Cardiorenal acute kidney injury: Epidemiology, presentation, causes, pathophysiology and treatment

International Journal of Cardiology

Volumn 227, Issue , 2017, Pages 143-150

  Di Lullo, Luca ^a   Bellasi, Antonio ^b   Russo, Domenico ^c   Cozzolino, Mario ^d   Ronco, Claudio ^e  

^a Department of Nephrology and Dialysis   (Italy)

^b ASST Lariana ^*  (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e SAN BORTOLO HOSPITAL   (Italy)

Author keywords

Acute kidney injury; Biomarkers; Renal replacement therapy; Type 3 cardiorenal syndrome

Indexed keywords

URINARY TRACT AGENT;

ACUTE DISEASE; ACUTE KIDNEY FAILURE; BIOCHEMICAL ANALYSIS; CARDIORENAL SYNDROME; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; CHRONIC KIDNEY DISEASE; CLINICAL FEATURE; CONTINUOUS RENAL REPLACEMENT THERAPY; CORONARY ARTERY DISEASE; DISEASE CLASSIFICATION; DISEASE COURSE; DISEASE MARKER; DISEASE PREDISPOSITION; ECHOGRAPHY; HEART ELECTROPHYSIOLOGY; HEART INJURY; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE FIBROSIS; HEART PERFORMANCE; HIGH RISK PATIENT; HUMAN; HYPERKALEMIA; HYPERVOLEMIA; HYPOCALCEMIA; INCIDENCE; LABORATORY DIAGNOSIS; METABOLIC ACIDOSIS; NONHUMAN; PATHOPHYSIOLOGY; PREVALENCE; PRIORITY JOURNAL; RENAL REPLACEMENT THERAPY; REVIEW; RISK FACTOR; ACUTE KIDNEY INJURY; CARDIO-RENAL SYNDROME; DIAGNOSTIC IMAGING; FEMALE; HEMODIALYSIS; MALE; MORTALITY; PROCEDURES; PROGNOSIS; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

ACUTE KIDNEY INJURY; CARDIO-RENAL SYNDROME; FEMALE; HUMANS; INCIDENCE; MALE; PROGNOSIS; RENAL DIALYSIS; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 84994765419     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2016.11.156     Document Type: Review

References (73)

1. [1] Ronco, C., McCullough, P., Anker, S.D., et al. Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative. Eur. Heart J. 31 (2010), 703–711.
2. [2] Prabhu, S.D., Cytokine-induced modulation of cardiac function. Circ. Res. 95:12 (Dec 10 2004), 1140–1153.
3. [3] Kingma, J.G. Jr., Vincent, C., Rouleau, J.R., Kingma, I., Influence of acute renal failure on coronary vasoregulation in dogs. J. Am. Soc. Nephrol. 17:5 (May 2006), 1316–1324.
4. [4] Bagshaw, S.M., Cruz, D.N., Aspromonte, N., et al., for the Acute Dialysis Quality Initiative (ADQI) Consensus Group, Epidemiology of cardio-renal syndrome: workgroup statements from the 7th ADQI Consensus Conference. Nephrol. Dial. Transplant. 25 (2010), 1406–1416.
5. [5] Bellomo, R., Ronco, C., Kellum, J.A., Mehta, R.L., Palevsky, P.M., the ADQI Workgroup, Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs. The Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit. Care 8 (2004), R204–R212.
6. [6] Mehta, R.L., Kellum, J.A., Shah, S.V., et al. Acute kidney injury network (AKIN): report of an initiative to improve outcomes in acute kidney injury. Crit. Care, 11, 2007, R31.
7. [7] Lewington, A., Kanagasundaram, S., Renal Association Clinical Practice Guidelines on acute kidney injury. Nephron Clin. Pract. 118:Suppl. 1 (2011), c349–390.
8. [8] Uchino, S., Kellum, J.A., Bellomo, R., et al. Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) investigators. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294 (2005), 813–818.
9. [9] Dickstein, K., Cohen-Solal, A., Filipatos, G., et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur. J. Heart Fail. 10 (2008), 933–989.
10. [10] Jessup, M., Abraham, W.T., Casey, D.E., et al. ACCF/AHA guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation 119 (2009), 1977–2016.
11. [11] Gheorghiade, M., Zannad, F., Sopko, G., et al. Failure syndromes: current state and framework for future research. Circulation 112 (2005), 3958–3968.
12. [12] Heywood, J.T., Fonarow, G.C., Costanzo, M.R., et al. High prevalence of renal dysfunction and its impact on outcome in 118465 patients hospitalized with acute decompensated heart failure: a report from the ADHERE database. J. Card. Fail. 13 (2007), 422–430.
13. [13] Siirila-Waris, K., Lassus, J., Melin, J., et al. Characteristics, outcomes, and predictors of 1 year mortality in patients hospitalized for acute heart failure. Eur. Heart J. 27 (2006), 3011–3017.
14. [14] Ali, T., Khan, I., Simpson, W., et al. Incidence and outcomes in acute kidney injury: a comprehensive population-based study. J. Am. Soc. Nephrol. 18 (2007), 1292–1298.
15. [15] De Abreu, K.L.S., Silva Junior, G.B., Carreto, A.G.C., et al. Acute kidney injury after trauma: prevalence, clinical characteristics and RIFLE classification. Indian J. Crit. Care Med. 14 (2010), 121–128.
16. [16] Raine, A., Margreiter, R., Brunner, F., et al. Report on management of renal failure in Europe. XXII. Nephrol. Dial. Transplant. 7:Suppl. 2 (1992), 7–35.
17. [17] Schwilk, B., Wiedeck, H., Stein, B., et al. Epidemiology of acute renal failure and outcome of haemodiafiltration in intensive care. Intensive Care Med. 23 (1997), 1204–1211.
18. [18] Song, J.H., Humes, H.D., Renal cell therapy and beyond. Semin. Dial. 22 (2009), 603–609.
19. [19] Wen, X., Murugan, R., Peng, Z., Kellum, J.A., Pathophysiology of acute kidney injury: a new perspective. Contrib. Nephrol. 165 (2010), 39–45.
20. [20] Bongartz, L.G., Cramer, M.J., Doevendans, P.A., Joles, J.A., Braam, B., The severe cardiorenal syndrome: ‘Guyton revisited’. Eur. Heart J. 26:1 (Jan 2005), 11–17.
21. [21] Ma, X.L., Lefer, D.J., Lefer, A.M., Rothlein, R., Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion. Circulation 86:3 (Sep 1992), 937–946.
22. [22] Blake, P., Hasegawa, Y., Khosla, M.C., Fouad-Tarazi, F., Sakura, N., Paganini, E.P., Isolation of “myocardial depressant factor (s)” from the ultrafiltrate of heart failure patients with acute renal failure. ASAIO J. 42:5 (Sep-Oct 1996), M911–M915.
23. [23] Edmunds, N.J., Lal, H., Woodward, B., Effects of tumour necrosis factor-alpha on left ventricular function in the rat isolated perfused heart: possible mechanisms for a decline in cardiac function. Br. J. Pharmacol. 126:1 (Jan 1999), 189–196.
24. [24] Rauchhaus, M., Doehner, W., Francis, D.P., et al. Plasma cytokine parameters and mortality in patients with chronic heart failure. Circulation 102:25 (Dec 19 2000), 3060–3067.
25. [25] Chuasuwan, A., Kellum, J.A., Cardio-renal syndrome type 3: epidemiology, pathophysiology, and treatment. Semin. Nephrol. 32:1 (January 2012), 31–39.
26. [26] Kajstura, J., Cigola, E., Malhotra, A., et al. Angiotensin II induces apoptosis of adult ventricular myocytes in vitro. J. Mol. Cell. Cardiol. 29:3 (Mar 1997), 859–870.
27. [27] Kingma, J.G. Jr., Vincent, C., Rouleau, J.R., Kingma, I., Influence of acute renal failure on coronary vasoregulation in dogs. J. Am. Soc. Nephrol. 17:5 (May 2006), 1316–1324.
28. [28] Nath, K.A., Grande, J.P., Croatt, A.J., et al. Transgenic sickle mice are markedly sensitive to renal ischemia–reperfusion injury. Am. J. Pathol. 166:4 (Apr 2005), 963–972.
29. [29] Kelly, K.J., Distant effects of experimental renal ischemia/reperfusion injury. J. Am. Soc. Nephrol. 14:6 (Jun 2003), 1549–1558.
30. [30] Bryant, D., Becker, L., Richardson, J., et al. Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha. Circulation 97 (1998), 1375–1381.
31. [31] Liu, Y.H., D'Ambrosio, M., Liao, T.D., et al. N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin. American journal of physiology. Heart Circ. Physiol. 296:2 (Feb 2009), H404–H412.
32. [32] De Deyn, P.P., vanholder, R., D'Hooge, R., Nitric oxide in uremia: effects of several potentially toxic guanidino compounds. Kidney Int.(Suppl. 84), 2003, S25–S28.
33. [33] Scheuer, J., Stezoski, W., The effects of uremic compounds on cardiac function and metabolism. J. Mol. Cell. Cardiol. 5 (1973), 287–300.
34. [34] Jackson, G., Gibbs, C.R., Davies, M.K., Lip, G.Y., ABC of heart failure. Pathophysiology. Br. Med. J. 320 (2000), 167–170.
35. [35] Li, L., Lee, E.W., Ji, H., Zukowska, Z., Neuropeptide Y-induced acceleration of postangioplasty occlusion of rat carotid artery. Arterioscler. Thromb. Vasc. Biol. 23 (2003), 1204–1210.
36. [36] Shah, B.N., Greaves, K., The cardio-renal syndrome: a review. Int. J. Nephrol., 2011, 920195, 10.4061/2011/920195.
37. [37] Qin, F., Patel, R., Yan, C., Liu, W., NADPH oxidase is involved in angiotensin II-induced apoptosis in H9C2 cardiac muscle cells: effects of apocynin. Free Radic. Biol. Med. 40 (2005), 236–246.
38. [38] Chabrashvili, T., Kitiyakara, C., Blau, J., et al. Effects of ANF II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285 (2003), R117–R124.
39. [39] Nakagami, H., Takemoto, M., Liao, J.K., NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy. J. Mol. Cell. Cardiol. 35 (2003), 851–859.
40. [40] Griendling, K.K., Minieri, C.A., Ollerenshaw, J.D., Alexander, R.W., Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ. Res. 74 (1994), 1141–1148.
41. [41] Shannon, T.R., Pogwizd, S.M., Bers, D.M., Elevated sarcoplasmic reticulum Ca2 + leak in intact ventricular myocytes from rabbits in heart failure. Circulation research., 93(7), Oct 3 2003, 592–594.
42. [42] Licurse, A., Kim, M.C., Dziura, J., Forman, H.P., Formica, R.N., Makarov, D.V., Parikh, C.R., Gross, C.P., Renal ultrasonography in the evaluation of acute kidney injury: developing a risk stratification framework. Arch. Intern. Med. 170 (2010), 1900–1907.
43. [43] Ozmen, C.A., Akin, D., Bilek, S.U., Bayrak, A.H., Senturk, S., Nazaroglu, H., Ultrasound as a diagnostic tool to differentiate acute from chronic renal failure. Clin. Nephrol. 74 (2010), 46–52.
44. [44] Darmon, M., Schortgen, F., Vargas, F., Liazydi, A., Schlemmer, B., Brun-Buisson, C., Brochard, L., Diagnostic accuracy of Doppler renal resistive index for reversibility of acute kidney injury in critically ill patients. Intensive Care Med, 2011.
45. [45] Di Lullo, L., Floccari, F., Granata, A., D'Amelio, A., Rivera, R., Fiorini, F., Malaguti, M., Timio, Ultrasonography: Ariadne's thread in the diagnosis of cardiorenal syndrome. Cardiorenal Med. 2:1 (Feb 2012), 11–17 (Epub 2011 Nov 30).
46. [46] Negishi, K., Noiri, E., Doi, K., et al. Monitoring of urinary L-type fatty acid-binding protein predicts histological severity of acute kidney injury. Am. J. Pathol. 174 (2009), 1154–1159.
47. [47] Hu, M.-C., Shi, M., Zhang, J., et al. Klotho deficiency is an early biomarker of renal ischemia–reperfusion injury and its replacement is protective. Kidney Int. 78 (2010), 1240–1251.
48. [48] Reeves, W.B., Kwon, O., Ramesh, G., Netrin-1 and kidney injury. II. Netrin-1 is an early biomarker of acute kidney injury. Am. J. Physiol. Ren. Physiol., 294, 2007 (F731–F8).
49. [49] Hayashi, H., Sato, W., Maruyama, S., et al. Urinary Midkine as a biomarker of acute kidney injury: comparison with three major biomarkers; NAG, IL-18 and NGAL [abstract]. NDT Plus, 2, 2009 (ii 1634, Suppl 2).
50. [50] McCullough, P.A., Nowak, R.M., McCord, J., et al. B-type natriuretic peptide and clinical judgment in emergency diagnosis of heart failure: analysis from Breathing Not Properly (BNP) Multinational Study. Circulation 106 (2002), 416–422.
51. [51] Wu, A.H., Jaffe, A.S., Apple, F.S., et al. National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: use of cardiac troponin and B-type natriuretic peptide or N-terminal proB-type natriuretic peptide for etiologies other than acute coronary syndromes and heart failure. Clin. Chem. 53 (2007), 2086–2096.
52. [52] Januzzi, J.L. Jr., Camargo, C.A., Anwaruddin, S., et al. The N-terminal pro-BNP investigation of dyspnea in the emergency department (PRIDE) study. Am. J. Cardiol. 95 (2005), 948–954.
53. [53] Di Lullo, L., Barbera, V., Santoboni, A., Bellasi, A., Cozzolino, M., De Pascalis, A., Rivera, R., Balducci, A., Russo, D., Ronco, C., Troponins and chronic kidney disease. G. Ital. Nefrol., 32(4), Jul-Aug 2015.
54. [54] Glatz, J.F., Vander Vusse, F.J., Maessen, J.G., et al. Fatty acid-binding protein as marker of muscle injury: experimental findings and clinical application. Acta Anaesthesiol. Scand. Suppl. 111 (1997), 292–294.
55. [55] Taglieri, N., Fernandez-Berges, D.J., Koenig, W., et al. Plasma cystatin C for prediction of 1-year cardiac events in Mediterranean patients with non-ST elevation acute coronary syndromes. Atherosclerosis 209 (2010), 300–305.
56. [56] Furtado, M.V., Rossini, A.P., Campani, R.B., et al. Interleukin-18: an independent predictor of cardiovascular events in patients with acute coronary syndrome after 6 months of follow-up. Coron. Artery Dis. 20 (2009), 327–331.
57. [57] Liyan, C., Jie, Z., Xiaozhou, H., Prognostic value of combination of heart-type fatty acid-binding protein and ischemia-modified albumin in patients with acute coronary syndromes and normal troponin T value. J. Clin. Lab. Anal. 23 (2009), 14–18.
58. [58] Mehta, R.L., Pascual, M.T., Soroko, S.H., et al. Diuretics, mortality, and nonrecovery of renal function in acute renal failure. JAMA 288 (2002), 2547–2553.
59. [59] Bellomo, R., Kellum, J.A., Ronco, C., Acute kidney injury. Lancet 380 (2012), 756–766.
60. [60] Srisawat, N., Murugan, R., Lee, M., Kong, L., Carter, M., Angus, D.C., et al. Plasma neutrophil gelatinase-associated lipocalin predicts recovery from acute kidney injury following community-acquired pneumonia. Kidney Int. 80 (2011), 545–552.
61. [61] Srisawat, N., Wen, X., Lee, M., Kong, L., Elder, M., Carter, M., et al. Urinary biomarkers and renal recovery in critically ill patients with renal support. Clin. J. Am. Soc. Nephrol. 6 (2011), 1815–1823.
62. [62] Payen, D., Mateo, J., Cavaillon, J.M., Fraisse, F., Floriot, C., Vicaut, E., Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: a randomized controlled trial. Crit. Care Med. 37 (2009), 803–810.
63. [63] Karvellas, C.J., Farhat, M.R., Sajjad, I., Mogensen, S.S., Leung, A.A., Wald, R., et al. A comparison of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury: a systematic review and meta-analysis. Crit. Care, 15, 2011, R72.
64. [64] Clec'h, C., Darmon, M., Lautrette, A., Chemouni, F., Azoulay, E., Schwebel, C., et al. Efficacy of renal replacement therapy in critically ill patients: a propensity analysis. Crit. Care, 16, 2012, R236.
65. [65] Bellomo, R., Cass, A., Cole, L., Finfer, S., Gallagher, M., Lee, J., et al. An observational study fluid balance and patient outcomes in the randomized evaluation of normal vs augmented level of replacement therapy trial. Crit. Care Med. 40 (2012), 1753–1760.
66. [66] Uchino, S., Bellomo, R., Morimatsu, H., Morgera, S., Schetz, M., Tan, I., et al. Discontinuation of continuous renal replacement therapy: a post hoc analysis of a prospective multicenter observational study. Crit. Care Med. 37 (2009), 2576–2582.
67. [67] Schneider, A.G., Bellomo, R., Bagshaw, S.M., Glassford, N.J., Lo, S., Jun, M., et al. Choice of renal replacement therapy modality and dialysis dependence after acute kidney injury: a systematic review and meta-analysis. Intensive Care Med. 39 (2013), 987–997.
68. [68] Berbece, A.N., Richardson, R.M., Sustained low-efficiency dialysis in the ICU: cost, anticoagulation, and solute removal. Kidney Int. 70 (2006), 963–968.
69. [69] Kumar, V.A., Craig, M., Depner, T.A., Yeun, J.Y., Extended daily dialysis: a new approach to renal replacement for acute renal failure in the intensive care unit. Am. J. Kidney Dis. 36 (2000), 294–300.
70. [70] Wu, V.C., Wang, C.H., Wang, W.J., Lin, Y.F., Hu, F.C., Chen, Y.W., et al. Sustained low-efficiency dialysis versus continuous veno-venous hemofiltration for postsurgical acute renal failure. Am. J. Surg. 199 (2010), 466–476.
71. [71] Schwenger, V., Weigand, M.A., Hoffmann, O., Dikow, R., Kihm, L.P., Seckinger, J., et al. Sustained low efficiency dialysis using a single-pass batch system in acute kidney injury—a randomized interventional trial: the REnal Replacement Therapy Study in Intensive Care Unit Pati Ents. Crit. Care, 16, 2012, R140.
72. [72] Legrand, M., Darmon, M., Joannidis, M., Payen, D., Management of renal replacement therapy in ICU patients: an international survey. Intensive Care Med. 39 (2013), 101–108.
73. [73] Bellomo, R., Cass, A., Cole, L., Finfer, S., Gallagher, M., Lo, S., et al. Intensity of continuous renal-replacement therapy in critically ill patients. N. Engl. J. Med. 361 (2009), 1627–1638.