or carboplatin following initial treatment with these compounds. Gynecol Oncol 1990, 36(2): 207-11.
    • (1990) Gynecol Oncol , vol.36 , Issue.2 , pp. 207-211
    • Gore, M.E.1    Fryatt, I.2    Wiltshaw, E.3    Dawson, T.4
  • 6
    • 0031897980 scopus 로고    scopus 로고
    • Second-line therapy with paclitaxel and carboplatin for recurrent disease following first-line therapy with paclitaxel and platinum in ovarian or peritoneal carcinoma
    • Rose, P.G., Fusco, N., Fluellen, L., Rodriguez, M. Second-line therapy with paclitaxel and carboplatin for recurrent disease following first-line therapy with paclitaxel and platinum in ovarian or peritoneal carcinoma. J Clin Oncol 1998, 16(4): 1494-7.
    • (1998) J Clin Oncol , vol.16 , Issue.4 , pp. 1494-1497
    • Rose, P.G.1    Fusco, N.2    Fluellen, L.3    Rodriguez, M.4
  • 7
    • 39749113438 scopus 로고    scopus 로고
    • Phase III trial of gemcitabine compared with pegylated liposomal doxorubicin in progressive or recurrent ovarian cancer
    • Ferrandina, G., Ludovisi, M., Lorusso, D. et al. Phase III trial of gemcitabine compared with pegylated liposomal doxorubicin in progressive or recurrent ovarian cancer. J Clin Oncol 2008, 26(6): 890-6.
    • (2008) J Clin Oncol , vol.26 , Issue.6 , pp. 890-896
    • Ferrandina, G.1    Ludovisi, M.2    Lorusso, D.3
  • 8
    • 0035879099 scopus 로고    scopus 로고
    • Recurrent epithelial ovarian carcinoma: A randomized phase III study of pegylated liposomal doxorubicin versus topotecan
    • Gordon, A.N., Fleagle, J.T., Guthrie, D., Parkin, D.E., Gore, M.E., Lacave, A.J. Recurrent epithelial ovarian carcinoma: a randomized phase III study of pegylated liposomal doxorubicin versus topotecan. J Clin Oncol 2001, 19(14): 3312-22.
    • (2001) J Clin Oncol , vol.19 , Issue.14 , pp. 3312-3322
    • Gordon, A.N.1    Fleagle, J.T.2    Guthrie, D.3    Parkin, D.E.4    Gore, M.E.5    Lacave, A.J.6
  • 9
    • 1942503303 scopus 로고    scopus 로고
    • Distribution functionality and gene regulation of folate receptor isoforms: Implications in targeted therapy
    • Elnakat, H., Ratnam, M. Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy. Adv Drug Deliv Rev 2004, 56(8): 1067-84.
    • (2004) Adv Drug Deliv Rev , vol.56 , Issue.8 , pp. 1067-1084
    • Elnakat, H.1    Ratnam, M.2
  • 10
    • 33947362046 scopus 로고    scopus 로고
    • The folate receptor: What does it promise in tissue-targeted therapeutics?
    • Salazar, M.D., Ratnam, M. The folate receptor: what does it promise in tissue-targeted therapeutics? Cancer Metastasis Rev 2007, 26(1): 141-52.
    • (2007) Cancer Metastasis Rev , vol.26 , Issue.1 , pp. 141-152
    • Salazar, M.D.1    Ratnam, M.2
  • 11
    • 84943764538 scopus 로고    scopus 로고
    • Targeting the folate receptor: Diagnostic and therapeutic approaches to personalize cancer treatments
    • Ledermann, J.A., Canevari, S., Thigpen, T. Targeting the folate receptor: diagnostic and therapeutic approaches to personalize cancer treatments. Ann Oncol 2015, 26(10): 2034-43.
    • (2015) Ann Oncol , vol.26 , Issue.10 , pp. 2034-2043
    • Ledermann, J.A.1    Canevari, S.2    Thigpen, T.3
  • 13
    • 0031944910 scopus 로고    scopus 로고
    • Expression of folate binding protein as a prognostic factor for response to platinum-containing chemotherapy and survival in human ovarian cancer
    • Toffoli, G., Russo, A., Gallo, A. et al. Expression of folate binding protein as a prognostic factor for response to platinum-containing chemotherapy and survival in human ovarian cancer. Int J Cancer 1998, 79(2): 121-6.
    • (1998) Int J Cancer , vol.79 , Issue.2 , pp. 121-126
    • Toffoli, G.1    Russo, A.2    Gallo, A.3
  • 14
    • 84904291201 scopus 로고    scopus 로고
    • Targeted drug delivery via folate receptors in recurrent ovarian cancer: A review
    • Marchetti, C., Palaia, I., Giorgini, M. et al. Targeted drug delivery via folate receptors in recurrent ovarian cancer: a review. Onco Targets Ther 2014, 7: 1223-36.
    • (2014) Onco Targets Ther , vol.7 , pp. 1223-1236
    • Marchetti, C.1    Palaia, I.2    Giorgini, M.3
  • 15
    • 84925456254 scopus 로고    scopus 로고
    • Role of the folate receptor in ovarian cancer treatment: Evidence, mechanism, and clinical implications
    • Vergote, I.B., Marth, C., Coleman, R.L. Role of the folate receptor in ovarian cancer treatment: evidence, mechanism, and clinical implications. Cancer Metastasis Rev 2015, 34(1): 41-52.
    • (2015) Cancer Metastasis Rev , vol.34 , Issue.1 , pp. 41-52
    • Vergote, I.B.1    Marth, C.2    Coleman, R.L.3
  • 16
    • 84976870682 scopus 로고    scopus 로고
    • Antibody-drug conjugates for cancer therapy
    • Thomas, A., Teicher, B.A., Hassan, R. Antibody-drug conjugates for cancer therapy. Lancet Oncol 2016, 17(6): e254-62.
    • (2016) Lancet Oncol , vol.17 , Issue.6 , pp. e254-e262
    • Thomas, A.1    Teicher, B.A.2    Hassan, R.3
  • 17
    • 84874343465 scopus 로고    scopus 로고
    • Drug-conjugated antibodies for the treatment of cancer
    • Lambert, J.M. Drug-conjugated antibodies for the treatment of cancer. Br J Clin Pharmacol 2013, 76(2): 248-62.
    • (2013) Br J Clin Pharmacol , vol.76 , Issue.2 , pp. 248-262
    • Lambert, J.M.1
  • 18
    • 84962759595 scopus 로고    scopus 로고
    • Targeting the folate receptor for the treatment of ovarian cancer
    • Lutz, R.J. Targeting the folate receptor for the treatment of ovarian cancer. Transl Cancer Res 2015, 4: 118-26.
    • (2015) Transl Cancer Res , vol.4 , pp. 118-126
    • Lutz, R.J.1
  • 19
    • 74949139946 scopus 로고    scopus 로고
    • Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates
    • Erickson, H.K., Widdison, W.C., Mayo, M.F., Whiteman, K., Audette, C., Wilhelm, S.D., Singh, R. Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates. Bioconjug Chem 2010, 21(1): 84-92.
    • (2010) Bioconjug Chem , vol.21 , Issue.1 , pp. 84-92
    • Erickson, H.K.1    Widdison, W.C.2    Mayo, M.F.3    Whiteman, K.4    Audette, C.5    Wilhelm, S.D.6    Singh, R.7
  • 20
    • 84930639143 scopus 로고    scopus 로고
    • Design of coltuximab ravtansine, a CD19-targeting antibody-drug conjugate (ADC) for the treatment of B-cell malignancies: Structure-activity relationships and preclinical evaluation
    • Hong, E.E., Erickson, H., Lutz, R.J. et al. Design of coltuximab ravtansine, a CD19-targeting antibody-drug conjugate (ADC) for the treatment of B-cell malignancies: structure-activity relationships and preclinical evaluation. Mol Pharm 2015, 12(6): 1703-16.
    • (2015) Mol Pharm , vol.12 , Issue.6 , pp. 1703-1716
    • Hong, E.E.1    Erickson, H.2    Lutz, R.J.3
  • 21
    • 84942085714 scopus 로고    scopus 로고
    • IMGN853, a folate receptoralpha (FRα)-targeting antibody-drug conjugate, exhibits potent targeted antitumor activity against FRα-expressing tumors
    • Ab, O., Whiteman, K.R., Bartle, L.M. et al. IMGN853, a folate receptoralpha (FRα)-targeting antibody-drug conjugate, exhibits potent targeted antitumor activity against FRα-expressing tumors. Mol Cancer Ther 2015, 14(7): 1605-13.
    • (2015) Mol Cancer Ther , vol.14 , Issue.7 , pp. 1605-1613
    • Ab, O.1    Whiteman, K.R.2    Bartle, L.M.3
  • 22
    • 33645500289 scopus 로고    scopus 로고
    • Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing
    • Erickson, H.K., Park, P.U., Widdison, W.C. et al. Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing. Cancer Res 2006, 66(8): 4426-33.
    • (2006) Cancer Res , vol.66 , Issue.8 , pp. 4426-4433
    • Erickson, H.K.1    Park, P.U.2    Widdison, W.C.3
  • 23
    • 33644787435 scopus 로고    scopus 로고
    • Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen
    • Kovtun, Y.V., Audette, C.A., Ye, Y. et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res 2006, 66(6): 3214-21.
    • (2006) Cancer Res , vol.66 , Issue.6 , pp. 3214-3221
    • Kovtun, Y.V.1    Audette, C.A.2    Ye, Y.3
  • 24
    • 0019515510 scopus 로고
    • Differential killing efficacy of twenty antitumor drugs on proliferating and nonproliferating human tumor cells
    • Drewinko, B., Patchen, M., Yang, L.Y., Barlogie, B. Differential killing efficacy of twenty antitumor drugs on proliferating and nonproliferating human tumor cells. Cancer Res 1981, 41(6): 2328-33.
    • (1981) Cancer Res , vol.41 , Issue.6 , pp. 2328-2333
    • Drewinko, B.1    Patchen, M.2    Yang, L.Y.3    Barlogie, B.4
  • 26
    • 84995682148 scopus 로고    scopus 로고
    • IMGN (mirvetuximab soravtansine), a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC): Single-agent activity in platinum resistant epithelial ovarian cancer (EOC) patients (pts
    • Abst 5567
    • Moore, K.N., Martin, L.P., Matulonis, U.A. et al. IMGN (mirvetuximab soravtansine), a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC): Single-agent activity in platinum resistant epithelial ovarian cancer (EOC) patients (pts). J Clin Oncol [52nd Annu Meet Am Soc Clin Oncol (ASCO) (June 3-7, Chicago) 2016] 2016, 34(Suppl.): Abst 5567.
    • (2016) J Clin Oncol [52nd Annu Meet Am Soc Clin Oncol (ASCO) (June 3-7, Chicago 2016] , vol.34
    • Moore, K.N.1    Martin, L.P.2    Matulonis, U.A.3
  • 27
    • 84906269444 scopus 로고    scopus 로고
    • Relationship of pharmacokinetics (PK), toxicity, and initial evidence of clinical activity with IMGN853, a folate receptor alpha (FRa) targeting antibody drug conjugate in patients (Pts) with epithelial ovarian cancer (EOC) and other FRa-positive solid tumors
    • Abst 5571
    • Moore, K.N., Ponte, J., LoRusso, P. et al. Relationship of pharmacokinetics (PK), toxicity, and initial evidence of clinical activity with IMGN853, a folate receptor alpha (FRa) targeting antibody drug conjugate in patients (Pts) with epithelial ovarian cancer (EOC) and other FRa-positive solid tumors. J Clin Oncol [50th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2014] 2014, 32(5s): Abst 5571.
    • (2014) J Clin Oncol [50th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago 2014] , vol.32 , Issue.5 S
    • Moore, K.N.1    Ponte, J.2    LoRusso, P.3
  • 28
    • 84903154260 scopus 로고    scopus 로고
    • A phase I, first-in-human study to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of IMGN853 in patients (Pts) with epithelial ovarian cancer (EOC) and other FOLR1-positive solid tumors
    • Abst 2573
    • Kurkjian, C., LoRusso, P., Sankhala, K.K. et al. A phase I, first-in-human study to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of IMGN853 in patients (Pts) with epithelial ovarian cancer (EOC) and other FOLR1-positive solid tumors. J Clin Oncol [49th Annu Meet Am Soc Clin Oncol (ASCO) (May 31-June 4, Chicago) 2013] 2013, 31(Suppl.): Abst 2573.
    • (2013) J Clin Oncol [49th Annu Meet Am Soc Clin Oncol (ASCO) (May 31-June 4, Chicago 2013] , vol.31
    • Kurkjian, C.1    LoRusso, P.2    Sankhala, K.K.3
  • 29
    • 84973295062 scopus 로고    scopus 로고
    • Ocular adverse events associated with antibody-drug conjugates in human clinical trials
    • Eaton, J.S., Miller, P.E., Mannis, M.J., Murphy, C.J. Ocular adverse events associated with antibody-drug conjugates in human clinical trials. J Ocul Pharmacol Ther 2015, 31(10): 589-604.
    • (2015) J Ocul Pharmacol Ther , vol.31 , Issue.10 , pp. 589-604
    • Eaton, J.S.1    Miller, P.E.2    Mannis, M.J.3    Murphy, C.J.4
  • 30
    • 84964970071 scopus 로고    scopus 로고
    • Preliminary single agent activity of IMGN853, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in platinum-resistant epithelial ovarian cancer (EOC) patients (pts): Phase i trial
    • Abst 5518
    • Moore, K.N., Martin, L.P., Seward, S.M. et al. Preliminary single agent activity of IMGN853, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in platinum-resistant epithelial ovarian cancer (EOC) patients (pts): phase I trial. J Clin Oncol [51st Annu Meet Am Soc Clin Oncol (ASCO) (May 29-June 2, Chicago) 2015] 2015, 33(Suppl.): Abst 5518.
    • (2015) J Clin Oncol [51st Annu Meet Am Soc Clin Oncol (ASCO) (May 29-June 2, Chicago 2015] , vol.33
    • Moore, K.N.1    Martin, L.P.2    Seward, S.M.3
  • 31
    • 84899837376 scopus 로고    scopus 로고
    • Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized phase III trial
    • Pujade-Lauraine, E., Hilpert, F., Weber, B. et al. Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized phase III trial. J Clin Oncol 2014, 32(13): 1302-8.
    • (2014) J Clin Oncol , vol.32 , Issue.13 , pp. 1302-1308
    • Pujade-Lauraine, E.1    Hilpert, F.2    Weber, B.3
  • 32
    • 84867114224 scopus 로고    scopus 로고
    • The impact of second to sixth line therapy on survival of relapsed ovarian cancer after primary taxane/ platinum-based therapy
    • Hanker, L.C., Loibl, S., Burchardi, N. et al. The impact of second to sixth line therapy on survival of relapsed ovarian cancer after primary taxane/ platinum-based therapy. Ann Oncol 2012, 23(10): 2605-12.
    • (2012) Ann Oncol , vol.23 , Issue.10 , pp. 2605-2612
    • Hanker, L.C.1    Loibl, S.2    Burchardi, N.3
  • 33
    • 84883377128 scopus 로고    scopus 로고
    • Targeting CD19 in B-cell lymphoma: Emerging role of SAR3419
    • Raufi, A., Ebrahim, A.S., Al-Katib, A. Targeting CD19 in B-cell lymphoma: emerging role of SAR3419. Cancer Manag Res 2013, 5: 225-33.
    • (2013) Cancer Manag Res , vol.5 , pp. 225-233
    • Raufi, A.1    Ebrahim, A.S.2    Al-Katib, A.3
  • 34
    • 67650733509 scopus 로고    scopus 로고
    • P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients
    • Tang, R., Cohen, S., Perrot, J.Y. et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer 2009, 9: 199.
    • (2009) BMC Cancer , vol.9 , pp. 199
    • Tang, R.1    Cohen, S.2    Perrot, J.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.