Effects of Metformin on Endocrine and Metabolic Parameters in Patients with Polycystic Ovary Syndrome

Hormone and Metabolic Research

Volumn 49, Issue 2, 2017, Pages 103-108

  Zahra, M ^a   Shah, M ^a   Ali, A ^a,b   Rahim, R ^c  

^a KHYBER MEDICAL UNIVERSITY   (Pakistan)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c LADY READING HOSPITAL   (Pakistan)

Author keywords

diabetes; INSL3; insulin; metformin; polycystic ovary syndrome; visfatin

Indexed keywords

FOLLITROPIN; GLUCOSE; INSULIN; INSULIN LIKE PEPTIDE 3; LUTEINIZING HORMONE; METFORMIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OVARY PEPTIDE HORMONE; UNCLASSIFIED DRUG; HORMONE; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG MECHANISM; ENZYME BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS MODEL ASSESSMENT; HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; OVARY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; BLOOD; DEMOGRAPHY; DRUG EFFECTS; ENDOCRINE SYSTEM; HEMODYNAMICS; METABOLISM; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; POLYCYSTIC OVARY SYNDROME;

DEMOGRAPHY; ENDOCRINE SYSTEM; FEMALE; HEMODYNAMICS; HORMONES; HUMANS; METFORMIN; ORGAN SIZE; OVARY; PLACEBOS; POLYCYSTIC OVARY SYNDROME;

EID: 84994641721     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0042-119041     Document Type: Article

References (42)

1. These authors contributed equally to this work
2. Haqq L McFarlane J Dieberg G Smart N Effect of lifestyle intervention on the reproductive endocrine profile in female with polycystic ovary syndrome: a systematic review and meta-analysis Endocr Connect 2014 3 36 46
3. Ott J Kurz C Nouri K Wirth S Vytiska-Binstorfer E Huber J C Mayerhofer K Pregnancy outcome in female with polycystic ovary syndrome comparing the effects of laparoscopic ovary drilling and clomiphene citrate stimulation in female pre-treated with metformin: a retrospective study Reprod Biol Endocrinol 2010 8 45
4. Jones G L Palep-Singh M Ledger W L Balen A H JenkinsonC Campbell M J Lashen H Do South Asian female with PCOS have poorer health-related quality of life than Caucasian female with PCOS? A comparative cross-sectional study Health Qual Life Outcomes 2010 8 149
5. Tabassum R Imtiaz F Sharafat S Shukar-Ud-Din S Nusrat U Prevalence and clinical profile of insulin resistance in young female of poly cystic ovary syndrome: A study from Pakistan Pak J Med Sci 2013 29 593 596
6. Zhuo Z Wang A Yu H Effect of metformin intervention during pregnancy on the gestational diabetes mellitus in female with polycystic ovary syndrome.a systematic review and meta-analysis J Diabetes Res 2014 381231
7. Norman R J Metformin-comparison with other therapies in ovulation induction in polycystic ovary syndrome J Clin Endocrinol Metab 2004 89 4797 4800
8. Webber L J Stubbs S Stark J Trew G H Margara R Hardy K Franks S Formation and early development of follicles in the polycystic ovary Lancet 2003 362 1017 1021
9. Bhattacharya S M Abnormal glucose tolerance in polycystic ovary syndrome J Obstet Gynaecol Res 2008 34 228 232
10. Pesant M H Baillargeon J P Clinically useful predictors of conversion to abnormal glucose tolerance in female with polycystic ovary syndrome Fertil Steril 2010 95 210 215
11. Teede H J Stuckey B G Polycystic ovary syndrome and abnormal glucose tolerance Med J Aust 2007 187 324
12. Lakkakula B V ThangaveluM Godla U R Genetic variants associated with insulin signaling and glucose homeostasis in the pathogenesis of insulin resistance in polycystic ovary syndrome: a systematic review J Assist Reprod Genet 2013 30 883 895
13. Baptiste C G Battista M C Trottier A Baillargeon J P Insulin and hyperandrogenism in female with polycystic ovary syndrome J Steroid Biochem Mol Biol 2009 122 42 52
14. Bay K Hartung S Ivell R Schumacher M Jurgensen D Jorgensen N Holm M Skakkebaek N E Andersson A M Insulin-like factor 3 serum levels in 135 normal men and 85 men with testicular disorders: relationship to the luteinizing hormone-testosterone axis J Clin Endocrinol Metab 2005 90 3410 3418
15. Gambineri A Patton L De Iasio R Palladoro F Pagotto U Pasquali R Insulin-like factor 3: a new circulating hormone related to luteinizing hormone-dependent ovary hyperandrogenism in the polycystic ovary syndrome J Clin Endocrinol Metab 2007 92 2066 2073
16. Bamberger A M Ivell R Balvers M Kelp B Bamberger C M RiethdorfL Löning T Relaxin-like factor (RLF): a new specific marker for Leydig cells in the ovary Int J Gynecol Pathol 1999 18 163 168
17. Jonard S Robert Y Cortet-Rudelli C Pigny P Decanter C Dewailly D Ultrasound examination of polycystic ovaries: is it worth counting the follicles? Hum Reprod 2003 18 598 603
18. Zimmermann S Schotitler P Engel W Adham I M Mouse leydig insulinlike(Ley I-L) gene:structure and expression during testis and ovary development J Clin Endocrinol Metab 2000 85 139 146
19. Fukuhara A Matsuda M Nishizawa M Segawa K Tanaka M Kishimoto K Matsuki Y Murakami M Ichisaka T Murakami H Watanabe E Takagi T Akiyoshi M Ohtsubo T Kihara S Yamashita S Makishima M Funahashi T Yamanaka S Hiramatsu R Matsuzawa Y Shimomura I Visfatin: a protein secreted by visceral fat that mimics the effects of insulin Science 2005 307 426 430
20. Chen M P Chung F M Chang D M Tsai J C Huang H F Shin S J Lee Y J Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus JClin Endocrinol Metab 2006 91 295 299
21. Yu-Duan T Chao-PingW Chih-Yu C Li-Wen L Tsun-Mei L Chia-Chang H Fu-Mei C Hsien-Chang L Hsia-Fen H Yau-Jiunn L Jer-Yiing H Elevated plasma level of visfatin/pre-b cell colony-enhancing factor in male oral squamous cell carcinoma patients Med Oral Patol Oral Cir Bucal 2012 18 e180 e186
22. Berndt J Kloting N Kralisch S Kovacs P Fasshauer M Schon M R Stumvoll M Blüher M Plasma visfatin concentrations and fat depot-specific mRNA expression in humans Diabetes 2005 54 2911 2916
23. Kumar P Khan K Effects of metformin use in pregnant patients with polycystic ovary syndrome J Hum Reprod Sci 2012 5 166
24. Tang T Lord J M Norman R J Yasmin E Balen A H Insulin-sensitizing drugs (metformin, rosigilatazone, piogilatazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligoamenorrhoea and subfertility Cochrane Database Syst Rev 2009 16 CD003053 10.1002/14651858.CD003053.pub5
25. Adamska A Karczewska-Kupczewska M Nikolajuk A Otziomek E Gorska M Kowalska I Strączkowski M Normal metabolic flexibility despite insulin resistance female with polycystic ovary syndrome Endocr J 2013 60 1107 1113
26. Albu A Radian S Fica S Barbu C G Biochemical hyperandrogenism is associated with metabolic syndrome independently of adiposity and insulin resistance in Romanian polycystic ovary syndrome patients Endocrine 2015 48 696 704
27. Baillargeon J P Carpentier A Role of insulin in the hyperandrogenemia of lean female with polycystic ovary syndrome and normal insulin sensitivity Fertiln Steril 2007 88 886 893
28. Saxena P Prakash A Nigam A Effect of metformin therapy on 2-h post-glucose insulin levels in patients of polycystic ovary syndrome J Hum Reprod Sci 2010 3 139 142
29. Baillargeon J P Jakubowicz D J Iuorno M J Jakubowicz S Nestler J E Effects of metformin and rosiglitazone, alone and in combination, in nonobese female with polycystic ovary syndrome and normal indices of insulin sensitivity Fertil Steril 2004 82 893 902
30. Chou K H von Eye Corleta H Capp E Spritzer P M Clinical, metabolic and endocrine parameters in response to metformin in obese female with polycystic ovary syndrome: a randomized, double-blind and placebo-controlled trial Horm Metab Res 2003 35 86 91
31. Orbetzova M M Kamenov Z A Kolarov G B Orbetzova V T Genchev G D Genov N S Zacharieva S Z Metabolic disturbances in female with polycystic ovary syndrome Folia Medica 2003 45 12 20
32. Ulie L Sharpless M Polycystic ovary syndrome and the metabolic syndrome Clin Diabet 2003 21 154 161
33. Eisenhardt S Schwarzmann N Henschel V Germeyer A von Wolff M Hamann A Strowitzki T Early effects of metformin in female with polycystic ovary syndrome: a prospective J Clin Endocrinol Metab 2006 91 946 952
34. Moghetti P Castello R Negri C Tosi F Perrone F Caputo M Zanolin E Muggeo M Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation J Clin Endocrinol Metab 2000 85 139 146
35. Oner G Muderris I I Clinical, endocrine and metabolic effects of metformin vs N-acetyl-cysteine in women with polycystic ovary syndrome Eur J Obst Gyn Reprod Biol 2011 159 127 131
36. Chan T F Chen Y L Chen H H Lee C H Jong S B Tsai E M Increased plasma visfatin concentrations in female with polycystic ovary syndrome Fertil Steril 2007 88 401 405
37. Tan B K Chen J Digby J E Keay S D Kennedy C R Randeva H S Increased visfatin messenger ribonucleic acid and protein levels in adipose tissue and adipocytes in female with polycystic ovary syndrome: parallel increase in plasma visfatin J Clin Endocrinol Metab 2006 91 5022 5028
38. Karakose M Cakal E Ertan K Delibasi T The metabolic effects of drugs used for the treatment of polycystic ovary syndrome J Turk Ger Gynecol Assoc 2013 14 168 173
39. Kowalska I Straczkowski M Nikolajuk A Adamska A Karczewska-KupczewskaM Otziomek E Wolczynski S Gorska M Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese female with polycystic ovary syndrome Hum Reprod 2007 22 1824 1829
40. Morin-Papunen L C VauhkonenI Koivunen R M Ruokonen A Tapanainen J S Insulin sensitivity, insulin secretion, and metabolic and hormonal parameters in healthy female and female with polycystic ovary syndrome Hum Reprod 2000 15 1266 1274
41. Pelusi C Fanelli F Pariali M Zanotti L Gambineri A Pasquali R Parallel variations of insulin-like peptide 3 (INSL3) and antimullerian hormone (AMH) in female with the polycystic ovary syndrome according to menstrual cycle pattern J Clin Endocrinol Metab 2013 98 E1575 E1582
42. Szydlarska D Grzesiuk W Trybuch A Kondracka A Kowalikl Bar-AndziqK E Insulin like Factor 3-a new hormone related to polycystic ovary syndrome? Endokrynol Pol 2012 63 356 361