N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 296, Issue 2, 2009, Pages

  Liu, Yun He ^a   D'Ambrosio, Martin ^a   Liao, Tang Dong ^a   Peng, Hongmei ^a   Rhaleb, Nour Eddine ^a   Sharma, Umesh ^a   Andre, Sabine ^b   Gabius, Hans J ^b   Carretero, Oscar A ^a  

^a HENRY FORD HOSPITAL   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cardiac dysfunction; Fibrosis; Inflammation; N acetyl seryl aspartyl lysyl proline

Indexed keywords

COLLAGEN; GALECTIN 3; ISOPRENALINE; LECTIN; SERASPENIDE; SMAD3 PROTEIN; SODIUM CHLORIDE; TRANSFORMING GROWTH FACTOR BETA; ANTIINFLAMMATORY AGENT; CARDIOTONIC AGENT; MADH3 PROTEIN, RAT; OLIGOPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDITIS; CELL ADHESION; CELL INFILTRATION; CONTROLLED STUDY; FIBROSING ALVEOLITIS; HEART ATRIUM CONTRACTION; HEART DISEASE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FILLING PRESSURE; HEART MUSCLE FIBROSIS; HEART OUTPUT; HEART VENTRICLE HYPERTROPHY; HISTOLOGY; MACROPHAGE; MALE; MAST CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STAINING; WESTERN BLOTTING; ANIMAL; BLOOD; BLOOD PRESSURE; BODY WEIGHT; CARDIOMEGALY; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DOPPLER ECHOCARDIOGRAPHY; DRUG EFFECT; FIBROSIS; HEART CONTRACTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART RATE; HEART STROKE VOLUME; HEART VENTRICLE REMODELING; HEMODYNAMICS; INFLAMMATION; INFUSION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOOD PRESSURE; BODY WEIGHT; CARDIAC OUTPUT; CARDIOMEGALY; CARDIOTONIC AGENTS; COLLAGEN; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY, DOPPLER; FIBROSIS; GALECTIN 3; HEART RATE; HEMODYNAMICS; INFLAMMATION; INFUSIONS, PARENTERAL; ISOPROTERENOL; MACROPHAGES; MALE; MAST CELLS; MYOCARDIAL CONTRACTION; MYOCARDIUM; OLIGOPEPTIDES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; STROKE VOLUME; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 61949375975     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00747.2008     Document Type: Article

References (44)

1. Ahmad N, Gabius HJ, Andre S, Kaltner H, Sabesan S, Roy R, Liu B, Macaluso F, Brewer CF. Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes. J Biol Chem 279: 10841-10847, 2004.
2. Andre S, Unverzagt C, Kojima S, Frank M, Seifert J, Fink C, Kayser K, von der Lieth CW, Gabius HJ. Determination of modulation of ligand properties of synthetic complex-type biantennary N-glycans by introduction of bisecting GlcNAc in silico, in vitro and in vivo. Eur J Biochem 271: 118-134, 2004.
3. Azizi M, Rousseau A, Ezan E, Guyene TT, Michelet S, Grognet JM, Lenfant M, Corvol P, Ménard J. Acute angiotensin-converting enzyme inhibition increases the plasma level of the natural stem cell regulator A-acetyl-seryl-aspartyl-lysyl-proline. J Clin Invest 97: 839-844, 1996.
4. Balakumar P, Singh AP, Ganti SS, Krishan P, Ramasamy S, Singh M. Resident cardiac mast cells: are they the major culprit in the pathogenesis of cardiac hypertrophy? Basic Clin Pharmacol Toxicol 102: 5-9, 2008.
5. Belvisi L, Bernardi A, Colombo M, Manzoni L, Potenza D, Scolastico C, Giannini G, Marcellini M, Riccioni T, Castorina M, Logiudice P, Pisano C. Targeting integrins: insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids. Bioorg Med Chem 14: 169 -180, 2006.
6. Bujak M, Frangogiannis NG. The role of TGF-beta signaling in myo- cardial infarction and cardiac remodeling. Cardiovasc Res 74: 184 -195, 2007.
7. Cavasin MA, Liao TD, Yang XP, Yang JJ, Carretero OA. Decreased endogenous levels of Ac-SDKP promote organ fibrosis. Hypertension 50: 130 -136, 2007.
8. Chiariello M, Ambrosio G, Cappelli-Bigazzi M, Perrone-Filardi P, Brigante F, Sifola C. A biochemical method for the quantitation of myocardial scarring after experimental coronary artery occlusion. J Mol Cell Cardiol 18: 283-290, 1986.
9. Cingolani OH, Yang XP, Liu YH, Villanueva M, Rhaleb NE, Carretero OA. Reduction of cardiac fibrosis decreases systolic performance without affecting diastolic function in hypertensive rats. Hypertension 43: 1067-1073, 2004.
10. Damoiseaux JGMC, Dopp EA, Calame W, Chao D, MacPherson GG, Dijkstra CD. Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1. Immunology 83: 140-147, 1994.
11. Enerback L, Kolset SO, Kusche M, Hjerpe A, Lindahl U. Glycosami- noglycans in rat mucosal mast cells. Biochem J 227: 661-668, 1985.
12. Frangogiannis NG, Smith CW, Entman ML. The inflammatory response in myocardial infarction. Cardiovasc Res 53: 31-47, 2002.
13. Gabius HJ. Cell surface glycans: the why and how of their functionality as biochemical signals in lectin-mediated information transfer. Crit Rev Immunol 26: 43-79, 2006.
14. Hermans JJ, van Essen H, Struijker-Boudier HA, Johnson RM, Theeuwes F, Smits JF. Pharmacokinetic advantage of intrapericardially applied substances in the rat. J Pharmacol Exp Ther 301: 672-678, 2002.
15. Hochberg Y, Benjamini Y. More powerful procedures for multiple significance testing. Stat Med 9: 811-818, 1990.
16. Liu JM, Lawrence F, Kovacevic M, Bignon J, Papadimitriou E, Lallemand JY, Katsoris P, Potier P, Fromes Y, Wdzieczak-Bakala J. The tetrapeptide AcSDKP, an inhibitor of primitive hematopoietic cell proliferation, induces angiogenesis in vitro and in vivo. Blood 101: 3014-3020, 2003.
17. MacKinnon AC, Farnworth SL, Hodkinson PS, Henderson NC, Atkinson KM, Leffler H, Nilsson UJ, Haslett C, Forbes SJ, Sethi T.Regulation of alternative macrophage activation by galectin-3. J Immunol 180: 2650-2658, 2008.
18. Mann DL. Inflammatory mediators and the failing heart. Past, present, and the foreseeable future. Circ Res 91: 988-998, 2002.
19. Milting H, Ellinghaus P, Seewald M, Cakar H, Bohms B, Kassner A, Korfer R, Klein M, Krahn T, Kruska L, El BA, Kramer F. Plasma biomarkers of myocardial fibrosis and remodeling in terminal heart failure patients supported by mechanical circulatory support devices. J Heart Lung Transplant 27: 589-596, 2008.
20. Papaspyridonos M, McNeill E, de Bono JP, Smith A, Burnand KG, Channon KM, Greaves DR. Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction. Arterioscler Thromb Vasc Biol 28: 433-440, 2008.
21. Peng H, Carretero OA, Brigstock DR, Oja-Tebbe N, Rhaleb NE. Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension. Hypertension 42: 1164-1170, 2003.
22. Peng H, Carretero OA, Liao TD, Peterson EL, Rhaleb NE. Role of Ac-SDKP in the antifibrotic effect of angiotensin-converting enzyme inhibitors in hypertension-induced target organ damage. Hypertension 49: 1-9, 2007.
23. Peng H, Carretero OA, Raij L, Yang F, Kapke A, Rhaleb NE. Antifibrotic effects of A-acetyl-seryl-aspartyl-lysyl-proline on the heart and kidney in aldosterone-salt hypertensive rats. Hypertension 37: 794-800, 2001.
24. Peng H, Carretero OA, Vuljaj N, Liao TD, Motivala A, Peterson EL, Rhaleb NE. Angiotensin-converting enzyme inhibitors. A new mechanism of action. Circulation 112: 2436 -2445, 2005.
25. Pokharel S, Rasoul S, Roks AJM, van Leeuwen REW, van Luyn MJA, Deelman LE, Smits JF, Carretero OA, van Gilst WH, Pinto YM. N-acetyl-Ser-Asp-Lys- Pro inhibits phosphorylation of Smad2 in cardiac fibroblasts. Hypertension 40: 155-161, 2002.
26. Pokharel S, van Geel PP, Sharma UC, Cleutjens JPM, Bohnemeier H, Tian XL, Schunkert H, Crijns HJGM, Paul M, Pinto YM. Increased myocardial collagen content in transgenic rats overexpressing cardiac angiotensin- converting enzyme is related to enhanced breakdown of A- acetyl-Ser-Asp-Lys-Pro and increased phosphorylation of Smad2/3. Circulation 110: 3129-3135, 2004.
27. Prunier F, Gaertner R, Louedec L, Michel JB, Mercadier JJ, Escou- bet B. Doppler echocardiographic estimation of left ventricular end- diastolic pressure after MI in rats. Am J Physiol Heart Circ Physiol 283: H346-H352, 2002.
28. Rasoul S, Carretero OA, Peng H, Cavasin MA, Zhuo J, Sanchez- Mendoza A, Brigstock DR, Rhaleb NE. Antifibrotic effect of Ac-SDKP and angiotensin-converting enzyme inhibition in hypertension. J Hypertens 22: 593-603, 2004.
29. Rhaleb NE, Peng H, Harding P, Tayeh M, LaPointe MC, Carretero OA. Effect of A -acetyl-seryl-aspartyl-lysyl-proline on DNA and collagen synthesis in rat cardiac fibroblasts. Hypertension 37: 827-832, 2001.
30. Rhaleb NE, Peng H, Yang XP, Liu YH, Mehta D, Ezan E, Carretero OA. Long-term effect of A-acetyl-seryl-aspartyl-lysyl-proline on left ventricular collagen deposition in rats with 2-kidney, 1-clip hypertension. Circulation 103: 3136-3141, 2001.
31. Saragoca M, Tarazi RC. Impaired cardiac contractile response to iso- proterenol in the spontaneously hypertensive rat. Hypertension 3: 380-385, 1981.
32. Saussez S, Lorfevre F, Nonclercq D, Laurent G, Andre S, Journe F, Kiss R, Toubeau G, Gabius HJ. Towards functional glycomics by localization of binding sites for tissue lectins: lectin histochemical reac-tivity for galectins during diethylstilbestrol-induced kidney tumorigenesis in male Syrian hamster. Histochem Cell Biol 126: 57-69, 2006.
33. Sharma U, Rhaleb NE, Pokharel S, Harding P, Rasoul S, Peng H, Carretero OA. Novel anti-inflammatory mechanisms of N-Acetyl-Ser- Asp-Lys-Pro in hypertension-induced target organ damage. Am J Physiol Heart Circ Physiol 294: H1226-H1232, 2008.
34. Sharma UC, Pokharel S, Evelo CTA, Maessen JG. A systematic review of large scale and heterogeneous gene array data in heart failure. J Mol Cell Cardiol 38: 425-432, 2005.
35. Sharma UC, Pokharel S, van Brakel TJ, van Berlo JH, Cleutjens JPM, Schroen B, André S, Crijns HJGM, Gabius HJ, Maessen J, Pinto YM. Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. Circulation 110: 3121-3128, 2004.
36. Shiota N, Rysä J, Kovanen PT, Ruskoaho H, Kokkonen JO, Lindstedt KA. A role for cardiac mast cells in the pathogenesis of hypertensive heart disease. J Hypertens 21: 1935-1944, 2003.
37. Sweat F, Puchtler H, Rosenthal SI. Sirius Red F3BA as a stain for connective tissue. Arch Pathol 78: 69 -72, 1964.
38. van Amerongen MJ, Harmsen MC, van RN, Petersen AH, van Luyn MJ. Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice. Am J Pathol 170: 818-829, 2007.
39. van Kimmenade RR, Januzzi JL Jr, Ellinor PT, Sharma UC, Bakker JA, Low AF, Martinez A, Crijns HJ, MacRae CA, Menheere PP Pinto YM. Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure. J Am Coll Cardiol 48: 1217-1224, 2006.
40. Villalobo A, Nogales-González A, Gabius HJ. A guide to signaling pathways connecting protein-glycan interaction with the emerging versatile effector functionality of mammalian lectins. Trends Glycosci Gly- cotechnol 18: 1-37, 2006.
41. Wang D, Carretero OA, Yang XY, Rhaleb NE, Liu YH, Liao TD, Yang XP. A-acetyl-seryl-aspartyl-lysyl-proline stimulates angiogenesis in vitro and in vivo. Am J Physiol Heart Circ Physiol 287: H2099 -H2105, 2004.
42. Yang F, Yang XP, Liu YH, Xu J, Cingolani O, Rhaleb NE, Carretero OA. Ac-SDKP reverses inflammation and fibrosis in rats with heart failure after myocardial infarction. Hypertension 43: 229 -236, 2004.
43. Zhan Y, Brown C, Maynard E, Anshelevich A, Ni W, Ho IC, Oettgen P. Ets-1 is a critical regulator of Ang Il-mediated vascular inflammation and remodeling. J Clin Invest 115: 2508-2516, 2005.
44. Zimmer HG. Measurement of left ventricular hemodynamic parameters in closed-chest rats under control and various pathophysiologic conditions. Basic Res Cardiol 78: 77-84, 1983.