Neonatal Fc receptor FcRn is involved in intracellular transport of the Fc fusion protein aflibercept and its transition through retinal endothelial cells

Experimental Eye Research

Volumn 154, Issue , 2017, Pages 39-46

  Deissler, Heidrun L ^a   Lang, Gerhard K ^a   Lang, Gabriele E ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Aflibercept; Fc fusion protein; IgG; Internalization; Neonatal Fc receptor; Retinal endothelial cells; Transcytosis; Transport

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; AFLIBERCEPT; FC RECEPTOR; IMMUNOGLOBULIN G; NEONATAL FC RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN A; PROTEIN G; UNCLASSIFIED DRUG; FC RECEPTOR, NEONATAL; HLA ANTIGEN CLASS 1; HYBRID PROTEIN; RNA; VASCULOTROPIN RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG PROTEIN BINDING; DRUG UPTAKE; ENDOSOME; ENDOTHELIUM CELL; ENZYME INHIBITION; EXOCYTOSIS; HUMAN; IMMUNOFLUORESCENCE; IN VITRO STUDY; INTRACELLULAR TRANSPORT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; RAT; RETINAL ENDOTHELIAL CELL; RETINAL PIGMENT EPITHELIUM; TEMPERATURE DEPENDENCE; TRANSCYTOSIS; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL LINE; CYTOLOGY; DIABETIC RETINOPATHY; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; RABBITS AND HARES; RETINA;

ANIMALS; BLOTTING, WESTERN; CELL LINE; DIABETIC RETINOPATHY; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MICE; RABBITS; RECEPTORS, FC; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; RETINA; RNA; TRANSCYTOSIS;

EID: 84994899510     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2016.11.007     Document Type: Article

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