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Volumn 1863, Issue 1, 2017, Pages 292-297

Functional significance of exosomes applied in sepsis: A novel approach to therapy

Author keywords

Biomarker; Drug vehicle; Exosome; miRNA; Sepsis

Indexed keywords

CURCUMIN; DRUG VEHICLE; FLUORESCENT DYE; MICRORNA; NANOPARTICLE; PROTEIN; SMALL INTERFERING RNA; DRUG CARRIER;

EID: 84994765000     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2016.10.024     Document Type: Review
Times cited : (45)

References (51)
  • 1
    • 84957700973 scopus 로고    scopus 로고
    • Choice of fluid therapy in the initial management of sepsis, severe sepsis, and septic shock
    • [1] Chang, R., Holcomb, J.B., Choice of fluid therapy in the initial management of sepsis, severe sepsis, and septic shock. Shock 46:1 (2016), 17–26.
    • (2016) Shock , vol.46 , Issue.1 , pp. 17-26
    • Chang, R.1    Holcomb, J.B.2
  • 2
    • 48249107889 scopus 로고    scopus 로고
    • Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets
    • [2] Ayala*, A., M.P., Venet, F., Lomas-Neira, J., Swan, R., Chung, C.-S., Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets. Curr. Pharma. Des. 14 (2008), 1853–1859.
    • (2008) Curr. Pharma. Des. , vol.14 , pp. 1853-1859
    • Ayala, A.M.P.1    Venet, F.2    Lomas-Neira, J.3    Swan, R.4    Chung, C.-S.5
  • 3
    • 85027926151 scopus 로고    scopus 로고
    • The immunomodulatory properties of mesenchymal stem cells
    • [3] Marigo, I., Dazzi, F., The immunomodulatory properties of mesenchymal stem cells. Semin. Immunopathol. 33:6 (2011), 593–602.
    • (2011) Semin. Immunopathol. , vol.33 , Issue.6 , pp. 593-602
    • Marigo, I.1    Dazzi, F.2
  • 4
    • 58149326737 scopus 로고    scopus 로고
    • Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production
    • [4] Nemeth, K., et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat. Med. 15:1 (2009), 42–49.
    • (2009) Nat. Med. , vol.15 , Issue.1 , pp. 42-49
    • Nemeth, K.1
  • 5
    • 84887066242 scopus 로고    scopus 로고
    • A perspective on mesenchymal stromal cell transplantation in the treatment of sepsis
    • [5] Kusadasi, N., Groeneveld, A.B., A perspective on mesenchymal stromal cell transplantation in the treatment of sepsis. Shock 40:5 (2013), 352–357.
    • (2013) Shock , vol.40 , Issue.5 , pp. 352-357
    • Kusadasi, N.1    Groeneveld, A.B.2
  • 6
    • 84880305357 scopus 로고    scopus 로고
    • Adipose-derived mesenchymal stromal cells induce immunomodulatory macrophages which protect from experimental colitis and sepsis
    • [6] Anderson, P., Souza-Moreira, L., Morell, M., Caro, M., O'Valle, F., Gonzalez-Rey, E., Delgado, M., Adipose-derived mesenchymal stromal cells induce immunomodulatory macrophages which protect from experimental colitis and sepsis. Gut 62 (2013), 1131–1141.
    • (2013) Gut , vol.62 , pp. 1131-1141
    • Anderson, P.1    Souza-Moreira, L.2    Morell, M.3    Caro, M.4    O'Valle, F.5    Gonzalez-Rey, E.6    Delgado, M.7
  • 7
    • 36249021493 scopus 로고    scopus 로고
    • Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair—current views
    • [7] Phinney, D.G., Prockop, D.J., Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair—current views. Stem Cells 25:11 (2007), 2896–2902.
    • (2007) Stem Cells , vol.25 , Issue.11 , pp. 2896-2902
    • Phinney, D.G.1    Prockop, D.J.2
  • 8
    • 84964211348 scopus 로고    scopus 로고
    • Lymphatic transport of exosomes as a rapid route of information dissemination to the lymph node
    • [8] Srinivasan, S., Vannberg, F.O., Dixon, J.B., Lymphatic transport of exosomes as a rapid route of information dissemination to the lymph node. Sci. Rep., 6, 2016, 24436.
    • (2016) Sci. Rep. , vol.6 , pp. 24436
    • Srinivasan, S.1    Vannberg, F.O.2    Dixon, J.B.3
  • 9
    • 84860858416 scopus 로고    scopus 로고
    • Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials
    • [9] Vlassov, A.V., et al. Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim. Biophys. Acta 1820:7 (2012), 940–948.
    • (2012) Biochim. Biophys. Acta , vol.1820 , Issue.7 , pp. 940-948
    • Vlassov, A.V.1
  • 10
    • 84899825335 scopus 로고    scopus 로고
    • A comprehensive overview of exosomes as drug delivery vehicles — endogenous nanocarriers for targeted cancer therapy
    • [10] Johnsen, K.B., et al. A comprehensive overview of exosomes as drug delivery vehicles — endogenous nanocarriers for targeted cancer therapy. Biochim. Biophys. Acta 1846:1 (2014), 75–87.
    • (2014) Biochim. Biophys. Acta , vol.1846 , Issue.1 , pp. 75-87
    • Johnsen, K.B.1
  • 11
    • 33646146422 scopus 로고    scopus 로고
    • Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery
    • [11] Ratajczak, J., et al. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 20:5 (2006), 847–856.
    • (2006) Leukemia , vol.20 , Issue.5 , pp. 847-856
    • Ratajczak, J.1
  • 12
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: exosomes, microvesicles, and friends
    • [12] Raposo, G., Stoorvogel, W., Extracellular vesicles: exosomes, microvesicles, and friends. J. Cell Biol. 200:4 (2013), 373–383.
    • (2013) J. Cell Biol. , vol.200 , Issue.4 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 13
    • 84930345994 scopus 로고    scopus 로고
    • Isolation of extracellular vesicles: determining the correct approach (review)
    • [13] Szatanek, R., et al. Isolation of extracellular vesicles: determining the correct approach (review). Int. J. Mol. Med. 36:1 (2015), 11–17.
    • (2015) Int. J. Mol. Med. , vol.36 , Issue.1 , pp. 11-17
    • Szatanek, R.1
  • 14
    • 0345701525 scopus 로고    scopus 로고
    • Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59
    • [14] Clayton, A., et al. Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59. Eur. J. Immunol. 33:2 (2003), 522–531.
    • (2003) Eur. J. Immunol. , vol.33 , Issue.2 , pp. 522-531
    • Clayton, A.1
  • 15
    • 76649094917 scopus 로고    scopus 로고
    • Proteomics analysis of A33 immuno affinity purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature
    • [15] Suresh Mathivanan, J.W.E.L., Tauro, B.J., Ji, H., Moritz, R.L., Simpson, R.J., Proteomics analysis of A33 immuno affinity purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature. Mol. Cell. Proteomics 9 (2010), 197–208.
    • (2010) Mol. Cell. Proteomics , vol.9 , pp. 197-208
    • Suresh Mathivanan, J.W.E.L.1    Tauro, B.J.2    Ji, H.3    Moritz, R.L.4    Simpson, R.J.5
  • 16
    • 84971298295 scopus 로고    scopus 로고
    • From structures to functions: insights into exosomes as promising drug delivery vehicles
    • [16] Ren, J., et al. From structures to functions: insights into exosomes as promising drug delivery vehicles. Biomater. Sci. 4:6 (2016), 910–921.
    • (2016) Biomater. Sci. , vol.4 , Issue.6 , pp. 910-921
    • Ren, J.1
  • 17
    • 70349143140 scopus 로고    scopus 로고
    • Lipopolysaccharide preconditioning enhances the efficacy of mesenchymal stem cells transplantation in a rat model of acute myocardial infarction
    • [17] Yao, Y., et al. Lipopolysaccharide preconditioning enhances the efficacy of mesenchymal stem cells transplantation in a rat model of acute myocardial infarction. J. Biomed. Sci., 16, 2009, 74.
    • (2009) J. Biomed. Sci. , vol.16 , pp. 74
    • Yao, Y.1
  • 18
    • 84904689513 scopus 로고    scopus 로고
    • Functional significance of macrophage-derived exosomes in inflammation and pain
    • [18] McDonald, M.K., et al. Functional significance of macrophage-derived exosomes in inflammation and pain. Pain 155:8 (2014), 1527–1539.
    • (2014) Pain , vol.155 , Issue.8 , pp. 1527-1539
    • McDonald, M.K.1
  • 19
    • 84966429024 scopus 로고    scopus 로고
    • Plant microRNAs as novel immunomodulatory agents
    • [19] Cavalieri, D., et al. Plant microRNAs as novel immunomodulatory agents. Sci. Rep., 6, 2016, 25761.
    • (2016) Sci. Rep. , vol.6 , pp. 25761
    • Cavalieri, D.1
  • 20
    • 77952094971 scopus 로고    scopus 로고
    • Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor-factor VIII [corrected]
    • [20] Miksa, M., et al. Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor-factor VIII [corrected]. J. Immunol. 183:9 (2009), 5983–5990.
    • (2009) J. Immunol. , vol.183 , Issue.9 , pp. 5983-5990
    • Miksa, M.1
  • 21
    • 84912151115 scopus 로고    scopus 로고
    • Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages
    • [21] Momen-Heravi, F., et al. Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages. Nanomedicine 10:7 (2014), 1517–1527.
    • (2014) Nanomedicine , vol.10 , Issue.7 , pp. 1517-1527
    • Momen-Heravi, F.1
  • 22
    • 84870261424 scopus 로고    scopus 로고
    • Suppression of inflammation by tumor-derived exosomes: a kind of natural liposome packaged with multifunctional proteins
    • [22] Teng, H., et al. Suppression of inflammation by tumor-derived exosomes: a kind of natural liposome packaged with multifunctional proteins. J. Liposome Res. 22:4 (2012), 346–352.
    • (2012) J. Liposome Res. , vol.22 , Issue.4 , pp. 346-352
    • Teng, H.1
  • 23
    • 84893188871 scopus 로고    scopus 로고
    • Tumor-derived exosomes are enriched in DeltaNp73, which promotes oncogenic potential in acceptor cells and correlates with patient survival
    • [23] Soldevilla, B., et al. Tumor-derived exosomes are enriched in DeltaNp73, which promotes oncogenic potential in acceptor cells and correlates with patient survival. Hum. Mol. Genet. 23:2 (2014), 467–478.
    • (2014) Hum. Mol. Genet. , vol.23 , Issue.2 , pp. 467-478
    • Soldevilla, B.1
  • 24
    • 84966417274 scopus 로고    scopus 로고
    • Illuminating the physiology of extracellular vesicles
    • [24] Choi, H., Lee, D.S., Illuminating the physiology of extracellular vesicles. Stem Cell Res. Ther., 7(1), 2016, 55.
    • (2016) Stem Cell Res. Ther. , vol.7 , Issue.1 , pp. 55
    • Choi, H.1    Lee, D.S.2
  • 25
    • 84862645100 scopus 로고    scopus 로고
    • Human embryonic mesenchymal stem cell-derived conditioned medium rescues kidney function in rats with established chronic kidney disease
    • [25] van Koppen, A., et al. Human embryonic mesenchymal stem cell-derived conditioned medium rescues kidney function in rats with established chronic kidney disease. PLoS One, 7(6), 2012, e38746.
    • (2012) PLoS One , vol.7 , Issue.6 , pp. e38746
    • van Koppen, A.1
  • 26
    • 84883382523 scopus 로고    scopus 로고
    • MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles
    • [26] Xin, H., et al. MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles. Stem Cells 31:12 (2013), 2737–2746.
    • (2013) Stem Cells , vol.31 , Issue.12 , pp. 2737-2746
    • Xin, H.1
  • 27
    • 84876241933 scopus 로고    scopus 로고
    • Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis
    • [27] Li, T., et al. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis. Stem Cells Dev. 22:6 (2013), 845–854.
    • (2013) Stem Cells Dev. , vol.22 , Issue.6 , pp. 845-854
    • Li, T.1
  • 28
    • 84870239895 scopus 로고    scopus 로고
    • Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension
    • [28] Lee, C., et al. Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation 126:22 (2012), 2601–2611.
    • (2012) Circulation , vol.126 , Issue.22 , pp. 2601-2611
    • Lee, C.1
  • 29
    • 80053574021 scopus 로고    scopus 로고
    • Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain
    • [29] Zhuang, X., et al. Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol. Ther. 19:10 (2011), 1769–1779.
    • (2011) Mol. Ther. , vol.19 , Issue.10 , pp. 1769-1779
    • Zhuang, X.1
  • 30
    • 77956264919 scopus 로고    scopus 로고
    • A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes
    • [30] Sun, D., et al. A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Mol. Ther. 18:9 (2010), 1606–1614.
    • (2010) Mol. Ther. , vol.18 , Issue.9 , pp. 1606-1614
    • Sun, D.1
  • 31
    • 84969895688 scopus 로고    scopus 로고
    • Comparison of two endogenous delivery agents in cancer therapy: exosomes and ferritin
    • [31] Li, L., Zhang, L., Knez, M., Comparison of two endogenous delivery agents in cancer therapy: exosomes and ferritin. Pharmacol. Res. 110 (2016), 1–9.
    • (2016) Pharmacol. Res. , vol.110 , pp. 1-9
    • Li, L.1    Zhang, L.2    Knez, M.3
  • 32
    • 84934903985 scopus 로고    scopus 로고
    • Exosome-delivered microRNAs modulate the inflammatory response to endotoxin
    • [32] Alexander, M., et al. Exosome-delivered microRNAs modulate the inflammatory response to endotoxin. Nat. Commun., 6, 2015, 7321.
    • (2015) Nat. Commun. , vol.6 , pp. 7321
    • Alexander, M.1
  • 33
    • 84890907806 scopus 로고    scopus 로고
    • Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
    • [33] Villarroya-Beltri, C., et al. Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat. Commun., 4, 2013, 2980.
    • (2013) Nat. Commun. , vol.4 , pp. 2980
    • Villarroya-Beltri, C.1
  • 34
    • 84941931780 scopus 로고    scopus 로고
    • LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b
    • [34] Ti, D.D., et al. LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b. J. Transl. Med., 13, 2015, 14.
    • (2015) J. Transl. Med. , vol.13 , pp. 14
    • Ti, D.D.1
  • 35
    • 84969964600 scopus 로고    scopus 로고
    • Exosome derived from human umbilical cord mesenchymal stem cell mediates MiR-181c attenuating burn-induced excessive inflammation
    • [35] Li, X., et al. Exosome derived from human umbilical cord mesenchymal stem cell mediates MiR-181c attenuating burn-induced excessive inflammation. EBioMedicine 8 (2016), 72–82.
    • (2016) EBioMedicine , vol.8 , pp. 72-82
    • Li, X.1
  • 36
    • 84942296903 scopus 로고    scopus 로고
    • Topology, dynamics, and heterogeneity in immune signaling
    • [36] Webb, J.T., Behar, M., Topology, dynamics, and heterogeneity in immune signaling. Wiley Interdiscip. Rev. Syst. Biol. Med. 7:5 (2015), 285–300.
    • (2015) Wiley Interdiscip. Rev. Syst. Biol. Med. , vol.7 , Issue.5 , pp. 285-300
    • Webb, J.T.1    Behar, M.2
  • 37
    • 84941104852 scopus 로고    scopus 로고
    • Exosomal miR-223 contributes to mesenchymal stem cell-elicited cardioprotection in polymicrobial sepsis
    • [37] Wang, X., et al. Exosomal miR-223 contributes to mesenchymal stem cell-elicited cardioprotection in polymicrobial sepsis. Sci. Rep., 5, 2015, 13721.
    • (2015) Sci. Rep. , vol.5 , pp. 13721
    • Wang, X.1
  • 38
    • 77958495102 scopus 로고    scopus 로고
    • MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development
    • [38] O'Connell, R.M., et al. MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity 33:4 (2010), 607–619.
    • (2010) Immunity , vol.33 , Issue.4 , pp. 607-619
    • O'Connell, R.M.1
  • 39
    • 84923174611 scopus 로고    scopus 로고
    • Sorting it out: regulation of exosome loading
    • [39] Villarroya-Beltri, C., et al. Sorting it out: regulation of exosome loading. Semin. Cancer Biol. 28 (2014), 3–13.
    • (2014) Semin. Cancer Biol. , vol.28 , pp. 3-13
    • Villarroya-Beltri, C.1
  • 40
    • 84876915447 scopus 로고    scopus 로고
    • The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes
    • [40] Perez-Hernandez, D., et al. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. J. Biol. Chem. 288:17 (2013), 11649–11661.
    • (2013) J. Biol. Chem. , vol.288 , Issue.17 , pp. 11649-11661
    • Perez-Hernandez, D.1
  • 41
    • 85006202925 scopus 로고    scopus 로고
    • Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges
    • [41] Ha, D., Yang, N., Nadithe, V., Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges. Acta Pharm. Sin. B 6:4 (2016), 287–296.
    • (2016) Acta Pharm. Sin. B , vol.6 , Issue.4 , pp. 287-296
    • Ha, D.1    Yang, N.2    Nadithe, V.3
  • 42
    • 2442637158 scopus 로고    scopus 로고
    • Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells
    • [42] Miyasaka, K., et al. Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells. Eur. J. Immunol. 34:5 (2004), 1414–1422.
    • (2004) Eur. J. Immunol. , vol.34 , Issue.5 , pp. 1414-1422
    • Miyasaka, K.1
  • 44
    • 84937485520 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the regulation of the MFG-E8 gene promoter activity in physiological and inflammatory conditions
    • [44] Wang, X., et al. Molecular mechanisms underlying the regulation of the MFG-E8 gene promoter activity in physiological and inflammatory conditions. J. Cell. Biochem. 116:9 (2015), 1867–1879.
    • (2015) J. Cell. Biochem. , vol.116 , Issue.9 , pp. 1867-1879
    • Wang, X.1
  • 45
    • 33745587596 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis
    • [45] Miksa, M., et al. Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis. Shock 25:6 (2006), 586–593.
    • (2006) Shock , vol.25 , Issue.6 , pp. 586-593
    • Miksa, M.1
  • 46
    • 84926451271 scopus 로고    scopus 로고
    • Exosomes as drug delivery vehicles for Parkinson's disease therapy
    • [46] Haney, M.J., et al. Exosomes as drug delivery vehicles for Parkinson's disease therapy. J. Control. Release 207 (2015), 18–30.
    • (2015) J. Control. Release , vol.207 , pp. 18-30
    • Haney, M.J.1
  • 47
    • 84879409612 scopus 로고    scopus 로고
    • Exosomes for drug delivery — a novel application for the mesenchymal stem cell
    • [47] Lai, R.C., et al. Exosomes for drug delivery — a novel application for the mesenchymal stem cell. Biotechnol. Adv. 31:5 (2013), 543–551.
    • (2013) Biotechnol. Adv. , vol.31 , Issue.5 , pp. 543-551
    • Lai, R.C.1
  • 48
    • 84937630931 scopus 로고    scopus 로고
    • Cell-derived vesicles for drug therapy and diagnostics: opportunities and challenges
    • [48] Fuhrmann, G., Herrmann, I.K., Stevens, M.M., Cell-derived vesicles for drug therapy and diagnostics: opportunities and challenges. Nano Today 10:3 (2015), 397–409.
    • (2015) Nano Today , vol.10 , Issue.3 , pp. 397-409
    • Fuhrmann, G.1    Herrmann, I.K.2    Stevens, M.M.3
  • 49
    • 78650624101 scopus 로고    scopus 로고
    • RNA interference in the clinic: challenges and future directions
    • [49] Pecot, C.V., et al. RNA interference in the clinic: challenges and future directions. Nat. Rev. Cancer 11:1 (2011), 59–67.
    • (2011) Nat. Rev. Cancer , vol.11 , Issue.1 , pp. 59-67
    • Pecot, C.V.1
  • 50
    • 84856389509 scopus 로고    scopus 로고
    • RNA-based therapeutics: current progress and future prospects
    • [50] Burnett, J.C., Rossi, J.J., RNA-based therapeutics: current progress and future prospects. Chem. Biol. 19:1 (2012), 60–71.
    • (2012) Chem. Biol. , vol.19 , Issue.1 , pp. 60-71
    • Burnett, J.C.1    Rossi, J.J.2
  • 51
    • 84939287430 scopus 로고    scopus 로고
    • Integrated systems for exosome investigation
    • [51] Peterson, M.F., et al. Integrated systems for exosome investigation. Methods 87 (2015), 31–45.
    • (2015) Methods , vol.87 , pp. 31-45
    • Peterson, M.F.1


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