Inhibition of the accumulation of uremic toxins in the blood and their precursors in the feces after oral administration of lebenin®, a lactic acid bacteria preparation, to uremic patients undergoing hemodialysis?

Nephron

Volumn 74, Issue 2, 1996, Pages 349-355

  Hida, Miho ^a   Aiba, Yuji ^c   Sawamura, Sadaaki ^b   Suzuki, Nobuyuki ^c   Satoh, Takeshi ^a   Koga, Yasuhiro ^b  

^a Tokai University   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Sagami Research Laboratories   (Japan)

Author keywords

Indican; Indole; Intestinal microflora; Lactic acid bacteria; Phenols; Stool

Indexed keywords

INDICAN; LEBENIN; PARA CRESOL; PHENOL DERIVATIVE; UNCLASSIFIED DRUG; UREMIC TOXIN;

ADULT; AEROBIC BACTERIUM; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL OVERGROWTH; BIOACCUMULATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FECES; FECES MICROFLORA; FEMALE; HEMODIALYSIS; HUMAN; INTESTINE FLORA; LACTIC ACID BACTERIUM; MALE; ORAL DRUG ADMINISTRATION; PRECURSOR; PRIORITY JOURNAL; UREMIA;

ADMINISTRATION, ORAL; ADULT; BACTERIA, AEROBIC; BACTERIA, ANAEROBIC; BIFIDOBACTERIUM; CAPSULES; CRESOLS; ENTEROCOCCUS FAECALIS; FECES; FEMALE; HUMANS; INDICAN; LACTOBACILLUS ACIDOPHILUS; MALE; MIDDLE AGED; PHENOL; PHENOLS; RENAL DIALYSIS; UREMIA;

EID: 0029834566     PISSN: 16608151     EISSN: 22353186     Source Type: Journal    
DOI: 10.1159/000189334     Document Type: Article

References (27)

1. Wardlcr EN: A study of the possible toxic metabolites of uremia on red cell metabolism. Acta Haematol 1970:43:129-143.
2. Muting D: Studies on the pathogenesis of uremia: Comparative determination of glucoronic acid, indican. free and bound phenols in the scrum, cerebrospinal fluid, and urine of renal diseases with and without uremia. Clin Chirn Acta 1965:12:551-554.
3. Rabincr SF. Molinas F: The role of phenol and phenolic acids on the thrombocytopathv and defective platelet aggregation of patients with renal failure. Am J Med 1970:49:346-351.
4. Bone E, Tamrna A. Hill M: The production of urinary phenols by gut bacteria and their possible role in the causation of large bowel cancer. Am J Clin Nutr 1976:29:1448-1454.
5. Wardle EN. Wilkinson K: Free phenols in chronic renal failure. Clin Nephrol 1976:6: 361-364.
6. Bowmer CJ, Lindup WE: Decreased drug binding in uremia: Effect of indoxyl sulphate and other endogenous substances on the drugs and dyes to human albumin. Biochem Pharmacol 1982:31:319-323.
7. Kawashima Y: Study on the uremic protein binding inhibitors as uremic toxin: Toxic effect on ervthroid colony formation, lymphocyte blast formation and renal function. Jpn J Nephrol 1989:31:47-57.
8. Rauschenbakh MO. Zharova EI. Protasova TCI: Blastomogenic properties of certain metabolites of tryptophan. Acta Unio lnt Contra Cancrum 1963:19:660.
9. Oyasu R. Kitajima T. Hopp ML. Sumie H: Enhancement of urinary bladder tumorigencsis in hamsters by coadministration of 2-acetyl-aminofluorcne and indole. Cancer Res 1972; 32:2027-2033.
10. Wengle B. Hcllslrom K: Volatile phenols in scrum of uremic patients. Clin Sei 1972:43: 493-498.
11. Niwa T. Macda K. Ohki T. Saito A. Kobayashi K: A gas chromatographic-mass spcctromelric analysis for phenols in uremic scrum. Clin Chitii Acta 1981:110:51-57.
12. Schuck O. Vidlakova M. Erben J. Nadvorni-kova H. Tcplan V. Reitschlagerova V: The plasma concentration and renal elimination of phenols in patients with chronic renal insufficiency. Czech Med 1989:12:117-124.
13. Schuck O. Vidlakova M. Erben J: Renal excretion of phenols in patients with chronic renal insufficiency. Nephron 1989:53:279-280.
14. Niwa T: Phenol and p-cresol accumulated in uremic scrum measured by HPLC with fluorescence detection. Clin Chem 1993:39:108- 111.
15. Niwa T. Takeda N. Tatcmatsu A. Macda K: Accumulation of indoxyl sulfate, an inhibitor of drug binding, in uremic serum as demonstrated by internal-surface rcverscd-phasc liquid chromatography. Clin Chem 1988:34: 2264-2267.
16. Niwa T. Yazawa T. Kodama T, Uchara Y, Macda K, Yamada K: Efficient removal of albumin-bound furancarboxylic acid, an inhibitor of erythropoicsis. by continuous ambulatory peritoneal dialysis. Nephron 1990:56:241- 245.
17. Tanaka R. Kan T. Tejima H. Kuroshima T, Kodaira S. Suzuki S. Terashima N. Mutai M: Effects on the fecal flora by the administration of II bifidum 4007 and II breve 4006 in infant and adult. Jpn J Pediatr 1980:33:2483-2492.
18. Yamashita M. Fujisaki M. Oogushi H. Kai H. Uchida S: Effects on the fecal flora by the administration of 3 kinds of Lactobactcriaccae (in Japanese). Clin Microbiol 1986:13:729- 738.
19. Yoshihara I: Simultaneous gas chromatographic microdetermination of indole, skatol and p- cresol in gastrointestinal contents of domestic animals. Agric Biol Chem 1979:43:1985- 1987.
20. Takeda N. Niwa K. Maeda K. Shibata M. Tate-matsu A: Rapid assay for indoxyl sulfate in uremic scrum by intestinal-surfacc reversed-phase high-performance liquid chromatography. J Chromatogr 1988:431:418-423.
21. Benno Y. Mitsuoka T: Impact oBifidobacterium longiim on human fecal microflora. Microbiol Immunol 1992;36:683-694.
22. Mitsuoka T. Sega T. Yamamoto Y: Eine ver-bessele Methodik der qualitativen und quantitativen Analyse der Darmllora von Menschen und Tieren. Zcntralbl Bakteriol Parasitcnkd Infektionskr Hyg I Abt Orig 1965.A 195:455-469.
23. Bakke OM: Studies on the degradation of tyrosine bv rat caecal contents. Scand J Gastroenterol 1969:4:603-608.
24. Holdeman LV. Cato EP. Moore WEC: Anaerobic Laboratory' Manual, ed 4. Blacksburg. Anaerobe Laboratory. Virginia Polytechnic Institute and State University, 1977.
25. Ohashi N. Kiyona H: Cresol and phenol poisoning. Jpn J Acute Med 1988;12:1342-1346.
26. Niwa T. Miyazaki T. Hashimoto N. Hayashi H. Isc M. Uhara Y. Maeda K: Suppressed scrum and urine levels of indoxyl sulfate by oral sorbent in experimental uremic rats. Am J Nephrol 1992;12:201-206.
27. Niwa T. Emoto Y. Maeda K. Uehara Y. Yamada N. Shibata M: Oral sorbent suppresses accumulation of albumin-bound indoxyl sulphate in serum of haemodialysis patients. Nephrol Dial Ttransplant 1991:6:105-109.