-
1
-
-
84920703518
-
Causes of death C. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the global burden of disease study 2013
-
Mortality GBD. Causes of death C. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the global burden of disease study 2013. Lancet. 2015;385:117–71.
-
(2015)
Lancet
, vol.385
, pp. 117-171
-
-
Mortality, G.B.D.1
-
2
-
-
84871055775
-
A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the global burden of disease study 2010
-
Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the global burden of disease study 2010. Lancet. 2012;380:2224–60.
-
(2012)
Lancet
, vol.380
, pp. 2224-2260
-
-
Lim, S.S.1
Vos, T.2
Flaxman, A.D.3
Danaei, G.4
Shibuya, K.5
Adair-Rohani, H.6
-
3
-
-
0031733696
-
Clinical epidemiology of cardiovascular disease in chronic renal disease
-
COI: 1:STN:280:DyaK1M%2Fjs1emtA%3D%3D
-
Foley RN, Parfrey PS, Sarnak MJ. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis. 1998;32:S112–9.
-
(1998)
Am J Kidney Dis
, vol.32
, pp. S112-S119
-
-
Foley, R.N.1
Parfrey, P.S.2
Sarnak, M.J.3
-
4
-
-
84884547666
-
Prevalence of hypertension and obesity in patients with type 2 diabetes mellitus in observational studies: a systematic literature review
-
Colosia AD, Palencia R, Khan S. Prevalence of hypertension and obesity in patients with type 2 diabetes mellitus in observational studies: a systematic literature review. Diabetes Metab Syndr Obes. 2013;6:327–38.
-
(2013)
Diabetes Metab Syndr Obes
, vol.6
, pp. 327-338
-
-
Colosia, A.D.1
Palencia, R.2
Khan, S.3
-
5
-
-
0034641550
-
Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study
-
COI: 1:STN:280:DC%2BD3cvisFWnsw%3D%3D
-
Adler AI, Stratton IM, Neil HA, Yudkin JS, Matthews DR, Cull CA, et al. Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study. BMJ. 2000;321:412–9.
-
(2000)
BMJ
, vol.321
, pp. 412-419
-
-
Adler, A.I.1
Stratton, I.M.2
Neil, H.A.3
Yudkin, J.S.4
Matthews, D.R.5
Cull, C.A.6
-
6
-
-
84960094179
-
Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis
-
Ettehad D, Emdin CA, Kiran A, Anderson SG, Callender T, Emberson J, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet. 2016;387:957–67.
-
(2016)
Lancet
, vol.387
, pp. 957-967
-
-
Ettehad, D.1
Emdin, C.A.2
Kiran, A.3
Anderson, S.G.4
Callender, T.5
Emberson, J.6
-
7
-
-
84930077401
-
Comparative efficacy and safety of blood pressure-lowering agents in adults with diabetes and kidney disease: a network meta-analysis
-
COI: 1:CAS:528:DC%2BC2MXpt1Ojsb8%3D
-
Palmer SC, Mavridis D, Navarese E, Craig JC, Tonelli M, Salanti G, et al. Comparative efficacy and safety of blood pressure-lowering agents in adults with diabetes and kidney disease: a network meta-analysis. Lancet. 2015;385:2047–56.
-
(2015)
Lancet
, vol.385
, pp. 2047-2056
-
-
Palmer, S.C.1
Mavridis, D.2
Navarese, E.3
Craig, J.C.4
Tonelli, M.5
Salanti, G.6
-
8
-
-
84893549987
-
Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth joint national committee (JNC 8)
-
COI: 1:CAS:528:DC%2BC2cXis1aktr8%3D
-
James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth joint national committee (JNC 8). JAMA. 2014;311:507–20.
-
(2014)
JAMA
, vol.311
, pp. 507-520
-
-
James, P.A.1
Oparil, S.2
Carter, B.L.3
Cushman, W.C.4
Dennison-Himmelfarb, C.5
Handler, J.6
-
9
-
-
84874318834
-
Efficacy and safety of dual blockade of the renin-angiotensin system: meta-analysis of randomised trials
-
Makani H, Bangalore S, Desouza KA, Shah A, Messerli FH. Efficacy and safety of dual blockade of the renin-angiotensin system: meta-analysis of randomised trials. BMJ. 2013;346:f360.
-
(2013)
BMJ
, vol.346
, pp. f360
-
-
Makani, H.1
Bangalore, S.2
Desouza, K.A.3
Shah, A.4
Messerli, F.H.5
-
10
-
-
84902266944
-
Multiple ascending dose study with the new renin inhibitor VTP-27999: nephrocentric consequences of too much renin inhibition
-
COI: 1:CAS:528:DC%2BC2cXms1Wltb8%3D
-
Balcarek J, Seva Pessoa B, Bryson C, Azizi M, Menard J, Garrelds IM, et al. Multiple ascending dose study with the new renin inhibitor VTP-27999: nephrocentric consequences of too much renin inhibition. Hypertension. 2014;63:942–50.
-
(2014)
Hypertension
, vol.63
, pp. 942-950
-
-
Balcarek, J.1
Seva Pessoa, B.2
Bryson, C.3
Azizi, M.4
Menard, J.5
Garrelds, I.M.6
-
11
-
-
0023185327
-
Why do the kidneys release renin in patients with congestive heart failure? A nephrocentric view of converting-enzyme inhibition
-
COI: 1:STN:280:DyaL2s3mslehug%3D%3D
-
Packer M. Why do the kidneys release renin in patients with congestive heart failure? A nephrocentric view of converting-enzyme inhibition. Am J Cardiol. 1987;60:179–84.
-
(1987)
Am J Cardiol
, vol.60
, pp. 179-184
-
-
Packer, M.1
-
12
-
-
84875213364
-
Aliskiren accumulation in the kidney: no major role for binding to renin or prorenin
-
COI: 1:CAS:528:DC%2BC3sXjsVKgtbk%3D
-
Lange S, Fraune C, Alenina N, Bader M, Danser AH, Frenay AR, et al. Aliskiren accumulation in the kidney: no major role for binding to renin or prorenin. J Hypertens. 2013;31:713–9.
-
(2013)
J Hypertens
, vol.31
, pp. 713-719
-
-
Lange, S.1
Fraune, C.2
Alenina, N.3
Bader, M.4
Danser, A.H.5
Frenay, A.R.6
-
13
-
-
0022389183
-
Proteins of the kidney microvillar membrane. The 130 kDa protein in pig kidney, recognized by monoclonal antibody GK5C1, is an ectoenzyme with aminopeptidase activity
-
COI: 1:CAS:528:DyaL2MXmtFWrurg%3D
-
Gee NS, Kenny AJ. Proteins of the kidney microvillar membrane. The 130 kDa protein in pig kidney, recognized by monoclonal antibody GK5C1, is an ectoenzyme with aminopeptidase activity. Biochem J. 1985;230:753–64.
-
(1985)
Biochem J
, vol.230
, pp. 753-764
-
-
Gee, N.S.1
Kenny, A.J.2
-
14
-
-
0024271006
-
Ultrastructural localization of angiotensin I-converting enzyme (EC 3.4.15.1) and neutral metalloendopeptidase (EC 3.4.24.11) in the proximal tubule of the human kidney
-
COI: 1:CAS:528:DyaL1MXnt12itA%3D%3D
-
Schulz WW, Hagler HK, Buja LM, Erdos EG. Ultrastructural localization of angiotensin I-converting enzyme (EC 3.4.15.1) and neutral metalloendopeptidase (EC 3.4.24.11) in the proximal tubule of the human kidney. Lab Invest. 1988;59:789–97.
-
(1988)
Lab Invest
, vol.59
, pp. 789-797
-
-
Schulz, W.W.1
Hagler, H.K.2
Buja, L.M.3
Erdos, E.G.4
-
15
-
-
0028856125
-
Comparison of candoxatril and atrial natriuretic factor in healthy men. Effects on hemodynamics, sympathetic activity, heart rate variability, and endothelin
-
COI: 1:CAS:528:DyaK28XmslOgug%3D%3D
-
Ando S, Rahman MA, Butler GC, Senn BL, Floras JS. Comparison of candoxatril and atrial natriuretic factor in healthy men. Effects on hemodynamics, sympathetic activity, heart rate variability, and endothelin. Hypertension. 1995;26:1160–6.
-
(1995)
Hypertension
, vol.26
, pp. 1160-1166
-
-
Ando, S.1
Rahman, M.A.2
Butler, G.C.3
Senn, B.L.4
Floras, J.S.5
-
16
-
-
6444220362
-
The role of the renin-angiotensin-aldosterone system in heart failure
-
COI: 1:CAS:528:DC%2BD2cXpslGhsrw%3D
-
Unger T, Li J. The role of the renin-angiotensin-aldosterone system in heart failure. J Renin-Angiotensin-Aldosterone Syst. 2004;5 Suppl 1:S7–10.
-
(2004)
J. Renin-Angiotensin-Aldosterone Syst
, vol.5
, pp. S7-S10
-
-
Unger, T.1
Li, J.2
-
17
-
-
0042848809
-
Cardiovascular effects of natriuretic peptides and their interrelation with endothelin-1
-
COI: 1:CAS:528:DC%2BD3sXkslCrtbg%3D
-
Han B, Hasin Y. Cardiovascular effects of natriuretic peptides and their interrelation with endothelin-1. Cardiovasc Drugs Ther. 2003;17:41–52.
-
(2003)
Cardiovasc Drugs Ther
, vol.17
, pp. 41-52
-
-
Han, B.1
Hasin, Y.2
-
18
-
-
77956817833
-
Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi)
-
COI: 1:CAS:528:DC%2BC3cXks1Clt7o%3D
-
Gu J, Noe A, Chandra P, Al-Fayoumi S, Ligueros-Saylan M, Sarangapani R, et al. Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi). J Clin Pharmacol. 2010;50:401–14.
-
(2010)
J Clin Pharmacol
, vol.50
, pp. 401-414
-
-
Gu, J.1
Noe, A.2
Chandra, P.3
Al-Fayoumi, S.4
Ligueros-Saylan, M.5
Sarangapani, R.6
-
19
-
-
84961202555
-
Disposition and metabolism of [(14)C] sacubitril/valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects
-
COI: 1:CAS:528:DC%2BC28XjslKiu7g%3D
-
Flarakos J, Du Y, Bedman T, Al-Share Q, Jordaan P, Chandra P, et al. Disposition and metabolism of [(14)C] sacubitril/valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects. Xenobiotica. 2016;46:986–1000.
-
(2016)
Xenobiotica
, vol.46
, pp. 986-1000
-
-
Flarakos, J.1
Du, Y.2
Bedman, T.3
Al-Share, Q.4
Jordaan, P.5
Chandra, P.6
-
20
-
-
84971637016
-
Effect of renal function on the pharmacokinetics of LCZ696 (sacubitril/valsartan), an angiotensin receptor neprilysin inhibitor
-
COI: 1:CAS:528:DC%2BC28XovVais74%3D
-
Ayalasomayajula SP, Langenickel TH, Jordaan P, Zhou W, Chandra P, Albrecht D, et al. Effect of renal function on the pharmacokinetics of LCZ696 (sacubitril/valsartan), an angiotensin receptor neprilysin inhibitor. Eur J Clin Pharmacol. 2016;72:1065–73.
-
(2016)
Eur J Clin Pharmacol
, vol.72
, pp. 1065-1073
-
-
Ayalasomayajula, S.P.1
Langenickel, T.H.2
Jordaan, P.3
Zhou, W.4
Chandra, P.5
Albrecht, D.6
-
21
-
-
0031022244
-
Pharmacokinetics, disposition and biotransformation of [14C]-radiolabelled valsartan in healthy male volunteers after a single oral dose
-
COI: 1:CAS:528:DyaK2sXhtVyjt78%3D
-
Waldmeier F, Flesch G, Muller P, Winkler T, Kriemler HP, Buhlmayer P, et al. Pharmacokinetics, disposition and biotransformation of [14C]-radiolabelled valsartan in healthy male volunteers after a single oral dose. Xenobiotica. 1997;27:59–71.
-
(1997)
Xenobiotica
, vol.27
, pp. 59-71
-
-
Waldmeier, F.1
Flesch, G.2
Muller, P.3
Winkler, T.4
Kriemler, H.P.5
Buhlmayer, P.6
-
22
-
-
38149032565
-
Effects of combined AT1 receptor antagonist/NEP inhibitor on vascular remodeling and cardiac fibrosis in SHRSP
-
COI: 1:CAS:528:DC%2BD1cXlsVyhtg%3D%3D
-
Pu Q, Brassard P, Javeshghani DM, Iglarz M, Webb RL, Amiri F, et al. Effects of combined AT1 receptor antagonist/NEP inhibitor on vascular remodeling and cardiac fibrosis in SHRSP. J Hypertens. 2008;26:322–33.
-
(2008)
J Hypertens
, vol.26
, pp. 322-333
-
-
Pu, Q.1
Brassard, P.2
Javeshghani, D.M.3
Iglarz, M.4
Webb, R.L.5
Amiri, F.6
-
23
-
-
84925029305
-
Angiotensin receptor neprilysin inhibitor LCZ696 attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy
-
von Lueder TG, Wang BH, Kompa AR, Huang L, Webb R, Jordaan P, et al. Angiotensin receptor neprilysin inhibitor LCZ696 attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy. Circ Heart Fail. 2015;8:71–8.
-
(2015)
Circ. Heart Fail
, vol.8
, pp. 71-78
-
-
von Lueder, T.G.1
Wang, B.H.2
Kompa, A.R.3
Huang, L.4
Webb, R.5
Jordaan, P.6
-
24
-
-
84931281961
-
Pre-treatment with LCZ696, an orally active angiotensin receptor neprilysin inhibitor, prevents ischemic brain damage
-
COI: 1:CAS:528:DC%2BC2MXhtlGgur%2FL
-
Bai HY, Mogi M, Nakaoka H, Kan-No H, Tsukuda K, Chisaka T, et al. Pre-treatment with LCZ696, an orally active angiotensin receptor neprilysin inhibitor, prevents ischemic brain damage. Eur J Pharmacol. 2015;762:293–8.
-
(2015)
Eur J Pharmacol
, vol.762
, pp. 293-298
-
-
Bai, H.Y.1
Mogi, M.2
Nakaoka, H.3
Kan-No, H.4
Tsukuda, K.5
Chisaka, T.6
-
25
-
-
77950628157
-
Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study
-
COI: 1:CAS:528:DC%2BC3cXksFClsbw%3D
-
Ruilope LM, Dukat A, Bohm M, Lacourciere Y, Gong J, Lefkowitz MP. Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study. Lancet. 2010;375:1255–66.
-
(2010)
Lancet
, vol.375
, pp. 1255-1266
-
-
Ruilope, L.M.1
Dukat, A.2
Bohm, M.3
Lacourciere, Y.4
Gong, J.5
Lefkowitz, M.P.6
-
26
-
-
84953931431
-
LCZ696, an angiotensin receptor-neprilysin inhibitor, improves cardiac function with the attenuation of fibrosis in heart failure with reduced ejection fraction in streptozotocin-induced diabetic mice
-
COI: 1:CAS:528:DC%2BC28XlvF2ksL4%3D
-
Suematsu Y, Miura S, Goto M, Matsuo Y, Arimura T, Kuwano T, et al. LCZ696, an angiotensin receptor-neprilysin inhibitor, improves cardiac function with the attenuation of fibrosis in heart failure with reduced ejection fraction in streptozotocin-induced diabetic mice. Eur J Heart Fail. 2016;18:386–93.
-
(2016)
Eur J Heart Fail
, vol.18
, pp. 386-393
-
-
Suematsu, Y.1
Miura, S.2
Goto, M.3
Matsuo, Y.4
Arimura, T.5
Kuwano, T.6
-
27
-
-
85014114230
-
Blood pressure-independent renoprotection in diabetic rats treated with AT1 receptor-neprilysin inhibition compared with AT1 receptor blockade alone
-
COI: 1:CAS:528:DC%2BC28XpvVWltLc%3D
-
Roksnoer LC, van Veghel R, van Groningen MC, de Vries R, Garrelds IM, Bhaggoe UM, et al. Blood pressure-independent renoprotection in diabetic rats treated with AT1 receptor-neprilysin inhibition compared with AT1 receptor blockade alone. Clin Sci (Lond). 2016;130:1209–20.
-
(2016)
Clin Sci (Lond)
, vol.130
, pp. 1209-1220
-
-
Roksnoer, L.C.1
van Veghel, R.2
van Groningen, M.C.3
de Vries, R.4
Garrelds, I.M.5
Bhaggoe, U.M.6
-
28
-
-
84934437930
-
Optimum AT1 receptor-neprilysin inhibition has superior cardioprotective effects compared with AT1 receptor blockade alone in hypertensive rats
-
COI: 1:CAS:528:DC%2BC2MXls1ejsrs%3D, This study demonstrates that the degree of NEPi is critical: if dosed too high, NEPi can induce a rise in circulating endothelin-1 levels and consequently, a rise in blood pressure
-
Roksnoer LC, Van Veghel R, De Vries R, Garrelds IM, Bhaggoe UM, Friesema EC, et al. Optimum AT1 receptor-neprilysin inhibition has superior cardioprotective effects compared with AT1 receptor blockade alone in hypertensive rats. Kidney Int. 2015;88:109–20. This study demonstrates that the degree of NEPi is critical: if dosed too high, NEPi can induce a rise in circulating endothelin-1 levels and consequently, a rise in blood pressure.
-
(2015)
Kidney Int
, vol.88
, pp. 109-120
-
-
Roksnoer, L.C.1
Van Veghel, R.2
De Vries, R.3
Garrelds, I.M.4
Bhaggoe, U.M.5
Friesema, E.C.6
-
29
-
-
84930948387
-
Meta-analysis of large-scale randomized trials to determine the effectiveness of inhibition of the renin-angiotensin aldosterone system in heart failure
-
COI: 1:CAS:528:DC%2BC2MXnsF2nsbg%3D
-
Emdin CA, Callender T, Cao J, McMurray JJ, Rahimi K. Meta-analysis of large-scale randomized trials to determine the effectiveness of inhibition of the renin-angiotensin aldosterone system in heart failure. Am J Cardiol. 2015;116:155–61.
-
(2015)
Am J Cardiol
, vol.116
, pp. 155-161
-
-
Emdin, C.A.1
Callender, T.2
Cao, J.3
McMurray, J.J.4
Rahimi, K.5
-
30
-
-
85019316271
-
The CONSENSUS trial study group
-
Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). The CONSENSUS trial study group. N Engl J Med. 1987;316:1429–35.
-
(1987)
N Engl J Med
, vol.316
, pp. 1429-1435
-
-
-
31
-
-
0025913812
-
The SOLVD investigators
-
Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD investigators. N Engl J Med. 1991;325:293–302.
-
(1991)
N Engl J Med
, vol.325
, pp. 293-302
-
-
-
32
-
-
84989872584
-
Combined neprilysin and renin-angiotensin system inhibition in heart failure with reduced ejection fraction: a meta-analysis
-
COI: 1:CAS:528:DC%2BC28Xhs1Skt7fI
-
Solomon SD, Claggett B, McMurray JJ, Hernandez AF, Fonarow GC. Combined neprilysin and renin-angiotensin system inhibition in heart failure with reduced ejection fraction: a meta-analysis. Eur J Heart Fail. 2016;18:1238–43.
-
(2016)
Eur J Heart Fail
, vol.18
, pp. 1238-1243
-
-
Solomon, S.D.1
Claggett, B.2
McMurray, J.J.3
Hernandez, A.F.4
Fonarow, G.C.5
-
33
-
-
0037143601
-
Comparison of omapatrilat and enalapril in patients with chronic heart failure: the omapatrilat versus enalapril randomized trial of utility in reducing events (OVERTURE)
-
COI: 1:CAS:528:DC%2BD38XntlSqsrc%3D
-
Packer M, Califf RM, Konstam MA, Krum H, McMurray JJ, Rouleau JL, et al. Comparison of omapatrilat and enalapril in patients with chronic heart failure: the omapatrilat versus enalapril randomized trial of utility in reducing events (OVERTURE). Circulation. 2002;106:920–6.
-
(2002)
Circulation
, vol.106
, pp. 920-926
-
-
Packer, M.1
Califf, R.M.2
Konstam, M.A.3
Krum, H.4
McMurray, J.J.5
Rouleau, J.L.6
-
34
-
-
1642452758
-
Omapatrilat and enalapril in patients with hypertension: the omapatrilat cardiovascular treatment vs. Enalapril (OCTAVE) trial
-
COI: 1:CAS:528:DC%2BD2cXmvF2gtw%3D%3D
-
Kostis JB, Packer M, Black HR, Schmieder R, Henry D, Levy E. Omapatrilat and enalapril in patients with hypertension: the omapatrilat cardiovascular treatment vs. Enalapril (OCTAVE) trial. Am J Hypertens. 2004;17:103–11.
-
(2004)
Am J Hypertens
, vol.17
, pp. 103-111
-
-
Kostis, J.B.1
Packer, M.2
Black, H.R.3
Schmieder, R.4
Henry, D.5
Levy, E.6
-
35
-
-
84907087561
-
Angiotensin-neprilysin inhibition versus enalapril in heart failure
-
This study demonstrates that ARNI greatly reduces the risk of death and hospitalization in heart failure patients with reduced ejection fraction when compared to current golden standard treatment
-
McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014;371:993–1004. This study demonstrates that ARNI greatly reduces the risk of death and hospitalization in heart failure patients with reduced ejection fraction when compared to current golden standard treatment.
-
(2014)
N Engl J Med
, vol.371
, pp. 993-1004
-
-
McMurray, J.J.1
Packer, M.2
Desai, A.S.3
Gong, J.4
Lefkowitz, M.P.5
Rizkala, A.R.6
-
36
-
-
84962521111
-
Influence of ejection fraction on outcomes and efficacy of sacubitril/valsartan (LCZ696) in heart failure with reduced ejection fraction: the prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure (PARADIGM-HF) trial
-
COI: 1:CAS:528:DC%2BC28XksVKjtrc%3D
-
Solomon SD, Claggett B, Desai AS, Packer M, Zile M, Swedberg K, et al. Influence of ejection fraction on outcomes and efficacy of sacubitril/valsartan (LCZ696) in heart failure with reduced ejection fraction: the prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure (PARADIGM-HF) trial. Circ Heart Fail. 2016;9, e002744.
-
(2016)
Circ. Heart Fail
, vol.9
-
-
Solomon, S.D.1
Claggett, B.2
Desai, A.S.3
Packer, M.4
Zile, M.5
Swedberg, K.6
-
37
-
-
84939603387
-
Effect of the angiotensin-receptor-neprilysin inhibitor LCZ696 compared with enalapril on mode of death in heart failure patients
-
Desai AS, McMurray JJ, Packer M, Swedberg K, Rouleau JL, Chen F, et al. Effect of the angiotensin-receptor-neprilysin inhibitor LCZ696 compared with enalapril on mode of death in heart failure patients. Eur Heart J. 2015;36:1990–7.
-
(2015)
Eur Heart J
, vol.36
, pp. 1990-1997
-
-
Desai, A.S.1
McMurray, J.J.2
Packer, M.3
Swedberg, K.4
Rouleau, J.L.5
Chen, F.6
-
38
-
-
84924243546
-
Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure
-
COI: 1:CAS:528:DC%2BC2MXnslShug%3D%3D
-
Packer M, McMurray JJ, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, et al. Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure. Circulation. 2015;131:54–61.
-
(2015)
Circulation
, vol.131
, pp. 54-61
-
-
Packer, M.1
McMurray, J.J.2
Desai, A.S.3
Gong, J.4
Lefkowitz, M.P.5
Rizkala, A.R.6
-
39
-
-
84981715657
-
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC
-
Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2016;18:891–975.
-
(2016)
Eur J Heart Fail
, vol.18
, pp. 891-975
-
-
Ponikowski, P.1
Voors, A.A.2
Anker, S.D.3
Bueno, H.4
Cleland, J.G.5
Coats, A.J.6
-
40
-
-
84867745957
-
The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial
-
COI: 1:CAS:528:DC%2BC38Xht1KjtbfF
-
Solomon SD, Zile M, Pieske B, Voors A, Shah A, Kraigher-Krainer E, et al. The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial. Lancet. 2012;380:1387–95.
-
(2012)
Lancet
, vol.380
, pp. 1387-1395
-
-
Solomon, S.D.1
Zile, M.2
Pieske, B.3
Voors, A.4
Shah, A.5
Kraigher-Krainer, E.6
-
41
-
-
82555200331
-
Prognostic value of baseline plasma amino-terminal pro-brain natriuretic peptide and its interactions with irbesartan treatment effects in patients with heart failure and preserved ejection fraction: findings from the I-PRESERVE trial
-
COI: 1:CAS:528:DC%2BC3MXhtlOnt7nO
-
Anand IS, Rector TS, Cleland JG, Kuskowski M, McKelvie RS, Persson H, et al. Prognostic value of baseline plasma amino-terminal pro-brain natriuretic peptide and its interactions with irbesartan treatment effects in patients with heart failure and preserved ejection fraction: findings from the I-PRESERVE trial. Circ Heart Fail. 2011;4:569–77.
-
(2011)
Circ Heart Fail
, vol.4
, pp. 569-577
-
-
Anand, I.S.1
Rector, T.S.2
Cleland, J.G.3
Kuskowski, M.4
McKelvie, R.S.5
Persson, H.6
-
42
-
-
84901983713
-
Independence of the blood pressure lowering effect and efficacy of the angiotensin receptor neprilysin inhibitor, LCZ696, in patients with heart failure with preserved ejection fraction: an analysis of the PARAMOUNT trial
-
COI: 1:CAS:528:DC%2BC2cXpsVKru7Y%3D
-
Jhund PS, Claggett B, Packer M, Zile MR, Voors AA, Pieske B, et al. Independence of the blood pressure lowering effect and efficacy of the angiotensin receptor neprilysin inhibitor, LCZ696, in patients with heart failure with preserved ejection fraction: an analysis of the PARAMOUNT trial. Eur J Heart Fail. 2014;16:671–7.
-
(2014)
Eur J Heart Fail
, vol.16
, pp. 671-677
-
-
Jhund, P.S.1
Claggett, B.2
Packer, M.3
Zile, M.R.4
Voors, A.A.5
Pieske, B.6
-
43
-
-
84955319328
-
Risk related to pre-diabetes mellitus and diabetes mellitus in heart failure with reduced ejection fraction: insights from Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial
-
Kristensen SL, Preiss D, Jhund PS, Squire I, Cardoso JS, Merkely B et al. Risk related to pre-diabetes mellitus and diabetes mellitus in heart failure with reduced ejection fraction: insights from Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial. Circ Heart Fail. 2016;9.
-
(2016)
Circ Heart Fail
, pp. 9
-
-
Kristensen, S.L.1
Preiss, D.2
Jhund, P.S.3
Squire, I.4
Cardoso, J.S.5
Merkely, B.6
-
44
-
-
84926664621
-
Safety and efficacy of LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor, in Japanese patients with hypertension and renal dysfunction
-
COI: 1:CAS:528:DC%2BC2MXlvFWqsr4%3D, This study is the first to demonstrate that ARNI exerts beneficial effects beyond blood pressure lowering: ARNI can reduce albuminuria and thus improve renal outcome in hypertensive, CKD patients
-
Ito S, Satoh M, Tamaki Y, Gotou H, Charney A, Okino N, et al. Safety and efficacy of LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor, in Japanese patients with hypertension and renal dysfunction. Hypertens Res. 2015;38:269–75. This study is the first to demonstrate that ARNI exerts beneficial effects beyond blood pressure lowering: ARNI can reduce albuminuria and thus improve renal outcome in hypertensive, CKD patients.
-
(2015)
Hypertens Res
, vol.38
, pp. 269-275
-
-
Ito, S.1
Satoh, M.2
Tamaki, Y.3
Gotou, H.4
Charney, A.5
Okino, N.6
-
45
-
-
84928609455
-
Renal effects of the angiotensin receptor neprilysin inhibitor LCZ696 in patients with heart failure and preserved ejection fraction
-
COI: 1:CAS:528:DC%2BC2MXntFGltbc%3D
-
Voors AA, Gori M, Liu LC, Claggett B, Zile MR, Pieske B, et al. Renal effects of the angiotensin receptor neprilysin inhibitor LCZ696 in patients with heart failure and preserved ejection fraction. Eur J Heart Fail. 2015;17:510–7.
-
(2015)
Eur J Heart Fail
, vol.17
, pp. 510-517
-
-
Voors, A.A.1
Gori, M.2
Liu, L.C.3
Claggett, B.4
Zile, M.R.5
Pieske, B.6
-
46
-
-
0022973258
-
Atrial natriuretic peptide causes pre-glomerular vasodilatation and post-glomerular vasoconstriction in rat kidney
-
COI: 1:CAS:528:DyaL2sXksVKhtg%3D%3D
-
Marin-Grez M, Fleming JT, Steinhausen M. Atrial natriuretic peptide causes pre-glomerular vasodilatation and post-glomerular vasoconstriction in rat kidney. Nature. 1986;324:473–6.
-
(1986)
Nature
, vol.324
, pp. 473-476
-
-
Marin-Grez, M.1
Fleming, J.T.2
Steinhausen, M.3
-
47
-
-
0026702407
-
Determinants of intra-individual variation in kidney function in normoalbuminuric insulin-dependent diabetic patients: importance of atrial natriuretic peptide and glycaemic control
-
COI: 1:STN:280:DyaK3s%2FkslOjtQ%3D%3D
-
Pedersen MM, Christiansen JS, Pedersen EB, Mogensen CE. Determinants of intra-individual variation in kidney function in normoalbuminuric insulin-dependent diabetic patients: importance of atrial natriuretic peptide and glycaemic control. Clin Sci (Lond). 1992;83:445–51.
-
(1992)
Clin Sci (Lond)
, vol.83
, pp. 445-451
-
-
Pedersen, M.M.1
Christiansen, J.S.2
Pedersen, E.B.3
Mogensen, C.E.4
-
48
-
-
0032993031
-
Atrial natriuretic peptide increases albuminuria in type I diabetic patients: evidence for blockade of tubular protein reabsorption
-
COI: 1:STN:280:DyaK1M7pt12mtQ%3D%3D
-
Jacobs EM, Vervoort G, Branten AJ, Klasen I, Smits P, Wetzels JF. Atrial natriuretic peptide increases albuminuria in type I diabetic patients: evidence for blockade of tubular protein reabsorption. Eur J Clin Investig. 1999;29:109–15.
-
(1999)
Eur. J. Clin. Investig
, vol.29
, pp. 109-115
-
-
Jacobs, E.M.1
Vervoort, G.2
Branten, A.J.3
Klasen, I.4
Smits, P.5
Wetzels, J.F.6
-
49
-
-
84929162610
-
Combined angiotensin receptor blockade and neprilysin inhibition attenuates angiotensin-II mediated renal cellular collagen synthesis
-
Wang BH, von Lueder TG, Kompa AR, Huang L, Webb R, Jordaan P, et al. Combined angiotensin receptor blockade and neprilysin inhibition attenuates angiotensin-II mediated renal cellular collagen synthesis. Int J Cardiol. 2015;186:104–5.
-
(2015)
Int J Cardiol
, vol.186
, pp. 104-105
-
-
Wang, B.H.1
von Lueder, T.G.2
Kompa, A.R.3
Huang, L.4
Webb, R.5
Jordaan, P.6
-
50
-
-
84861813805
-
Prevalence, patterns of treatment, and control of hypertension in predialysis patients with chronic kidney disease
-
COI: 1:CAS:528:DC%2BC38Xht1WrsbrN
-
Sarafidis PA, Sharpe CC, Wood E, Blacklock R, Rumjon A, Al-Yassin A, et al. Prevalence, patterns of treatment, and control of hypertension in predialysis patients with chronic kidney disease. Nephron Clin Pract. 2012;120:c147–55.
-
(2012)
Nephron Clin. Pract
, vol.120
, pp. c147-c155
-
-
Sarafidis, P.A.1
Sharpe, C.C.2
Wood, E.3
Blacklock, R.4
Rumjon, A.5
Al-Yassin, A.6
-
52
-
-
0033621739
-
Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition
-
COI: 1:CAS:528:DC%2BD3cXosFyqtg%3D%3D
-
Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, et al. Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat Med. 2000;6:143–50.
-
(2000)
Nat Med
, vol.6
, pp. 143-150
-
-
Iwata, N.1
Tsubuki, S.2
Takaki, Y.3
Watanabe, K.4
Sekiguchi, M.5
Hosoki, E.6
-
53
-
-
80052266213
-
The amyloid cascade hypothesis for Alzheimer’s disease: an appraisal for the development of therapeutics
-
COI: 1:CAS:528:DC%2BC3MXhtVelsL3L
-
Karran E, Mercken M, De Strooper B. The amyloid cascade hypothesis for Alzheimer’s disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov. 2011;10:698–712.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 698-712
-
-
Karran, E.1
Mercken, M.2
De Strooper, B.3
-
54
-
-
84960155668
-
The effect of LCZ696 (sacubitril/valsartan) on amyloid-beta concentrations in cerebrospinal fluid in healthy subjects
-
COI: 1:CAS:528:DC%2BC28XmtF2lsLg%3D
-
Langenickel TH, Tsubouchi C, Ayalasomayajula S, Pal P, Valentin MA, Hinder M, et al. The effect of LCZ696 (sacubitril/valsartan) on amyloid-beta concentrations in cerebrospinal fluid in healthy subjects. Br J Clin Pharmacol. 2016;81:878–90.
-
(2016)
Br J Clin Pharmacol
, vol.81
, pp. 878-890
-
-
Langenickel, T.H.1
Tsubouchi, C.2
Ayalasomayajula, S.3
Pal, P.4
Valentin, M.A.5
Hinder, M.6
-
55
-
-
84893833082
-
Differences in amyloid-beta clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling
-
COI: 1:CAS:528:DC%2BC2cXjsVWgsbk%3D
-
Qosa H, Abuasal BS, Romero IA, Weksler B, Couraud PO, Keller JN, et al. Differences in amyloid-beta clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling. Neuropharmacology. 2014;79:668–78.
-
(2014)
Neuropharmacology
, vol.79
, pp. 668-678
-
-
Qosa, H.1
Abuasal, B.S.2
Romero, I.A.3
Weksler, B.4
Couraud, P.O.5
Keller, J.N.6
-
56
-
-
0035947207
-
Metabolic regulation of brain Abeta by neprilysin
-
COI: 1:CAS:528:DC%2BD3MXktVyqsrc%3D
-
Iwata N, Tsubuki S, Takaki Y, Shirotani K, Lu B, Gerard NP, et al. Metabolic regulation of brain Abeta by neprilysin. Science. 2001;292:1550–2.
-
(2001)
Science
, vol.292
, pp. 1550-1552
-
-
Iwata, N.1
Tsubuki, S.2
Takaki, Y.3
Shirotani, K.4
Lu, B.5
Gerard, N.P.6
-
57
-
-
84938816535
-
Influence of glycosylation on diagnostic and prognostic accuracy of N-terminal pro-B-type natriuretic peptide in acute dyspnea: data from the Akershus cardiac examination 2 study
-
This study critically addresses the measurements of BNP and NT-proBNP
-
Rosjo H, Dahl MB, Jorgensen M, Roysland R, Brynildsen J, Cataliotti A, et al. Influence of glycosylation on diagnostic and prognostic accuracy of N-terminal pro-B-type natriuretic peptide in acute dyspnea: data from the Akershus cardiac examination 2 study. Clin Chem. 2015;61:1087–97. This study critically addresses the measurements of BNP and NT-proBNP.
-
(2015)
Clin Chem
, vol.61
, pp. 1087-1097
-
-
Rosjo, H.1
Dahl, M.B.2
Jorgensen, M.3
Roysland, R.4
Brynildsen, J.5
Cataliotti, A.6
-
58
-
-
84939424765
-
Elevated plasma B-type natriuretic peptide concentrations directly inhibit circulating neprilysin activity in heart failure
-
Vodovar N, Seronde MF, Laribi S, Gayat E, Lassus J, Januzzi Jr JL, et al. Elevated plasma B-type natriuretic peptide concentrations directly inhibit circulating neprilysin activity in heart failure. JACC Heart Fail. 2015;3:629–36.
-
(2015)
JACC Heart Fail
, vol.3
, pp. 629-636
-
-
Vodovar, N.1
Seronde, M.F.2
Laribi, S.3
Gayat, E.4
Lassus, J.5
Januzzi, J.L.6
|