메뉴 건너뛰기




Volumn 6, Issue 11, 2016, Pages 1276-1292

Long-range chromatin interactions drive mutant TERT promoter activation

Author keywords

[No Author keywords available]

Indexed keywords

GA BINDING PROTEIN; GENOMIC DNA; HISTONE; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR ETS 1; TUMOR PROMOTER; CHROMATIN; TELOMERASE; TERT PROTEIN, HUMAN;

EID: 84995407566     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-16-0177     Document Type: Article
Times cited : (125)

References (42)
  • 1
  • 2
    • 0033788565 scopus 로고    scopus 로고
    • The end of the (DNA) line
    • Blackburn EH. The end of the (DNA) line. Nat Struct Biol 2000; 7: 847-50.
    • (2000) Nat Struct Biol , vol.7 , pp. 847-850
    • Blackburn, E.H.1
  • 3
    • 77649180958 scopus 로고    scopus 로고
    • Telomeres: Protecting chromosomes against genome instability
    • O’Sullivan RJ, Karlseder J. Telomeres: Protecting chromosomes against genome instability. Nat Rev Mol Cell Biol 2010; 11: 171-81.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 171-181
    • O’Sullivan, R.J.1    Karlseder, J.2
  • 4
    • 0035584117 scopus 로고    scopus 로고
    • Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells
    • Yi X, Shay JW, Wright WE. Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells. Nucleic Acids Res 2001; 29: 4818-25.
    • (2001) Nucleic Acids Res , vol.29 , pp. 4818-4825
    • Yi, X.1    Shay, J.W.2    Wright, W.E.3
  • 5
    • 19844382620 scopus 로고    scopus 로고
    • Senescence and immortalization: Role of telomeres and telomerase
    • Shay JW, Wright WE. Senescence and immortalization: Role of telomeres and telomerase. Carcinogenesis 2005; 26: 867-74.
    • (2005) Carcinogenesis , vol.26 , pp. 867-874
    • Shay, J.W.1    Wright, W.E.2
  • 8
    • 84876067164 scopus 로고    scopus 로고
    • TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
    • Killela PJ, Reitman ZJ, Jiao Y, Bettegowda C, Agrawal N, Diaz LA Jr, et al. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci USA 2013; 110: 6021-6.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 6021-6026
    • Killela, P.J.1    Reitman, Z.J.2    Jiao, Y.3    Bettegowda, C.4    Agrawal, N.5    Diaz Jr, L.A.6
  • 11
    • 84930677573 scopus 로고    scopus 로고
    • Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer
    • Bell RJ, Rube HT, Kreig A, Mancini A, Fouse SD, Nagarajan R P, et al. Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer. Science 2015; 348: 1036-9.
    • (2015) Science , vol.348 , pp. 1036-1039
    • Bell, R.J.1    Rube, H.T.2    Kreig, A.3    Mancini, A.4    Fouse, S.D.5    Nagarajan, R.P.6
  • 12
    • 84879493810 scopus 로고    scopus 로고
    • Epigenetic regulation of the human telomerase reverse transciptase gene: A potential therapeutic target for the treatment of leukemia (Review)
    • Sui X, Kong N, Wang Z, Pan H. Epigenetic regulation of the human telomerase reverse transciptase gene: A potential therapeutic target for the treatment of leukemia (Review). Oncol Lett 2013; 6: 317-22.
    • (2013) Oncol Lett , vol.6 , pp. 317-322
    • Sui, X.1    Kong, N.2    Wang, Z.3    Pan, H.4
  • 13
    • 84946712059 scopus 로고    scopus 로고
    • Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers
    • Stern JL, Theodorescu D, Vogelstein B, Papadopoulos N, Cech TR. Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers. Genes Dev 2015; 29: 2219-24.
    • (2015) Genes Dev , vol.29 , pp. 2219-2224
    • Stern, J.L.1    Theodorescu, D.2    Vogelstein, B.3    Papadopoulos, N.4    Cech, T.R.5
  • 14
    • 79959466181 scopus 로고    scopus 로고
    • Genomic and biochemical insights into the specificity of ETS transcription factors
    • Hollenhorst PC, McIntosh LP, Graves BJ. Genomic and biochemical insights into the specificity of ETS transcription factors. Annu Rev Biochem 2011; 80: 437-71.
    • (2011) Annu Rev Biochem , vol.80 , pp. 437-471
    • Hollenhorst, P.C.1    McIntosh, L.P.2    Graves, B.J.3
  • 16
    • 0034141710 scopus 로고    scopus 로고
    • Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition
    • Cowley DO, Graves BJ. Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition. Genes Dev 2000; 14: 366-76.
    • (2000) Genes Dev , vol.14 , pp. 366-376
    • Cowley, D.O.1    Graves, B.J.2
  • 17
    • 0034677922 scopus 로고    scopus 로고
    • The alpha and beta subunits of the GA-binding protein form a stable heterodimer in solution. Revised model of heterotetrameric complex assembly
    • Chinenov Y, Henzl M, Martin ME. The alpha and beta subunits of the GA-binding protein form a stable heterodimer in solution. Revised model of heterotetrameric complex assembly. J Biol Chem 2000; 275: 7749-56.
    • (2000) J Biol Chem , vol.275 , pp. 7749-7756
    • Chinenov, Y.1    Henzl, M.2    Martin, M.E.3
  • 18
    • 84942986703 scopus 로고    scopus 로고
    • Non-canonical NF-kappaB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation
    • Li Y, Zhou QL, Sun W, Chandrasekharan P, Cheng HS, Ying Z, et al. Non-canonical NF-kappaB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation. Nat Cell Biol 2015; 17: 1327-38.
    • (2015) Nat Cell Biol , vol.17 , pp. 1327-1338
    • Li, Y.1    Zhou, Q.L.2    Sun, W.3    Chandrasekharan, P.4    Cheng, H.S.5    Ying, Z.6
  • 19
    • 84881436148 scopus 로고    scopus 로고
    • High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions
    • Nault JC, Mallet M, Pilati C, Calderaro J, Bioulac-Sage P, Laurent C, et al. High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions. Nat Commun 2013; 4: 2218.
    • (2013) Nat Commun , vol.4 , pp. 2218
    • Nault, J.C.1    Mallet, M.2    Pilati, C.3    Calderaro, J.4    Bioulac-Sage, P.5    Laurent, C.6
  • 20
    • 84942512008 scopus 로고    scopus 로고
    • Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells
    • Barutcu AR, Lajoie BR, McCord RP, Tye CE, Hong D, Messier T L, et al. Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells. Genome Biol 2015; 16: 214.
    • (2015) Genome Biol , vol.16 , pp. 214
    • Barutcu, A.R.1    Lajoie, B.R.2    McCord, R.P.3    Tye, C.E.4    Hong, D.5    Messier, T.L.6
  • 21
    • 33750203582 scopus 로고    scopus 로고
    • Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra-and interchromosomal interactions
    • Zhao Z, Tavoosidana G, Sjolinder M, Gondor A, Mariano P, Wang S, et al. Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra-and interchromosomal interactions. Nat Genet 2006; 38: 1341-7.
    • (2006) Nat Genet , vol.38 , pp. 1341-1347
    • Zhao, Z.1    Tavoosidana, G.2    Sjolinder, M.3    Gondor, A.4    Mariano, P.5    Wang, S.6
  • 22
    • 0029162563 scopus 로고
    • Telomere elongation in immortal human cells without detectable telomerase activity
    • Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 1995; 14: 4240-8.
    • (1995) EMBO J , vol.14 , pp. 4240-4248
    • Bryan, T.M.1    Englezou, A.2    Gupta, J.3    Bacchetti, S.4    Reddel, R.R.5
  • 23
    • 84976884426 scopus 로고    scopus 로고
    • JASPAR 2016: A major expansion and update of the open-access database of transcription factor binding profiles
    • Mathelier A, Fornes O, Arenillas DJ, Chen CY, Denay G, Lee J, et al. JASPAR 2016: A major expansion and update of the open-access database of transcription factor binding profiles. Nucleic Acids Res 2016; 44: D110-5.
    • (2016) Nucleic Acids Res , vol.44 , pp. D110-D115
    • Mathelier, A.1    Fornes, O.2    Arenillas, D.J.3    Chen, C.Y.4    Denay, G.5    Lee, J.6
  • 24
    • 0041806599 scopus 로고    scopus 로고
    • The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis
    • Dey A, Chitsaz F, Abbasi A, Misteli T, Ozato K. The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis. Proc Natl Acad Sci USA 2003; 100: 8758-63.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8758-8763
    • Dey, A.1    Chitsaz, F.2    Abbasi, A.3    Misteli, T.4    Ozato, K.5
  • 25
    • 84903712622 scopus 로고    scopus 로고
    • BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma
    • Bhadury J, Nilsson LM, Muralidharan SV, Green LC, Li Z, Gesner EM, et al. BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma. Proc Natl Acad Sci USA 2014; 111: E2721-30.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E2721-E2730
    • Bhadury, J.1    Nilsson, L.M.2    Muralidharan, S.V.3    Green, L.C.4    Li, Z.5    Gesner, E.M.6
  • 29
    • 68249156463 scopus 로고    scopus 로고
    • Formation of a unique endto-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex interactive ligands
    • Palumbo SL, Ebbinghaus SW, Hurley LH. Formation of a unique endto-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex interactive ligands. J Am Chem Soc 2009; 131: 10878-91.
    • (2009) J Am Chem Soc , vol.131 , pp. 10878-10891
    • Palumbo, S.L.1    Ebbinghaus, S.W.2    Hurley, L.H.3
  • 31
    • 84929000151 scopus 로고    scopus 로고
    • Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity
    • Koh CM, Khattar E, Leow SC, Liu CY, Muller J, Ang WX, et al. Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity. J Clin Invest 2015; 125: 2109-22.
    • (2015) J Clin Invest , vol.125 , pp. 2109-2122
    • Koh, C.M.1    Khattar, E.2    Leow, S.C.3    Liu, C.Y.4    Muller, J.5    Ang, W.X.6
  • 33
    • 84921334204 scopus 로고    scopus 로고
    • Dual roles of c-Myc in the regulation of hTERT gene
    • Zhao Y, Cheng D, Wang S, Zhu J. Dual roles of c-Myc in the regulation of hTERT gene. Nucleic Acids Res 2014; 42: 10385-98.
    • (2014) Nucleic Acids Res , vol.42 , pp. 10385-10398
    • Zhao, Y.1    Cheng, D.2    Wang, S.3    Zhu, J.4
  • 34
    • 84870310006 scopus 로고    scopus 로고
    • Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: From fixation to computation
    • Splinter E, de Wit E, van de Werken HJ, Klous P, de Laat W. Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: from fixation to computation. Methods 2012; 58: 221-30.
    • (2012) Methods , vol.58 , pp. 221-230
    • Splinter, E.1    de Wit, E.2    van de Werken, H.J.3    Klous, P.4    de Laat, W.5
  • 36
    • 84995438420 scopus 로고    scopus 로고
    • Available from, Date accessed: October 26
    • Buffalo V. Scythe 2012. Available from: https://github.com/vsbuffalo/ scythe. Date accessed: October 26, 2015.
    • (2015) Scythe 2012
    • Buffalo, V.1
  • 37
    • 84926382871 scopus 로고    scopus 로고
    • TagDust2: A generic method to extract reads from sequencing data
    • Lassmann T. TagDust2: A generic method to extract reads from sequencing data. BMC Bioinformatics 2015; 16: 24.
    • (2015) BMC Bioinformatics , vol.16 , pp. 24
    • Lassmann, T.1
  • 38
    • 84859210032 scopus 로고    scopus 로고
    • Fast gapped-read alignment with Bowtie 2
    • Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2. Nat Methods 2012; 9: 357-9.
    • (2012) Nat Methods , vol.9 , pp. 357-359
    • Langmead, B.1    Salzberg, S.L.2
  • 39
    • 84880531963 scopus 로고    scopus 로고
    • R3Cseq: An R/Bioconductor package for the discovery of long-range genomic interactions from chromosome conformation capture and next-generation sequencing data
    • Thongjuea S, Stadhouders R, Grosveld FG, Soler E, Lenhard B. r3Cseq: an R/Bioconductor package for the discovery of long-range genomic interactions from chromosome conformation capture and next-generation sequencing data. Nucleic Acids Res 2013; 41: e132.
    • (2013) Nucleic Acids Res , vol.41
    • Thongjuea, S.1    Stadhouders, R.2    Grosveld, F.G.3    Soler, E.4    Lenhard, B.5
  • 41
    • 34548565667 scopus 로고    scopus 로고
    • Quantitative analysis of chromosome conformation capture assays (3C-qPCR)
    • Hagege H, Klous P, Braem C, Splinter E, Dekker J, Cathala G, et al. Quantitative analysis of chromosome conformation capture assays (3C-qPCR). Nat Protoc 2007; 2: 1722-33.
    • (2007) Nat Protoc , vol.2 , pp. 1722-1733
    • Hagege, H.1    Klous, P.2    Braem, C.3    Splinter, E.4    Dekker, J.5    Cathala, G.6
  • 42
    • 84930973562 scopus 로고    scopus 로고
    • Quantitative assessment of telomerase components in cancer cell lines
    • Akincilar SC, Low KC, Liu CY, Yan TD, Oji A, Ikawa M, et al. Quantitative assessment of telomerase components in cancer cell lines. FEBS Lett 2015; 589: 974-84.
    • (2015) FEBS Lett , vol.589 , pp. 974-984
    • Akincilar, S.C.1    Low, K.C.2    Liu, C.Y.3    Yan, T.D.4    Oji, A.5    Ikawa, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.