Defective branched chain amino acid catabolism contributes to cardiac dysfunction and remodeling following myocardial infarction

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 311, Issue 5, 2016, Pages H1160-H1169

  Wang, Wei ^a   Zhang, Fuyang ^a   Xia, Yunlong ^a   Zhao, Shihao ^a   Yan, Wenjun ^a   Wang, Helin ^a   Lee, Yan ^a   Li, Congye ^a   Zhang, Ling ^a   Lian, Kun ^a   Gao, Erhe ^b   Cheng, Hexiang ^a   Tao, Ling ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Branched chain amino acids; Heart failure; Mammalian target of rapamycin; Myocardial infarction; Remodelling

Indexed keywords

2 OXOISOVALERATE DEHYDROGENASE (LIPOAMIDE); 3,6 DICHLOROBENZO(BETA)THIOPHENE 2 CARBOXYLIC ACID; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; BRANCHED CHAIN AMINO ACID; BRANCHED CHAIN KETOACID DEHYDROGENASE KINASE; COLLAGEN TYPE 1; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN; MYOSIN HEAVY CHAIN BETA; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN; PROTEIN PP2CM; RAPAMYCIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; (3-METHYL-2-OXOBUTANOATE DEHYDROGENASE (LIPOAMIDE)) KINASE; FATTY ACID; GLUCOSE; MTOR PROTEIN, MOUSE; PPM1A PROTEIN, HUMAN; PROTEIN KINASE; PROTEIN PHOSPHATASE 2C; TARGET OF RAPAMYCIN KINASE;

ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIAC REMODELING; CARDITIS; CATABOLISM; CONTROLLED STUDY; CORONARY ARTERY LIGATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROSING ALVEOLITIS; GENE EXPRESSION; HEART DISEASE; HEART FAILURE; HEART INFARCTION; LIVER; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE; ANIMAL; CARDIAC MUSCLE; COMPLICATION; CORONARY BLOOD VESSEL; ECHOCARDIOGRAPHY; HEART LEFT VENTRICLE FUNCTION; HEART VENTRICLE REMODELING; LIGATION; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SURGERY; TUNEL ASSAY; WESTERN BLOTTING;

3-METHYL-2-OXOBUTANOATE DEHYDROGENASE (LIPOAMIDE); AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; BLOTTING, WESTERN; CORONARY VESSELS; ECHOCARDIOGRAPHY; FATTY ACIDS; GLUCOSE; HEART FAILURE; IN SITU NICK-END LABELING; LIGATION; MALE; MICE; MYOCARDIAL INFARCTION; MYOCARDIUM; NATRIURETIC PEPTIDE, BRAIN; PROTEIN KINASES; PROTEIN PHOSPHATASE 2C; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84994593466     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00114.2016     Document Type: Article

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