The influence of CKD on colonic microbial metabolism

Journal of the American Society of Nephrology

Volumn 27, Issue 5, 2016, Pages 1389-1399

  Poesen, Ruben ^a   Windey, Karen ^b   Neven, Ellen ^c   Kuypers, Dirk ^a   De Preter, Vicky ^b   Augustijns, Patrick ^d   D'Haese, Patrick ^c   Evenepoel, Pieter ^a   Verbeke, Kristin ^b   Meijers, Björn ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY OF ANTWERP   (Belgium)

^d DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATE BINDING AGENT; VOLATILE ORGANIC COMPOUND;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; COLON FLORA; CONFERENCE PAPER; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; HEMODIALYSIS; HEMODIALYSIS PATIENT; HOUSEHOLD; HUMAN; KIDNEY FUNCTION; MAINTENANCE THERAPY; MALE; MASS FRAGMENTOGRAPHY; METABOLITE; MICROBIAL METABOLISM; NEPHRECTOMY; NONHUMAN; NUTRITIONAL COUNSELING; PRIORITY JOURNAL; RAT; ANIMAL; COLON; METABOLISM; MICROBIOLOGY; MICROFLORA; MIDDLE AGED; RENAL INSUFFICIENCY, CHRONIC; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; COLON; FEMALE; HUMANS; MALE; MICROBIOTA; MIDDLE AGED; RATS; RENAL DIALYSIS; RENAL INSUFFICIENCY, CHRONIC; YOUNG ADULT;

EID: 84995369690     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2015030279     Document Type: Conference Paper

References (37)

1. Shanahan F: The gut microbiota in 2011: Translating the microbiota to medicine. Nat Rev Gastroenterol Hepatol 9: 72-74, 2012
2. Wikoff WR, Anfora AT, Liu J, Schultz PG, Lesley SA, Peters EC, Siuzdak G: Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A 106: 3698-3703, 2009
3. Aronov PA, Luo FJ, Plummer NS, Quan Z, Holmes S, Hostetter TH, Meyer TW: Colonic contribution to uremic solutes. J Am Soc Nephrol 22: 1769-1776, 2011
4. Meyer TW, Hostetter TH: Uremic solutes from colon microbes. Kidney Int 81: 949-954, 2012
5. Evenepoel P, Meijers BK, Bammens BR, Verbeke K: Uremic toxins originating from colonic microbial metabolism. Kidney Int Suppl 114: S12-S19, 2009
6. Meijers BK, Claes K, Bammens B, de Loor H, Viaene L, Verbeke K, Kuypers D, Vanrenterghem Y, Evenepoel P: p-Cresol and cardiovascular risk inmild-to-moderate kidney disease. Clin J AmSoc Nephrol 5: 1182-1189, 2010
7. Barreto FC, Barreto DV, Liabeuf S, Meert N, Glorieux G, Temmar M, Choukroun G, Vanholder R, Massy ZA; European Uremic Toxin Work Group (EUTox): Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clin J Am Soc Nephrol 4: 1551-1558, 2009
8. Poesen R, Viaene L, Verbeke K, Claes K, Bammens B, Sprangers B, Naesens M, Vanrenterghem Y, Kuypers D, Evenepoel P, Meijers B: Renal clearance and intestinal generation of p-cresyl sulfate and indoxyl sulfate in CKD. Clin J Am Soc Nephrol 8: 1508-1514, 2013
9. Meijers BK, Evenepoel P: The gut-kidney axis: indoxyl sulfate, p-cresyl sulfate andCKDprogression. NephrolDial Transplant 26: 759-761, 2011
10. Vaziri ND, Wong J, Pahl M, Piceno YM, Yuan J, DeSantis TZ, Ni Z, Nguyen TH, Andersen GL: Chronic kidney disease alters intestinal microbial flora. Kidney Int 83: 308-315, 2013
11. Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R: Diversity, stability and resilience of the human gut microbiota. Nature 489: 220-230, 2012
12. Macfarlane GT, Macfarlane S: Models for intestinal fermentation: association between food components, delivery systems, bioavailability and functional interactions in the gut. Curr Opin Biotechnol 18: 156-162, 2007
13. Smith EA, Macfarlane GT: Enumeration of human colonic bacteria producing phenolic and indolic compounds: effects of pH, carbohydrate availability and retention time on dissimilatory aromatic amino acid metabolism. J Appl Bacteriol 81: 288-302, 1996
14. Cummings JH, Hill MJ, Bone ES, Branch WJ, Jenkins DJ: The effect of meat protein and dietary fiber on colonic function and metabolism. II. Bacterial metabolites in feces and urine. Am J Clin Nutr 32: 2094-2101, 1979
15. Bammens B, Verbeke K, Vanrenterghem Y, Evenepoel P: Evidence for impaired assimilation of protein in chronic renal failure. Kidney Int 64: 2196-2203, 2003
16. Wu MJ, Chang CS, Cheng CH, Chen CH, Lee WC, Hsu YH, Shu KH, Tang MJ: Colonic transit time in long-term dialysis patients. Am J Kidney Dis 44: 322-327, 2004
17. Kalantar-Zadeh K, Kopple JD, Deepak S, Block D, Block G: Food intake characteristics of hemodialysis patients as obtained by food frequency questionnaire. J Ren Nutr 12: 17-31, 2002
18. De Preter V, Van Staeyen G, Esser D, Rutgeerts P, Verbeke K: Development of a screening method to determine the pattern of fermentation metabolites in faecal samples using on-line purge-and-trap gas chromatographic-mass spectrometric analysis. J Chromatogr A 1216: 1476-1483, 2009
19. Bammens B, Evenepoel P, Keuleers H, Verbeke K, Vanrenterghem Y: Free serum concentrations of the protein-bound retention solute pcresol predict mortality in hemodialysis patients. Kidney Int 69: 1081-1087, 2006
20. Liabeuf S, Barreto DV, Barreto FC, Meert N, Glorieux G, Schepers E, Temmar M, Choukroun G, Vanholder R, Massy ZA; European Uraemic Toxin Work Group (EUTox): Free p-cresylsulphate is a predictor of mortality in patients at different stages of chronic kidney disease. Nephrol Dial Transplant 25: 1183-1191, 2010
21. Meijers BK, Bammens B, De Moor B, Verbeke K, Vanrenterghem Y, Evenepoel P: Free p-cresol is associated with cardiovascular disease in hemodialysis patients. Kidney Int 73: 1174-1180, 2008
22. Wu IW, Hsu KH, Lee CC, Sun CY, Hsu HJ, Tsai CJ, Tzen CY, Wang YC, Lin CY, Wu MS: p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease. Nephrol Dial Transplant 26: 938-947, 2011
23. Wong J, Piceno YM, Desantis TZ, Pahl M, Andersen GL, Vaziri ND: Expansion of urease-and uricase-containing, indole-and p-cresolforming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD. Am J Nephrol 39: 230-237, 2014
24. Magnusson M, Magnusson KE, Sundqvist T, Denneberg T: Impaired intestinal barrier function measured by differently sized polyethylene glycols in patients with chronic renal failure. Gut 32: 754-759, 1991
25. Vaziri ND, Yuan J, Rahimi A, Ni Z, Said H, Subramanian VS: Disintegration of colonic epithelial tight junction in uremia: a likely cause of CKD-associated inflammation. Nephrol Dial Transplant 27: 2686-2693, 2012
26. McIntyre CW, Harrison LE, Eldehni MT, Jefferies HJ, Szeto CC, John SG, SigristMK, Burton JO, Hothi D, Korsheed S,Owen PJ, Lai KB, Li PK: Circulating endotoxemia: a novel factor in systemic inflammation and cardiovascular disease in chronic kidney disease. Clin J Am Soc Nephrol 6: 133-141, 2011
27. Song SJ, Lauber C, Costello EK, Lozupone CA, Humphrey G, Berg-Lyons D, Caporaso JG, Knights D, Clemente JC, Nakielny S, Gordon JI, Fierer N, Knight R: Cohabiting family members share microbiota with one another and with their dogs. eLife 2: e00458, 2013
28. Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, ContrerasM,Magris M, Hidalgo G, Baldassano RN, Anokhin AP, Heath AC, Warner B, Reeder J, Kuczynski J, Caporaso JG, Lozupone CA, Lauber C, Clemente JC, Knights D, Knight R, Gordon JI: Human gut microbiome viewed across age and geography. Nature 486: 222-227, 2012
29. Lax S, Smith DP, Hampton-Marcell J, Owens SM, Handley KM, Scott NM, Gibbons SM, Larsen P, Shogan BD, Weiss S, Metcalf JL, Ursell LK, Vázquez-Baeza Y, Van Treuren W, Hasan NA, Gibson MK, Colwell R, Dantas G, Knight R, Gilbert JA: Longitudinal analysis of microbial interaction between humans and the indoor environment. Science 345: 1048-1052, 2014
30. Tung J, Barreiro LB, Burns MB, Grenier JC, Lynch J, Grieneisen LE, Altmann J, Alberts SC, Blekhman R, Archie EA: Social networks predict gut microbiome composition in wild baboons. eLife 4: 05224, 2015
31. Meinardi S, Jin KB, Barletta B, Blake DR, Vaziri ND: Exhaled breath and fecal volatile organic biomarkers of chronic kidney disease. Biochim Biophys Acta 1830: 2531-2537, 2013
32. Tremaroli V, Bäckhed F: Functional interactions between the gut microbiota and host metabolism. Nature 489: 242-249, 2012
33. Meijers BK, De Preter V, Verbeke K, Vanrenterghem Y, Evenepoel P: p-Cresyl sulfate serum concentrations in haemodialysis patients are reduced by the prebiotic oligofructose-enriched inulin. Nephrol Dial Transplant 25: 219-224, 2010
34. HidaM,Aiba Y, Sawamura S, SuzukiN, Satoh T, Koga Y: Inhibition of the accumulation of uremic toxins in the blood and their precursors in the feces after oral administration of Lebenin, a lactic acid bacteria preparation, to uremic patients undergoing hemodialysis. Nephron 74: 349-355, 1996
35. Takayama F, Taki K, Niwa T: Bifidobacterium in gastro-resistant seamless capsule reduces serum levels of indoxyl sulfate in patients on hemodialysis. Am J Kidney Dis 41[Suppl 1]: S142-S145, 2003
36. De Preter V,Ghebretinsae AH, Abrahantes JC,Windey K, Rutgeerts P, Verbeke K: Impact of the synbiotic combination of Lactobacillus casei shirota and oligofructose-enriched inulin on the fecal volatile metabolite profile in healthy subjects. Mol Nutr Food Res 55: 714-722, 2011
37. Benjamini Y, Hochberg Y: Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. J R Stat Soc, Series B 57: 289-300, 1995