Insulin-like factor 3 - A new hormone related to polycystic ovary syndrome?

Endokrynologia Polska

Volumn 63, Issue 5, 2012, Pages 356-361

  Szydlarska, Dorota ^a,b   Grzesiuk, Wiesław ^b   Trybuch, Agnieszka ^c   Kondracka, Agnieszka ^b   Kowalik, Ilona ^c   Bar Andziak, Ewa ^b  

^a CENTRAL CLINICAL HOSPITAL OF THE MINISTRY OF INTERIOR   (Poland)

^b MEDICAL UNIVERSITY OF WARSAW   (Poland)

^c INSTITUTE OF CARDIOLOGY   (Poland)

Author keywords

Hyperandrogenism; Insulin like factor 3; Luteinising hormone; Polycystic ovary syndrome

Indexed keywords

ANDROSTENEDIONE; FOLLITROPIN; GLUCOSE; HORMONE; INSULIN; INSULIN LIKE FACTOR 3; LUTEINIZING HORMONE; PRASTERONE SULFATE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; OBESITY; OVARY POLYCYSTIC DISEASE; TESTOSTERONE BLOOD LEVEL; WAIST HIP RATIO;

ADULT; ANDROSTENEDIONE; BODY MASS INDEX; BODY WEIGHT; CASE-CONTROL STUDIES; FEMALE; HUMANS; INSULIN; LUTEINIZING HORMONE; POLYCYSTIC OVARY SYNDROME; PROTEINS; STATISTICS AS TOPIC; TESTOSTERONE; YOUNG ADULT;

EID: 84870883777     PISSN: 0423104X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Bay K, Andersson AM. Human testicular insulin-like factor 3: in relation to development, reproductive hormones and andrological disorders. Int J Androl 2011; 34: 97-109.
2. Gambineri A, Patton L, De Iasio R et al. Insulin-like factor 3: a new circulating hormone related to luteinizing hormone-dependent ovarian hyperandrogenism in the polycystic ovary syndrome. J Clin Endocrinol Metab 2007; 92: 2066-2073. (Pubitemid 46997102)
3. Nef S, Parada LF. Cryptorchidism in mice mutant for Insl3. Nat Genet 1999; 2: 295-299. (Pubitemid 29297259)
4. Zimmermann S, Schottler P, Engel W et al. Mouse Leydig insulinlike (Ley I-L) gene: structure and expression during testis and ovary development. Mol Reprod Dev 1997; 47: 30-38. (Pubitemid 27173047)
5. Kawamura K, Kumagai J, Sudo S et al. Paracrine regulation of mammalian oocyte maturation and male germ cell survival. Proc Natl Acad Sci USA 2004; 101: 7323-7328. (Pubitemid 38638031)
6. Foresta C, Bettella A, Vinanzi C et al. Insulin-like factor 3: a novel circulating hormone of testis origin in humans. J Clin Endocrinol Metab 2004; 89: 5952-5958. (Pubitemid 39628399)
7. Mehrabian F, Khani B, Kelishadi R et al. The prevalence of polycystic ovary syndrome in Iranian women based on different diagnostic criteria. Endokrynol Pol 2011; 62: 238-242.
8. Lenarcik A, Bidzińska-Speichert B, Tworowska-Bardzińska U et al. Hormonal abnormalities in first-degree relatives of women with polycystic ovary syndrome (PCOS). Endokrynol Pol 2011; 62: 129-133.
9. Ehrmann DA, Barnes RB, Rosenfield RL. Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endocr Rev 1995; 16: 322-353.
10. Jonard S, Robert Y, Cortet-Rudelli C et al. Ultrasound examination of polycystic ovaries: is it worth counting the follicles? Hum Reprod 2003; 8: 598-603. (Pubitemid 36329332)
11. Taylor AE, McCourt B, Martin KA et al. Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome. J Clin Endocrinol Metab 1997; 82: 2248-2256. (Pubitemid 27287593)
12. Szydlarska D, Grzesiuk W, Bar-Andziak E. Evolution of polycystic ovary syndromes. Gin Pol Med Project 2010; 4: 63-68.
13. Foltyn W, Strzelczyk J, Marek B et al. Selected markers of endothelial dysfunction in women with polycystic ovary syndrome. Endokrynol Pol 2011; 62: 243-248.
14. Bałdys-Waligórska A, Krzentowska-Korek A, Gołkowski F et al. The predictive value of the IGF-1 level in acromegaly patients treated by surgery and a somatostatin analogue. Endokrynol Pol 2011; 62: 401-408.
15. Azziz R, Carmina, E, Dewailly D et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril 2009; 91: 456-488.
16. European Society of Hypertension Working Group on Blood Pressure Monitoring. European Society of Hypertension recommendations for conventional, ambulatory and home blood pressure measurement. J Hypertens 2003; 21: 821-848.
17. Matthews DR, Hosker JP, Rudenski AS et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419. (Pubitemid 15018832)
18. Gooren LJ. Late-onset hypogonadism. Front Horm Res 2009; 37: 62-73.
19. Wang C, Nieschlag E, Swerdloff R et al. Investigation, treatment and monitoring of late-onset hypogonadism in males. Int J Androl 2008; 32: 1-10.
20. Anand-Ivell R, Ivell R, Driscoll DA et al. INSL3 levels in amniotic fluid from human male fetuses. Hum Reprod 2008; 23: 1180-1186. (Pubitemid 351757313)
21. Gambineri A, Pelusi C, Vicennati V et al. Obesity and the polycystic ovary syndrome. Int J Obes Relat Metab Disord 2002; 26: 883-896. (Pubitemid 34756169)
22. La Zovic G, Radivojevic U, Milicevi S et al. Influence of adiposity on leptin, LH and androgen level in lean, overweight and obese PCOS patients. Int J Fertil Womens Med 2007; 52: 82-88.
23. Lewandowski KC, Cajdler-Łuba A, Salata I et al. The utility of the gonadotrophin releasing hormone (GnRH) test in the diagnosis of polycystic ovary syndrome (PCOS). Endokrynol Pol 2011; 62: 120-128.
24. Poretsky L, Cataldo NA, Rosenwaks Z et al. The insulin-related ovarian regulatory system in health and disease. Endocr Rev 1999; 20: 535-582. (Pubitemid 30647079)
25. Ehrmann DA. Polycystic ovary syndrome. N Engl J Med 2005; 352: 1223-1236.
26. Bamberger AM, Ivell R, Balvers M et al. Relaxin-like factor (RLF), a novel member of the insulin-IGF-relaxin family, is a new specific marker for hilus Leydig cells in the human ovary. Int J Gynecol Pathol 1999; 18: 163-168. (Pubitemid 29153284)
27. Balvers M, Spiess AN, Domagalski R et al. Relaxin-like factor expression as a marker of differentiation in the mouse testis and ovary. Endocrinology 1998; 139: 2960-2970. (Pubitemid 28512409)
28. Anand-Ivel R, Hiendleder S, Viñoles C et al. INSL3 in the ruminant: a powerful indicator of gender- and genetic-specific feto-maternal dialogue. PLoS One 2011; 6: e19821.
29. Irving-Rodgers HF, Bathgate RAD, Ivell R et al. Dynamic changes in the expression of relaxin-like factor (Insl3), cholesterol side-chain cleavage cytochrome P450, and 3β-hydroxysteroid dehydrogenase in bovine ovarian follicles during growth and atresia. Biol Reprod 2002; 66: 934-943. (Pubitemid 34263112)
30. Zarreh-Hoshyari-Khah MR, Einspanier A, Ivell R. Differential splicing and expression of the relaxin-like factor gene in reproductive tissues of the marmoset monkey (Callithrix Jacchus). Biol Reprod 1999; 60: 445-453. (Pubitemid 29063888)