3D Bioprinting a Cell-Laden Bone Matrix for Breast Cancer Metastasis Study

ACS Applied Materials and Interfaces

Volumn 8, Issue 44, 2016, Pages 30017-30026

  Zhou, Xuan ^a   Zhu, Wei ^a   Nowicki, Margaret ^a   Miao, Shida ^a   Cui, Haitao ^a   Holmes, Benjamin ^a   Glazer, Robert I ^c   Zhang, Lijie Grace ^a,b  

^a The George Washington University   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

Author keywords

3D bioprinting; bone matrix; breast cancer cells; mesenchymal stem cells; osteoblasts

Indexed keywords

3D PRINTERS; BIOMIMETIC PROCESSES; BIOMIMETICS; BONE; CELL ENGINEERING; CELLS; CYTOLOGY; DISEASES; ENDOTHELIAL CELLS; FLOWCHARTING; NANOCRYSTALS; OSTEOBLASTS; PATHOLOGY; PHOSPHATASES; STEM CELLS;

ALKALINE PHOSPHATASE ACTIVITY; BIOPRINTING; BONE MATRIX; BREAST CANCER CELLS; HUMAN BONE MARROW MESENCHYMAL STEM CELLS; INTERACTIVE EFFECT; MESENCHYMAL STEM CELL; VASCULAR ENDOTHELIAL GROWTH FACTOR;

CELL CULTURE;

VASCULOTROPIN A;

BIOPRINTING; BONE; BONE MATRIX; BREAST TUMOR; CELL DIFFERENTIATION; HUMAN; MESENCHYMAL STROMA CELL; METASTASIS;

BIOPRINTING; BONE AND BONES; BONE MATRIX; BREAST NEOPLASMS; CELL DIFFERENTIATION; HUMANS; MESENCHYMAL STROMAL CELLS; NEOPLASM METASTASIS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84994765076     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.6b10673     Document Type: Article

References (37)

1. Siegel, R. L.; Miller, K. D.; Jemal, A. Cancer Statistics, 2016 Ca-Cancer J. Clin. 2016, 66 (1) 7-30 10.3322/caac.21332
2. Weigelt, B.; Peterse, J. L.; van 't Veer, L. J. Breast Cancer Metastasis: Markers and Models Nat. Rev. Cancer 2005, 5 (8) 591-602 10.1038/nrc1670
3. Nicolson, G. L. Paracrine and Autocrine Growth Mechanisms in Tumor Metastasis to Specific Sites with Particular Emphasis on Brain and Lung Metastasis Cancer Metastasis Rev. 1993, 12 (3-4) 325-343 10.1007/BF00665961
4. Coleman, R. E.; Rubens, R. D. The Clinical Course of Bone Metastases from Breast Cancer Br. J. Cancer 1987, 55 (1) 61-66 10.1038/bjc.1987.13
5. Kim, J. B. Three-Dimensional Tissue Culture Models in Cancer Biology Semin. Cancer Biol. 2005, 15 (5) 365-377 10.1016/j.semcancer.2005.05.002
6. Karnoub, A. E.; Dash, A. B.; Vo, A. P.; Sullivan, A.; Brooks, M. W.; Bell, G. W.; Richardson, A. L.; Polyak, K.; Tubo, R.; Weinberg, R. A. Mesenchymal Stem Cells within Tumour Stroma Promote Breast Cancer Metastasis Nature 2007, 449 (7162) 557-563 10.1038/nature06188
7. Weilbaecher, K. N.; Guise, T. A.; McCauley, L. K. Cancer to Bone: A Fatal Attraction Nat. Rev. Cancer 2011, 11 (6) 411-425 10.1038/nrc3055
8. Zhu, W.; Holmes, B.; Glazer, R. I.; Zhang, L. G. 3d Printed Nanocomposite Matrix for the Study of Breast Cancer Bone Metastasis Nanomedicine 2016, 12 (1) 69-79 10.1016/j.nano.2015.09.010
9. Zhu, W.; Wang, M.; Fu, Y.; Castro, N. J.; Fu, S. W.; Zhang, L. G. Engineering a Biomimetic Three-Dimensional Nanostructured Bone Model for Breast Cancer Bone Metastasis Study Acta Biomater. 2015, 14, 164-174 10.1016/j.actbio.2014.12.008
10. Zhu, W.; Castro, N. J.; Cui, H.; Zhou, X.; Boualam, B.; McGrane, R.; Glazer, R. I.; Zhang, L. G. A 3d Printed Nano Bone Matrix for Characterization of Breast Cancer Cell and Osteoblast Interactions Nanotechnology 2016, 27 (31) 315103 10.1088/0957-4484/27/31/315103
11. Van Den Bulcke, A. I.; Bogdanov, B.; De Rooze, N.; Schacht, E. H.; Cornelissen, M.; Berghmans, H. Structural and Rheological Properties of Methacrylamide Modified Gelatin Hydrogels Biomacromolecules 2000, 1 (1) 31-38 10.1021/bm990017d
12. Wang, M.; Cheng, X.; Zhu, W.; Holmes, B.; Keidar, M.; Zhang, L. G. Design of Biomimetic and Bioactive Cold Plasma-Modified Nanostructured Scaffolds for Enhanced Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells Tissue Eng., Part A 2014, 20 (5-6) 1060-1071 10.1089/ten.tea.2013.0235
13. Zhou, X.; Castro, N. J.; Zhu, W.; Cui, H.; Aliabouzar, M.; Sarkar, K.; Zhang, L. G. Improved Human Bone Marrow Mesenchymal Stem Cell Osteogenesis in 3d Bioprinted Tissue Scaffolds with Low Intensity Pulsed Ultrasound Stimulation Sci. Rep. 2016, 6, 32876 10.1038/srep32876
14. Yue, K.; Trujillo-de Santiago, G.; Alvarez, M. M.; Tamayol, A.; Annabi, N.; Khademhosseini, A. Synthesis, Properties, and Biomedical Applications of Gelatin Methacryloyl (Gelma) Hydrogels Biomaterials 2015, 73, 254-271 10.1016/j.biomaterials.2015.08.045
15. Nichol, J. W.; Koshy, S. T.; Bae, H.; Hwang, C. M.; Yamanlar, S.; Khademhosseini, A. Cell-Laden Microengineered Gelatin Methacrylate Hydrogels Biomaterials 2010, 31 (21) 5536-5544 10.1016/j.biomaterials.2010.03.064
16. Du, Y.; Lo, E.; Ali, S.; Khademhosseini, A. Directed Assembly of Cell-Laden Microgels for Fabrication of 3d Tissue Constructs Proc. Natl. Acad. Sci. U. S. A. 2008, 105 (28) 9522-9527 10.1073/pnas.0801866105
17. Im, O.; Li, J.; Wang, M.; Zhang, L. G.; Keidar, M. Biomimetic Three-Dimensional Nanocrystalline Hydroxyapatite and Magnetically Synthesized Single-Walled Carbon Nanotube Chitosan Nanocomposite for Bone Regeneration Int. J. Nanomed. 2012, 7, 2087-2099 10.2147/IJN.S29743
18. Zhang, L.; Rodriguez, J.; Raez, J.; Myles, A. J.; Fenniri, H.; Webster, T. J. Biologically Inspired Rosette Nanotubes and Nanocrystalline Hydroxyapatite Hydrogel Nanocomposites as Improved Bone Substitutes Nanotechnology 2009, 20 (17) 175101 10.1088/0957-4484/20/17/175101
19. Jha, A. K.; Jackson, W. M.; Healy, K. E. Controlling Osteogenic Stem Cell Differentiation Via Soft Bioinspired Hydrogels PLoS One 2014, 9 (6) e98640 10.1371/journal.pone.0098640
20. Pathi, S. P.; Kowalczewski, C.; Tadipatri, R.; Fischbach, C. A Novel 3-D Mineralized Tumor Model to Study Breast Cancer Bone Metastasis PLoS One 2010, 5 (1) e8849 10.1371/journal.pone.0008849
21. Pathi, S. P.; Lin, D. D.; Dorvee, J. R.; Estroff, L. A.; Fischbach, C. Hydroxyapatite Nanoparticle-Containing Scaffolds for the Study of Breast Cancer Bone Metastasis Biomaterials 2011, 32 (22) 5112-5122 10.1016/j.biomaterials.2011.03.055
22. Clézardin, P. Therapeutic Targets for Bone Metastases in Breast Cancer Breast Cancer Res. 2011, 13 (2) 207 10.1186/bcr2835
23. Talukdar, S.; Kundu, S. C. Engineered 3d Silk-Based Metastasis Models: Interactions between Human Breast Adenocarcinoma, Mesenchymal Stem Cells and Osteoblast-Like Cells Adv. Funct. Mater. 2013, 23 (42) 5249-5260 10.1002/adfm.201300312
24. Sosnoski, D. M.; Krishnan, V.; Kraemer, W. J.; Dunn-Lewis, C.; Mastro, A. M. Changes in Cytokines of the Bone Microenvironment During Breast Cancer Metastasis Int. J. Breast Cancer 2012, 2012, 9 10.1155/2012/160265
25. Carmeliet, P. Vegf as a Key Mediator of Angiogenesis in Cancer Oncology 2005, 69 (3) 4-10 10.1159/000088478
26. Subia, B.; Dey, T.; Sharma, S.; Kundu, S. C. Target Specific Delivery of Anticancer Drug in Silk Fibroin Based 3d Distribution Model of Bone-Breast Cancer Cells ACS Appl. Mater. Interfaces 2015, 7 (4) 2269-2279 10.1021/am506094c
27. Goel, H. L.; Mercurio, A. M. Vegf Targets the Tumour Cell Nat. Rev. Cancer 2013, 13 (12) 871-882 10.1038/nrc3627
28. Pittenger, M. F.; Mackay, A. M.; Beck, S. C.; Jaiswal, R. K.; Douglas, R.; Mosca, J. D.; Moorman, M. A.; Simonetti, D. W.; Craig, S.; Marshak, D. R. Multilineage Potential of Adult Human Mesenchymal Stem Cells Science 1999, 284 (5411) 143-147 10.1126/science.284.5411.143
29. Beyer Nardi, N.; da Silva Meirelles, L. Mesenchymal Stem Cells: Isolation, in Vitro Expansion and Characterization Handb. Exp. Pharmacol. 2006, 174 (174) 249-282 10.1007/3-540-31265-X-11
30. Caplan, A. I. Mesenchymal Stem Cells J. Orthop. Res. 1991, 9 (5) 641-650 10.1002/jor.1100090504
31. Minguell, J. J.; Erices, A.; Conget, P. Mesenchymal Stem Cells Exp. Biol. Med. 2001, 226 (6) 507-520
32. Lv, H.; Li, L.; Sun, M.; Zhang, Y.; Chen, L.; Rong, Y.; Li, Y. Mechanism of Regulation of Stem Cell Differentiation by Matrix Stiffness Stem Cell Res. Ther. 2015, 6 (1) 103 10.1186/s13287-015-0083-4
33. Park, J. S.; Chu, J. S.; Tsou, A. D.; Diop, R.; Tang, Z.; Wang, A.; Li, S. The Effect of Matrix Stiffness on the Differentiation of Mesenchymal Stem Cells in Response to Tgf-Beta Biomaterials 2011, 32 (16) 3921-3930 10.1016/j.biomaterials.2011.02.019
34. Catelas, I.; Sese, N.; Wu, B. M.; Dunn, J. C.; Helgerson, S.; Tawil, B. Human Mesenchymal Stem Cell Proliferation and Osteogenic Differentiation in Fibrin Gels in Vitro Tissue Eng. 2006, 12 (8) 2385-2396 10.1089/ten.2006.12.2385
35. Engler, A. J.; Sen, S.; Sweeney, H. L.; Discher, D. E. Matrix Elasticity Directs Stem Cell Lineage Specification Cell 2006, 126 (4) 677-689 10.1016/j.cell.2006.06.044
36. Tse, J. R.; Engler, A. J. Stiffness Gradients Mimicking in Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate PLoS One 2011, 6 (1) e15978 10.1371/journal.pone.0015978
37. Zhang, L.; Chen, Y.; Rodriguez, J.; Fenniri, H.; Webster, T. J. Biomimetic Helical Rosette Nanotubes and Nanocrystalline Hydroxyapatite Coatings on Titanium for Improving Orthopedic Implants Int. J. Nanomed. 2008, 3 (3) 323-334