Partial Nephrectomy Versus Radical Nephrectomy for Clinical T1b and T2 Renal Tumors: A Systematic Review and Meta-analysis of Comparative Studies

European Urology

Volumn 71, Issue 4, 2017, Pages 606-617

  Mir, Maria Carmen ^a   Derweesh, Ithaar ^b   Porpiglia, Francesco ^c   Zargar, Homayoun ^d   Mottrie, Alexandre ^e   Autorino, Riccardo ^f  

^a HOSPITAL DEL MAR   (Spain)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO HEALTH SYSTEM   (United States)

^c UNIVERSITY OF TURIN   (Italy)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e OLV HOSPITAL   (Belgium)

^f UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

Kidney cancer; Partial nephrectomy; Radical nephrectomy; Renal function; Renal mass; Renal neoplasm

Indexed keywords

BLEEDING; CANCER STAGING; CANCER SURGERY; CHARLSON COMORBIDITY INDEX; CHRONIC KIDNEY FAILURE; ESTIMATED GLOMERULAR FILTRATION RATE; FRAILTY; HUMAN; INTERMETHOD COMPARISON; KIDNEY FUNCTION; KIDNEY TUMOR; LENGTH OF STAY; META ANALYSIS; MORTALITY; OUTCOME ASSESSMENT; PARTIAL NEPHRECTOMY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RADICAL NEPHRECTOMY; RECURRENCE RISK; REVIEW; SYSTEMATIC REVIEW; TUMOR RECURRENCE; TUMOR VOLUME; GLOMERULUS FILTRATION RATE; NEPHRECTOMY; OPERATIVE BLOOD LOSS; PATHOLOGY; POSTOPERATIVE COMPLICATION; PROCEDURES; RENAL CELL CARCINOMA; TREATMENT OUTCOME;

BLOOD LOSS, SURGICAL; CARCINOMA, RENAL CELL; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY NEOPLASMS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEPHRECTOMY; POSTOPERATIVE COMPLICATIONS; RENAL INSUFFICIENCY, CHRONIC; TREATMENT OUTCOME;

EID: 84995529469     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2016.08.060     Document Type: Review

References (60)

1. [1] Ljungberg, B., Bensalah, K., Canfield, S., et al. EAU guidelines on renal cell carcinoma: 2014 update. Eur Urol 67 (2015), 913–924.
2. [2] Campbell, S.C., Novick, A.C., Belldegrun, A., et al. Guideline for management of the clinical T1 renal mass. J Urol 182 (2009), 1271–1279.
3. [3] Lee, H.J., Liss, M.A., Derweesh, I.H., Outcomes of partial nephrectomy for clinical T1b and T2 renal tumors. Curr Opin Urol 24 (2014), 448–452.
4. [4] Huang, W.C., Levey, A.S., Serio, A.M., et al. Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study. Lancet Oncol 7 (2006), 735–740.
5. [5] Go, A.S., Chertow, G.M., Fan, D., et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351 (2004), 1296–1305.
6. [6] Scosyrev, E., Messing, E.M., Sylvester, R., Campbell, S., Van Poppel, H., Renal function after nephron-sparing surgery versus radical nephrectomy: results from EORTC randomized trial 30904. Eur Urol 65 (2014), 372–377.
7. [7] Lane, B.R., Campbell, S.C., Demirjian, S., Fergany, A.F., Surgically induced chronic kidney disease may be associated with a lower risk of progression and mortality than medical chronic kidney disease. J Urol 189 (2013), 1649–1655.
8. [8] Weight, C.J., Miller, D.C., Campbell, S.C., et al. The management of a clinical T1b renal tumor in the presence of a normal contralateral kidney. J Urol 189 (2013), 1198–1202.
9. [9] Crépel, M., Jeldres, C., Perrotte, P., et al. Nephron-sparing surgery is equally effective to radical nephrectomy for T1BN0M0 renal cell carcinoma: a population-based assessment. Urology 75 (2010), 271–275.
10. [10] Badalato, G.M., Kates, M., Wisnivesky, J.P., Choudhury, A.R., McKiernan, J.M., Survival after partial and radical nephrectomy for the treatment of stage T1bN0M0 renal cell carcinoma (RCC) in the USA: a propensity scoring approach. BJU Int 109 (2012), 1457–1462.
11. [11] Hadjipavlou, M., Khan, F., Fowler, S., et al. Partial vs radical nephrectomy for T1 renal tumours: an analysis from the British Association of Urological Surgeons Nephrectomy Audit. BJU Int 117 (2016), 62–71.
12. [12] Meskawi, M., Becker, A., Bianchi, M., et al. Partial and radical nephrectomy provide comparable long-term cancer control for T1b renal cell carcinoma. Int J Urol 21 (2014), 122–128.
13. [13] Hansen, J., Sun, M., Bianchi, M., et al. Assessment of cancer control outcomes in patients with high-risk renal cell carcinoma treated with partial nephrectomy. Urology 80 (2012), 347–353.
14. [14] Kopp, R.P., Mehrazin, R., Palazzi, K.L., et al. Survival outcomes after radical and partial nephrectomy for clinical T2 renal tumours categorised by R.E.N.A.L. nephrometry score. BJU Int 114 (2014), 708–718.
15. [15] Long, C.J., Canter, D.J., Kutikov, A., et al. Partial nephrectomy for renal masses ≥7 cm: technical, oncological and functional outcomes. BJU Int 109 (2012), 1450–1456.
16. [16] Maddox, M., Mandava, S., Liu, J., Boonjindasup, A., Lee, B.R., Robotic partial nephrectomy for clinical stage T1b tumors: intermediate oncologic and functional outcomes. Clin Genitourin Cancer 13 (2015), 94–99.
17. [17] Joniau, S., Vander Eeckt, K., Srirangam, S.J., Van Poppel, H., Outcome of nephron-sparing surgery for T1b renal cell carcinoma. BJU Int 103 (2009), 1344–1348.
18. [18] Becker, F., Roos, F.C., Janssen, M., et al. Short-term functional and oncologic outcomes of nephron-sparing surgery for renal tumours ≥7 cm. Eur Urol 59 (2011), 931–937.
19. [19] Bigot, P., Hétet, J.F., Bernhard, J.C., et al. Nephron-sparing surgery for renal tumors measuring more than 7 cm: morbidity, and functional and oncological outcomes. Clin Genitourin Cancer 12 (2014), e19–e27.
20. [20] Kim, S.P., Thompson, R.H., Boorjian, S.A., et al. Comparative effectiveness for survival and renal function of partial and radical nephrectomy for localized renal tumors: a systematic review and meta-analysis. J Urol 188 (2012), 51–57.
21. [21] Hozo, S.P., Djulbegovic, B., Hozo, I., Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol, 5, 2005, 13.
22. [22] Roos, F.C., Brenner, W., Müller, M., et al. Oncologic long-term outcome of elective nephron-sparing surgery versus radical nephrectomy in patients with renal cell carcinoma stage pT1b or greater in a matched-pair cohort. Urology 77 (2011), 803–808.
23. [23] Roos, F.C., Brenner, W., Thomas, C., et al. Functional analysis of elective nephron-sparing surgery vs radical nephrectomy for renal tumors larger than 4 cm. Urology 79 (2012), 607–613.
24. [24] Kopp, R.P., Liss, M.A., Mehrazin, R., et al. Analysis of renal functional outcomes after radical or partial nephrectomy for renal masses ≥7 cm Using the RENAL score. Urology 86 (2015), 312–319.
25. [25] Patard, J.J., Shvarts, O., Lam, J.S., et al. Safety and efficacy of partial nephrectomy for all T1 tumors based on an international multicenter experience. J Urol 171 (2004), 2181–2185.
26. [26] Dash, A., Vickers, A.J., Schachter, L.R., Bach, A.M., Snyder, M.E., Russo, P., Comparison of outcomes in elective partial vs radical nephrectomy for clear cell renal cell carcinoma of 4-7 cm. BJU Int 97 (2006), 939–945.
27. [27] Mitchell, R.E., Gilbert, S.M., Murphy, A.M., Olsson, C.A., Benson, M.C., McKiernan, J.M., Partial nephrectomy and radical nephrectomy offer similar cancer outcomes in renal cortical tumors 4 cm or larger. Urology 67 (2006), 260–264.
28. [28] Simmons, M.N., Weight, C.J., Gill, I.S., Laparoscopic radical versus partial nephrectomy for tumors >4 cm: intermediate-term oncologic and functional outcomes. Urology 73 (2009), 1077–1082.
29. [29] Antonelli, A., Cozzoli, A., Nicolai, M., et al. Nephron-sparing surgery versus radical nephrectomy in the treatment of intracapsular renal cell carcinoma up to 7 cm. Eur Urol 53 (2008), 803–809.
30. [30] Thompson, R.H., Siddiqui, S., Lohse, C.M., Leibovich, B.C., Russo, P., Blute, M.L., Partial versus radical nephrectomy for 4 to 7 cm renal cortical tumors. J Urol 182 (2009), 2601–2606.
31. [31] Weight, C.J., Larson, B.T., Fergany, A.F., et al. Nephrectomy induced chronic renal insufficiency is associated with increased risk of cardiovascular death and death from any cause in patients with localized cT1b renal masses. J Urol 183 (2010), 1317–1323.
32. [32] Deklaj, T., Lifshitz, D.A., Shikanov, S.A., Katz, M.H., Zorn, K.C., Shalhav, A.L., Laparoscopic radical versus laparoscopic partial nephrectomy for clinical T1bN0M0 renal tumors: comparison of perioperative, pathological, and functional outcomes. J Endourol 24 (2010), 1603–1607.
33. [33] Kim, J.M., Song, P.H., Kim, H.T., Park, T.C., Comparison of partial and radical nephrectomy for pT1b renal cell carcinoma. Korean J Urol 51 (2010), 596–600.
34. [34] Weight, C.J., Larson, B.T., Gao, T., et al. Elective partial nephrectomy in patients with clinical T1b renal tumors is associated with improved overall survival. Urology 76 (2010), 631–637.
35. [35] Antonelli, A., Ficarra, V., Bertini, R., et al. Elective partial nephrectomy is equivalent to radical nephrectomy in patients with clinical T1 renal cell carcinoma: results of a retrospective, comparative, multi-institutional study. BJU Int 109 (2012), 1013–1018.
36. [36] Iizuka, J., Kondo, T., Hashimoto, Y., Kobayashi, H., et al. Similar functional outcomes after partial nephrectomy for clinical T1b and T1a renal cell carcinoma. Int J Urol 19 (2012), 980–986.
37. [37] Brewer, K., O'Malley, R.L., Hayn, M., et al. Perioperative and renal function outcomes of minimally invasive partial nephrectomy for T1b and T2a kidney tumors. J Endourol 26 (2012), 244–248.
38. [38] Milonas, D., Skulčius, G., Baltrimavičius, R., et al. Comparison of long-term results after nephron-sparing surgery and radical nephrectomy in treating 4- to 7-cm renal cell carcinoma. Medicina (Kaunas) 49 (2013), 223–228.
39. [39] Pignot, G., Bigot, P., Bernhard, J.C., et al. Nephron-sparing surgery is superior to radical nephrectomy in preserving renal function benefit even when expanding indications beyond the traditional 4-cm cutoff. Urol Oncol 32 (2014), 1024–1030.
40. [40] Jang, H.A., Kim, J.W., Byun, S.S., et al. Oncologic and Functional outcomes after partial nephrectomy versus radical nephrectomy in T1b renal cell carcinoma: a multicenter, matched case-control study in Korean patients. Cancer Res Treat 48 (2016), 612–620.
41. [41] Margulis, V., Tamboli, P., Jacobsohn, K.M., Swanson, D.A., Wood, C.G., Oncological efficacy and safety of nephron-sparing surgery for selected patients with locally advanced renal cell carcinoma. BJU Int 100 (2007), 1235–1239.
42. [42] Jeldres, C., Patard, J.J., Capitanio, U., et al. Partial versus radical nephrectomy in patients with adverse clinical or pathologic characteristics. Urology 73 (2009), 1300–1305.
43. [43] Breau, R.H., Crispen, P.L., Jimenez, R.E., Lohse, C.M., Blute, M.L., Leibovich, B.C., Outcome of stage T2 or greater renal cell cancer treated with partial nephrectomy. J Urol 183 (2010), 903–908.
44. [44] Van Poppel, H., Da Pozzo, L., Albrecht, W., et al. A prospective, randomised EORTC intergroup phase 3 study comparing the oncologic outcome of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma. Eur Urol 59 (2011), 543–552.
45. [45] Makary, M.A., Segev, D.L., Pronovost, P.J., et al. Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg 210 (2010), 901–908.
46. [46] Klatte, T., Ficarra, V., Gratzke, C., et al. A literature review of renal surgical anatomy and surgical strategies for partial nephrectomy. Eur Urol 68 (2015), 980–992.
47. [47] Van Poppel, H., Da Pozzo, L., Albrecht, W., et al. A prospective randomized EORTC intergroup phase 3 study comparing the complications of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma. Eur Urol 51 (2007), 1606–1615.
48. [48] Lane, B.R., Demirjian, S., Derweesh, I.H., Riedinger, C.B., Fergany, A.F., Campbell, S.C., Is all chronic kidney disease created equal?. Curr Opin Urol 24 (2014), 127–134.
49. [49] Lane, B.R., Demirjian, S., Derweesh, I.H., et al. Survival and functional stability in chronic kidney disease due to surgical removal of nephrons: importance of the new baseline glomerular filtration rate. Eur Urol 68 (2015), 996–1003.
50. [50] Karellas, M.E., O'Brien, M.F., Jang, T.L., Bernstein, M., Russo, P., Partial nephrectomy for selected renal cortical tumours of ≥7 cm. BJU Int 106 (2010), 1484–1487.
51. [51] Peycelon, M., Hupertan, V., Comperat, E., et al. Long-term outcomes after nephron sparing surgery for renal cell carcinoma larger than 4 cm. J Urol 181 (2009), 35–41.
52. [52] Panesar, S.S., Bhandari, M., Darzi, A., Athanasiou, T., Meta-analysis: a practical decision making tool for surgeons. Int J Surg 7 (2009), 291–296.
53. [53] Zwahlen, M., Renehan, A., Egger, M., Meta-analysis in medical research: potentials and limitations. Urol Oncol 26 (2008), 320–329.
54. [54] Volpe, A., Amparore, D., Mottrie, A., Treatment outcomes of partial nephrectomy for T1b tumours. Curr Opin Urol 23 (2013), 403–410.
55. [55] Choi, J.E., You, J.H., Kim, D.K., Rha, K.H., Lee, S.H., Comparison of perioperative outcomes between robotic and laparoscopic partial nephrectomy: a systematic review and meta-analysis. Eur Urol 67 (2015), 891–901.
56. [56] Ficarra, V., Bhayani, S., Porter, J., et al. Robot-assisted partial nephrectomy for renal tumors larger than 4 cm: results of a multicenter, international series. World J Urol 30 (2012), 665–670.
57. [57] Brandao, L.F., Zargar, H., Autorino, R., et al. Robot-assisted partial nephrectomy for ≥7 cm renal masses: a comparative outcome analysis. Urology 84 (2014), 602–608.
58. [58] Gupta, G.N., Boris, R., Chung, P., Linehan, W.M., Pinto, P.A., Bratslavsky, G., Robot-assisted laparoscopic partial nephrectomy for tumors greater than 4 cm and high nephrometry score: feasibility, renal functional, and oncological outcomes with minimum 1 year follow-up. Urol Oncol 31 (2013), 51–56.
59. [59] Masson-Lecomte, A., Yates, D.R., Bensalah, K., et al. Robot-assisted laparoscopic nephron sparing surgery for tumors over 4 cm: operative results and preliminary oncologic outcomes from a multicentre French study. Eur J Surg Oncol 39 (2013), 799–803.
60. [60] Shuch, B., Amin, A., Armstrong, A.J., et al. Understanding pathologic variants of renal cell carcinoma: distilling therapeutic opportunities from biologic complexity. Eur Urol 67 (2015), 85–97.