Targeting amino acid metabolism for molecular imaging of inflammation early after myocardial infarction

Theranostics

Volumn 6, Issue 11, 2016, Pages 1768-1779

  Thackeray, James T ^a   Bankstahl, Jens P ^a   Wang, Yong ^a   Wollert, Kai C ^a   Bengel, Frank M ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

11C methionine; Inflammation; Macrophages; Myocardial infarction; Positron emission tomography (PET)

Indexed keywords

ALPHA4 INTEGRIN; CD11B ANTIGEN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; METHIONINE C 11; CARBON; METHIONINE;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIAC MUSCLE; CELL INFILTRATION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG ACCUMULATION; DRUG DISTRIBUTION; HEART LEFT VENTRICLE; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MALE; MOLECULAR IMAGING; MOUSE; NONHUMAN; REPERFUSION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; ANIMAL; C57BL MOUSE; DIAGNOSTIC IMAGING; DISEASE MODEL; HEART INFARCTION; METABOLISM; PATHOLOGY; POSITRON EMISSION TOMOGRAPHY; PROCEDURES;

ANIMALS; CARBON ISOTOPES; DISEASE MODELS, ANIMAL; INFLAMMATION; MACROPHAGES; METHIONINE; MICE; MICE, INBRED C57BL; MOLECULAR IMAGING; MYOCARDIAL INFARCTION; POSITRON-EMISSION TOMOGRAPHY;

EID: 84995466195     PISSN: None     EISSN: 18387640     Source Type: Journal    
DOI: 10.7150/thno.15929     Document Type: Article

References (42)

1. White DA, Su Y, Kanellakis P, Kiriazis H, Morand EF, Bucala R, et al. Differential roles of cardiac and leukocyte derived macrophage migration inhibitory factor in inflammatory responses and cardiac remodelling post myocardial infarction. J Mol Cell Cardiol. 2014; 69: 32-42.
2. Kempf T, Zarbock A, Widera C, Butz S, Stadtmann A, Rossaint J, et al. GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med. 2011; 17: 581-8.
3. Bengel FM, George RT, Schuleri KH, Lardo AC, Wollert KC. Image-guided therapies for myocardial repair: concepts and practical implementation. Eur Heart J Cardiovasc Imaging. 2013; 14: 741-51.
4. Nahrendorf M, Frantz S, Swirski FK, Mulder WJ, Randolph G, Ertl G, et al. Imaging systemic inflammatory networks in ischemic heart disease. J Am Coll Cardiol. 2015; 65: 1583-91.
5. Wollenweber T, Roentgen P, Schafer A, Schatka I, Zwadlo C, Brunkhorst T, et al. Characterizing the inflammatory tissue response to acute myocardial infarction by clinical multimodality noninvasive imaging. Circ Cardiovasc Imaging. 2014; 7: 811-8.
6. Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F, et al. PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol. 2012; 59: 153-63.
7. Thackeray JT, Bankstahl JP, Wang Y, Korf-Klingebiel M, Walte A, Wittneben A, et al. Targeting post-infarct inflammation by PET imaging: comparison of (68)Ga-citrate and (68)Ga-DOTATATE with (18)F-FDG in a mouse model. Eur J Nucl Med Mol Imaging. 2015; 42: 317-27.
8. Thackeray JT, Bankstahl JP, Wang Y, Wollert KC, Bengel FM. Clinically relevant strategies for lowering cardiomyocyte glucose uptake for 18F-FDG imaging of myocardial inflammation in mice. Eur J Nucl Med Mol Imaging. 2015; 42: 771-80.
9. Wykrzykowska J, Lehman S, Williams G, Parker JA, Palmer MR, Varkey S, et al. Imaging of inflamed and vulnerable plaque in coronary arteries with 18F-FDG PET/CT in patients with suppression of myocardial uptake using a low-carbohydrate, high-fat preparation. J Nucl Med. 2009; 50: 563-8.
10. Deng SM, Zhang B, Wu YW, Zhang W, Chen YY. Detection of glioma recurrence by (1)(1)C-methionine positron emission tomography and dynamic susceptibility contrast-enhanced magnetic resonance imaging: a meta-analysis. Nucl Med Commun. 2013; 34: 758-66.
11. Harris SM, Davis JC, Snyder SE, Butch ER, Vavere AL, Kocak M, et al. Evaluation of the biodistribution of 11C-methionine in children and young adults. J Nucl Med. 2013; 54: 1902-8.
12. Morooka M, Kubota K, Kadowaki H, Ito K, Okazaki O, Kashida M, et al. 11C-methionine PET of acute myocardial infarction. J Nucl Med. 2009; 50: 1283-7.
13. Taki J, Wakabayashi H, Inaki A, Imanaka-Yoshida K, Hiroe M, Ogawa K, et al. 14C-Methionine uptake as a potential marker of inflammatory processes after myocardial ischemia and reperfusion. J Nucl Med. 2013; 54: 431-6.
14. Langstrom B, Antoni G, Gullberg P, Halldin C, Malmborg P, Nagren K, et al. Synthesis of L-and D-[methyl-11C]methionine. J Nucl Med. 1987; 28: 1037-40.
15. Satomi T, Ogawa M, Mori I, Ishino S, Kubo K, Magata Y, et al. Comparison of contrast agents for atherosclerosis imaging using cultured macrophages: FDG versus ultrasmall superparamagnetic iron oxide. J Nucl Med. 2013; 54: 999-1004.
16. Korf-Klingebiel M, Reboll MR, Klede S, Brod T, Pich A, Polten F, et al. Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction. Nat Med. 2015; 21: 140-9.
17. Kuang Y, Wang F, Corn DJ, Tian H, Lee Z. In vitro characterization of uptake mechanism of L-[methyl-(3)H]-methionine in hepatocellular carcinoma. Mol Imaging Biol. 2014; 16: 459-68.
18. Korf-Klingebiel M, Kempf T, Schluter KD, Willenbockel C, Brod T, Heineke J, et al. Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction. Circulation. 2011; 123: 504-14.
19. Thackeray JT, Derlin T, Haghikia A, Napp LC, Wang Y, Ross TL, et al. Molecular Imaging of the Chemokine Receptor CXCR4 After Acute Myocardial Infarction. JACC Cardiovasc Imaging. 2015; 8: 1417-26.
20. Swirski FK, Nahrendorf M. Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science. 2013; 339: 161-6.
21. Weirather J, Hofmann UD, Beyersdorf N, Ramos GC, Vogel B, Frey A, et al. Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte/macrophage differentiation. Circ Res. 2014; 115: 55-67.
22. Hofmann U, Beyersdorf N, Weirather J, Podolskaya A, Bauersachs J, Ertl G, et al. Activation of CD4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice. Circulation. 2012; 125: 1652-63.
23. Glaudemans AW, Enting RH, Heesters MA, Dierckx RA, van Rheenen RW, Walenkamp AM, et al. Value of 11C-methionine PET in imaging brain tumours and metastases. Eur J Nucl Med Mol Imaging. 2013; 40: 615-35.
24. Kubota K. From tumor biology to clinical Pet: a review of positron emission tomography (PET) in oncology. Ann Nucl Med. 2001; 15: 471-86.
25. Fueger BJ, Czernin J, Hildebrandt I, Tran C, Halpern BS, Stout D, et al. Impact of animal handling on the results of 18F-FDG PET studies in mice. J Nucl Med. 2006; 47: 999-1006.
26. Kim EJ, Kim S, Kang DO, Seo HS. Metabolic activity of the spleen and bone marrow in patients with acute myocardial infarction evaluated by 18f-fluorodeoxyglucose positron emission tomograpic imaging. Circ Cardiovasc Imaging. 2014; 7: 454-60.
27. Yoo MY, Paeng JC, Cheon GJ, Lee DS, Chung JK, Kim EE, et al. Prognostic Value of Metabolic Tumor Volume on (11)C-Methionine PET in Predicting Progression-Free Survival in High-Grade Glioma. Nucl Med Mol Imaging. 2015; 49: 291-7.
28. Cicuendez M, Lorenzo-Bosquet C, Cuberas-Borros G, Martinez-Ricarte F, Cordero E, Martinez-Saez E, et al. Role of [(11)C] methionine positron emission tomography in the diagnosis and prediction of survival in brain tumours. Clin Neurol Neurosurg. 2015; 139: 328-33.
29. Deloar HM, Fujiwara T, Nakamura T, Itoh M, Imai D, Miyake M, et al. Estimation of internal absorbed dose of L-[methyl-11C]methionine using whole-body positron emission tomography. Eur J Nucl Med. 1998; 25: 629-33.
30. Barron HV, Harr SD, Radford MJ, Wang Y, Krumholz HM. The association between white blood cell count and acute myocardial infarction mortality in patients > or =65 years of age: findings from the cooperative cardiovascular project. J Am Coll Cardiol. 2001; 38: 1654-61.
31. Ammirati E, Cannistraci CV, Cristell NA, Vecchio V, Palini AG, Tornvall P, et al. Identification and predictive value of interleukin-6+ interleukin-10+ and interleukin-6-interleukin-10+ cytokine patterns in ST-elevation acute myocardial infarction. Circ Res. 2012; 111: 1336-48.
32. Nahrendorf M, Pittet MJ, Swirski FK. Monocytes: protagonists of infarct inflammation and repair after myocardial infarction. Circulation. 2010; 121: 2437-45.
33. Horckmans M, Ring L, Duchene J, Santovito D, Schloss MJ, Drechsler M, et al. Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype. Eur Heart J. 2016.
34. Zarbock A, Kempf T, Wollert KC, Vestweber D. Leukocyte integrin activation and deactivation: novel mechanisms of balancing inflammation. J Mol Med (Berl). 2012; 90: 353-9.
35. Kempf T, Zarbock A, Vestweber D, Wollert KC. Anti-inflammatory mechanisms and therapeutic opportunities in myocardial infarct healing. J Mol Med (Berl). 2012; 90: 361-9.
36. Rogers IS, Nasir K, Figueroa AL, Cury RC, Hoffmann U, Vermylen DA, et al. Feasibility of FDG imaging of the coronary arteries: comparison between acute coronary syndrome and stable angina. JACC Cardiovasc Imaging. 2010; 3: 388-97.
37. Piriou N, Sassier J, Pallardy A, Serfaty JM, Trochu JN. Utility of cardiac FDG-PET imaging coupled to magnetic resonance for the management of an acute myocarditis with non-informative endomyocardial biopsy. Eur Heart J Cardiovasc Imaging. 2015; 16: 574.
38. Tang R, Wang JT, Wang L, Le K, Huang Y, Hickey AJ, et al. Impact of Patient Preparation on the Diagnostic Performance of 18F-FDG PET in Cardiac Sarcoidosis: A Systematic Review and Meta-analysis. Clin Nucl Med. 2015.
39. Lapa C, Reiter T, Werner RA, Ertl G, Wester HJ, Buck AK, et al. [(68)Ga]Pentixafor-PET/CT for Imaging of Chemokine Receptor 4 Expression After Myocardial Infarction. JACC Cardiovasc Imaging. 2015; 8: 1466-8.
40. Sanchez-Crespo A, Andreo P, Larsson SA. Positron flight in human tissues and its influence on PET image spatial resolution. Eur J Nucl Med Mol Imaging. 2004; 31: 44-51.
41. Weber WA, Wester HJ, Grosu AL, Herz M, Dzewas B, Feldmann HJ, et al. O-(2-[18F]fluoroethyl)-L-tyrosine and L-[methyl-11C]methionine uptake in brain tumours: initial results of a comparative study. Eur J Nucl Med. 2000; 27: 542-9.
42. Tong X, Garofalakis A, Dubois A, Boisgard R, Duconge F, Trebossen R, et al. Co-registration of glucose metabolism with positron emission tomography and vascularity with fluorescent diffuse optical tomography in mouse tumors. EJNMMI Res. 2012; 2: 19.